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Q9BSB4

- ATGA1_HUMAN

UniProt

Q9BSB4 - ATGA1_HUMAN

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Protein

Autophagy-related protein 101

Gene

ATG101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.2 Publications

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein complex binding Source: UniProtKB

GO - Biological processi

  1. autophagic vacuole assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:ATG101
Synonyms:C12orf44
ORF Names:PP894
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25679. ATG101.

Subcellular locationi

Cytoplasm 1 Publication. Preautophagosomal structure 1 Publication
Note: Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.

GO - Cellular componenti

  1. pre-autophagosomal structure Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Autophagy-related protein 101PRO_0000294322Add
BLAST

Proteomic databases

MaxQBiQ9BSB4.
PaxDbiQ9BSB4.
PRIDEiQ9BSB4.

PTM databases

PhosphoSiteiQ9BSB4.

Expressioni

Gene expression databases

BgeeiQ9BSB4.
CleanExiHS_C12orf44.
ExpressionAtlasiQ9BSB4. baseline and differential.
GenevestigatoriQ9BSB4.

Organism-specific databases

HPAiHPA039904.

Interactioni

Subunit structurei

Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2946739,EBI-2946739
ATG13O751436EBI-2946739,EBI-2798775
MAP1LC3CQ9BXW42EBI-2946739,EBI-2603996

Protein-protein interaction databases

BioGridi121948. 38 interactions.
DIPiDIP-60653N.
IntActiQ9BSB4. 38 interactions.
MINTiMINT-6780987.
STRINGi9606.ENSP00000338990.

Structurei

3D structure databases

ProteinModelPortaliQ9BSB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiNOG315429.
GeneTreeiENSGT00390000016511.
HOGENOMiHOG000008086.
InParanoidiQ9BSB4.
OMAiMGQISLE.
OrthoDBiEOG7DFXD6.
PhylomeDBiQ9BSB4.
TreeFamiTF320996.

Family and domain databases

InterProiIPR012445. ATG101.
[Graphical view]
PANTHERiPTHR13292. PTHR13292. 1 hit.
PfamiPF07855. DUF1649. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,003
Last modified:June 1, 2001 - v1
Checksum:i69A881EAF9A07659
GO

Sequence cautioni

The sequence AAG17273.1 differs from that shown. Reason: Frameshift at position 110.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471I → T in BAB13907. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021835 mRNA. Translation: BAB13907.1.
AF218031 mRNA. Translation: AAG17273.1. Frameshift.
AC025259 Genomic DNA. No translation available.
BC005151 mRNA. Translation: AAH05151.1.
BC009937 mRNA. Translation: AAH09937.1.
CCDSiCCDS8820.1.
RefSeqiNP_001092143.1. NM_001098673.1.
NP_068753.2. NM_021934.4.
UniGeneiHs.9911.

Genome annotation databases

EnsembliENST00000336854; ENSP00000338990; ENSG00000123395.
GeneIDi60673.
KEGGihsa:60673.
UCSCiuc001rzu.4. human.

Polymorphism databases

DMDMi74732983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021835 mRNA. Translation: BAB13907.1 .
AF218031 mRNA. Translation: AAG17273.1 . Frameshift.
AC025259 Genomic DNA. No translation available.
BC005151 mRNA. Translation: AAH05151.1 .
BC009937 mRNA. Translation: AAH09937.1 .
CCDSi CCDS8820.1.
RefSeqi NP_001092143.1. NM_001098673.1.
NP_068753.2. NM_021934.4.
UniGenei Hs.9911.

3D structure databases

ProteinModelPortali Q9BSB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121948. 38 interactions.
DIPi DIP-60653N.
IntActi Q9BSB4. 38 interactions.
MINTi MINT-6780987.
STRINGi 9606.ENSP00000338990.

PTM databases

PhosphoSitei Q9BSB4.

Polymorphism databases

DMDMi 74732983.

Proteomic databases

MaxQBi Q9BSB4.
PaxDbi Q9BSB4.
PRIDEi Q9BSB4.

Protocols and materials databases

DNASUi 60673.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336854 ; ENSP00000338990 ; ENSG00000123395 .
GeneIDi 60673.
KEGGi hsa:60673.
UCSCi uc001rzu.4. human.

Organism-specific databases

CTDi 60673.
GeneCardsi GC12P052464.
H-InvDB HIX0010645.
HGNCi HGNC:25679. ATG101.
HPAi HPA039904.
MIMi 615089. gene.
neXtProti NX_Q9BSB4.
PharmGKBi PA143485374.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315429.
GeneTreei ENSGT00390000016511.
HOGENOMi HOG000008086.
InParanoidi Q9BSB4.
OMAi MGQISLE.
OrthoDBi EOG7DFXD6.
PhylomeDBi Q9BSB4.
TreeFami TF320996.

Miscellaneous databases

GeneWikii Autophagy-related_protein_101.
GenomeRNAii 60673.
NextBioi 65473.
SOURCEi Search...

Gene expression databases

Bgeei Q9BSB4.
CleanExi HS_C12orf44.
ExpressionAtlasi Q9BSB4. baseline and differential.
Genevestigatori Q9BSB4.

Family and domain databases

InterProi IPR012445. ATG101.
[Graphical view ]
PANTHERi PTHR13292. PTHR13292. 1 hit.
Pfami PF07855. DUF1649. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  5. "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy."
    Mercer C.A., Kaliappan A., Dennis P.B.
    Autophagy 5:649-662(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG13, COMPLEX FORMATION WITH ULK1 AND RB1CC1.
  6. "Atg101, a novel mammalian autophagy protein interacting with Atg13."
    Hosokawa N., Sasaki T., Iemura S.I., Natsume T., Hara T., Mizushima N.
    Autophagy 5:973-979(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AUTOPHAGY FACTOR, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH ATG13.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATGA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSB4
Secondary accession number(s): Q9HAE2, Q9HBN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3