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Q9BSJ2 (GCP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-tubulin complex component 2

Short name=GCP-2
Short name=hGCP2
Alternative name(s):
Gamma-ring complex protein 103 kDa
Short name=h103p
Short name=hGrip103
Spindle pole body protein Spc97 homolog
Short name=hSpc97
Gene names
Name:TUBGCP2
Synonyms:GCP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Subunit structure

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome.

Tissue specificity

Ubiquitously expressed.

Sequence similarities

Belongs to the TUBGCP family.

Sequence caution

The sequence BC005011 differs from that shown. Reason: Frameshift at position 513.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 1 (identifier: Q9BSJ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BSJ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9BSJ2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     205-205: I → IVLLRWNLALSPRLKCSGVISAHCNLHLP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 902902Gamma-tubulin complex component 2
PRO_0000078113

Regions

Compositional bias109 – 1124Poly-Ala

Amino acid modifications

Modified residue831Phosphotyrosine Ref.6

Natural variations

Alternative sequence1 – 130130Missing in isoform 2.
VSP_044698
Alternative sequence2051I → IVLLRWNLALSPRLKCSGVI SAHCNLHLP in isoform 3.
VSP_045982
Natural variant1111A → T.
Corresponds to variant rs2298121 [ dbSNP | Ensembl ].
VAR_022126
Natural variant1931I → T.
Corresponds to variant rs11101682 [ dbSNP | Ensembl ].
VAR_049249
Natural variant8091A → T.
Corresponds to variant rs11101677 [ dbSNP | Ensembl ].
VAR_049250

Experimental info

Sequence conflict2791E → G in BAG59730. Ref.2
Sequence conflict6411L → F in BC005011. Ref.4
Isoform 3:
Sequence conflict2091R → G in AAI43248. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 4FAAF864A3758E6A

FASTA902102,534
        10         20         30         40         50         60 
MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK VKIAEFSRTP 

        70         80         90        100        110        120 
EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ NAKERAELAA AAVGSSTTSI 

       130        140        150        160        170        180 
NVPAAASKIS MQELEELRKQ LGSVATGSTL QQSLELKRKM LRDKQNKKNS GQHLPIFPAW 

       190        200        210        220        230        240 
VYERPALIGD FLIGAGISTD TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVSAQPLAG 

       250        260        270        280        290        300 
RQSRTFLVDP NLDLSIRELV HRILPVAASY SAVTRFIEEK SSFEYGQVNH ALAAAMRTLV 

       310        320        330        340        350        360 
KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC LGGSTLSLLH 

       370        380        390        400        410        420 
DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII HDPYSEFMVE EHELRKERIQ 

       430        440        450        460        470        480 
EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI LSTGKYLNVV RECGHDVTCP VAKEIIYTLK 

       490        500        510        520        530        540 
ERAYVEQIEK AFNYASKVLL DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR 

       550        560        570        580        590        600 
KPVEDITPPR LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM 

       610        620        630        640        650        660 
AHADPTELAL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH VERQLCSVWI 

       670        680        690        700        710        720 
SNKTAKQHSL HSAQWFAGAF TLRQRMLNFV QNIQYYMMFE VMEPTWHILE KNLKSASNID 

       730        740        750        760        770        780 
DVLGHHTGFL DTCLKDCMLT NPELLKVFSK LMSVCVMFTN CMQKFTQSMK LDGELGGQTL 

       790        800        810        820        830        840 
EHSTVLGLPA GAEERARKEL ARKHLAEHAD TVQLVSGFEA TINKFDKNFS AHLLDLLARL 

       850        860        870        880        890        900 
SIYSTSDCEH GMASVISRLD FNGFYTERLE RLSAERSQKA TPQVPVLRGP PAPAPRVAVT 


AQ 

« Hide

Isoform 2 [UniParc].

Checksum: 648F3F29C7510172
Show »

FASTA77288,091
Isoform 3 [UniParc].

Checksum: E90F119D86C00010
Show »

FASTA930105,628

References

« Hide 'large scale' references
[1]"The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p."
Murphy S.M., Urbani L., Stearns T.
J. Cell Biol. 141:663-674(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Cervix carcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain and Pancreas.
[5]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[6]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF042379 mRNA. Translation: AAC39728.1.
AK297251 mRNA. Translation: BAG59730.1.
AL360181, AL592071 Genomic DNA. Translation: CAH70275.1.
BC005011 mRNA. No translation available.
BC093770 mRNA. Translation: AAH93770.1.
BC111957 mRNA. Translation: AAI11958.1.
BC143247 mRNA. Translation: AAI43248.1.
RefSeqNP_001243546.1. NM_001256617.1.
NP_001243547.1. NM_001256618.1.
NP_006650.1. NM_006659.3.
UniGeneHs.523370.

3D structure databases

ProteinModelPortalQ9BSJ2.
SMRQ9BSJ2. Positions 388-764.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116055. 23 interactions.
IntActQ9BSJ2. 20 interactions.
MINTMINT-1152554.
STRING9606.ENSP00000252936.

PTM databases

PhosphoSiteQ9BSJ2.

Polymorphism databases

DMDM21450889.

Proteomic databases

PaxDbQ9BSJ2.
PRIDEQ9BSJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252936; ENSP00000252936; ENSG00000130640. [Q9BSJ2-1]
ENST00000368563; ENSP00000357551; ENSG00000130640. [Q9BSJ2-1]
ENST00000417178; ENSP00000395666; ENSG00000130640. [Q9BSJ2-3]
ENST00000543663; ENSP00000446093; ENSG00000130640. [Q9BSJ2-4]
GeneID10844.
KEGGhsa:10844.
UCSCuc001lmf.2. human. [Q9BSJ2-1]

Organism-specific databases

CTD10844.
GeneCardsGC10M135094.
HGNCHGNC:18599. TUBGCP2.
HPAHPA037885.
neXtProtNX_Q9BSJ2.
PharmGKBPA38598.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268971.
HOGENOMHOG000273895.
HOVERGENHBG026103.
InParanoidQ9BSJ2.
KOK16569.
OMALTEDKEX.
OrthoDBEOG7FFMR6.
PhylomeDBQ9BSJ2.
TreeFamTF324047.

Enzyme and pathway databases

ReactomeREACT_115566. Cell Cycle.

Gene expression databases

ArrayExpressQ9BSJ2.
BgeeQ9BSJ2.
CleanExHS_TUBGCP2.
GenevestigatorQ9BSJ2.

Family and domain databases

InterProIPR007259. TUBGCP.
[Graphical view]
PANTHERPTHR19302. PTHR19302. 1 hit.
PfamPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTUBGCP2. human.
GeneWikiTUBGCP2.
GenomeRNAi10844.
NextBio41170.
PROQ9BSJ2.

Entry information

Entry nameGCP2_HUMAN
AccessionPrimary (citable) accession number: Q9BSJ2
Secondary accession number(s): B4DM18 expand/collapse secondary AC list , B7ZKL8, F5H4E0, F5H4L0, O43632, Q5VWX7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM