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Q9BSA9

- TM175_HUMAN

UniProt

Q9BSA9 - TM175_HUMAN

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Protein

Transmembrane protein 175

Gene
TMEM175
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 175
Gene namesi
Name:TMEM175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:28709. TMEM175.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Transmembranei310 – 33021Helical; Reviewed predictionAdd
BLAST
Transmembranei340 – 36021Helical; Reviewed predictionAdd
BLAST
Transmembranei378 – 39821Helical; Reviewed predictionAdd
BLAST
Transmembranei417 – 43721Helical; Reviewed predictionAdd
BLAST
Transmembranei453 – 47321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Transmembrane protein 175PRO_0000282588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BSA9.
PaxDbiQ9BSA9.
PRIDEiQ9BSA9.

PTM databases

PhosphoSiteiQ9BSA9.

Expressioni

Gene expression databases

ArrayExpressiQ9BSA9.
BgeeiQ9BSA9.
CleanExiHS_TMEM175.
GenevestigatoriQ9BSA9.

Organism-specific databases

HPAiHPA023327.

Interactioni

Protein-protein interaction databases

BioGridi124013. 2 interactions.
STRINGi9606.ENSP00000264771.

Structurei

3D structure databases

ProteinModelPortaliQ9BSA9.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM175 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82925.
HOGENOMiHOG000154616.
HOVERGENiHBG059914.
InParanoidiQ9BSA9.
OMAiYAFHFPH.
PhylomeDBiQ9BSA9.
TreeFamiTF328838.

Family and domain databases

InterProiIPR010617. DUF1211_TMEM175.
[Graphical view]
PfamiPF06736. DUF1211. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BSA9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV    50
MILPVTHTEI SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ 100
VVGKTDDTLA LLNLACMMTI TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI 150
GVVQALIVGY AFHFPHLLSP QIQRSAHRAL YRRHVLGIVL QGPALCFAAA 200
IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP SAHPVEVFSF 250
DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV 300
AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA 350
FVGGLPLAYQ QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH 400
QAETLQPSVW FGGREHVLMF AKLALYPCAS LLAFASTCLL SRFSVGIFHL 450
MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA RPEHPPPAPT GQDDPQSQLL 500
PAPC 504
Length:504
Mass (Da):55,615
Last modified:June 1, 2001 - v1
Checksum:i7FEE4C22CA248094
GO
Isoform 2 (identifier: Q9BSA9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:388
Mass (Da):42,847
Checksum:i179ED37576BCB367
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651Q → P.
Corresponds to variant rs34884217 [ dbSNP | Ensembl ].
VAR_053873
Natural varianti393 – 3931M → T.
Corresponds to variant rs34311866 [ dbSNP | Ensembl ].
VAR_053874

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2. VSP_024213Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834199 mRNA. Translation: CAD38888.1.
CH471131 Genomic DNA. Translation: EAW82633.1.
CH471131 Genomic DNA. Translation: EAW82638.1.
BC005158 mRNA. Translation: AAH05158.1.
CCDSiCCDS3341.1. [Q9BSA9-1]
RefSeqiNP_115702.1. NM_032326.2. [Q9BSA9-1]
XP_005272361.1. XM_005272304.1. [Q9BSA9-2]
XP_005272362.1. XM_005272305.2. [Q9BSA9-2]
XP_005272363.1. XM_005272306.2. [Q9BSA9-2]
UniGeneiHs.478936.

Genome annotation databases

EnsembliENST00000264771; ENSP00000264771; ENSG00000127419. [Q9BSA9-1]
ENST00000515740; ENSP00000427039; ENSG00000127419. [Q9BSA9-2]
GeneIDi84286.
KEGGihsa:84286.
UCSCiuc003gbq.3. human. [Q9BSA9-1]

Polymorphism databases

DMDMi74732981.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834199 mRNA. Translation: CAD38888.1 .
CH471131 Genomic DNA. Translation: EAW82633.1 .
CH471131 Genomic DNA. Translation: EAW82638.1 .
BC005158 mRNA. Translation: AAH05158.1 .
CCDSi CCDS3341.1. [Q9BSA9-1 ]
RefSeqi NP_115702.1. NM_032326.2. [Q9BSA9-1 ]
XP_005272361.1. XM_005272304.1. [Q9BSA9-2 ]
XP_005272362.1. XM_005272305.2. [Q9BSA9-2 ]
XP_005272363.1. XM_005272306.2. [Q9BSA9-2 ]
UniGenei Hs.478936.

3D structure databases

ProteinModelPortali Q9BSA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124013. 2 interactions.
STRINGi 9606.ENSP00000264771.

PTM databases

PhosphoSitei Q9BSA9.

Polymorphism databases

DMDMi 74732981.

Proteomic databases

MaxQBi Q9BSA9.
PaxDbi Q9BSA9.
PRIDEi Q9BSA9.

Protocols and materials databases

DNASUi 84286.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264771 ; ENSP00000264771 ; ENSG00000127419 . [Q9BSA9-1 ]
ENST00000515740 ; ENSP00000427039 ; ENSG00000127419 . [Q9BSA9-2 ]
GeneIDi 84286.
KEGGi hsa:84286.
UCSCi uc003gbq.3. human. [Q9BSA9-1 ]

Organism-specific databases

CTDi 84286.
GeneCardsi GC04P000917.
H-InvDB HIX0004008.
HGNCi HGNC:28709. TMEM175.
HPAi HPA023327.
neXtProti NX_Q9BSA9.
PharmGKBi PA162405946.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82925.
HOGENOMi HOG000154616.
HOVERGENi HBG059914.
InParanoidi Q9BSA9.
OMAi YAFHFPH.
PhylomeDBi Q9BSA9.
TreeFami TF328838.

Miscellaneous databases

ChiTaRSi TMEM175. human.
GenomeRNAii 84286.
NextBioi 73901.
PROi Q9BSA9.

Gene expression databases

ArrayExpressi Q9BSA9.
Bgeei Q9BSA9.
CleanExi HS_TMEM175.
Genevestigatori Q9BSA9.

Family and domain databases

InterProi IPR010617. DUF1211_TMEM175.
[Graphical view ]
Pfami PF06736. DUF1211. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTM175_HUMAN
AccessioniPrimary (citable) accession number: Q9BSA9
Secondary accession number(s): D3DVN4, Q8ND13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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