Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translational activator of cytochrome c oxidase 1

Gene

TACO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Translational activator of cytochrome c oxidase 1
Alternative name(s):
Coiled-coil domain-containing protein 44
Translational activator of mitochondrially-encoded cytochrome c oxidase I
Gene namesi
Name:TACO1
Synonyms:CCDC44
ORF Names:PRO0477
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136463.7.
HGNCiHGNC:24316. TACO1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Leigh syndrome (LS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
See also OMIM:256000

Keywords - Diseasei

Leigh syndrome, Primary mitochondrial disease

Organism-specific databases

DisGeNETi51204.
MalaCardsiTACO1.
MIMi256000. phenotype.
OpenTargetsiENSG00000136463.
Orphaneti70474. Leigh syndrome with cardiomyopathy.
PharmGKBiPA165433031.

Polymorphism and mutation databases

BioMutaiTACO1.
DMDMi33516968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001759421 – 297Translational activator of cytochrome c oxidase 1Add BLAST297

Proteomic databases

EPDiQ9BSH4.
MaxQBiQ9BSH4.
PaxDbiQ9BSH4.
PeptideAtlasiQ9BSH4.
PRIDEiQ9BSH4.

PTM databases

iPTMnetiQ9BSH4.
PhosphoSitePlusiQ9BSH4.
SwissPalmiQ9BSH4.

Expressioni

Gene expression databases

BgeeiENSG00000136463.
CleanExiHS_CCDC44.
GenevisibleiQ9BSH4. HS.

Organism-specific databases

HPAiHPA021626.
HPA021643.
HPA024294.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119377. 8 interactors.
IntActiQ9BSH4. 16 interactors.
MINTiMINT-1460586.
STRINGi9606.ENSP00000258975.

Structurei

3D structure databases

ProteinModelPortaliQ9BSH4.
SMRiQ9BSH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 227Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the TACO1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2972. Eukaryota.
COG0217. LUCA.
GeneTreeiENSGT00390000012820.
HOGENOMiHOG000228370.
InParanoidiQ9BSH4.
KOiK18189.
OMAiKWSTIKH.
OrthoDBiEOG091G0I1M.
PhylomeDBiQ9BSH4.
TreeFamiTF300070.

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
3.30.70.980. 2 hits.
HAMAPiMF_00693. Transcrip_reg_TACO1. 1 hit.
InterProiView protein in InterPro
IPR017856. Integrase-like_N.
IPR002876. Transcrip_reg_TACO1-like.
IPR026564. Transcrip_reg_TACO1-like_dom3.
IPR029072. YebC-like.
PANTHERiPTHR12532. PTHR12532. 1 hit.
PfamiView protein in Pfam
PF01709. Transcrip_reg. 1 hit.
SUPFAMiSSF75625. SSF75625. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BSH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAWAAASLS RAAARCLLAR GPGVRAAPPR DPRPSHPEPR GCGAAPGRTL
60 70 80 90 100
HFTAAVPAGH NKWSKVRHIK GPKDVERSRI FSKLCLNIRL AVKEGGPNPE
110 120 130 140 150
HNSNLANILE VCRSKHMPKS TIETALKMEK SKDTYLLYEG RGPGGSSLLI
160 170 180 190 200
EALSNSSHKC QADIRHILNK NGGVMAVGAR HSFDKKGVIV VEVEDREKKA
210 220 230 240 250
VNLERALEMA IEAGAEDVKE TEDEEERNVF KFICDASSLH QVRKKLDSLG
260 270 280 290
LCSVSCALEF IPNSKVQLAE PDLEQAAHLI QALSNHEDVI HVYDNIE
Length:297
Mass (Da):32,477
Last modified:June 1, 2001 - v1
Checksum:i079C4716F32EE6FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168L → M in AAF24044 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052934145G → S. Corresponds to variant dbSNP:rs35252424Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315375 mRNA. Translation: BAG37768.1.
CH471109 Genomic DNA. Translation: EAW94304.1.
BC005049 mRNA. Translation: AAH05049.1.
BC007744 mRNA. Translation: AAH07744.1.
AL833861 mRNA. Translation: CAD38719.1.
AF090929 mRNA. Translation: AAF24044.1.
CCDSiCCDS11640.1.
RefSeqiNP_057444.2. NM_016360.3.
UniGeneiHs.174134.

Genome annotation databases

EnsembliENST00000258975; ENSP00000258975; ENSG00000136463.
GeneIDi51204.
KEGGihsa:51204.
UCSCiuc002jbd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTACO1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSH4
Secondary accession number(s): B2RD21, Q8N3N6, Q9UI60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries