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Q9BSE4

- HERP2_HUMAN

UniProt

Q9BSE4 - HERP2_HUMAN

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Protein
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene
HERPUD2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in the unfolded protein response (UPR) pathway By similarity.

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB-KW
  2. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene namesi
Name:HERPUD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21915. HERPUD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
PRO_0000280627Add
BLAST

Proteomic databases

MaxQBiQ9BSE4.
PaxDbiQ9BSE4.
PRIDEiQ9BSE4.

PTM databases

PhosphoSiteiQ9BSE4.

Expressioni

Gene expression databases

ArrayExpressiQ9BSE4.
BgeeiQ9BSE4.
CleanExiHS_HERPUD2.
GenevestigatoriQ9BSE4.

Organism-specific databases

HPAiHPA015630.

Interactioni

Protein-protein interaction databases

BioGridi122114. 2 interactions.
IntActiQ9BSE4. 3 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156
Beta strandi19 – 213
Beta strandi24 – 285
Helixi34 – 4411
Turni51 – 533
Beta strandi56 – 583
Beta strandi61 – 633
Helixi70 – 734
Turni74 – 763
Beta strandi78 – 847

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDBNMR-A9-85[»]
ProteinModelPortaliQ9BSE4.
SMRiQ9BSE4. Positions 9-85.

Miscellaneous databases

EvolutionaryTraceiQ9BSE4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8980Ubiquitin-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 13846Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259558.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9BSE4.
OMAiDNQFPGQ.
OrthoDBiEOG7QRQWK.
PhylomeDBiQ9BSE4.
TreeFamiTF324319.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSE4-1 [UniParc]FASTAAdd to Basket

« Hide

MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL    50
TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN 100
RESHEALASS SNSSSDHSGS TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ 150
TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF PVYPAFSPLQ MLWWQQMYAH 200
QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP PAPNLVAQEN 250
RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS 300
RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL 350
EEMERLMDDG LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG 400
PPQVAN 406
Length:406
Mass (Da):45,147
Last modified:May 18, 2010 - v2
Checksum:iE21BDCB03E1CD08A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081A → T.1 Publication
Corresponds to variant rs3779234 [ dbSNP | Ensembl ].
VAR_031182
Natural varianti200 – 2001H → L.
Corresponds to variant rs2305335 [ dbSNP | Ensembl ].
VAR_031183

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055708 mRNA. Translation: BAG51558.1.
AK315685 mRNA. Translation: BAG38050.1.
AC018647 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23973.1.
CH471073 Genomic DNA. Translation: EAW94051.1.
BC005091 mRNA. Translation: AAH05091.1.
BC020264 mRNA. Translation: AAH20264.1.
AK025966 mRNA. Translation: BAB15300.1.
CCDSiCCDS5446.1.
RefSeqiNP_071768.3. NM_022373.4.
UniGeneiHs.643051.

Genome annotation databases

EnsembliENST00000311350; ENSP00000310729; ENSG00000122557.
ENST00000396081; ENSP00000379390; ENSG00000122557.
GeneIDi64224.
KEGGihsa:64224.
UCSCiuc003tes.4. human.

Polymorphism databases

DMDMi296434524.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055708 mRNA. Translation: BAG51558.1 .
AK315685 mRNA. Translation: BAG38050.1 .
AC018647 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23973.1 .
CH471073 Genomic DNA. Translation: EAW94051.1 .
BC005091 mRNA. Translation: AAH05091.1 .
BC020264 mRNA. Translation: AAH20264.1 .
AK025966 mRNA. Translation: BAB15300.1 .
CCDSi CCDS5446.1.
RefSeqi NP_071768.3. NM_022373.4.
UniGenei Hs.643051.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KDB NMR - A 9-85 [» ]
ProteinModelPortali Q9BSE4.
SMRi Q9BSE4. Positions 9-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122114. 2 interactions.
IntActi Q9BSE4. 3 interactions.

PTM databases

PhosphoSitei Q9BSE4.

Polymorphism databases

DMDMi 296434524.

Proteomic databases

MaxQBi Q9BSE4.
PaxDbi Q9BSE4.
PRIDEi Q9BSE4.

Protocols and materials databases

DNASUi 64224.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311350 ; ENSP00000310729 ; ENSG00000122557 .
ENST00000396081 ; ENSP00000379390 ; ENSG00000122557 .
GeneIDi 64224.
KEGGi hsa:64224.
UCSCi uc003tes.4. human.

Organism-specific databases

CTDi 64224.
GeneCardsi GC07M035672.
HGNCi HGNC:21915. HERPUD2.
HPAi HPA015630.
neXtProti NX_Q9BSE4.
PharmGKBi PA144596425.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259558.
HOGENOMi HOG000252989.
HOVERGENi HBG051899.
InParanoidi Q9BSE4.
OMAi DNQFPGQ.
OrthoDBi EOG7QRQWK.
PhylomeDBi Q9BSE4.
TreeFami TF324319.

Miscellaneous databases

ChiTaRSi HERPUD2. human.
EvolutionaryTracei Q9BSE4.
GenomeRNAii 64224.
NextBioi 66158.
PROi Q9BSE4.

Gene expression databases

ArrayExpressi Q9BSE4.
Bgeei Q9BSE4.
CleanExi HS_HERPUD2.
Genevestigatori Q9BSE4.

Family and domain databases

InterProi IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney epithelium and Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-108.
    Tissue: Colon and Placenta.
  6. "Structure of human homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 2 (HERPUD2 or HERP)."
    Northeast structural genomics consortium (NESG)
    Submitted (MAY-2012) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 9-85.

Entry informationi

Entry nameiHERP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSE4
Secondary accession number(s): A4D1Y8, Q9H6F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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