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Protein

Small membrane A-kinase anchor protein

Gene

C2orf88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Small membrane A-kinase anchor protein
Short name:
Small membrane AKAP
Short name:
smAKAP
Gene namesi
Name:C2orf88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28191. C2orf88.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Loss of plasma membrane localization. 1 Publication
Mutagenesisi3 – 31C → A: Loss of plasma membrane localization. 1 Publication

Organism-specific databases

PharmGKBiPA164717227.

Polymorphism and mutation databases

BioMutaiC2orf88.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCurated
Chaini2 – 9594Small membrane A-kinase anchor proteinPRO_0000348430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Lipidationi3 – 31S-palmitoyl cysteine1 Publication
Modified residuei40 – 401PhosphoserineBy similarity

Post-translational modificationi

May be palmitoylated at Cys-3.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9BSF0.
PaxDbiQ9BSF0.
PRIDEiQ9BSF0.

PTM databases

iPTMnetiQ9BSF0.
PhosphoSiteiQ9BSF0.
SwissPalmiQ9BSF0.

Expressioni

Tissue specificityi

Expressed in heart (at protein level).1 Publication

Gene expression databases

BgeeiQ9BSF0.
ExpressionAtlasiQ9BSF0. baseline and differential.
GenevisibleiQ9BSF0. HS.

Organism-specific databases

HPAiHPA049549.

Interactioni

Subunit structurei

Interacts with PRKAR1A and PRKAR1B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZMIZ2Q8NF64-23EBI-744298,EBI-10182121

Protein-protein interaction databases

BioGridi124008. 9 interactions.
IntActiQ9BSF0. 9 interactions.
MINTiMINT-1464332.
STRINGi9606.ENSP00000345107.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5HVZX-ray2.00C56-79[»]
ProteinModelPortaliQ9BSF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 7419PKA-RI-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the small membrane AKAP family.Curated

Phylogenomic databases

eggNOGiENOG410J194. Eukaryota.
ENOG410Z7R6. LUCA.
GeneTreeiENSGT00390000011537.
HOGENOMiHOG000111341.
InParanoidiQ9BSF0.
OMAiNIKYYDI.
PhylomeDBiQ9BSF0.
TreeFamiTF338355.

Family and domain databases

InterProiIPR027969. Small_membr_AKAP.
[Graphical view]
PfamiPF15127. SmAKAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BSF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCMKSKQTF PFPTIYEGEK QHESEEPFMP EERCLPRMAS PVNVKEEVKE
60 70 80 90
PPGTNTVILE YAHRLSQDIL CDALQQWACN NIKYHDIPYI ESEGP
Length:95
Mass (Da):10,970
Last modified:September 2, 2008 - v2
Checksum:i9E6DDFAF29F29551
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → Q in AK075168 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561T → I.1 Publication
Corresponds to variant rs6753459 [ dbSNP | Ensembl ].
VAR_046151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313395 mRNA. Translation: BAG36193.1.
AK075168 mRNA. No translation available.
AC010679 Genomic DNA. Translation: AAX93233.1.
CH471058 Genomic DNA. Translation: EAX10878.1.
CH471058 Genomic DNA. Translation: EAX10879.1.
BC005083 mRNA. Translation: AAH05083.1.
CCDSiCCDS42792.1.
RefSeqiNP_001035984.1. NM_001042519.1.
NP_001035985.1. NM_001042520.1.
NP_001035986.1. NM_001042521.1.
NP_115697.2. NM_032321.2.
XP_005246962.1. XM_005246905.1.
XP_006712858.1. XM_006712795.2.
XP_011510284.1. XM_011511982.1.
XP_011510285.1. XM_011511983.1.
XP_011510286.1. XM_011511984.1.
XP_011510287.1. XM_011511985.1.
XP_011510288.1. XM_011511986.1.
XP_011510289.1. XM_011511987.1.
UniGeneiHs.389311.

Genome annotation databases

EnsembliENST00000340623; ENSP00000345107; ENSG00000187699.
ENST00000396974; ENSP00000380172; ENSG00000187699.
ENST00000409870; ENSP00000386649; ENSG00000187699.
ENST00000443551; ENSP00000405225; ENSG00000187699.
GeneIDi84281.
KEGGihsa:84281.
UCSCiuc002urq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313395 mRNA. Translation: BAG36193.1.
AK075168 mRNA. No translation available.
AC010679 Genomic DNA. Translation: AAX93233.1.
CH471058 Genomic DNA. Translation: EAX10878.1.
CH471058 Genomic DNA. Translation: EAX10879.1.
BC005083 mRNA. Translation: AAH05083.1.
CCDSiCCDS42792.1.
RefSeqiNP_001035984.1. NM_001042519.1.
NP_001035985.1. NM_001042520.1.
NP_001035986.1. NM_001042521.1.
NP_115697.2. NM_032321.2.
XP_005246962.1. XM_005246905.1.
XP_006712858.1. XM_006712795.2.
XP_011510284.1. XM_011511982.1.
XP_011510285.1. XM_011511983.1.
XP_011510286.1. XM_011511984.1.
XP_011510287.1. XM_011511985.1.
XP_011510288.1. XM_011511986.1.
XP_011510289.1. XM_011511987.1.
UniGeneiHs.389311.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5HVZX-ray2.00C56-79[»]
ProteinModelPortaliQ9BSF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124008. 9 interactions.
IntActiQ9BSF0. 9 interactions.
MINTiMINT-1464332.
STRINGi9606.ENSP00000345107.

PTM databases

iPTMnetiQ9BSF0.
PhosphoSiteiQ9BSF0.
SwissPalmiQ9BSF0.

Polymorphism and mutation databases

BioMutaiC2orf88.

Proteomic databases

MaxQBiQ9BSF0.
PaxDbiQ9BSF0.
PRIDEiQ9BSF0.

Protocols and materials databases

DNASUi84281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340623; ENSP00000345107; ENSG00000187699.
ENST00000396974; ENSP00000380172; ENSG00000187699.
ENST00000409870; ENSP00000386649; ENSG00000187699.
ENST00000443551; ENSP00000405225; ENSG00000187699.
GeneIDi84281.
KEGGihsa:84281.
UCSCiuc002urq.4. human.

Organism-specific databases

CTDi84281.
GeneCardsiC2orf88.
HGNCiHGNC:28191. C2orf88.
HPAiHPA049549.
MIMi615117. gene.
neXtProtiNX_Q9BSF0.
PharmGKBiPA164717227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J194. Eukaryota.
ENOG410Z7R6. LUCA.
GeneTreeiENSGT00390000011537.
HOGENOMiHOG000111341.
InParanoidiQ9BSF0.
OMAiNIKYYDI.
PhylomeDBiQ9BSF0.
TreeFamiTF338355.

Miscellaneous databases

GenomeRNAii84281.
PROiQ9BSF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BSF0.
ExpressionAtlasiQ9BSF0. baseline and differential.
GenevisibleiQ9BSF0. HS.

Family and domain databases

InterProiIPR027969. Small_membr_AKAP.
[Graphical view]
PfamiPF15127. SmAKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-56.
    Tissue: Uterus.
  6. "A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane."
    Burgers P.P., Ma Y., Margarucci L., Mackey M., van der Heyden M.A., Ellisman M., Scholten A., Taylor S.S., Heck A.J.
    J. Biol. Chem. 287:43789-43797(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 6-33 AND 38-95, FUNCTION, INTERACTION WITH PRKAR1A AND PRKAR1B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-3, MUTAGENESIS OF GLY-2 AND CYS-3.

Entry informationi

Entry nameiSMAKA_HUMAN
AccessioniPrimary (citable) accession number: Q9BSF0
Secondary accession number(s): D3DPI3, P0C876, Q53TC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.