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Protein

Nucleolar protein 10

Gene

NOL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 10
Gene namesi
Name:NOL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25862. NOL10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671257.

Polymorphism and mutation databases

BioMutaiNOL10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688Nucleolar protein 10PRO_0000051101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BSC4.
MaxQBiQ9BSC4.
PaxDbiQ9BSC4.
PRIDEiQ9BSC4.

2D gel databases

SWISS-2DPAGEQ9BSC4.

PTM databases

iPTMnetiQ9BSC4.
PhosphoSiteiQ9BSC4.

Expressioni

Gene expression databases

BgeeiQ9BSC4.
CleanExiHS_NOL10.
ExpressionAtlasiQ9BSC4. baseline and differential.
GenevisibleiQ9BSC4. HS.

Organism-specific databases

HPAiHPA035286.
HPA043075.

Interactioni

Protein-protein interaction databases

BioGridi123023. 30 interactions.
IntActiQ9BSC4. 5 interactions.
MINTiMINT-3060916.
STRINGi9606.ENSP00000371101.

Structurei

3D structure databases

ProteinModelPortaliQ9BSC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 8239WD 1Add
BLAST
Repeati88 – 12437WD 2Add
BLAST
Repeati127 – 16337WD 3Add
BLAST
Repeati170 – 20536WD 4Add
BLAST
Repeati219 – 25840WD 5Add
BLAST
Repeati262 – 30039WD 6Add
BLAST
Repeati304 – 34138WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili423 – 44624Sequence analysisAdd
BLAST
Coiled coili514 – 58976Sequence analysisAdd
BLAST
Coiled coili640 – 67334Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat NOL10/ENP2 family.Curated
Contains 7 WD repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2321. Eukaryota.
ENOG410XQ2D. LUCA.
GeneTreeiENSGT00390000007900.
HOGENOMiHOG000182967.
HOVERGENiHBG082041.
InParanoidiQ9BSC4.
KOiK14788.
OMAiYVEFHSQ.
OrthoDBiEOG7SXW2S.
PhylomeDBiQ9BSC4.
TreeFamiTF105808.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR012580. NUC153.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08159. NUC153. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKDVDVR RRIELIQDFE
60 70 80 90 100
MPTVCTTIKV SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF
110 120 130 140 150
EILSDDYSKI VFLHNDRYIE FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY
160 170 180 190 200
FVGASSEVYR LNLEQGRYLN PLQTDAAENN VCDINSVHGL FATGTIEGRV
210 220 230 240 250
ECWDPRTRNR VGLLDCALNS VTADSEINSL PTISALKFNG ALTMAVGTTT
260 270 280 290 300
GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLILSA DSRIVKMWNK
310 320 330 340 350
NSGKIFTSLE PEHDLNDVCL YPNSGMLLTA NETPKMGIYY IPVLGPAPRW
360 370 380 390 400
CSFLDNLTEE LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH
410 420 430 440 450
GFFMDIRLYH KVKLMVNPFA YEEYRKDKIR QKIEETRAQR VQLKKLPKVN
460 470 480 490 500
KELALKLIEE EEEKQKSTWK KKVKSLPNIL TDDRFKVMFE NPDFQVDEES
510 520 530 540 550
EEFRLLNPLV SKISEKRKKK LRLLEQQELR EKEEEEEPEG KPSDAESSES
560 570 580 590 600
SDDEKAWVEE VRKQRRLLQQ EEKVKRQERL KEDQQTVLKP QFYEIKAGEE
610 620 630 640 650
FRSFKDSATK QKLMNKTLED RLKIEAKNGT LSVSDTTVGS KQLTFTLKRS
660 670 680
EQQKKQQEAE KLHRQERKRL RRSAGHLKSR HKRGRSFH
Length:688
Mass (Da):80,302
Last modified:June 1, 2001 - v1
Checksum:i27C3C9E0D7A4FA33
GO
Isoform 2 (identifier: Q9BSC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-302: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):74,509
Checksum:i13A71D5045CD8B2F
GO
Isoform 3 (identifier: Q9BSC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     151-154: FVGA → MTTQ
     343-345: VLG → PSL
     346-688: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,578
Checksum:i106DF2BDCA17093A
GO
Isoform 4 (identifier: Q9BSC4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-96: Missing.

Show »
Length:662
Mass (Da):77,148
Checksum:i63AD4D21BC5C50ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti494 – 4941F → L in BAB14836 (PubMed:14702039).Curated
Sequence conflicti570 – 5701Q → R in BAB14836 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti635 – 6351D → N.
Corresponds to variant rs2287059 [ dbSNP | Ensembl ].
VAR_060041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 150150Missing in isoform 3. 1 PublicationVSP_015454Add
BLAST
Alternative sequencei71 – 9626Missing in isoform 4. 1 PublicationVSP_045122Add
BLAST
Alternative sequencei151 – 1544FVGA → MTTQ in isoform 3. 1 PublicationVSP_015455
Alternative sequencei253 – 30250Missing in isoform 2. 1 PublicationVSP_015456Add
BLAST
Alternative sequencei343 – 3453VLG → PSL in isoform 3. 1 PublicationVSP_015457
Alternative sequencei346 – 688343Missing in isoform 3. 1 PublicationVSP_015458Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024000 mRNA. Translation: BAB14765.1.
AK024137 mRNA. Translation: BAB14836.1.
AK290680 mRNA. Translation: BAF83369.1.
AK297169 mRNA. Translation: BAG59662.1.
AC007314 Genomic DNA. Translation: AAK52071.2.
AC092687 Genomic DNA. Translation: AAY24068.1.
CH471053 Genomic DNA. Translation: EAX00955.1.
BC005125 mRNA. Translation: AAH05125.1.
CCDSiCCDS1673.2. [Q9BSC4-1]
CCDS58697.1. [Q9BSC4-4]
CCDS58698.1. [Q9BSC4-2]
RefSeqiNP_001248321.1. NM_001261392.1. [Q9BSC4-4]
NP_001248323.1. NM_001261394.1. [Q9BSC4-2]
NP_079170.2. NM_024894.3. [Q9BSC4-1]
UniGeneiHs.222494.

Genome annotation databases

EnsembliENST00000345985; ENSP00000263837; ENSG00000115761. [Q9BSC4-2]
ENST00000381685; ENSP00000371101; ENSG00000115761. [Q9BSC4-1]
ENST00000538384; ENSP00000439663; ENSG00000115761. [Q9BSC4-4]
GeneIDi79954.
KEGGihsa:79954.
UCSCiuc002rap.4. human. [Q9BSC4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024000 mRNA. Translation: BAB14765.1.
AK024137 mRNA. Translation: BAB14836.1.
AK290680 mRNA. Translation: BAF83369.1.
AK297169 mRNA. Translation: BAG59662.1.
AC007314 Genomic DNA. Translation: AAK52071.2.
AC092687 Genomic DNA. Translation: AAY24068.1.
CH471053 Genomic DNA. Translation: EAX00955.1.
BC005125 mRNA. Translation: AAH05125.1.
CCDSiCCDS1673.2. [Q9BSC4-1]
CCDS58697.1. [Q9BSC4-4]
CCDS58698.1. [Q9BSC4-2]
RefSeqiNP_001248321.1. NM_001261392.1. [Q9BSC4-4]
NP_001248323.1. NM_001261394.1. [Q9BSC4-2]
NP_079170.2. NM_024894.3. [Q9BSC4-1]
UniGeneiHs.222494.

3D structure databases

ProteinModelPortaliQ9BSC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123023. 30 interactions.
IntActiQ9BSC4. 5 interactions.
MINTiMINT-3060916.
STRINGi9606.ENSP00000371101.

PTM databases

iPTMnetiQ9BSC4.
PhosphoSiteiQ9BSC4.

Polymorphism and mutation databases

BioMutaiNOL10.

2D gel databases

SWISS-2DPAGEQ9BSC4.

Proteomic databases

EPDiQ9BSC4.
MaxQBiQ9BSC4.
PaxDbiQ9BSC4.
PRIDEiQ9BSC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345985; ENSP00000263837; ENSG00000115761. [Q9BSC4-2]
ENST00000381685; ENSP00000371101; ENSG00000115761. [Q9BSC4-1]
ENST00000538384; ENSP00000439663; ENSG00000115761. [Q9BSC4-4]
GeneIDi79954.
KEGGihsa:79954.
UCSCiuc002rap.4. human. [Q9BSC4-1]

Organism-specific databases

CTDi79954.
GeneCardsiNOL10.
HGNCiHGNC:25862. NOL10.
HPAiHPA035286.
HPA043075.
MIMi616197. gene.
neXtProtiNX_Q9BSC4.
PharmGKBiPA142671257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2321. Eukaryota.
ENOG410XQ2D. LUCA.
GeneTreeiENSGT00390000007900.
HOGENOMiHOG000182967.
HOVERGENiHBG082041.
InParanoidiQ9BSC4.
KOiK14788.
OMAiYVEFHSQ.
OrthoDBiEOG7SXW2S.
PhylomeDBiQ9BSC4.
TreeFamiTF105808.

Miscellaneous databases

ChiTaRSiNOL10. human.
GenomeRNAii79954.
PROiQ9BSC4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BSC4.
CleanExiHS_NOL10.
ExpressionAtlasiQ9BSC4. baseline and differential.
GenevisibleiQ9BSC4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR012580. NUC153.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08159. NUC153. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Brain and Embryo.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOL10_HUMAN
AccessioniPrimary (citable) accession number: Q9BSC4
Secondary accession number(s): A8K3R5
, B4DLV0, Q53RC9, Q96TA5, Q9H7Y7, Q9H855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.