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Protein

Zinc finger protein 577

Gene

ZNF577

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 577
Gene namesi
Name:ZNF577
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161551.12
HGNCiHGNC:28673 ZNF577
neXtProtiNX_Q9BSK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84765
OpenTargetsiENSG00000161551
PharmGKBiPA134942499

Polymorphism and mutation databases

BioMutaiZNF577
DMDMi294862491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345901 – 485Zinc finger protein 577Add BLAST485

Proteomic databases

PaxDbiQ9BSK1
PeptideAtlasiQ9BSK1
PRIDEiQ9BSK1

PTM databases

iPTMnetiQ9BSK1
PhosphoSitePlusiQ9BSK1

Expressioni

Gene expression databases

BgeeiENSG00000161551
CleanExiHS_ZNF577
ExpressionAtlasiQ9BSK1 baseline and differential
GenevisibleiQ9BSK1 HS

Organism-specific databases

HPAiHPA041499
HPA046761

Interactioni

Protein-protein interaction databases

BioGridi1242465 interactors.
STRINGi9606.ENSP00000301399

Structurei

3D structure databases

ProteinModelPortaliQ9BSK1
SMRiQ9BSK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133760
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BSK1
KOiK09228
OMAiAFAHMSV
OrthoDBiEOG091G02KC
PhylomeDBiQ9BSK1
TreeFamiTF337922

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE
60 70 80 90 100
VMLENYINLV SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS
110 120 130 140 150
RRYAGKDSDA FGGYGRSCLH IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK
160 170 180 190 200
ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE RGEKPHGCGE CGKTFMRKIQ
210 220 230 240 250
LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK PYRCSKCGKA
260 270 280 290 300
FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
310 320 330 340 350
SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG
360 370 380 390 400
ERPYSCRECG KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM
410 420 430 440 450
SELIQEQKTV NTVPIEMPSS GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF
460 470 480
VVNQEFEQRI SLTNEVNVAP SVINYILYLT DIVSE
Length:485
Mass (Da):54,939
Last modified:April 20, 2010 - v3
Checksum:iF2DB53CD82CBF8D5
GO
Isoform 2 (identifier: Q9BSK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-153: Missing.

Show »
Length:426
Mass (Da):48,370
Checksum:iBB27DA1025B4C8D7
GO

Sequence cautioni

The sequence AAH04992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF82168 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW72049 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50E → G in BAF84501 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05513984A → V1 PublicationCorresponds to variant dbSNP:rs17856123Ensembl.1
Natural variantiVAR_055140123R → C1 PublicationCorresponds to variant dbSNP:rs17849895Ensembl.1
Natural variantiVAR_055141234R → K. Corresponds to variant dbSNP:rs9807847Ensembl.1
Natural variantiVAR_055142246K → E1 PublicationCorresponds to variant dbSNP:rs2288868Ensembl.1
Natural variantiVAR_055143346R → C. Corresponds to variant dbSNP:rs9807842Ensembl.1
Natural variantiVAR_033577357R → S. Corresponds to variant dbSNP:rs9807853Ensembl.1
Natural variantiVAR_055144373E → K. Corresponds to variant dbSNP:rs10407547Ensembl.1
Natural variantiVAR_055145375T → I. Corresponds to variant dbSNP:rs10407911Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04081095 – 153Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289479 mRNA Translation: BAF82168.1 Different initiation.
AK291812 mRNA Translation: BAF84501.1
AC006272 Genomic DNA No translation available.
AC011460 Genomic DNA No translation available.
AC074141 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72049.1 Sequence problems.
BC004992 mRNA Translation: AAH04992.1 Different initiation.
CCDSiCCDS12842.2 [Q9BSK1-1]
CCDS46160.1 [Q9BSK1-2]
RefSeqiNP_001129062.1, NM_001135590.1 [Q9BSK1-2]
NP_116068.2, NM_032679.2 [Q9BSK1-1]
XP_006723495.1, XM_006723432.3 [Q9BSK1-1]
XP_006723496.1, XM_006723433.2 [Q9BSK1-1]
XP_011525710.1, XM_011527408.2 [Q9BSK1-1]
XP_016882876.1, XM_017027387.1 [Q9BSK1-2]
UniGeneiHs.723015
Hs.729135

Genome annotation databases

EnsembliENST00000301399; ENSP00000301399; ENSG00000161551 [Q9BSK1-1]
ENST00000451628; ENSP00000389652; ENSG00000161551 [Q9BSK1-2]
ENST00000639636; ENSP00000491349; ENSG00000161551 [Q9BSK1-2]
GeneIDi84765
KEGGihsa:84765
UCSCiuc002pxx.6 human [Q9BSK1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN577_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK1
Secondary accession number(s): A8K0B4, A8K6Z7, C9JFB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 20, 2010
Last modified: February 28, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome