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Q9BSA9 (TM175_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 175
Gene names
Name:TMEM175
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM175 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosomal membrane

Inferred from direct assay PubMed 17897319. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BSA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BSA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Transmembrane protein 175
PRO_0000282588

Regions

Transmembrane36 – 5621Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane340 – 36021Helical; Potential
Transmembrane378 – 39821Helical; Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane453 – 47321Helical; Potential

Amino acid modifications

Modified residue61Phosphothreonine Ref.4

Natural variations

Alternative sequence1 – 116116Missing in isoform 2.
VSP_024213
Natural variant651Q → P.
Corresponds to variant rs34884217 [ dbSNP | Ensembl ].
VAR_053873
Natural variant3931M → T.
Corresponds to variant rs34311866 [ dbSNP | Ensembl ].
VAR_053874

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7FEE4C22CA248094

FASTA50455,615
        10         20         30         40         50         60 
MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV MILPVTHTEI 

        70         80         90        100        110        120 
SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ VVGKTDDTLA LLNLACMMTI 

       130        140        150        160        170        180 
TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI GVVQALIVGY AFHFPHLLSP QIQRSAHRAL 

       190        200        210        220        230        240 
YRRHVLGIVL QGPALCFAAA IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP 

       250        260        270        280        290        300 
SAHPVEVFSF DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV 

       310        320        330        340        350        360 
AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA FVGGLPLAYQ 

       370        380        390        400        410        420 
QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH QAETLQPSVW FGGREHVLMF 

       430        440        450        460        470        480 
AKLALYPCAS LLAFASTCLL SRFSVGIFHL MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA 

       490        500 
RPEHPPPAPT GQDDPQSQLL PAPC 

« Hide

Isoform 2 [UniParc].

Checksum: 179ED37576BCB367
Show »

FASTA38842,847

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[4]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL834199 mRNA. Translation: CAD38888.1.
CH471131 Genomic DNA. Translation: EAW82633.1.
CH471131 Genomic DNA. Translation: EAW82638.1.
BC005158 mRNA. Translation: AAH05158.1.
RefSeqNP_115702.1. NM_032326.2.
XP_005272361.1. XM_005272304.1.
XP_005272362.1. XM_005272305.2.
XP_005272363.1. XM_005272306.2.
UniGeneHs.478936.

3D structure databases

ProteinModelPortalQ9BSA9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124013. 2 interactions.
STRING9606.ENSP00000264771.

PTM databases

PhosphoSiteQ9BSA9.

Polymorphism databases

DMDM74732981.

Proteomic databases

PaxDbQ9BSA9.
PRIDEQ9BSA9.

Protocols and materials databases

DNASU84286.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264771; ENSP00000264771; ENSG00000127419. [Q9BSA9-1]
ENST00000515740; ENSP00000427039; ENSG00000127419. [Q9BSA9-2]
GeneID84286.
KEGGhsa:84286.
UCSCuc003gbq.3. human. [Q9BSA9-1]

Organism-specific databases

CTD84286.
GeneCardsGC04P000917.
H-InvDBHIX0004008.
HGNCHGNC:28709. TMEM175.
HPAHPA023327.
neXtProtNX_Q9BSA9.
PharmGKBPA162405946.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82925.
HOGENOMHOG000154616.
HOVERGENHBG059914.
InParanoidQ9BSA9.
OMAYAFHFPH.
PhylomeDBQ9BSA9.
TreeFamTF328838.

Gene expression databases

ArrayExpressQ9BSA9.
BgeeQ9BSA9.
CleanExHS_TMEM175.
GenevestigatorQ9BSA9.

Family and domain databases

InterProIPR010617. DUF1211_TMEM175.
[Graphical view]
PfamPF06736. DUF1211. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM175. human.
GenomeRNAi84286.
NextBio73901.
PROQ9BSA9.

Entry information

Entry nameTM175_HUMAN
AccessionPrimary (citable) accession number: Q9BSA9
Secondary accession number(s): D3DVN4, Q8ND13
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM