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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Gene

HERPUD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the unfolded protein response (UPR) pathway.By similarity

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB-KW
  2. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene namesi
Name:HERPUD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21915. HERPUD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinPRO_0000280627Add
BLAST

Proteomic databases

MaxQBiQ9BSE4.
PaxDbiQ9BSE4.
PRIDEiQ9BSE4.

PTM databases

PhosphoSiteiQ9BSE4.

Expressioni

Gene expression databases

BgeeiQ9BSE4.
CleanExiHS_HERPUD2.
ExpressionAtlasiQ9BSE4. baseline and differential.
GenevestigatoriQ9BSE4.

Organism-specific databases

HPAiHPA015630.

Interactioni

Protein-protein interaction databases

BioGridi122114. 2 interactions.
IntActiQ9BSE4. 3 interactions.

Structurei

Secondary structure

1
406
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156Combined sources
Beta strandi19 – 213Combined sources
Beta strandi24 – 285Combined sources
Helixi34 – 4411Combined sources
Turni51 – 533Combined sources
Beta strandi56 – 583Combined sources
Beta strandi61 – 633Combined sources
Helixi70 – 734Combined sources
Turni74 – 763Combined sources
Beta strandi78 – 847Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDBNMR-A9-85[»]
ProteinModelPortaliQ9BSE4.
SMRiQ9BSE4. Positions 9-85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSE4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8980Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 13846Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259558.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9BSE4.
OMAiDNQFPGQ.
OrthoDBiEOG7QRQWK.
PhylomeDBiQ9BSE4.
TreeFamiTF324319.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL
60 70 80 90 100
TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN
110 120 130 140 150
RESHEALASS SNSSSDHSGS TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ
160 170 180 190 200
TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF PVYPAFSPLQ MLWWQQMYAH
210 220 230 240 250
QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP PAPNLVAQEN
260 270 280 290 300
RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
310 320 330 340 350
RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL
360 370 380 390 400
EEMERLMDDG LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG

PPQVAN
Length:406
Mass (Da):45,147
Last modified:May 18, 2010 - v2
Checksum:iE21BDCB03E1CD08A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081A → T.1 Publication
Corresponds to variant rs3779234 [ dbSNP | Ensembl ].
VAR_031182
Natural varianti200 – 2001H → L.
Corresponds to variant rs2305335 [ dbSNP | Ensembl ].
VAR_031183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055708 mRNA. Translation: BAG51558.1.
AK315685 mRNA. Translation: BAG38050.1.
AC018647 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23973.1.
CH471073 Genomic DNA. Translation: EAW94051.1.
BC005091 mRNA. Translation: AAH05091.1.
BC020264 mRNA. Translation: AAH20264.1.
AK025966 mRNA. Translation: BAB15300.1.
CCDSiCCDS5446.1.
RefSeqiNP_071768.3. NM_022373.4.
UniGeneiHs.643051.

Genome annotation databases

EnsembliENST00000311350; ENSP00000310729; ENSG00000122557.
ENST00000396081; ENSP00000379390; ENSG00000122557.
GeneIDi64224.
KEGGihsa:64224.
UCSCiuc003tes.4. human.

Polymorphism databases

DMDMi296434524.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055708 mRNA. Translation: BAG51558.1.
AK315685 mRNA. Translation: BAG38050.1.
AC018647 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23973.1.
CH471073 Genomic DNA. Translation: EAW94051.1.
BC005091 mRNA. Translation: AAH05091.1.
BC020264 mRNA. Translation: AAH20264.1.
AK025966 mRNA. Translation: BAB15300.1.
CCDSiCCDS5446.1.
RefSeqiNP_071768.3. NM_022373.4.
UniGeneiHs.643051.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDBNMR-A9-85[»]
ProteinModelPortaliQ9BSE4.
SMRiQ9BSE4. Positions 9-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122114. 2 interactions.
IntActiQ9BSE4. 3 interactions.

PTM databases

PhosphoSiteiQ9BSE4.

Polymorphism databases

DMDMi296434524.

Proteomic databases

MaxQBiQ9BSE4.
PaxDbiQ9BSE4.
PRIDEiQ9BSE4.

Protocols and materials databases

DNASUi64224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311350; ENSP00000310729; ENSG00000122557.
ENST00000396081; ENSP00000379390; ENSG00000122557.
GeneIDi64224.
KEGGihsa:64224.
UCSCiuc003tes.4. human.

Organism-specific databases

CTDi64224.
GeneCardsiGC07M035672.
HGNCiHGNC:21915. HERPUD2.
HPAiHPA015630.
neXtProtiNX_Q9BSE4.
PharmGKBiPA144596425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG259558.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9BSE4.
OMAiDNQFPGQ.
OrthoDBiEOG7QRQWK.
PhylomeDBiQ9BSE4.
TreeFamiTF324319.

Miscellaneous databases

ChiTaRSiHERPUD2. human.
EvolutionaryTraceiQ9BSE4.
GenomeRNAii64224.
NextBioi66158.
PROiQ9BSE4.

Gene expression databases

BgeeiQ9BSE4.
CleanExiHS_HERPUD2.
ExpressionAtlasiQ9BSE4. baseline and differential.
GenevestigatoriQ9BSE4.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney epithelium and Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-108.
    Tissue: Colon and Placenta.
  6. "Structure of human homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 2 (HERPUD2 or HERP)."
    Northeast structural genomics consortium (NESG)
    Submitted (MAY-2012) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 9-85.

Entry informationi

Entry nameiHERP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSE4
Secondary accession number(s): A4D1Y8, Q9H6F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.