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Q9BSJ2

- GCP2_HUMAN

UniProt

Q9BSJ2 - GCP2_HUMAN

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Protein
Gamma-tubulin complex component 2
Gene
TUBGCP2, GCP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. microtubule nucleation Source: ProtInc
  3. mitotic cell cycle Source: Reactome
  4. protein complex assembly Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 2
Short name:
GCP-2
Short name:
hGCP2
Alternative name(s):
Gamma-ring complex protein 103 kDa
Short name:
h103p
Short name:
hGrip103
Spindle pole body protein Spc97 homolog
Short name:
hSpc97
Gene namesi
Name:TUBGCP2
Synonyms:GCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:18599. TUBGCP2.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasmic microtubule Source: ProtInc
  3. cytosol Source: Reactome
  4. microtubule organizing center Source: ProtInc
  5. spindle pole Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Gamma-tubulin complex component 2
PRO_0000078113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BSJ2.
PaxDbiQ9BSJ2.
PRIDEiQ9BSJ2.

PTM databases

PhosphoSiteiQ9BSJ2.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

ArrayExpressiQ9BSJ2.
BgeeiQ9BSJ2.
CleanExiHS_TUBGCP2.
GenevestigatoriQ9BSJ2.

Organism-specific databases

HPAiHPA037885.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

Protein-protein interaction databases

BioGridi116055. 21 interactions.
IntActiQ9BSJ2. 20 interactions.
MINTiMINT-1152554.
STRINGi9606.ENSP00000252936.

Structurei

3D structure databases

ProteinModelPortaliQ9BSJ2.
SMRiQ9BSJ2. Positions 388-764.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 1124Poly-Ala

Sequence similaritiesi

Belongs to the TUBGCP family.

Phylogenomic databases

eggNOGiNOG268971.
HOGENOMiHOG000273895.
HOVERGENiHBG026103.
InParanoidiQ9BSJ2.
KOiK16569.
OMAiLTEDKEX.
OrthoDBiEOG7FFMR6.
PhylomeDBiQ9BSJ2.
TreeFamiTF324047.

Family and domain databases

InterProiIPR007259. TUBGCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms may exist. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 1 (identifier: Q9BSJ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK    50
VKIAEFSRTP EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ 100
NAKERAELAA AAVGSSTTSI NVPAAASKIS MQELEELRKQ LGSVATGSTL 150
QQSLELKRKM LRDKQNKKNS GQHLPIFPAW VYERPALIGD FLIGAGISTD 200
TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVSAQPLAG RQSRTFLVDP 250
NLDLSIRELV HRILPVAASY SAVTRFIEEK SSFEYGQVNH ALAAAMRTLV 300
KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC 350
LGGSTLSLLH DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII 400
HDPYSEFMVE EHELRKERIQ EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI 450
LSTGKYLNVV RECGHDVTCP VAKEIIYTLK ERAYVEQIEK AFNYASKVLL 500
DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR KPVEDITPPR 550
LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM 600
AHADPTELAL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH 650
VERQLCSVWI SNKTAKQHSL HSAQWFAGAF TLRQRMLNFV QNIQYYMMFE 700
VMEPTWHILE KNLKSASNID DVLGHHTGFL DTCLKDCMLT NPELLKVFSK 750
LMSVCVMFTN CMQKFTQSMK LDGELGGQTL EHSTVLGLPA GAEERARKEL 800
ARKHLAEHAD TVQLVSGFEA TINKFDKNFS AHLLDLLARL SIYSTSDCEH 850
GMASVISRLD FNGFYTERLE RLSAERSQKA TPQVPVLRGP PAPAPRVAVT 900
AQ 902
Length:902
Mass (Da):102,534
Last modified:June 6, 2002 - v2
Checksum:i4FAAF864A3758E6A
GO
Isoform 2 (identifier: Q9BSJ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: No experimental confirmation available.

Show »
Length:772
Mass (Da):88,091
Checksum:i648F3F29C7510172
GO
Isoform 3 (identifier: Q9BSJ2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-205: I → IVLLRWNLALSPRLKCSGVISAHCNLHLP

Note: No experimental confirmation available.

Show »
Length:930
Mass (Da):105,628
Checksum:iE90F119D86C00010
GO

Sequence cautioni

The sequence BC005011 differs from that shown. Reason: Frameshift at position 513.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111A → T.
Corresponds to variant rs2298121 [ dbSNP | Ensembl ].
VAR_022126
Natural varianti193 – 1931I → T.
Corresponds to variant rs11101682 [ dbSNP | Ensembl ].
VAR_049249
Natural varianti809 – 8091A → T.
Corresponds to variant rs11101677 [ dbSNP | Ensembl ].
VAR_049250

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 130130Missing in isoform 2.
VSP_044698Add
BLAST
Alternative sequencei205 – 2051I → IVLLRWNLALSPRLKCSGVI SAHCNLHLP in isoform 3.
VSP_045982

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791E → G in BAG59730. 1 Publication
Sequence conflicti641 – 6411L → F in BC005011. 1 Publication
Isoform 3 (identifier: Q9BSJ2-4)
Sequence conflicti209 – 2091R → G in AAI43248. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042379 mRNA. Translation: AAC39728.1.
AK297251 mRNA. Translation: BAG59730.1.
AL360181, AL592071 Genomic DNA. Translation: CAH70275.1.
BC005011 mRNA. No translation available.
BC093770 mRNA. Translation: AAH93770.1.
BC111957 mRNA. Translation: AAI11958.1.
BC143247 mRNA. Translation: AAI43248.1.
CCDSiCCDS58104.1. [Q9BSJ2-3]
CCDS58105.1. [Q9BSJ2-4]
CCDS7676.1. [Q9BSJ2-1]
RefSeqiNP_001243546.1. NM_001256617.1. [Q9BSJ2-4]
NP_001243547.1. NM_001256618.1. [Q9BSJ2-3]
NP_006650.1. NM_006659.3. [Q9BSJ2-1]
XP_006717659.1. XM_006717596.1. [Q9BSJ2-1]
UniGeneiHs.523370.

Genome annotation databases

EnsembliENST00000252936; ENSP00000252936; ENSG00000130640. [Q9BSJ2-1]
ENST00000368563; ENSP00000357551; ENSG00000130640. [Q9BSJ2-1]
ENST00000417178; ENSP00000395666; ENSG00000130640. [Q9BSJ2-3]
ENST00000543663; ENSP00000446093; ENSG00000130640. [Q9BSJ2-4]
GeneIDi10844.
KEGGihsa:10844.
UCSCiuc001lmf.2. human. [Q9BSJ2-1]

Polymorphism databases

DMDMi21450889.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042379 mRNA. Translation: AAC39728.1 .
AK297251 mRNA. Translation: BAG59730.1 .
AL360181 , AL592071 Genomic DNA. Translation: CAH70275.1 .
BC005011 mRNA. No translation available.
BC093770 mRNA. Translation: AAH93770.1 .
BC111957 mRNA. Translation: AAI11958.1 .
BC143247 mRNA. Translation: AAI43248.1 .
CCDSi CCDS58104.1. [Q9BSJ2-3 ]
CCDS58105.1. [Q9BSJ2-4 ]
CCDS7676.1. [Q9BSJ2-1 ]
RefSeqi NP_001243546.1. NM_001256617.1. [Q9BSJ2-4 ]
NP_001243547.1. NM_001256618.1. [Q9BSJ2-3 ]
NP_006650.1. NM_006659.3. [Q9BSJ2-1 ]
XP_006717659.1. XM_006717596.1. [Q9BSJ2-1 ]
UniGenei Hs.523370.

3D structure databases

ProteinModelPortali Q9BSJ2.
SMRi Q9BSJ2. Positions 388-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116055. 21 interactions.
IntActi Q9BSJ2. 20 interactions.
MINTi MINT-1152554.
STRINGi 9606.ENSP00000252936.

PTM databases

PhosphoSitei Q9BSJ2.

Polymorphism databases

DMDMi 21450889.

Proteomic databases

MaxQBi Q9BSJ2.
PaxDbi Q9BSJ2.
PRIDEi Q9BSJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252936 ; ENSP00000252936 ; ENSG00000130640 . [Q9BSJ2-1 ]
ENST00000368563 ; ENSP00000357551 ; ENSG00000130640 . [Q9BSJ2-1 ]
ENST00000417178 ; ENSP00000395666 ; ENSG00000130640 . [Q9BSJ2-3 ]
ENST00000543663 ; ENSP00000446093 ; ENSG00000130640 . [Q9BSJ2-4 ]
GeneIDi 10844.
KEGGi hsa:10844.
UCSCi uc001lmf.2. human. [Q9BSJ2-1 ]

Organism-specific databases

CTDi 10844.
GeneCardsi GC10M135094.
HGNCi HGNC:18599. TUBGCP2.
HPAi HPA037885.
neXtProti NX_Q9BSJ2.
PharmGKBi PA38598.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268971.
HOGENOMi HOG000273895.
HOVERGENi HBG026103.
InParanoidi Q9BSJ2.
KOi K16569.
OMAi LTEDKEX.
OrthoDBi EOG7FFMR6.
PhylomeDBi Q9BSJ2.
TreeFami TF324047.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSi TUBGCP2. human.
GeneWikii TUBGCP2.
GenomeRNAii 10844.
NextBioi 41170.
PROi Q9BSJ2.

Gene expression databases

ArrayExpressi Q9BSJ2.
Bgeei Q9BSJ2.
CleanExi HS_TUBGCP2.
Genevestigatori Q9BSJ2.

Family and domain databases

InterProi IPR007259. TUBGCP.
[Graphical view ]
PANTHERi PTHR19302. PTHR19302. 1 hit.
Pfami PF04130. Spc97_Spc98. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p."
    Murphy S.M., Urbani L., Stearns T.
    J. Cell Biol. 141:663-674(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cervix carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Pancreas.
  5. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGCP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSJ2
Secondary accession number(s): B4DM18
, B7ZKL8, F5H4E0, F5H4L0, O43632, Q5VWX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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