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Protein

Mitochondrial import inner membrane translocase subunit Tim29

Gene

TIMM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.2 Publications

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim291 Publication
Short name:
TIM291 Publication
Gene namesi
Name:TIMM29Imported
Synonyms:c19orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25152. TIMM29.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 59Mitochondrial matrix2 PublicationsAdd BLAST28
Transmembranei60 – 77HelicalSequence analysisAdd BLAST18
Topological domaini78 – 260Mitochondrial intermembrane2 PublicationsAdd BLAST183

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial inner membrane protein insertion complex Source: UniProtKB
  • mitochondrial intermembrane space Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142444.
PharmGKBiPA147358399.

Polymorphism and mutation databases

BioMutaiC19orf52.
DMDMi74732998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000027100632 – 260Mitochondrial import inner membrane translocase subunit Tim29Add BLAST229

Proteomic databases

EPDiQ9BSF4.
MaxQBiQ9BSF4.
PaxDbiQ9BSF4.
PeptideAtlasiQ9BSF4.
PRIDEiQ9BSF4.

PTM databases

iPTMnetiQ9BSF4.
PhosphoSitePlusiQ9BSF4.

Expressioni

Gene expression databases

BgeeiENSG00000142444.
CleanExiHS_C19orf52.
ExpressionAtlasiQ9BSF4. baseline and differential.
GenevisibleiQ9BSF4. HS.

Organism-specific databases

HPAiHPA041858.

Interactioni

Subunit structurei

Component of the TIM22 complex, whose core is composed of TIMM22, associated with TIMM10B, TIMM9, TIMM10 and TIMM29 (PubMed:27554484, PubMed:27718247). Interacts directly with TIMM10B (PubMed:27554484). Interacts with TOMM40; linking the TIM22 complex to the TOM complex (PubMed:27554484). Interacts directly with oxidized TIMM22 (PubMed:27718247).2 Publications

Protein-protein interaction databases

BioGridi124736. 30 interactors.
IntActiQ9BSF4. 8 interactors.
STRINGi9606.ENSP00000270502.

Structurei

3D structure databases

ProteinModelPortaliQ9BSF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4545. Eukaryota.
ENOG4111K8C. LUCA.
GeneTreeiENSGT00390000018541.
HOGENOMiHOG000111996.
HOVERGENiHBG067802.
InParanoidiQ9BSF4.
OMAiYAEACRD.
OrthoDBiEOG091G0ZEJ.
PhylomeDBiQ9BSF4.
TreeFamiTF313304.

Family and domain databases

InterProiView protein in InterPro
IPR019322. TIMM29.
PANTHERiPTHR21435. PTHR21435. 1 hit.
PfamiView protein in Pfam
PF10171. Tim29. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BSF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRRFW SRRRAEAGDA VVAKPGVWAR LGSWARALLR DYAEACRDAS
60 70 80 90 100
AEARARPGRA AVYVGLLGGA AACFTLAPSE GAFEEALLEA SGTLLLLAPA
110 120 130 140 150
TRNRESEAFV QRLLWLRGRG RLRYVNLGLC SLVYEAPFDA QASLYQARCR
160 170 180 190 200
YLQPRWTDFP GRVLDVGFVG RWWVLGAWMR DCDINDDEFL HLPAHLRVVG
210 220 230 240 250
PQQLHSETNE RLFDEKYKPV VLTDDQVDQA LWEEQVLQKE KKDRLALSQA
260
HSLVQAEAPR
Length:260
Mass (Da):29,233
Last modified:March 1, 2004 - v2
Checksum:i000324A28C9F2902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011442 Genomic DNA. No translation available.
BC005075 mRNA. Translation: AAH05075.2.
BC007244 mRNA. Translation: AAH07244.2.
BC011833 mRNA. Translation: AAH11833.1.
CCDSiCCDS12252.1.
RefSeqiNP_612367.1. NM_138358.2.
UniGeneiHs.164026.

Genome annotation databases

EnsembliENST00000270502; ENSP00000270502; ENSG00000142444.
GeneIDi90580.
KEGGihsa:90580.
UCSCiuc002mqd.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTIM29_HUMAN
AccessioniPrimary (citable) accession number: Q9BSF4
Secondary accession number(s): Q96EY6, Q96IT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2004
Last modified: June 7, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot