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Protein

Small membrane A-kinase anchor protein

Gene

C2orf88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Small membrane A-kinase anchor protein
Short name:
Small membrane AKAP
Short name:
smAKAP
Gene namesi
Name:C2orf88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187699.10
HGNCiHGNC:28191 C2orf88
MIMi615117 gene
neXtProtiNX_Q9BSF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Loss of plasma membrane localization. 1 Publication1
Mutagenesisi3C → A: Loss of plasma membrane localization. 1 Publication1

Organism-specific databases

DisGeNETi84281
OpenTargetsiENSG00000187699
PharmGKBiPA164717227

Polymorphism and mutation databases

BioMutaiC2orf88

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00003484302 – 95Small membrane A-kinase anchor proteinAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi3S-palmitoyl cysteine1 Publication1
Modified residuei40PhosphoserineBy similarity1
Modified residuei92PhosphoserineCombined sources1

Post-translational modificationi

May be palmitoylated at Cys-3.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9BSF0
PaxDbiQ9BSF0
PeptideAtlasiQ9BSF0
PRIDEiQ9BSF0

PTM databases

iPTMnetiQ9BSF0
PhosphoSitePlusiQ9BSF0
SwissPalmiQ9BSF0

Expressioni

Tissue specificityi

Expressed in heart (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000187699
ExpressionAtlasiQ9BSF0 baseline and differential
GenevisibleiQ9BSF0 HS

Organism-specific databases

HPAiHPA049549

Interactioni

Subunit structurei

Interacts with PRKAR1A and PRKAR1B.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124008, 10 interactors
IntActiQ9BSF0, 10 interactors
STRINGi9606.ENSP00000345107

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 74Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HVZX-ray2.00C56-79[»]
ProteinModelPortaliQ9BSF0
SMRiQ9BSF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 74PKA-RI-bindingAdd BLAST19

Sequence similaritiesi

Belongs to the small membrane AKAP family.Curated

Phylogenomic databases

eggNOGiENOG410J194 Eukaryota
ENOG410Z7R6 LUCA
GeneTreeiENSGT00390000011537
HOGENOMiHOG000111341
InParanoidiQ9BSF0
OMAiNIKYYDI
OrthoDBiEOG091G10JT
PhylomeDBiQ9BSF0
TreeFamiTF338355

Family and domain databases

InterProiView protein in InterPro
IPR027969 Small_membr_AKAP
PANTHERiPTHR36471 PTHR36471, 1 hit
PfamiView protein in Pfam
PF15127 SmAKAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BSF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCMKSKQTF PFPTIYEGEK QHESEEPFMP EERCLPRMAS PVNVKEEVKE
60 70 80 90
PPGTNTVILE YAHRLSQDIL CDALQQWACN NIKYHDIPYI ESEGP
Length:95
Mass (Da):10,970
Last modified:September 2, 2008 - v2
Checksum:i9E6DDFAF29F29551
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → Q in AK075168 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04615156T → I1 PublicationCorresponds to variant dbSNP:rs6753459Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313395 mRNA Translation: BAG36193.1
AK075168 mRNA No translation available.
AC010679 Genomic DNA Translation: AAX93233.1
CH471058 Genomic DNA Translation: EAX10878.1
CH471058 Genomic DNA Translation: EAX10879.1
BC005083 mRNA Translation: AAH05083.1
CCDSiCCDS42792.1
RefSeqiNP_001035984.1, NM_001042519.1
NP_001035985.1, NM_001042520.1
NP_001035986.1, NM_001042521.1
NP_115697.2, NM_032321.2
XP_005246962.1, XM_005246905.1
XP_006712858.1, XM_006712795.2
XP_011510284.1, XM_011511982.1
XP_011510285.1, XM_011511983.1
XP_011510286.1, XM_011511984.2
XP_011510287.1, XM_011511985.2
XP_011510288.1, XM_011511986.2
XP_016860585.1, XM_017005096.1
UniGeneiHs.389311

Genome annotation databases

EnsembliENST00000340623; ENSP00000345107; ENSG00000187699
ENST00000396974; ENSP00000380172; ENSG00000187699
ENST00000409870; ENSP00000386649; ENSG00000187699
ENST00000443551; ENSP00000405225; ENSG00000187699
GeneIDi84281
KEGGihsa:84281
UCSCiuc002urq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSMAKA_HUMAN
AccessioniPrimary (citable) accession number: Q9BSF0
Secondary accession number(s): D3DPI3, P0C876, Q53TC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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