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Protein

Haloacid dehalogenase-like hydrolase domain-containing protein 3

Gene

HDHD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Haloacid dehalogenase-like hydrolase domain-containing protein 3
Gene namesi
Name:HDHD3
Synonyms:C9orf158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28171. HDHD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868152.

Polymorphism and mutation databases

BioMutaiHDHD3.
DMDMi74752302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Haloacid dehalogenase-like hydrolase domain-containing protein 3PRO_0000287313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151N6-acetyllysine; alternateCombined sources
Modified residuei15 – 151N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BSH5.
MaxQBiQ9BSH5.
PaxDbiQ9BSH5.
PeptideAtlasiQ9BSH5.
PRIDEiQ9BSH5.

PTM databases

iPTMnetiQ9BSH5.
PhosphoSiteiQ9BSH5.
SwissPalmiQ9BSH5.

Expressioni

Gene expression databases

BgeeiENSG00000119431.
CleanExiHS_HDHD3.
GenevisibleiQ9BSH5. HS.

Organism-specific databases

HPAiHPA020427.
HPA024158.
HPA024585.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-745201,EBI-358993

Protein-protein interaction databases

BioGridi123632. 4 interactions.
IntActiQ9BSH5. 1 interaction.
MINTiMINT-1481645.

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 124Combined sources
Turni16 – 183Combined sources
Beta strandi19 – 235Combined sources
Helixi25 – 3511Combined sources
Helixi42 – 5918Combined sources
Helixi62 – 676Combined sources
Helixi71 – 8515Combined sources
Helixi91 – 10414Combined sources
Helixi108 – 1103Combined sources
Beta strandi111 – 1133Combined sources
Helixi117 – 12610Combined sources
Beta strandi130 – 1367Combined sources
Helixi141 – 1477Combined sources
Helixi151 – 1533Combined sources
Beta strandi157 – 1593Combined sources
Helixi160 – 1634Combined sources
Helixi170 – 18011Combined sources
Helixi184 – 1863Combined sources
Beta strandi187 – 1926Combined sources
Helixi194 – 1974Combined sources
Helixi199 – 2024Combined sources
Turni203 – 2053Combined sources
Beta strandi207 – 2115Combined sources
Helixi219 – 2246Combined sources
Helixi227 – 2293Combined sources
Beta strandi230 – 2334Combined sources
Helixi234 – 2363Combined sources
Helixi237 – 24610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K1ZX-ray1.55A8-247[»]
ProteinModelPortaliQ9BSH5.
SMRiQ9BSH5. Positions 7-247.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSH5.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG3085. Eukaryota.
COG1011. LUCA.
GeneTreeiENSGT00390000015582.
HOGENOMiHOG000075006.
HOVERGENiHBG101862.
InParanoidiQ9BSH5.
OMAiWHIGDSW.
OrthoDBiEOG091G0OVJ.
PhylomeDBiQ9BSH5.
TreeFamiTF315144.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR011949. HAD-SF_hydro_IA_REG-2-like.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02252. DREG-2. 1 hit.
TIGR01549. HAD-SF-IA-v1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BSH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRLQIRLL TWDVKDTLLR LRHPLGEAYA TKARAHGLEV EPSALEQGFR
60 70 80 90 100
QAYRAQSHSF PNYGLSHGLT SRQWWLDVVL QTFHLAGVQD AQAVAPIAEQ
110 120 130 140 150
LYKDFSHPCT WQVLDGAEDT LRECRTRGLR LAVISNFDRR LEGILGGLGL
160 170 180 190 200
REHFDFVLTS EAAGWPKPDP RIFQEALRLA HMEPVVAAHV GDNYLCDYQG
210 220 230 240 250
PRAVGMHSFL VVGPQALDPV VRDSVPKEHI LPSLAHLLPA LDCLEGSTPG

L
Length:251
Mass (Da):28,000
Last modified:June 1, 2001 - v1
Checksum:iAFB5AF5C286A55DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461G → E.
Corresponds to variant rs1043836 [ dbSNP | Ensembl ].
VAR_032298

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315401 mRNA. Translation: BAG37794.1.
AL137066 Genomic DNA. Translation: CAH70098.1.
BC005048 mRNA. Translation: AAH05048.1.
BC031878 mRNA. Translation: AAH31878.1.
CCDSiCCDS6793.1.
RefSeqiNP_001291438.1. NM_001304509.1.
NP_001291439.1. NM_001304510.1.
NP_001291440.1. NM_001304511.1.
NP_112496.1. NM_031219.3.
UniGeneiHs.7739.

Genome annotation databases

EnsembliENST00000238379; ENSP00000238379; ENSG00000119431.
ENST00000374180; ENSP00000363295; ENSG00000119431.
GeneIDi81932.
KEGGihsa:81932.
UCSCiuc004bhi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315401 mRNA. Translation: BAG37794.1.
AL137066 Genomic DNA. Translation: CAH70098.1.
BC005048 mRNA. Translation: AAH05048.1.
BC031878 mRNA. Translation: AAH31878.1.
CCDSiCCDS6793.1.
RefSeqiNP_001291438.1. NM_001304509.1.
NP_001291439.1. NM_001304510.1.
NP_001291440.1. NM_001304511.1.
NP_112496.1. NM_031219.3.
UniGeneiHs.7739.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K1ZX-ray1.55A8-247[»]
ProteinModelPortaliQ9BSH5.
SMRiQ9BSH5. Positions 7-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123632. 4 interactions.
IntActiQ9BSH5. 1 interaction.
MINTiMINT-1481645.

PTM databases

iPTMnetiQ9BSH5.
PhosphoSiteiQ9BSH5.
SwissPalmiQ9BSH5.

Polymorphism and mutation databases

BioMutaiHDHD3.
DMDMi74752302.

Proteomic databases

EPDiQ9BSH5.
MaxQBiQ9BSH5.
PaxDbiQ9BSH5.
PeptideAtlasiQ9BSH5.
PRIDEiQ9BSH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238379; ENSP00000238379; ENSG00000119431.
ENST00000374180; ENSP00000363295; ENSG00000119431.
GeneIDi81932.
KEGGihsa:81932.
UCSCiuc004bhi.2. human.

Organism-specific databases

CTDi81932.
GeneCardsiHDHD3.
H-InvDBHIX0169357.
HGNCiHGNC:28171. HDHD3.
HPAiHPA020427.
HPA024158.
HPA024585.
neXtProtiNX_Q9BSH5.
PharmGKBiPA134868152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3085. Eukaryota.
COG1011. LUCA.
GeneTreeiENSGT00390000015582.
HOGENOMiHOG000075006.
HOVERGENiHBG101862.
InParanoidiQ9BSH5.
OMAiWHIGDSW.
OrthoDBiEOG091G0OVJ.
PhylomeDBiQ9BSH5.
TreeFamiTF315144.

Miscellaneous databases

ChiTaRSiHDHD3. human.
EvolutionaryTraceiQ9BSH5.
GenomeRNAii81932.
PROiQ9BSH5.

Gene expression databases

BgeeiENSG00000119431.
CleanExiHS_HDHD3.
GenevisibleiQ9BSH5. HS.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR011949. HAD-SF_hydro_IA_REG-2-like.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02252. DREG-2. 1 hit.
TIGR01549. HAD-SF-IA-v1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHDHD3_HUMAN
AccessioniPrimary (citable) accession number: Q9BSH5
Secondary accession number(s): B2RD47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.