Q9BSJ5 (CQ080_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C17orf80

Alternative name(s):
Cell migration-inducing gene 3 protein
Human lung cancer oncogene 8 protein
Short name=HLC-8

Gene names

Name:	C17orf80
ORF Names:	HLC8, MIG3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence caution	The sequence AAP72185.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91344.1 differs from that shown. Reason: Frameshift at position 121. The sequence BAB15680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BSJ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BSJ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     505-540: Missing.

Isoform 3 (identifier: Q9BSJ5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     578-583: KLCRPL → LQRWRK
     584-609: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	Uncharacterized protein C17orf80		PRO_0000284612
Regions
	Topological domain	1 – 552	552	Extracellular Potential
	Transmembrane	553 – 573	21	Helical; Potential
	Topological domain	574 – 609	36	Cytoplasmic Potential
Natural variations
	Alternative sequence	505 – 540	36	Missing in isoform 2.		VSP_024572
	Alternative sequence	578 – 583	6	KLCRPL → LQRWRK in isoform 3.		VSP_024573
	Alternative sequence	584 – 609	26	Missing in isoform 3.		VSP_024574
	Natural variant	226	1	G → S. Corresponds to variant rs9902726 [ dbSNP | Ensembl ].		VAR_031779
	Natural variant	322	1	K → Q. Corresponds to variant rs34784472 [ dbSNP | Ensembl ].		VAR_031780
	Natural variant	356	1	F → L. Ref.1 Corresponds to variant rs745143 [ dbSNP | Ensembl ].		VAR_031781
	Natural variant	395	1	H → N. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Corresponds to variant rs904384 [ dbSNP | Ensembl ].		VAR_031782
	Natural variant	396	1	C → R. Ref.1 Corresponds to variant rs904383 [ dbSNP | Ensembl ].		VAR_031783
	Natural variant	420	1	Q → H. Ref.1 Ref.3 Corresponds to variant rs745142 [ dbSNP | Ensembl ].		VAR_031784
	Natural variant	522	1	A → T. Ref.1 Ref.3 Corresponds to variant rs1566286 [ dbSNP | Ensembl ].		VAR_031785
Experimental info
	Sequence conflict	33	1	P → S in CAB66674. Ref.2
	Sequence conflict	484	1	C → R in BAB15680. Ref.4
	Sequence conflict	536	1	G → R in BAA91344. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 2579A2A739C10A43	FASTA	609	67,315
	10 20 30 40 50 60 MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP RAKKMKGPIK 70 80 90 100 110 120 DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL ERAATTKADK DIKNPIQPSF 130 140 150 160 170 180 KMLKNTKPMT TFQEETKAQF YASEKTSPKR ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP 190 200 210 220 230 240 SLSNQDRKYS STLPNDVQTT SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK 250 260 270 280 290 300 RVRTLLSNER DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL 310 320 330 340 350 360 TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER PHLSLFIPRE 370 380 390 400 410 420 TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV KALMESPEGQ LSLEPKSDSQ 430 440 450 460 470 480 FQASHTGCQS PLCSAQRHTP QSPFTNHAAA AGRKTLRSCM GLEWFPELYP GYLGLGVLPG 490 500 510 520 530 540 KPQCWNAMTQ KPQLISPQGE RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK 550 560 570 580 590 600 GWIRCNTTIR KSGFGGITML FTGYFVLCCS WSFRRLKKLC RPLPWKSTVP PCIGVAKTTG DCRSKTCLD
	Isoform 2 [UniParc]. Checksum: 3E1F7C5F2CC73F1E	FASTA	573	63,423
	10 20 30 40 50 60 MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP RAKKMKGPIK 70 80 90 100 110 120 DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL ERAATTKADK DIKNPIQPSF 130 140 150 160 170 180 KMLKNTKPMT TFQEETKAQF YASEKTSPKR ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP 190 200 210 220 230 240 SLSNQDRKYS STLPNDVQTT SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK 250 260 270 280 290 300 RVRTLLSNER DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL 310 320 330 340 350 360 TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER PHLSLFIPRE 370 380 390 400 410 420 TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV KALMESPEGQ LSLEPKSDSQ 430 440 450 460 470 480 FQASHTGCQS PLCSAQRHTP QSPFTNHAAA AGRKTLRSCM GLEWFPELYP GYLGLGVLPG 490 500 510 520 530 540 KPQCWNAMTQ KPQLISPQGE RLSQGWIRCN TTIRKSGFGG ITMLFTGYFV LCCSWSFRRL 550 560 570 KKLCRPLPWK STVPPCIGVA KTTGDCRSKT CLD
	Isoform 3 [UniParc]. Checksum: 104961298AAB38DE	FASTA	583	64,726
	10 20 30 40 50 60 MSDNPPRMEV CPYCKKPFKR LKSHLPYCKM IGPTIPTDQK VYQSKPATLP RAKKMKGPIK 70 80 90 100 110 120 DLIKAKGKEL ETENEERNSK LVVDKPEQTV KTFPLPAVGL ERAATTKADK DIKNPIQPSF 130 140 150 160 170 180 KMLKNTKPMT TFQEETKAQF YASEKTSPKR ELAKDLPKSG ESRCNPSEAG ASLLVGSIEP 190 200 210 220 230 240 SLSNQDRKYS STLPNDVQTT SGDLKLDKID PQRQELLVKL LDVPTGDCHI SPKNVSDGVK 250 260 270 280 290 300 RVRTLLSNER DSKGRDHLSG VPTDVTVTET PEKNTESLIL SLKMSSLGKI QVMEKQEKGL 310 320 330 340 350 360 TLGVETCGSK GNAEKSMSAT EKQERTVMSH GCENFNTRDS VTGKESQGER PHLSLFIPRE 370 380 390 400 410 420 TTYQFHSVSQ SSSQSLASLA TTFLQEKKAE AQNHHCVPDV KALMESPEGQ LSLEPKSDSQ 430 440 450 460 470 480 FQASHTGCQS PLCSAQRHTP QSPFTNHAAA AGRKTLRSCM GLEWFPELYP GYLGLGVLPG 490 500 510 520 530 540 KPQCWNAMTQ KPQLISPQGE RLSQVSLLER SSTHIRSLEP PAGLTTSNFS LMRLLGAVQK 550 560 570 580 GWIRCNTTIR KSGFGGITML FTGYFVLCCS WSFRRLKLQR WRK

References

[1]	"Identification of a new human cancer-related gene (HLC-8)." Kim J.W. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-609 (ISOFORM 1), VARIANTS LEU-356; ASN-395; ARG-396; HIS-420 AND THR-522.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-395. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-395; HIS-420 AND THR-522. Tissue: Lung and Trachea.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-395.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-395. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY163812 mRNA. Translation: AAO25513.1. AY239293 mRNA. Translation: AAP72185.1. Different initiation. AL136740 mRNA. Translation: CAB66674.1. AK000728 mRNA. Translation: BAA91344.1. Frameshift. AK027166 mRNA. Translation: BAB15680.1. Different initiation. AK292838 mRNA. Translation: BAF85527.1. AC087301 Genomic DNA. No translation available. AC097641 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW89118.1. BC005005 mRNA. Translation: AAH05005.1.
IPI	IPI00153031. IPI00300242. IPI00844397.
RefSeq	NP_001094091.1. NM_001100621.1. NP_001094092.1. NM_001100622.1. NP_060411.2. NM_017941.4.
UniGene	Hs.12929.
3D structure databases
ProteinModelPortal	Q9BSJ5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BSJ5. 1 interaction.
STRING	9606.ENSP00000351937.
PTM databases
PhosphoSite	Q9BSJ5.
Polymorphism databases
DMDM	74733017.
Proteomic databases
PaxDb	Q9BSJ5.
PRIDE	Q9BSJ5.
Protocols and materials databases
DNASU	55028.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268942; ENSP00000268942; ENSG00000141219. ENST00000359042; ENSP00000351937; ENSG00000141219. ENST00000426147; ENSP00000396970; ENSG00000141219. ENST00000535032; ENSP00000440551; ENSG00000141219. ENST00000577615; ENSP00000464132; ENSG00000141219.
GeneID	55028.
KEGG	hsa:55028.
UCSC	uc002jjk.1. human. uc002jjl.4. human. uc002jjm.4. human.
Organism-specific databases
CTD	55028.
GeneCards	GC17P071228.
HGNC	HGNC:29601. C17orf80.
HPA	HPA012896.
neXtProt	NX_Q9BSJ5.
PharmGKB	PA143485404.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38808.
HOVERGEN	HBG057035.
InParanoid	Q9BSJ5.
OMA	CKKPFKR.
OrthoDB	EOG4CRKZP.
PhylomeDB	Q9BSJ5.
Gene expression databases
ArrayExpress	Q9BSJ5.
Bgee	Q9BSJ5.
CleanEx	HS_C17orf80.
Genevestigator	Q9BSJ5.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	C17orf80. human.
GenomeRNAi	55028.
NextBio	58435.

Entry information

Entry name

CQ080_HUMAN

Accession

Primary (citable) accession number: Q9BSJ5
Secondary accession number(s): A8K9X3 , Q5JB45, Q6YAU3, Q9H0L9, Q9H5E6, Q9NWN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.