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Protein

Autophagy-related protein 101

Gene

ATG101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.2 Publications

GO - Molecular functioni

  • protein complex binding Source: UniProtKB

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • macroautophagy Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
SIGNORiQ9BSB4.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:ATG101
Synonyms:C12orf44
ORF Names:PP894
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25679. ATG101.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • pre-autophagosomal structure Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31H → S: Impairs interaction with ATG13; when associated with R-54. 1 Publication1
Mutagenesisi54D → R: Impairs interaction with ATG13; when associated with S-31. 1 Publication1
Mutagenesisi152I → D: Abolishes interaction with ATG13; when associated with D-153 and D-156. 1 Publication1
Mutagenesisi153I → D: Abolishes interaction with ATG13; when associated with D-152 and D-156. 1 Publication1
Mutagenesisi156V → D: Abolishes interaction with ATG13; when associated with D-152 and D-152. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000123395.
PharmGKBiPA143485374.

Polymorphism and mutation databases

BioMutaiATG101.
DMDMi74732983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943221 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

EPDiQ9BSB4.
MaxQBiQ9BSB4.
PaxDbiQ9BSB4.
PeptideAtlasiQ9BSB4.
PRIDEiQ9BSB4.

PTM databases

iPTMnetiQ9BSB4.
PhosphoSitePlusiQ9BSB4.

Expressioni

Gene expression databases

BgeeiENSG00000123395.
CleanExiHS_C12orf44.
ExpressionAtlasiQ9BSB4. baseline and differential.
GenevisibleiQ9BSB4. HS.

Organism-specific databases

HPAiHPA039904.

Interactioni

Subunit structurei

Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2946739,EBI-2946739
ATG13O7514310EBI-2946739,EBI-2798775
MAP1LC3CQ9BXW42EBI-2946739,EBI-2603996
RB1CC1Q8TDY27EBI-2946739,EBI-1047793

GO - Molecular functioni

  • protein complex binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121948. 46 interactors.
DIPiDIP-60653N.
IntActiQ9BSB4. 40 interactors.
MINTiMINT-6780987.
STRINGi9606.ENSP00000338990.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Helixi14 – 16Combined sources3
Helixi17 – 31Combined sources15
Beta strandi37 – 39Combined sources3
Helixi41 – 43Combined sources3
Beta strandi45 – 47Combined sources3
Beta strandi52 – 56Combined sources5
Beta strandi58 – 61Combined sources4
Beta strandi63 – 68Combined sources6
Helixi70 – 89Combined sources20
Beta strandi92 – 105Combined sources14
Beta strandi113 – 129Combined sources17
Helixi134 – 161Combined sources28
Helixi171 – 176Combined sources6
Beta strandi186 – 188Combined sources3
Beta strandi190 – 198Combined sources9
Beta strandi202 – 207Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WZGX-ray1.90A1-218[»]
5C50X-ray1.63A1-198[»]
ProteinModelPortaliQ9BSB4.
SMRiQ9BSB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG131 Publication5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493. Eukaryota.
ENOG410XP6A. LUCA.
GeneTreeiENSGT00390000016511.
HOGENOMiHOG000008086.
InParanoidiQ9BSB4.
KOiK19730.
OMAiMGQISLE.
OrthoDBiEOG091G076X.
PhylomeDBiQ9BSB4.
TreeFamiTF320996.

Family and domain databases

InterProiIPR012445. ATG101.
[Graphical view]
PANTHERiPTHR13292. PTHR13292. 1 hit.
PfamiPF07855. ATG101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,003
Last modified:June 1, 2001 - v1
Checksum:i69A881EAF9A07659
GO

Sequence cautioni

The sequence AAG17273 differs from that shown. Reason: Frameshift at position 110.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47I → T in BAB13907 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021835 mRNA. Translation: BAB13907.1.
AF218031 mRNA. Translation: AAG17273.1. Frameshift.
AC025259 Genomic DNA. No translation available.
BC005151 mRNA. Translation: AAH05151.1.
BC009937 mRNA. Translation: AAH09937.1.
CCDSiCCDS8820.1.
RefSeqiNP_001092143.1. NM_001098673.1.
NP_068753.2. NM_021934.4.
UniGeneiHs.9911.

Genome annotation databases

EnsembliENST00000336854; ENSP00000338990; ENSG00000123395.
GeneIDi60673.
KEGGihsa:60673.
UCSCiuc001rzu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021835 mRNA. Translation: BAB13907.1.
AF218031 mRNA. Translation: AAG17273.1. Frameshift.
AC025259 Genomic DNA. No translation available.
BC005151 mRNA. Translation: AAH05151.1.
BC009937 mRNA. Translation: AAH09937.1.
CCDSiCCDS8820.1.
RefSeqiNP_001092143.1. NM_001098673.1.
NP_068753.2. NM_021934.4.
UniGeneiHs.9911.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WZGX-ray1.90A1-218[»]
5C50X-ray1.63A1-198[»]
ProteinModelPortaliQ9BSB4.
SMRiQ9BSB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121948. 46 interactors.
DIPiDIP-60653N.
IntActiQ9BSB4. 40 interactors.
MINTiMINT-6780987.
STRINGi9606.ENSP00000338990.

PTM databases

iPTMnetiQ9BSB4.
PhosphoSitePlusiQ9BSB4.

Polymorphism and mutation databases

BioMutaiATG101.
DMDMi74732983.

Proteomic databases

EPDiQ9BSB4.
MaxQBiQ9BSB4.
PaxDbiQ9BSB4.
PeptideAtlasiQ9BSB4.
PRIDEiQ9BSB4.

Protocols and materials databases

DNASUi60673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336854; ENSP00000338990; ENSG00000123395.
GeneIDi60673.
KEGGihsa:60673.
UCSCiuc001rzu.5. human.

Organism-specific databases

CTDi60673.
GeneCardsiATG101.
H-InvDBHIX0010645.
HGNCiHGNC:25679. ATG101.
HPAiHPA039904.
MIMi615089. gene.
neXtProtiNX_Q9BSB4.
OpenTargetsiENSG00000123395.
PharmGKBiPA143485374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4493. Eukaryota.
ENOG410XP6A. LUCA.
GeneTreeiENSGT00390000016511.
HOGENOMiHOG000008086.
InParanoidiQ9BSB4.
KOiK19730.
OMAiMGQISLE.
OrthoDBiEOG091G076X.
PhylomeDBiQ9BSB4.
TreeFamiTF320996.

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
SIGNORiQ9BSB4.

Miscellaneous databases

GeneWikiiAutophagy-related_protein_101.
GenomeRNAii60673.
PROiQ9BSB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123395.
CleanExiHS_C12orf44.
ExpressionAtlasiQ9BSB4. baseline and differential.
GenevisibleiQ9BSB4. HS.

Family and domain databases

InterProiIPR012445. ATG101.
[Graphical view]
PANTHERiPTHR13292. PTHR13292. 1 hit.
PfamiPF07855. ATG101. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATGA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSB4
Secondary accession number(s): Q9HAE2, Q9HBN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.