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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

Gene

HERPUD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the unfolded protein response (UPR) pathway.By similarity

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Gene namesi
Name:HERPUD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122557.9.
HGNCiHGNC:21915. HERPUD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64224.
OpenTargetsiENSG00000122557.
PharmGKBiPA144596425.

Polymorphism and mutation databases

BioMutaiHERPUD2.
DMDMi296434524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002806271 – 406Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinAdd BLAST406

Proteomic databases

EPDiQ9BSE4.
MaxQBiQ9BSE4.
PaxDbiQ9BSE4.
PeptideAtlasiQ9BSE4.
PRIDEiQ9BSE4.

PTM databases

iPTMnetiQ9BSE4.
PhosphoSitePlusiQ9BSE4.

Expressioni

Gene expression databases

BgeeiENSG00000122557.
CleanExiHS_HERPUD2.
ExpressionAtlasiQ9BSE4. baseline and differential.
GenevisibleiQ9BSE4. HS.

Organism-specific databases

HPAiHPA015630.
HPA076087.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122114. 5 interactors.
IntActiQ9BSE4. 23 interactors.
STRINGi9606.ENSP00000310729.

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Beta strandi19 – 21Combined sources3
Beta strandi24 – 28Combined sources5
Helixi34 – 44Combined sources11
Turni51 – 53Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 63Combined sources3
Helixi70 – 73Combined sources4
Turni74 – 76Combined sources3
Beta strandi78 – 84Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KDBNMR-A9-85[»]
ProteinModelPortaliQ9BSE4.
SMRiQ9BSE4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSE4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 89Ubiquitin-likePROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 138Ser-richAdd BLAST46

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4583. Eukaryota.
ENOG410ZJAF. LUCA.
GeneTreeiENSGT00390000017671.
HOGENOMiHOG000252989.
HOVERGENiHBG051899.
InParanoidiQ9BSE4.
OMAiMYARHYY.
OrthoDBiEOG091G0P9J.
PhylomeDBiQ9BSE4.
TreeFamiTF324319.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BSE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL
60 70 80 90 100
TKDQRLVYSG RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN
110 120 130 140 150
RESHEALASS SNSSSDHSGS TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ
160 170 180 190 200
TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF PVYPAFSPLQ MLWWQQMYAH
210 220 230 240 250
QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP PAPNLVAQEN
260 270 280 290 300
RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
310 320 330 340 350
RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL
360 370 380 390 400
EEMERLMDDG LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG

PPQVAN
Length:406
Mass (Da):45,147
Last modified:May 18, 2010 - v2
Checksum:iE21BDCB03E1CD08A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031182108A → T1 PublicationCorresponds to variant dbSNP:rs3779234Ensembl.1
Natural variantiVAR_031183200H → L. Corresponds to variant dbSNP:rs2305335Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055708 mRNA. Translation: BAG51558.1.
AK315685 mRNA. Translation: BAG38050.1.
AC018647 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23973.1.
CH471073 Genomic DNA. Translation: EAW94051.1.
BC005091 mRNA. Translation: AAH05091.1.
BC020264 mRNA. Translation: AAH20264.1.
AK025966 mRNA. Translation: BAB15300.1.
CCDSiCCDS5446.1.
RefSeqiNP_071768.3. NM_022373.4.
XP_016867995.1. XM_017012506.1.
UniGeneiHs.643051.

Genome annotation databases

EnsembliENST00000311350; ENSP00000310729; ENSG00000122557.
ENST00000396081; ENSP00000379390; ENSG00000122557.
GeneIDi64224.
KEGGihsa:64224.
UCSCiuc003tes.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHERP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSE4
Secondary accession number(s): A4D1Y8, Q9H6F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references