Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BSB4

- ATGA1_HUMAN

UniProt

Q9BSB4 - ATGA1_HUMAN

Protein

Autophagy-related protein 101

Gene

ATG101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.2 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. protein complex binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole assembly Source: UniProtKB

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 101
    Gene namesi
    Name:ATG101
    Synonyms:C12orf44
    ORF Names:PP894
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25679. ATG101.

    Subcellular locationi

    Cytoplasm 1 Publication. Preautophagosomal structure 1 Publication
    Note: Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.

    GO - Cellular componenti

    1. pre-autophagosomal structure Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485374.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Autophagy-related protein 101PRO_0000294322Add
    BLAST

    Proteomic databases

    MaxQBiQ9BSB4.
    PaxDbiQ9BSB4.
    PRIDEiQ9BSB4.

    PTM databases

    PhosphoSiteiQ9BSB4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BSB4.
    BgeeiQ9BSB4.
    CleanExiHS_C12orf44.
    GenevestigatoriQ9BSB4.

    Organism-specific databases

    HPAiHPA039904.

    Interactioni

    Subunit structurei

    Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2946739,EBI-2946739
    ATG13O751436EBI-2946739,EBI-2798775
    MAP1LC3CQ9BXW42EBI-2946739,EBI-2603996

    Protein-protein interaction databases

    BioGridi121948. 38 interactions.
    DIPiDIP-60653N.
    IntActiQ9BSB4. 38 interactions.
    MINTiMINT-6780987.
    STRINGi9606.ENSP00000338990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BSB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG101 family.Curated

    Phylogenomic databases

    eggNOGiNOG315429.
    HOGENOMiHOG000008086.
    InParanoidiQ9BSB4.
    OMAiMGQISLE.
    OrthoDBiEOG7DFXD6.
    PhylomeDBiQ9BSB4.
    TreeFamiTF320996.

    Family and domain databases

    InterProiIPR012445. ATG101.
    [Graphical view]
    PANTHERiPTHR13292. PTHR13292. 1 hit.
    PfamiPF07855. DUF1649. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BSB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV    50
    GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL 100
    EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE 150
    KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL 200
    GTSVTTTMRR LIKDTLAL 218
    Length:218
    Mass (Da):25,003
    Last modified:June 1, 2001 - v1
    Checksum:i69A881EAF9A07659
    GO

    Sequence cautioni

    The sequence AAG17273.1 differs from that shown. Reason: Frameshift at position 110.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471I → T in BAB13907. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021835 mRNA. Translation: BAB13907.1.
    AF218031 mRNA. Translation: AAG17273.1. Frameshift.
    AC025259 Genomic DNA. No translation available.
    BC005151 mRNA. Translation: AAH05151.1.
    BC009937 mRNA. Translation: AAH09937.1.
    CCDSiCCDS8820.1.
    RefSeqiNP_001092143.1. NM_001098673.1.
    NP_068753.2. NM_021934.4.
    UniGeneiHs.9911.

    Genome annotation databases

    EnsembliENST00000336854; ENSP00000338990; ENSG00000123395.
    GeneIDi60673.
    KEGGihsa:60673.
    UCSCiuc001rzu.4. human.

    Polymorphism databases

    DMDMi74732983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021835 mRNA. Translation: BAB13907.1 .
    AF218031 mRNA. Translation: AAG17273.1 . Frameshift.
    AC025259 Genomic DNA. No translation available.
    BC005151 mRNA. Translation: AAH05151.1 .
    BC009937 mRNA. Translation: AAH09937.1 .
    CCDSi CCDS8820.1.
    RefSeqi NP_001092143.1. NM_001098673.1.
    NP_068753.2. NM_021934.4.
    UniGenei Hs.9911.

    3D structure databases

    ProteinModelPortali Q9BSB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121948. 38 interactions.
    DIPi DIP-60653N.
    IntActi Q9BSB4. 38 interactions.
    MINTi MINT-6780987.
    STRINGi 9606.ENSP00000338990.

    PTM databases

    PhosphoSitei Q9BSB4.

    Polymorphism databases

    DMDMi 74732983.

    Proteomic databases

    MaxQBi Q9BSB4.
    PaxDbi Q9BSB4.
    PRIDEi Q9BSB4.

    Protocols and materials databases

    DNASUi 60673.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336854 ; ENSP00000338990 ; ENSG00000123395 .
    GeneIDi 60673.
    KEGGi hsa:60673.
    UCSCi uc001rzu.4. human.

    Organism-specific databases

    CTDi 60673.
    GeneCardsi GC12P052463.
    H-InvDB HIX0010645.
    HGNCi HGNC:25679. ATG101.
    HPAi HPA039904.
    MIMi 615089. gene.
    neXtProti NX_Q9BSB4.
    PharmGKBi PA143485374.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315429.
    HOGENOMi HOG000008086.
    InParanoidi Q9BSB4.
    OMAi MGQISLE.
    OrthoDBi EOG7DFXD6.
    PhylomeDBi Q9BSB4.
    TreeFami TF320996.

    Miscellaneous databases

    GeneWikii Autophagy-related_protein_101.
    GenomeRNAii 60673.
    NextBioi 65473.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BSB4.
    Bgeei Q9BSB4.
    CleanExi HS_C12orf44.
    Genevestigatori Q9BSB4.

    Family and domain databases

    InterProi IPR012445. ATG101.
    [Graphical view ]
    PANTHERi PTHR13292. PTHR13292. 1 hit.
    Pfami PF07855. DUF1649. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Uterus.
    5. "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy."
      Mercer C.A., Kaliappan A., Dennis P.B.
      Autophagy 5:649-662(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ATG13, COMPLEX FORMATION WITH ULK1 AND RB1CC1.
    6. "Atg101, a novel mammalian autophagy protein interacting with Atg13."
      Hosokawa N., Sasaki T., Iemura S.I., Natsume T., Hara T., Mizushima N.
      Autophagy 5:973-979(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AUTOPHAGY FACTOR, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH ATG13.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATGA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BSB4
    Secondary accession number(s): Q9HAE2, Q9HBN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3