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Q9BSE4

- HERP2_HUMAN

UniProt

Q9BSE4 - HERP2_HUMAN

Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Gene

HERPUD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Could be involved in the unfolded protein response (UPR) pathway.By similarity

    GO - Biological processi

    1. response to unfolded protein Source: UniProtKB-KW
    2. spermatogenesis Source: Ensembl

    Keywords - Biological processi

    Unfolded protein response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
    Gene namesi
    Name:HERPUD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21915. HERPUD2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596425.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinPRO_0000280627Add
    BLAST

    Proteomic databases

    MaxQBiQ9BSE4.
    PaxDbiQ9BSE4.
    PRIDEiQ9BSE4.

    PTM databases

    PhosphoSiteiQ9BSE4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BSE4.
    BgeeiQ9BSE4.
    CleanExiHS_HERPUD2.
    GenevestigatoriQ9BSE4.

    Organism-specific databases

    HPAiHPA015630.

    Interactioni

    Protein-protein interaction databases

    BioGridi122114. 2 interactions.
    IntActiQ9BSE4. 3 interactions.

    Structurei

    Secondary structure

    1
    406
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 156
    Beta strandi19 – 213
    Beta strandi24 – 285
    Helixi34 – 4411
    Turni51 – 533
    Beta strandi56 – 583
    Beta strandi61 – 633
    Helixi70 – 734
    Turni74 – 763
    Beta strandi78 – 847

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KDBNMR-A9-85[»]
    ProteinModelPortaliQ9BSE4.
    SMRiQ9BSE4. Positions 9-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BSE4.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 8980Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi93 – 13846Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259558.
    HOGENOMiHOG000252989.
    HOVERGENiHBG051899.
    InParanoidiQ9BSE4.
    OMAiDNQFPGQ.
    OrthoDBiEOG7QRQWK.
    PhylomeDBiQ9BSE4.
    TreeFamiTF324319.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BSE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL    50
    TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN 100
    RESHEALASS SNSSSDHSGS TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ 150
    TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF PVYPAFSPLQ MLWWQQMYAH 200
    QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP PAPNLVAQEN 250
    RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS 300
    RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL 350
    EEMERLMDDG LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG 400
    PPQVAN 406
    Length:406
    Mass (Da):45,147
    Last modified:May 18, 2010 - v2
    Checksum:iE21BDCB03E1CD08A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081A → T.1 Publication
    Corresponds to variant rs3779234 [ dbSNP | Ensembl ].
    VAR_031182
    Natural varianti200 – 2001H → L.
    Corresponds to variant rs2305335 [ dbSNP | Ensembl ].
    VAR_031183

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055708 mRNA. Translation: BAG51558.1.
    AK315685 mRNA. Translation: BAG38050.1.
    AC018647 Genomic DNA. No translation available.
    CH236951 Genomic DNA. Translation: EAL23973.1.
    CH471073 Genomic DNA. Translation: EAW94051.1.
    BC005091 mRNA. Translation: AAH05091.1.
    BC020264 mRNA. Translation: AAH20264.1.
    AK025966 mRNA. Translation: BAB15300.1.
    CCDSiCCDS5446.1.
    RefSeqiNP_071768.3. NM_022373.4.
    UniGeneiHs.643051.

    Genome annotation databases

    EnsembliENST00000311350; ENSP00000310729; ENSG00000122557.
    ENST00000396081; ENSP00000379390; ENSG00000122557.
    GeneIDi64224.
    KEGGihsa:64224.
    UCSCiuc003tes.4. human.

    Polymorphism databases

    DMDMi296434524.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055708 mRNA. Translation: BAG51558.1 .
    AK315685 mRNA. Translation: BAG38050.1 .
    AC018647 Genomic DNA. No translation available.
    CH236951 Genomic DNA. Translation: EAL23973.1 .
    CH471073 Genomic DNA. Translation: EAW94051.1 .
    BC005091 mRNA. Translation: AAH05091.1 .
    BC020264 mRNA. Translation: AAH20264.1 .
    AK025966 mRNA. Translation: BAB15300.1 .
    CCDSi CCDS5446.1.
    RefSeqi NP_071768.3. NM_022373.4.
    UniGenei Hs.643051.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KDB NMR - A 9-85 [» ]
    ProteinModelPortali Q9BSE4.
    SMRi Q9BSE4. Positions 9-85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122114. 2 interactions.
    IntActi Q9BSE4. 3 interactions.

    PTM databases

    PhosphoSitei Q9BSE4.

    Polymorphism databases

    DMDMi 296434524.

    Proteomic databases

    MaxQBi Q9BSE4.
    PaxDbi Q9BSE4.
    PRIDEi Q9BSE4.

    Protocols and materials databases

    DNASUi 64224.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311350 ; ENSP00000310729 ; ENSG00000122557 .
    ENST00000396081 ; ENSP00000379390 ; ENSG00000122557 .
    GeneIDi 64224.
    KEGGi hsa:64224.
    UCSCi uc003tes.4. human.

    Organism-specific databases

    CTDi 64224.
    GeneCardsi GC07M035672.
    HGNCi HGNC:21915. HERPUD2.
    HPAi HPA015630.
    neXtProti NX_Q9BSE4.
    PharmGKBi PA144596425.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259558.
    HOGENOMi HOG000252989.
    HOVERGENi HBG051899.
    InParanoidi Q9BSE4.
    OMAi DNQFPGQ.
    OrthoDBi EOG7QRQWK.
    PhylomeDBi Q9BSE4.
    TreeFami TF324319.

    Miscellaneous databases

    ChiTaRSi HERPUD2. human.
    EvolutionaryTracei Q9BSE4.
    GenomeRNAii 64224.
    NextBioi 66158.
    PROi Q9BSE4.

    Gene expression databases

    ArrayExpressi Q9BSE4.
    Bgeei Q9BSE4.
    CleanExi HS_HERPUD2.
    Genevestigatori Q9BSE4.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney epithelium and Testis.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-108.
      Tissue: Colon and Placenta.
    6. "Structure of human homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 2 (HERPUD2 or HERP)."
      Northeast structural genomics consortium (NESG)
      Submitted (MAY-2012) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 9-85.

    Entry informationi

    Entry nameiHERP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BSE4
    Secondary accession number(s): A4D1Y8, Q9H6F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3