ID HERP2_HUMAN Reviewed; 406 AA. AC Q9BSE4; A4D1Y8; Q9H6F9; DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 24-JAN-2024, entry version 159. DE RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; GN Name=HERPUD2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney epithelium, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-108. RC TISSUE=Colon, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP STRUCTURE BY NMR OF 9-85. RG Northeast structural genomics consortium (NESG); RT "Structure of human homocysteine-inducible, endoplasmic reticulum stress- RT inducible, ubiquitin-like domain member 2 (HERPUD2 or HERP)."; RL Submitted (MAY-2012) to the PDB data bank. CC -!- FUNCTION: Could be involved in the unfolded protein response (UPR) CC pathway. {ECO:0000250}. CC -!- INTERACTION: CC Q9BSE4; Q5BKT4: ALG10; NbExp=3; IntAct=EBI-2868124, EBI-13064220; CC Q9BSE4; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-2868124, EBI-10269179; CC Q9BSE4; P52803: EFNA5; NbExp=3; IntAct=EBI-2868124, EBI-1753674; CC Q9BSE4; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-2868124, EBI-725665; CC Q9BSE4; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-2868124, EBI-12070086; CC Q9BSE4; Q96HR8: NAF1; NbExp=3; IntAct=EBI-2868124, EBI-2515597; CC Q9BSE4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-2868124, EBI-12363689; CC Q9BSE4; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-2868124, EBI-2823239; CC Q9BSE4; P30825: SLC7A1; NbExp=3; IntAct=EBI-2868124, EBI-4289564; CC Q9BSE4; Q969W0: SPTSSA; NbExp=3; IntAct=EBI-2868124, EBI-723396; CC Q9BSE4; Q9NYW0: TAS2R10; NbExp=3; IntAct=EBI-2868124, EBI-12963900; CC Q9BSE4; P55061: TMBIM6; NbExp=5; IntAct=EBI-2868124, EBI-1045825; CC Q9BSE4; Q7Z5S9: TMEM144; NbExp=3; IntAct=EBI-2868124, EBI-12876358; CC Q9BSE4; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-2868124, EBI-2852148; CC Q9BSE4; P63146: UBE2B; NbExp=3; IntAct=EBI-2868124, EBI-712629; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK055708; BAG51558.1; -; mRNA. DR EMBL; AK315685; BAG38050.1; -; mRNA. DR EMBL; AC018647; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236951; EAL23973.1; -; Genomic_DNA. DR EMBL; CH471073; EAW94051.1; -; Genomic_DNA. DR EMBL; BC005091; AAH05091.1; -; mRNA. DR EMBL; BC020264; AAH20264.1; -; mRNA. DR EMBL; AK025966; BAB15300.1; -; mRNA. DR CCDS; CCDS5446.1; -. DR RefSeq; NP_071768.3; NM_022373.4. DR RefSeq; XP_016867995.1; XM_017012506.1. DR PDB; 2KDB; NMR; -; A=9-85. DR PDBsum; 2KDB; -. DR AlphaFoldDB; Q9BSE4; -. DR BMRB; Q9BSE4; -. DR SMR; Q9BSE4; -. DR BioGRID; 122114; 24. DR IntAct; Q9BSE4; 22. DR STRING; 9606.ENSP00000379390; -. DR iPTMnet; Q9BSE4; -. DR PhosphoSitePlus; Q9BSE4; -. DR BioMuta; HERPUD2; -. DR DMDM; 296434524; -. DR EPD; Q9BSE4; -. DR jPOST; Q9BSE4; -. DR MassIVE; Q9BSE4; -. DR MaxQB; Q9BSE4; -. DR PaxDb; 9606-ENSP00000379390; -. DR PeptideAtlas; Q9BSE4; -. DR ProteomicsDB; 78881; -. DR Pumba; Q9BSE4; -. DR Antibodypedia; 2395; 123 antibodies from 23 providers. DR DNASU; 64224; -. DR Ensembl; ENST00000311350.8; ENSP00000310729.3; ENSG00000122557.11. DR Ensembl; ENST00000396081.5; ENSP00000379390.1; ENSG00000122557.11. DR GeneID; 64224; -. DR KEGG; hsa:64224; -. DR MANE-Select; ENST00000311350.8; ENSP00000310729.3; NM_022373.5; NP_071768.3. DR UCSC; uc003tes.5; human. DR AGR; HGNC:21915; -. DR CTD; 64224; -. DR DisGeNET; 64224; -. DR GeneCards; HERPUD2; -. DR HGNC; HGNC:21915; HERPUD2. DR HPA; ENSG00000122557; Low tissue specificity. DR neXtProt; NX_Q9BSE4; -. DR OpenTargets; ENSG00000122557; -. DR PharmGKB; PA144596425; -. DR VEuPathDB; HostDB:ENSG00000122557; -. DR eggNOG; KOG4583; Eukaryota. DR GeneTree; ENSGT00390000017671; -. DR HOGENOM; CLU_058243_0_0_1; -. DR InParanoid; Q9BSE4; -. DR OMA; TQYMQLM; -. DR OrthoDB; 5406902at2759; -. DR PhylomeDB; Q9BSE4; -. DR TreeFam; TF324319; -. DR PathwayCommons; Q9BSE4; -. DR SignaLink; Q9BSE4; -. DR BioGRID-ORCS; 64224; 19 hits in 1149 CRISPR screens. DR ChiTaRS; HERPUD2; human. DR EvolutionaryTrace; Q9BSE4; -. DR GenomeRNAi; 64224; -. DR Pharos; Q9BSE4; Tdark. DR PRO; PR:Q9BSE4; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q9BSE4; Protein. DR Bgee; ENSG00000122557; Expressed in cauda epididymis and 198 other cell types or tissues. DR ExpressionAtlas; Q9BSE4; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central. DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl. DR CDD; cd17119; Ubl_HERP2; 1. DR InterPro; IPR039751; HERPUD1/2. DR InterPro; IPR000626; Ubiquitin-like_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR12943:SF5; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN; 1. DR PANTHER; PTHR12943; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER; 1. DR Pfam; PF00240; ubiquitin; 1. DR SMART; SM00213; UBQ; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. DR Genevisible; Q9BSE4; HS. PE 1: Evidence at protein level; KW 3D-structure; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix; Unfolded protein response. FT CHAIN 1..406 FT /note="Homocysteine-responsive endoplasmic reticulum- FT resident ubiquitin-like domain member 2 protein" FT /id="PRO_0000280627" FT TRANSMEM 302..322 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 10..89 FT /note="Ubiquitin-like" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214" FT REGION 86..154 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 87..154 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 108 FT /note="A -> T (in dbSNP:rs3779234)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_031182" FT VARIANT 200 FT /note="H -> L (in dbSNP:rs2305335)" FT /id="VAR_031183" FT STRAND 10..15 FT /evidence="ECO:0007829|PDB:2KDB" FT STRAND 19..21 FT /evidence="ECO:0007829|PDB:2KDB" FT STRAND 24..28 FT /evidence="ECO:0007829|PDB:2KDB" FT HELIX 34..44 FT /evidence="ECO:0007829|PDB:2KDB" FT TURN 51..53 FT /evidence="ECO:0007829|PDB:2KDB" FT STRAND 56..58 FT /evidence="ECO:0007829|PDB:2KDB" FT STRAND 61..63 FT /evidence="ECO:0007829|PDB:2KDB" FT HELIX 70..73 FT /evidence="ECO:0007829|PDB:2KDB" FT TURN 74..76 FT /evidence="ECO:0007829|PDB:2KDB" FT STRAND 78..84 FT /evidence="ECO:0007829|PDB:2KDB" SQ SEQUENCE 406 AA; 45147 MW; E21BDCB03E1CD08A CRC64; MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN RESHEALASS SNSSSDHSGS TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF PVYPAFSPLQ MLWWQQMYAH QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP PAPNLVAQEN RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL EEMERLMDDG LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG PPQVAN //