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Protein

Uncharacterized protein C17orf80

Gene

C17orf80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C17orf80
Alternative name(s):
Cell migration-inducing gene 3 protein
Human lung cancer oncogene 8 protein
Short name:
HLC-8
Gene namesi
ORF Names:HLC8, MIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29601. C17orf80.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 552ExtracellularSequence analysisAdd BLAST552
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21
Topological domaini574 – 609CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55028.
OpenTargetsiENSG00000141219.
PharmGKBiPA143485404.

Polymorphism and mutation databases

BioMutaiC17orf80.
DMDMi317373351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846121 – 609Uncharacterized protein C17orf80Add BLAST609

Proteomic databases

EPDiQ9BSJ5.
MaxQBiQ9BSJ5.
PaxDbiQ9BSJ5.
PeptideAtlasiQ9BSJ5.
PRIDEiQ9BSJ5.

PTM databases

iPTMnetiQ9BSJ5.
PhosphoSitePlusiQ9BSJ5.

Expressioni

Gene expression databases

BgeeiENSG00000141219.
CleanExiHS_C17orf80.
ExpressionAtlasiQ9BSJ5. baseline and differential.
GenevisibleiQ9BSJ5. HS.

Organism-specific databases

HPAiHPA012896.

Interactioni

Protein-protein interaction databases

BioGridi120358. 24 interactors.
IntActiQ9BSJ5. 2 interactors.
STRINGi9606.ENSP00000351937.

Structurei

3D structure databases

ProteinModelPortaliQ9BSJ5.
SMRiQ9BSJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD8. Eukaryota.
ENOG4111ZKT. LUCA.
GeneTreeiENSGT00510000049019.
HOVERGENiHBG057035.
InParanoidiQ9BSJ5.
OMAiLEWFPEL.
OrthoDBiEOG091G0F0L.
PhylomeDBiQ9BSJ5.
TreeFamiTF324369.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP
60 70 80 90 100
RAKKMKGPIK DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL
110 120 130 140 150
ERAATTKADK DIKNPIQPSF KMLKNTKPMT TFQEETKAQF YASEKTSPKR
160 170 180 190 200
ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP SLSNQDRKYS STLPNDVQTT
210 220 230 240 250
SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK RVRTLLSNER
260 270 280 290 300
DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL
310 320 330 340 350
TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER
360 370 380 390 400
PHLSLFIPRE TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV
410 420 430 440 450
KALMESPEGQ LSLEPKSDSQ FQASHTGCQS PLCSAQRHTP QSPFTNHAAA
460 470 480 490 500
AGRKTLRSCM GLEWFPELYP GYLGLGVLPG KPQCWNAMTQ KPQLISPQGE
510 520 530 540 550
RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK GWIRCNTTIR
560 570 580 590 600
KSGFGGITML FTGYFVLCCS WSFRRLKKLC RPLPWKSTVP PCIGVAKTTG

DCRSKTCLD
Length:609
Mass (Da):67,315
Last modified:January 11, 2011 - v2
Checksum:i2579A2A739C10A43
GO
Isoform 2 (identifier: Q9BSJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-540: Missing.

Show »
Length:573
Mass (Da):63,423
Checksum:i3E1F7C5F2CC73F1E
GO
Isoform 3 (identifier: Q9BSJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-583: KLCRPL → LQRWRK
     584-609: Missing.

Show »
Length:583
Mass (Da):64,726
Checksum:i104961298AAB38DE
GO

Sequence cautioni

The sequence AAP72185 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91344 differs from that shown. Reason: Frameshift at position 121.Curated
The sequence BAB15680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33P → S in CAB66674 (PubMed:11230166).Curated1
Sequence conflicti484C → R in BAB15680 (PubMed:16625196).Curated1
Sequence conflicti536G → R in BAA91344 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031779226G → S. Corresponds to variant dbSNP:rs9902726Ensembl.1
Natural variantiVAR_031780322K → Q. Corresponds to variant dbSNP:rs34784472Ensembl.1
Natural variantiVAR_031781356F → L1 PublicationCorresponds to variant dbSNP:rs745143Ensembl.1
Natural variantiVAR_031782395H → N5 PublicationsCorresponds to variant dbSNP:rs904384Ensembl.1
Natural variantiVAR_031783396C → R1 PublicationCorresponds to variant dbSNP:rs904383Ensembl.1
Natural variantiVAR_031784420Q → H2 PublicationsCorresponds to variant dbSNP:rs745142Ensembl.1
Natural variantiVAR_031785522A → T2 PublicationsCorresponds to variant dbSNP:rs1566286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024572505 – 540Missing in isoform 2. 3 PublicationsAdd BLAST36
Alternative sequenceiVSP_024573578 – 583KLCRPL → LQRWRK in isoform 3. 1 Publication6
Alternative sequenceiVSP_024574584 – 609Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163812 mRNA. Translation: AAO25513.1.
AY239293 mRNA. Translation: AAP72185.1. Different initiation.
AL136740 mRNA. Translation: CAB66674.1.
AK000728 mRNA. Translation: BAA91344.1. Frameshift.
AK027166 mRNA. Translation: BAB15680.1. Different initiation.
AK292838 mRNA. Translation: BAF85527.1.
AC087301 Genomic DNA. No translation available.
AC097641 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89118.1.
BC005005 mRNA. Translation: AAH05005.1.
CCDSiCCDS11694.1. [Q9BSJ5-1]
CCDS42377.1. [Q9BSJ5-2]
CCDS45767.1. [Q9BSJ5-3]
RefSeqiNP_001094091.1. NM_001100621.2.
NP_001275699.1. NM_001288770.1.
NP_060411.2. NM_017941.5.
XP_005257544.1. XM_005257487.3. [Q9BSJ5-1]
XP_011523263.1. XM_011524961.1. [Q9BSJ5-1]
XP_011523264.1. XM_011524962.2. [Q9BSJ5-1]
XP_016880295.1. XM_017024806.1. [Q9BSJ5-1]
UniGeneiHs.12929.

Genome annotation databases

EnsembliENST00000268942; ENSP00000268942; ENSG00000141219. [Q9BSJ5-2]
ENST00000359042; ENSP00000351937; ENSG00000141219. [Q9BSJ5-1]
ENST00000426147; ENSP00000396970; ENSG00000141219. [Q9BSJ5-3]
ENST00000535032; ENSP00000440551; ENSG00000141219. [Q9BSJ5-1]
ENST00000577615; ENSP00000464132; ENSG00000141219. [Q9BSJ5-2]
GeneIDi55028.
KEGGihsa:55028.
UCSCiuc002jjk.3. human. [Q9BSJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCQ080_HUMAN
AccessioniPrimary (citable) accession number: Q9BSJ5
Secondary accession number(s): A8K9X3
, Q5JB45, Q6YAU3, Q9H0L9, Q9H5E6, Q9NWN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: January 11, 2011
Last modified: August 30, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations