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Protein

Agmatinase, mitochondrial

Gene

AGMAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.1 Publication

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase, mitochondrial (AGMAT)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Manganese 1PROSITE-ProRule annotation1
Metal bindingi185Manganese 1PROSITE-ProRule annotation1
Metal bindingi185Manganese 2PROSITE-ProRule annotation1
Metal bindingi187Manganese 2PROSITE-ProRule annotation1
Metal bindingi189Manganese 1PROSITE-ProRule annotation1
Metal bindingi276Manganese 1PROSITE-ProRule annotation1
Metal bindingi276Manganese 2PROSITE-ProRule annotation1
Metal bindingi278Manganese 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS04051-MONOMER.
ZFISH:HS04051-MONOMER.
BRENDAi3.5.3.11. 2681.
ReactomeiR-HSA-351143. Agmatine biosynthesis.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase, mitochondrial (EC:3.5.3.111 Publication)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:AGMAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18407. AGMAT.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi79814.
OpenTargetsiENSG00000116771.
PharmGKBiPA24619.

Polymorphism and mutation databases

BioMutaiAGMAT.
DMDMi126302602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000000208936 – 352Agmatinase, mitochondrialAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193N6-acetyllysineBy similarity1
Modified residuei217N6-acetyllysine; alternateBy similarity1
Modified residuei217N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BSE5.
MaxQBiQ9BSE5.
PaxDbiQ9BSE5.
PeptideAtlasiQ9BSE5.
PRIDEiQ9BSE5.

PTM databases

iPTMnetiQ9BSE5.
PhosphoSitePlusiQ9BSE5.

Expressioni

Tissue specificityi

Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000116771.
CleanExiHS_AGMAT.
ExpressionAtlasiQ9BSE5. baseline and differential.
GenevisibleiQ9BSE5. HS.

Organism-specific databases

HPAiHPA026443.
HPA028321.

Interactioni

Protein-protein interaction databases

BioGridi122909. 16 interactors.
STRINGi9606.ENSP00000364986.

Structurei

3D structure databases

ProteinModelPortaliQ9BSE5.
SMRiQ9BSE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2964. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204320.
HOVERGENiHBG023165.
InParanoidiQ9BSE5.
KOiK01480.
OMAiYELTTIM.
OrthoDBiEOG091G0HCM.
PhylomeDBiQ9BSE5.
TreeFamiTF328612.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BSE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLLASGCA RGPGPGVGAR PAAGLFHPGR RQSRQASDAP RNQPPSPEFV
60 70 80 90 100
ARPVGVCSMM RLPVQTSPEG LDAAFIGVPL DTGTSNRPGA RFGPRRIREE
110 120 130 140 150
SVMLGTVNPS TGALPFQSLM VADLGDVNVN LYNLQDSCRR IQEAYEKIVA
160 170 180 190 200
AGCIPLTLGG DHTITYPILQ AMAKKHGPVG LLHVDAHTDT TDKALGEKLY
210 220 230 240 250
HGAPFRRCVD EGLLDCKRVV QIGIRGSSTT LDPYRYNRSQ GFRVVLAEDC
260 270 280 290 300
WMKSLVPLMG EVRQQMGGKP IYISFDIDAL DPAYAPGTGT PEIAGLTPSQ
310 320 330 340 350
ALEIIRGCQG LNVMGCDLVE VSPPYDLSGN TALLAANLLF EMLCALPKVT

TV
Length:352
Mass (Da):37,660
Last modified:February 20, 2007 - v2
Checksum:i394738202353314A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145Y → C in BAB15633 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023485105G → R.3 PublicationsCorresponds to variant rs6429757dbSNPEnsembl.1
Natural variantiVAR_048332140R → Q.1 PublicationCorresponds to variant rs11580170dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057097 mRNA. Translation: AAL24446.1.
AK027037 mRNA. Translation: BAB15633.1.
AL121992 Genomic DNA. Translation: CAI22366.1.
BC005090 mRNA. Translation: AAH05090.1.
CCDSiCCDS160.1.
RefSeqiNP_079034.3. NM_024758.4.
UniGeneiHs.461532.

Genome annotation databases

EnsembliENST00000375826; ENSP00000364986; ENSG00000116771.
GeneIDi79814.
KEGGihsa:79814.
UCSCiuc001awv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057097 mRNA. Translation: AAL24446.1.
AK027037 mRNA. Translation: BAB15633.1.
AL121992 Genomic DNA. Translation: CAI22366.1.
BC005090 mRNA. Translation: AAH05090.1.
CCDSiCCDS160.1.
RefSeqiNP_079034.3. NM_024758.4.
UniGeneiHs.461532.

3D structure databases

ProteinModelPortaliQ9BSE5.
SMRiQ9BSE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122909. 16 interactors.
STRINGi9606.ENSP00000364986.

PTM databases

iPTMnetiQ9BSE5.
PhosphoSitePlusiQ9BSE5.

Polymorphism and mutation databases

BioMutaiAGMAT.
DMDMi126302602.

Proteomic databases

EPDiQ9BSE5.
MaxQBiQ9BSE5.
PaxDbiQ9BSE5.
PeptideAtlasiQ9BSE5.
PRIDEiQ9BSE5.

Protocols and materials databases

DNASUi79814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375826; ENSP00000364986; ENSG00000116771.
GeneIDi79814.
KEGGihsa:79814.
UCSCiuc001awv.3. human.

Organism-specific databases

CTDi79814.
DisGeNETi79814.
GeneCardsiAGMAT.
H-InvDBHIX0000155.
HGNCiHGNC:18407. AGMAT.
HPAiHPA026443.
HPA028321.
neXtProtiNX_Q9BSE5.
OpenTargetsiENSG00000116771.
PharmGKBiPA24619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2964. Eukaryota.
COG0010. LUCA.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204320.
HOVERGENiHBG023165.
InParanoidiQ9BSE5.
KOiK01480.
OMAiYELTTIM.
OrthoDBiEOG091G0HCM.
PhylomeDBiQ9BSE5.
TreeFamiTF328612.

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287.
BioCyciMetaCyc:HS04051-MONOMER.
ZFISH:HS04051-MONOMER.
BRENDAi3.5.3.11. 2681.
ReactomeiR-HSA-351143. Agmatine biosynthesis.

Miscellaneous databases

GeneWikiiAgmatinase.
GenomeRNAii79814.
PROiQ9BSE5.

Gene expression databases

BgeeiENSG00000116771.
CleanExiHS_AGMAT.
ExpressionAtlasiQ9BSE5. baseline and differential.
GenevisibleiQ9BSE5. HS.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPEB_HUMAN
AccessioniPrimary (citable) accession number: Q9BSE5
Secondary accession number(s): Q5TDH1, Q9H5J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.