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Protein

Tripartite motif-containing protein 51

Gene

TRIM51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 51
Alternative name(s):
SPRY domain-containing protein 5
Gene namesi
Name:TRIM51
Synonyms:SPRYD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19023. TRIM51.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949173.

Polymorphism and mutation databases

BioMutaiTRIM51.
DMDMi306526243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Tripartite motif-containing protein 51PRO_0000328724Add
BLAST

Proteomic databases

EPDiQ9BSJ1.
PaxDbiQ9BSJ1.
PRIDEiQ9BSJ1.

PTM databases

iPTMnetiQ9BSJ1.
PhosphoSiteiQ9BSJ1.

Expressioni

Gene expression databases

BgeeiQ9BSJ1.
CleanExiHS_SPRYD5.
GenevisibleiQ9BSJ1. HS.

Organism-specific databases

HPAiHPA044988.

Interactioni

Protein-protein interaction databases

BioGridi124248. 3 interactions.
IntActiQ9BSJ1. 3 interactions.
MINTiMINT-1466681.
STRINGi9606.ENSP00000395086.

Structurei

3D structure databases

ProteinModelPortaliQ9BSJ1.
SMRiQ9BSJ1. Positions 9-61, 93-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 452184B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiQ9BSJ1.
KOiK12019.
OMAiAQCSECK.
OrthoDBiEOG7MD4Q8.
PhylomeDBiQ9BSJ1.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGILQVFQ RALTCPICMN YFLDPVTIDC GHSFCRPCLY LNWQDTAVLA
60 70 80 90 100
QCSECKKTTR QRNLNTDICL KNMAFIARKA SLRQFLSSEE QICGMHRETK
110 120 130 140 150
KMFCEVDKSL LCLPCSNSQE HRNHIHCPIE WAAEERREEL LKKMQSLWEK
160 170 180 190 200
ACENLRNLNM ETTRTRCWKD YVSLRIEAIR AEYQKMPAFL HEEEQHHLER
210 220 230 240 250
LRKEGEDIFQ QLNESKARME HSRELLRGMY EDLKQMCHKA DVELLQAFGD
260 270 280 290 300
ILHRYESLLL QVSEPVNPEL SAGPITGLLD SLSGFRVDFT LQPERANSHI
310 320 330 340 350
FLCGDLRSMN VGCDPQDDPD ITGKSECFLV WGAQAFTSGK YYWEVHMGDS
360 370 380 390 400
WNWAFGVCNN YWKEKRQNDK IDGEEGLFLL GCVKEDTHCS LFTTSPLVVQ
410 420 430 440 450
YVPRPTSTVG LFLDCEGRTV SFVDVDQSSL IYTIPNCSFS PPLRPIFCCS

HF
Length:452
Mass (Da):52,285
Last modified:October 5, 2010 - v2
Checksum:i41C3D56D372A40AB
GO
Isoform 2 (identifier: Q9BSJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:309
Mass (Da):35,655
Checksum:i9A23D5754D2BF426
GO

Sequence cautioni

The sequence AAH05014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 143143Missing in isoform 2. 1 PublicationVSP_039765Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036111 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73688.1.
CH471076 Genomic DNA. Translation: EAW73689.1.
BC005014 mRNA. Translation: AAH05014.1. Different initiation.
DV080294 mRNA. No translation available.
RefSeqiNP_116070.2. NM_032681.3. [Q9BSJ1-1]
UniGeneiHs.326734.

Genome annotation databases

EnsembliENST00000244891; ENSP00000244891; ENSG00000124900. [Q9BSJ1-2]
ENST00000449290; ENSP00000395086; ENSG00000124900. [Q9BSJ1-1]
GeneIDi84767.
KEGGihsa:84767.
UCSCiuc010rip.3. human. [Q9BSJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036111 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73688.1.
CH471076 Genomic DNA. Translation: EAW73689.1.
BC005014 mRNA. Translation: AAH05014.1. Different initiation.
DV080294 mRNA. No translation available.
RefSeqiNP_116070.2. NM_032681.3. [Q9BSJ1-1]
UniGeneiHs.326734.

3D structure databases

ProteinModelPortaliQ9BSJ1.
SMRiQ9BSJ1. Positions 9-61, 93-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124248. 3 interactions.
IntActiQ9BSJ1. 3 interactions.
MINTiMINT-1466681.
STRINGi9606.ENSP00000395086.

PTM databases

iPTMnetiQ9BSJ1.
PhosphoSiteiQ9BSJ1.

Polymorphism and mutation databases

BioMutaiTRIM51.
DMDMi306526243.

Proteomic databases

EPDiQ9BSJ1.
PaxDbiQ9BSJ1.
PRIDEiQ9BSJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244891; ENSP00000244891; ENSG00000124900. [Q9BSJ1-2]
ENST00000449290; ENSP00000395086; ENSG00000124900. [Q9BSJ1-1]
GeneIDi84767.
KEGGihsa:84767.
UCSCiuc010rip.3. human. [Q9BSJ1-1]

Organism-specific databases

CTDi84767.
GeneCardsiTRIM51.
HGNCiHGNC:19023. TRIM51.
HPAiHPA044988.
neXtProtiNX_Q9BSJ1.
PharmGKBiPA134949173.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiQ9BSJ1.
KOiK12019.
OMAiAQCSECK.
OrthoDBiEOG7MD4Q8.
PhylomeDBiQ9BSJ1.
TreeFamiTF338674.

Miscellaneous databases

GenomeRNAii84767.
PROiQ9BSJ1.

Gene expression databases

BgeeiQ9BSJ1.
CleanExiHS_SPRYD5.
GenevisibleiQ9BSJ1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-259 (ISOFORM 1).

Entry informationi

Entry nameiTRI51_HUMAN
AccessioniPrimary (citable) accession number: Q9BSJ1
Secondary accession number(s): A6NMG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.