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Protein

Zinc finger protein 2

Gene

ZNF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2
Alternative name(s):
Zinc finger protein 2.2
Zinc finger protein 661
Gene namesi
Name:ZNF2
Synonyms:ZNF661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12991. ZNF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37571.

Polymorphism and mutation databases

BioMutaiZNF2.
DMDMi527504091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Zinc finger protein 2PRO_0000274049Add
BLAST

Proteomic databases

EPDiQ9BSG1.
MaxQBiQ9BSG1.
PaxDbiQ9BSG1.
PRIDEiQ9BSG1.

PTM databases

PhosphoSiteiQ9BSG1.

Expressioni

Gene expression databases

BgeeiQ9BSG1.
CleanExiHS_ZNF2.
ExpressionAtlasiQ9BSG1. baseline and differential.
GenevisibleiQ9BSG1. HS.

Organism-specific databases

HPAiHPA041358.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10297542,EBI-10172290
TSGA10Q9BZW73EBI-10297542,EBI-744794

Protein-protein interaction databases

BioGridi113381. 72 interactions.
IntActiQ9BSG1. 3 interactions.
MINTiMINT-8417733.
STRINGi9606.ENSP00000345392.

Structurei

3D structure databases

ProteinModelPortaliQ9BSG1.
SMRiQ9BSG1. Positions 169-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BSG1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
TreeFamiTF340946.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI
60 70 80 90 100
VSLGLPVPQP DVIFQLKRGD KPWMVDLHGS EEREWPESVS LDWETKPEIH
110 120 130 140 150
DASDKKSEGS LRECLGRQSP LCPKFEVHTP NGRMGTEKQS PSGETRKKSL
160 170 180 190 200
SRDKGLRRRR SALSREILTK ERHQECSDCG KTFFDHSSLT RHQRTHTGEK
210 220 230 240 250
PYDCRECGKA FSHRSSLSRH LMSHTGESPY ECSVCSKAFF DRSSLTVHQR
260 270 280 290 300
IHTGEKPFQC NECGKAFFDR SSLTRHQRIH TGESPYECHQ CGKAFSQKSI
310 320 330 340 350
LTRHQLIHTG RKPYECNECG KAFYGVSSLN RHQKAHAGDP RYQCNECGKA
360 370 380 390 400
FFDRSSLTQH QKIHTGDKPY ECSECGKAFS QRCRLTRHQR VHTGEKPFEC
410 420
TVCGKVFSSK SSVIQHQRRY AKQGID
Length:426
Mass (Da):48,863
Last modified:July 24, 2013 - v4
Checksum:i3392DBC6FC250843
GO
Isoform 2 (identifier: Q9BSG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Show »
Length:425
Mass (Da):48,707
Checksum:i8CB40D3EDB62147E
GO
Isoform 3 (identifier: Q9BSG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):44,034
Checksum:i589958B82B6E1F9D
GO
Isoform 4 (identifier: Q9BSG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-88: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,508
Checksum:iFF9497523DAEA39B
GO

Sequence cautioni

The sequence AAX88982.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 1111MAAVSPTTRCQ → RGAVFPGPEHSVPE in CAB52138 (PubMed:1945843).CuratedAdd
BLAST
Sequence conflicti370 – 3701Y → H in AAH05068 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 3. CuratedVSP_047658Add
BLAST
Alternative sequencei51 – 8838Missing in isoform 4. 1 PublicationVSP_054369Add
BLAST
Alternative sequencei157 – 1571Missing in isoform 2. 2 PublicationsVSP_047659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295739 mRNA. Translation: BAG58576.1.
AC092835 Genomic DNA. Translation: AAX88982.1. Sequence problems.
BC005068 mRNA. Translation: AAH05068.2.
BC009976 mRNA. Translation: AAH09976.2.
X60152 mRNA. Translation: CAB52138.1.
CCDSiCCDS42712.1. [Q9BSG1-2]
RefSeqiNP_001017396.1. NM_001017396.2.
NP_001269327.1. NM_001282398.1.
NP_066574.2. NM_021088.3. [Q9BSG1-2]
UniGeneiHs.590916.

Genome annotation databases

EnsembliENST00000614034; ENSP00000480297; ENSG00000275111. [Q9BSG1-2]
GeneIDi7549.
KEGGihsa:7549.
UCSCiuc032nuy.2. human. [Q9BSG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295739 mRNA. Translation: BAG58576.1.
AC092835 Genomic DNA. Translation: AAX88982.1. Sequence problems.
BC005068 mRNA. Translation: AAH05068.2.
BC009976 mRNA. Translation: AAH09976.2.
X60152 mRNA. Translation: CAB52138.1.
CCDSiCCDS42712.1. [Q9BSG1-2]
RefSeqiNP_001017396.1. NM_001017396.2.
NP_001269327.1. NM_001282398.1.
NP_066574.2. NM_021088.3. [Q9BSG1-2]
UniGeneiHs.590916.

3D structure databases

ProteinModelPortaliQ9BSG1.
SMRiQ9BSG1. Positions 169-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113381. 72 interactions.
IntActiQ9BSG1. 3 interactions.
MINTiMINT-8417733.
STRINGi9606.ENSP00000345392.

PTM databases

PhosphoSiteiQ9BSG1.

Polymorphism and mutation databases

BioMutaiZNF2.
DMDMi527504091.

Proteomic databases

EPDiQ9BSG1.
MaxQBiQ9BSG1.
PaxDbiQ9BSG1.
PRIDEiQ9BSG1.

Protocols and materials databases

DNASUi7549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614034; ENSP00000480297; ENSG00000275111. [Q9BSG1-2]
GeneIDi7549.
KEGGihsa:7549.
UCSCiuc032nuy.2. human. [Q9BSG1-1]

Organism-specific databases

CTDi7549.
GeneCardsiZNF2.
HGNCiHGNC:12991. ZNF2.
HPAiHPA041358.
MIMi194500. gene.
neXtProtiNX_Q9BSG1.
PharmGKBiPA37571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BSG1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
TreeFamiTF340946.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7549.
NextBioi29535.
PROiQ9BSG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BSG1.
CleanExiHS_ZNF2.
ExpressionAtlasiQ9BSG1. baseline and differential.
GenevisibleiQ9BSG1. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Hippocampus.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye and Muscle.
  4. "Members of the zinc finger protein gene family sharing a conserved N-terminal module."
    Rosati M., Marino M., Franze A., Tramontano A., Grimaldi G.
    Nucleic Acids Res. 19:5661-5667(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-393 (ISOFORM 2).

Entry informationi

Entry nameiZNF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSG1
Secondary accession number(s): A8MWV7
, B4DIR4, Q4ZFY6, Q96G44, Q9UMC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 24, 2013
Last modified: May 11, 2016
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.