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Protein

Zinc finger protein 577

Gene

ZNF577

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161551-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 577
Gene namesi
Name:ZNF577
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28673. ZNF577.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84765.
OpenTargetsiENSG00000161551.
ENSG00000283617.
PharmGKBiPA134942499.

Polymorphism and mutation databases

BioMutaiZNF577.
DMDMi294862491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345901 – 485Zinc finger protein 577Add BLAST485

Proteomic databases

PaxDbiQ9BSK1.
PeptideAtlasiQ9BSK1.
PRIDEiQ9BSK1.

PTM databases

iPTMnetiQ9BSK1.
PhosphoSitePlusiQ9BSK1.

Expressioni

Gene expression databases

BgeeiENSG00000161551.
CleanExiHS_ZNF577.
ExpressionAtlasiQ9BSK1. baseline and differential.
GenevisibleiQ9BSK1. HS.

Organism-specific databases

HPAiHPA041499.
HPA046761.

Interactioni

Protein-protein interaction databases

BioGridi124246. 1 interactor.
STRINGi9606.ENSP00000301399.

Structurei

3D structure databases

ProteinModelPortaliQ9BSK1.
SMRiQ9BSK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133760.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BSK1.
KOiK09228.
OMAiTFMRKIQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BSK1.
TreeFamiTF337922.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE
60 70 80 90 100
VMLENYINLV SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS
110 120 130 140 150
RRYAGKDSDA FGGYGRSCLH IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK
160 170 180 190 200
ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE RGEKPHGCGE CGKTFMRKIQ
210 220 230 240 250
LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK PYRCSKCGKA
260 270 280 290 300
FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
310 320 330 340 350
SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG
360 370 380 390 400
ERPYSCRECG KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM
410 420 430 440 450
SELIQEQKTV NTVPIEMPSS GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF
460 470 480
VVNQEFEQRI SLTNEVNVAP SVINYILYLT DIVSE
Length:485
Mass (Da):54,939
Last modified:April 20, 2010 - v3
Checksum:iF2DB53CD82CBF8D5
GO
Isoform 2 (identifier: Q9BSK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-153: Missing.

Show »
Length:426
Mass (Da):48,370
Checksum:iBB27DA1025B4C8D7
GO

Sequence cautioni

The sequence AAH04992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF82168 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW72049 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50E → G in BAF84501 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05513984A → V.1 PublicationCorresponds to variant rs17856123dbSNPEnsembl.1
Natural variantiVAR_055140123R → C.1 PublicationCorresponds to variant rs17849895dbSNPEnsembl.1
Natural variantiVAR_055141234R → K.Corresponds to variant rs9807847dbSNPEnsembl.1
Natural variantiVAR_055142246K → E.1 PublicationCorresponds to variant rs2288868dbSNPEnsembl.1
Natural variantiVAR_055143346R → C.Corresponds to variant rs9807842dbSNPEnsembl.1
Natural variantiVAR_033577357R → S.Corresponds to variant rs9807853dbSNPEnsembl.1
Natural variantiVAR_055144373E → K.Corresponds to variant rs10407547dbSNPEnsembl.1
Natural variantiVAR_055145375T → I.Corresponds to variant rs10407911dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04081095 – 153Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289479 mRNA. Translation: BAF82168.1. Different initiation.
AK291812 mRNA. Translation: BAF84501.1.
AC006272 Genomic DNA. No translation available.
AC011460 Genomic DNA. No translation available.
AC074141 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72049.1. Sequence problems.
BC004992 mRNA. Translation: AAH04992.1. Different initiation.
CCDSiCCDS12842.2. [Q9BSK1-1]
CCDS46160.1. [Q9BSK1-2]
RefSeqiNP_001129062.1. NM_001135590.1. [Q9BSK1-2]
NP_116068.2. NM_032679.2. [Q9BSK1-1]
XP_006723495.1. XM_006723432.3. [Q9BSK1-1]
XP_006723496.1. XM_006723433.2. [Q9BSK1-1]
XP_011525710.1. XM_011527408.2. [Q9BSK1-1]
XP_016882876.1. XM_017027387.1. [Q9BSK1-2]
UniGeneiHs.723015.
Hs.729135.

Genome annotation databases

EnsembliENST00000301399; ENSP00000301399; ENSG00000161551. [Q9BSK1-1]
GeneIDi84765.
KEGGihsa:84765.
UCSCiuc002pxx.6. human. [Q9BSK1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289479 mRNA. Translation: BAF82168.1. Different initiation.
AK291812 mRNA. Translation: BAF84501.1.
AC006272 Genomic DNA. No translation available.
AC011460 Genomic DNA. No translation available.
AC074141 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72049.1. Sequence problems.
BC004992 mRNA. Translation: AAH04992.1. Different initiation.
CCDSiCCDS12842.2. [Q9BSK1-1]
CCDS46160.1. [Q9BSK1-2]
RefSeqiNP_001129062.1. NM_001135590.1. [Q9BSK1-2]
NP_116068.2. NM_032679.2. [Q9BSK1-1]
XP_006723495.1. XM_006723432.3. [Q9BSK1-1]
XP_006723496.1. XM_006723433.2. [Q9BSK1-1]
XP_011525710.1. XM_011527408.2. [Q9BSK1-1]
XP_016882876.1. XM_017027387.1. [Q9BSK1-2]
UniGeneiHs.723015.
Hs.729135.

3D structure databases

ProteinModelPortaliQ9BSK1.
SMRiQ9BSK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124246. 1 interactor.
STRINGi9606.ENSP00000301399.

PTM databases

iPTMnetiQ9BSK1.
PhosphoSitePlusiQ9BSK1.

Polymorphism and mutation databases

BioMutaiZNF577.
DMDMi294862491.

Proteomic databases

PaxDbiQ9BSK1.
PeptideAtlasiQ9BSK1.
PRIDEiQ9BSK1.

Protocols and materials databases

DNASUi84765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301399; ENSP00000301399; ENSG00000161551. [Q9BSK1-1]
GeneIDi84765.
KEGGihsa:84765.
UCSCiuc002pxx.6. human. [Q9BSK1-1]

Organism-specific databases

CTDi84765.
DisGeNETi84765.
GeneCardsiZNF577.
HGNCiHGNC:28673. ZNF577.
HPAiHPA041499.
HPA046761.
neXtProtiNX_Q9BSK1.
OpenTargetsiENSG00000161551.
ENSG00000283617.
PharmGKBiPA134942499.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133760.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BSK1.
KOiK09228.
OMAiTFMRKIQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BSK1.
TreeFamiTF337922.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161551-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF577. human.
GenomeRNAii84765.
PROiQ9BSK1.

Gene expression databases

BgeeiENSG00000161551.
CleanExiHS_ZNF577.
ExpressionAtlasiQ9BSK1. baseline and differential.
GenevisibleiQ9BSK1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN577_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK1
Secondary accession number(s): A8K0B4, A8K6Z7, C9JFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.