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Protein

MARVEL domain-containing protein 1

Gene

MARVELD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 1
Gene namesi
Name:MARVELD1
Synonyms:MRVLDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28674. MARVELD1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cytoplasmcytoskeleton By similarity
  • Nucleus 1 Publication

  • Note: Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 599ExtracellularSequence analysis
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9414CytoplasmicSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Topological domaini116 – 13823ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 17314CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937190.

Polymorphism and mutation databases

BioMutaiMARVELD1.
DMDMi74752303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173MARVEL domain-containing protein 1PRO_0000271522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9BSK0.
PeptideAtlasiQ9BSK0.
PRIDEiQ9BSK0.

PTM databases

iPTMnetiQ9BSK0.
PhosphoSiteiQ9BSK0.
SwissPalmiQ9BSK0.

Expressioni

Tissue specificityi

Widely expressed in normal tissues. Down-regulated in multiple primary tumors.1 Publication

Gene expression databases

BgeeiENSG00000155254.
CleanExiHS_MARVELD1.
GenevisibleiQ9BSK0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000441365.

Structurei

3D structure databases

ProteinModelPortaliQ9BSK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 166141MARVELPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Pro

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000049375.
HOVERGENiHBG081949.
InParanoidiQ9BSK0.
OMAiALYGCCR.
OrthoDBiEOG091G11L9.
PhylomeDBiQ9BSK0.
TreeFamiTF316174.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPPPRQPP PQARAARGAV RLQRPFLRSP LGVLRLLQLL AGAAFWITIA
60 70 80 90 100
TSKYQGPVHF ALFVSVLFWL LTLGLYFLTL LGKHELVPVL GSRWLMVNVA
110 120 130 140 150
HDVLAAALYG AATGIMSDQM QRHSYCNLKD YPLPCAYHAF LAAAVCGGVC
160 170
HGLYLLSALY GCGRRCQGKQ EVA
Length:173
Mass (Da):18,914
Last modified:June 1, 2001 - v1
Checksum:iD39B3DBF06EB32EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355315 Genomic DNA. No translation available.
BC004995 mRNA. No translation available.
BC062544 mRNA. No translation available.
RefSeqiNP_113672.1. NM_031484.3.
UniGeneiHs.744073.

Genome annotation databases

EnsembliENST00000285605; ENSP00000441365; ENSG00000155254.
GeneIDi83742.
KEGGihsa:83742.
UCSCiuc001koj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355315 Genomic DNA. No translation available.
BC004995 mRNA. No translation available.
BC062544 mRNA. No translation available.
RefSeqiNP_113672.1. NM_031484.3.
UniGeneiHs.744073.

3D structure databases

ProteinModelPortaliQ9BSK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000441365.

PTM databases

iPTMnetiQ9BSK0.
PhosphoSiteiQ9BSK0.
SwissPalmiQ9BSK0.

Polymorphism and mutation databases

BioMutaiMARVELD1.
DMDMi74752303.

Proteomic databases

PaxDbiQ9BSK0.
PeptideAtlasiQ9BSK0.
PRIDEiQ9BSK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285605; ENSP00000441365; ENSG00000155254.
GeneIDi83742.
KEGGihsa:83742.
UCSCiuc001koj.5. human.

Organism-specific databases

CTDi83742.
GeneCardsiMARVELD1.
HGNCiHGNC:28674. MARVELD1.
neXtProtiNX_Q9BSK0.
PharmGKBiPA134937190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000049375.
HOVERGENiHBG081949.
InParanoidiQ9BSK0.
OMAiALYGCCR.
OrthoDBiEOG091G11L9.
PhylomeDBiQ9BSK0.
TreeFamiTF316174.

Miscellaneous databases

GenomeRNAii83742.
PROiQ9BSK0.

Gene expression databases

BgeeiENSG00000155254.
CleanExiHS_MARVELD1.
GenevisibleiQ9BSK0. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney bladder and liver. The reduced expression is owing to DNA methylation and could be reversed by pharmacologic demethylation (PubMed:19364627).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.