Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9BSJ5

- CQ080_HUMAN

UniProt

Q9BSJ5 - CQ080_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Uncharacterized protein C17orf80

Gene

C17orf80

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C17orf80
Alternative name(s):
Cell migration-inducing gene 3 protein
Human lung cancer oncogene 8 protein
Short name:
HLC-8
Gene namesi
ORF Names:HLC8, MIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29601. C17orf80.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 552552ExtracellularSequence AnalysisAdd
BLAST
Transmembranei553 – 57321HelicalSequence AnalysisAdd
BLAST
Topological domaini574 – 60936CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Uncharacterized protein C17orf80PRO_0000284612Add
BLAST

Proteomic databases

MaxQBiQ9BSJ5.
PaxDbiQ9BSJ5.
PRIDEiQ9BSJ5.

PTM databases

PhosphoSiteiQ9BSJ5.

Expressioni

Gene expression databases

BgeeiQ9BSJ5.
CleanExiHS_C17orf80.
ExpressionAtlasiQ9BSJ5. baseline and differential.
GenevestigatoriQ9BSJ5.

Organism-specific databases

HPAiHPA012896.

Interactioni

Protein-protein interaction databases

BioGridi120358. 4 interactions.
IntActiQ9BSJ5. 1 interaction.
STRINGi9606.ENSP00000351937.

Structurei

3D structure databases

ProteinModelPortaliQ9BSJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38808.
GeneTreeiENSGT00510000049019.
HOVERGENiHBG057035.
InParanoidiQ9BSJ5.
OMAiTMLFTGY.
OrthoDBiEOG7D2FDW.
PhylomeDBiQ9BSJ5.
TreeFamiTF324369.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BSJ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP
60 70 80 90 100
RAKKMKGPIK DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL
110 120 130 140 150
ERAATTKADK DIKNPIQPSF KMLKNTKPMT TFQEETKAQF YASEKTSPKR
160 170 180 190 200
ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP SLSNQDRKYS STLPNDVQTT
210 220 230 240 250
SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK RVRTLLSNER
260 270 280 290 300
DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL
310 320 330 340 350
TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER
360 370 380 390 400
PHLSLFIPRE TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV
410 420 430 440 450
KALMESPEGQ LSLEPKSDSQ FQASHTGCQS PLCSAQRHTP QSPFTNHAAA
460 470 480 490 500
AGRKTLRSCM GLEWFPELYP GYLGLGVLPG KPQCWNAMTQ KPQLISPQGE
510 520 530 540 550
RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK GWIRCNTTIR
560 570 580 590 600
KSGFGGITML FTGYFVLCCS WSFRRLKKLC RPLPWKSTVP PCIGVAKTTG

DCRSKTCLD
Length:609
Mass (Da):67,315
Last modified:January 11, 2011 - v2
Checksum:i2579A2A739C10A43
GO
Isoform 2 (identifier: Q9BSJ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-540: Missing.

Show »
Length:573
Mass (Da):63,423
Checksum:i3E1F7C5F2CC73F1E
GO
Isoform 3 (identifier: Q9BSJ5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-583: KLCRPL → LQRWRK
     584-609: Missing.

Show »
Length:583
Mass (Da):64,726
Checksum:i104961298AAB38DE
GO

Sequence cautioni

The sequence AAP72185.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91344.1 differs from that shown. Reason: Frameshift at position 121. Curated
The sequence BAB15680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331P → S in CAB66674. (PubMed:11230166)Curated
Sequence conflicti484 – 4841C → R in BAB15680. (PubMed:16625196)Curated
Sequence conflicti536 – 5361G → R in BAA91344. (PubMed:16625196)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261G → S.
Corresponds to variant rs9902726 [ dbSNP | Ensembl ].
VAR_031779
Natural varianti322 – 3221K → Q.
Corresponds to variant rs34784472 [ dbSNP | Ensembl ].
VAR_031780
Natural varianti356 – 3561F → L.1 Publication
Corresponds to variant rs745143 [ dbSNP | Ensembl ].
VAR_031781
Natural varianti395 – 3951H → N.5 Publications
Corresponds to variant rs904384 [ dbSNP | Ensembl ].
VAR_031782
Natural varianti396 – 3961C → R.1 Publication
Corresponds to variant rs904383 [ dbSNP | Ensembl ].
VAR_031783
Natural varianti420 – 4201Q → H.2 Publications
Corresponds to variant rs745142 [ dbSNP | Ensembl ].
VAR_031784
Natural varianti522 – 5221A → T.2 Publications
Corresponds to variant rs1566286 [ dbSNP | Ensembl ].
VAR_031785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei505 – 54036Missing in isoform 2. 3 PublicationsVSP_024572Add
BLAST
Alternative sequencei578 – 5836KLCRPL → LQRWRK in isoform 3. 1 PublicationVSP_024573
Alternative sequencei584 – 60926Missing in isoform 3. 1 PublicationVSP_024574Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163812 mRNA. Translation: AAO25513.1.
AY239293 mRNA. Translation: AAP72185.1. Different initiation.
AL136740 mRNA. Translation: CAB66674.1.
AK000728 mRNA. Translation: BAA91344.1. Frameshift.
AK027166 mRNA. Translation: BAB15680.1. Different initiation.
AK292838 mRNA. Translation: BAF85527.1.
AC087301 Genomic DNA. No translation available.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89118.1.
BC005005 mRNA. Translation: AAH05005.1.
CCDSiCCDS11694.1. [Q9BSJ5-1]
CCDS42377.1. [Q9BSJ5-2]
CCDS45767.1. [Q9BSJ5-3]
RefSeqiNP_001094091.1. NM_001100621.2.
NP_001094092.1. NM_001100622.2.
NP_001275699.1. NM_001288770.1.
NP_001275700.1. NM_001288771.1.
NP_060411.2. NM_017941.5.
XP_005257544.1. XM_005257487.2. [Q9BSJ5-1]
UniGeneiHs.12929.

Genome annotation databases

EnsembliENST00000268942; ENSP00000268942; ENSG00000141219. [Q9BSJ5-2]
ENST00000359042; ENSP00000351937; ENSG00000141219. [Q9BSJ5-1]
ENST00000426147; ENSP00000396970; ENSG00000141219. [Q9BSJ5-3]
ENST00000535032; ENSP00000440551; ENSG00000141219. [Q9BSJ5-1]
ENST00000577615; ENSP00000464132; ENSG00000141219. [Q9BSJ5-2]
GeneIDi55028.
KEGGihsa:55028.
UCSCiuc002jjk.1. human. [Q9BSJ5-3]
uc002jjl.4. human. [Q9BSJ5-2]
uc002jjm.4. human. [Q9BSJ5-1]

Polymorphism databases

DMDMi317373351.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163812 mRNA. Translation: AAO25513.1 .
AY239293 mRNA. Translation: AAP72185.1 . Different initiation.
AL136740 mRNA. Translation: CAB66674.1 .
AK000728 mRNA. Translation: BAA91344.1 . Frameshift.
AK027166 mRNA. Translation: BAB15680.1 . Different initiation.
AK292838 mRNA. Translation: BAF85527.1 .
AC087301 Genomic DNA. No translation available.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89118.1 .
BC005005 mRNA. Translation: AAH05005.1 .
CCDSi CCDS11694.1. [Q9BSJ5-1 ]
CCDS42377.1. [Q9BSJ5-2 ]
CCDS45767.1. [Q9BSJ5-3 ]
RefSeqi NP_001094091.1. NM_001100621.2.
NP_001094092.1. NM_001100622.2.
NP_001275699.1. NM_001288770.1.
NP_001275700.1. NM_001288771.1.
NP_060411.2. NM_017941.5.
XP_005257544.1. XM_005257487.2. [Q9BSJ5-1 ]
UniGenei Hs.12929.

3D structure databases

ProteinModelPortali Q9BSJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120358. 4 interactions.
IntActi Q9BSJ5. 1 interaction.
STRINGi 9606.ENSP00000351937.

PTM databases

PhosphoSitei Q9BSJ5.

Polymorphism databases

DMDMi 317373351.

Proteomic databases

MaxQBi Q9BSJ5.
PaxDbi Q9BSJ5.
PRIDEi Q9BSJ5.

Protocols and materials databases

DNASUi 55028.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268942 ; ENSP00000268942 ; ENSG00000141219 . [Q9BSJ5-2 ]
ENST00000359042 ; ENSP00000351937 ; ENSG00000141219 . [Q9BSJ5-1 ]
ENST00000426147 ; ENSP00000396970 ; ENSG00000141219 . [Q9BSJ5-3 ]
ENST00000535032 ; ENSP00000440551 ; ENSG00000141219 . [Q9BSJ5-1 ]
ENST00000577615 ; ENSP00000464132 ; ENSG00000141219 . [Q9BSJ5-2 ]
GeneIDi 55028.
KEGGi hsa:55028.
UCSCi uc002jjk.1. human. [Q9BSJ5-3 ]
uc002jjl.4. human. [Q9BSJ5-2 ]
uc002jjm.4. human. [Q9BSJ5-1 ]

Organism-specific databases

CTDi 55028.
GeneCardsi GC17P071228.
HGNCi HGNC:29601. C17orf80.
HPAi HPA012896.
neXtProti NX_Q9BSJ5.
PharmGKBi PA143485404.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38808.
GeneTreei ENSGT00510000049019.
HOVERGENi HBG057035.
InParanoidi Q9BSJ5.
OMAi TMLFTGY.
OrthoDBi EOG7D2FDW.
PhylomeDBi Q9BSJ5.
TreeFami TF324369.

Miscellaneous databases

ChiTaRSi C17orf80. human.
GenomeRNAii 55028.
NextBioi 58435.

Gene expression databases

Bgeei Q9BSJ5.
CleanExi HS_C17orf80.
ExpressionAtlasi Q9BSJ5. baseline and differential.
Genevestigatori Q9BSJ5.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Identification of a new human cancer-related gene (HLC-8)."
    Kim J.W.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-609 (ISOFORM 1), VARIANTS LEU-356; ASN-395; ARG-396; HIS-420 AND THR-522.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-395.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-395; HIS-420 AND THR-522.
    Tissue: Lung and Trachea.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-395.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-395.
    Tissue: Kidney.

Entry informationi

Entry nameiCQ080_HUMAN
AccessioniPrimary (citable) accession number: Q9BSJ5
Secondary accession number(s): A8K9X3
, Q5JB45, Q6YAU3, Q9H0L9, Q9H5E6, Q9NWN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3