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Protein

Cancer-related nucleoside-triphosphatase

Gene

NTPCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.1 Publication

Catalytic activityi

NTP + H2O = NDP + phosphate.

Kineticsi

  1. KM=5 µM for ATP1 Publication
  2. KM=46 µM for ADP1 Publication
  3. KM=4 µM for GTP1 Publication
  4. KM=6 µM for CTP1 Publication
  5. KM=7 µM for TTP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi9 – 16ATPCurated8
    Nucleotide bindingi109 – 116ATPCurated8

    GO - Molecular functioni

    Keywordsi

    Molecular functionHydrolase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06064-MONOMER
    SABIO-RKiQ9BSD7

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cancer-related nucleoside-triphosphatase (EC:3.6.1.15)
    Short name:
    NTPase
    Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
    Gene namesi
    Name:NTPCR
    Synonyms:C1orf57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000135778.11
    HGNCiHGNC:28204 NTPCR
    neXtProtiNX_Q9BSD7

    Subcellular locationi

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi114E → T: Reduced activity, especially towards ATP, GTP and TTP. 1 Publication1
    Mutagenesisi116G → H: Reduced activity, especially towards ATP, GTP and TTP. 1 Publication1

    Organism-specific databases

    DisGeNETi84284
    OpenTargetsiENSG00000135778
    PharmGKBiPA142672508

    Polymorphism and mutation databases

    BioMutaiNTPCR
    DMDMi54036528

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedCombined sources
    ChainiPRO_00001467112 – 190Cancer-related nucleoside-triphosphataseAdd BLAST189

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei2N-acetylalanineCombined sources1
    Modified residuei165N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    EPDiQ9BSD7
    MaxQBiQ9BSD7
    PaxDbiQ9BSD7
    PeptideAtlasiQ9BSD7
    PRIDEiQ9BSD7

    PTM databases

    iPTMnetiQ9BSD7
    PhosphoSitePlusiQ9BSD7

    Expressioni

    Gene expression databases

    BgeeiENSG00000135778
    CleanExiHS_C1orf57
    ExpressionAtlasiQ9BSD7 baseline and differential
    GenevisibleiQ9BSD7 HS

    Organism-specific databases

    HPAiHPA028125
    HPA054304

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi124011, 24 interactors
    IntActiQ9BSD7, 27 interactors
    STRINGi9606.ENSP00000355587

    Structurei

    Secondary structure

    1190
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi5 – 9Combined sources5
    Helixi15 – 28Combined sources14
    Beta strandi34 – 37Combined sources4
    Beta strandi40 – 42Combined sources3
    Beta strandi45 – 54Combined sources10
    Beta strandi59 – 64Combined sources6
    Beta strandi71 – 73Combined sources3
    Beta strandi76 – 83Combined sources8
    Helixi85 – 89Combined sources5
    Turni90 – 96Combined sources7
    Beta strandi110 – 112Combined sources3
    Turni117 – 121Combined sources5
    Helixi124 – 134Combined sources11
    Beta strandi140 – 143Combined sources4
    Helixi155 – 159Combined sources5
    Beta strandi164 – 168Combined sources5
    Beta strandi171 – 173Combined sources3
    Helixi174 – 176Combined sources3
    Helixi177 – 185Combined sources9

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2I3BNMR-A2-190[»]
    ProteinModelPortaliQ9BSD7
    SMRiQ9BSD7
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BSD7

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the THEP1 NTPase family.Curated

    Phylogenomic databases

    eggNOGiENOG410IXTM Eukaryota
    COG1618 LUCA
    GeneTreeiENSGT00390000018683
    HOVERGENiHBG058637
    InParanoidiQ9BSD7
    KOiK06928
    OMAiVCIIDEI
    PhylomeDBiQ9BSD7
    TreeFamiTF323592

    Family and domain databases

    HAMAPiMF_00796 NTPase_1, 1 hit
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR004948 Nuc-triphosphatase_THEP1
    IPR027417 P-loop_NTPase
    PfamiView protein in Pfam
    PF03266 NTPase_1, 1 hit
    SMARTiView protein in SMART
    SM00382 AAA, 1 hit
    SUPFAMiSSF52540 SSF52540, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BSD7-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MARHVFLTGP PGVGKTTLIH KASEVLKSSG VPVDGFYTEE VRQGGRRIGF
    60 70 80 90 100
    DVVTLSGTRG PLSRVGLEPP PGKRECRVGQ YVVDLTSFEQ LALPVLRNAD
    110 120 130 140 150
    CSSGPGQRVC VIDEIGKMEL FSQLFIQAVR QTLSTPGTII LGTIPVPKGK
    160 170 180 190
    PLALVEEIRN RKDVKVFNVT KENRNHLLPD IVTCVQSSRK
    Length:190
    Mass (Da):20,713
    Last modified:June 1, 2001 - v1
    Checksum:iB4B753F95796A210
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_053071106G → E. Corresponds to variant dbSNP:rs12123482Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF416713 mRNA Translation: AAL16807.1
    BC005102 mRNA Translation: AAH05102.1
    CCDSiCCDS1597.1
    RefSeqiNP_001316382.1, NM_001329453.1
    NP_115700.1, NM_032324.2
    UniGeneiHs.642715

    Genome annotation databases

    EnsembliENST00000366628; ENSP00000355587; ENSG00000135778
    GeneIDi84284
    KEGGihsa:84284
    UCSCiuc001hvj.2 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiNTPCR_HUMAN
    AccessioniPrimary (citable) accession number: Q9BSD7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 2001
    Last modified: May 23, 2018
    This is version 134 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

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