Q9BSA9 (TM175_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 175

Gene names

Name:

TMEM175

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM175 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BSA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BSA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Transmembrane protein 175		PRO_0000282588
Regions
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Transmembrane	340 – 360	21	Helical; Potential
	Transmembrane	378 – 398	21	Helical; Potential
	Transmembrane	417 – 437	21	Helical; Potential
	Transmembrane	453 – 473	21	Helical; Potential
Amino acid modifications
	Modified residue	6	1	Phosphothreonine Ref.4
Natural variations
	Alternative sequence	1 – 116	116	Missing in isoform 2.		VSP_024213
	Natural variant	65	1	Q → P. Corresponds to variant rs34884217 [ dbSNP | Ensembl ].		VAR_053873
	Natural variant	393	1	M → T. Corresponds to variant rs34311866 [ dbSNP | Ensembl ].		VAR_053874

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7FEE4C22CA248094	FASTA	504	55,615
	10 20 30 40 50 60 MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV MILPVTHTEI 70 80 90 100 110 120 SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ VVGKTDDTLA LLNLACMMTI 130 140 150 160 170 180 TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI GVVQALIVGY AFHFPHLLSP QIQRSAHRAL 190 200 210 220 230 240 YRRHVLGIVL QGPALCFAAA IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP 250 260 270 280 290 300 SAHPVEVFSF DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV 310 320 330 340 350 360 AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA FVGGLPLAYQ 370 380 390 400 410 420 QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH QAETLQPSVW FGGREHVLMF 430 440 450 460 470 480 AKLALYPCAS LLAFASTCLL SRFSVGIFHL MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA 490 500 RPEHPPPAPT GQDDPQSQLL PAPC
	Isoform 2 [UniParc]. Checksum: 179ED37576BCB367	FASTA	388	42,847
	10 20 30 40 50 60 MMTITFLPYT FSLMVTFPDV PLGIFLFCVC VIAIGVVQAL IVGYAFHFPH LLSPQIQRSA 70 80 90 100 110 120 HRALYRRHVL GIVLQGPALC FAAAIFSLFF VPLSYLLMVT VILLPYVSKV TGWCRDRLLG 130 140 150 160 170 180 HREPSAHPVE VFSFDLHEPL SKERVEAFSD GVYAIVATLL ILDICEDNVP DPKDVKERFS 190 200 210 220 230 240 GSLVAALSAT GPRFLAYFGS FATVGLLWFA HHSLFLHVRK ATRAMGLLNT LSLAFVGGLP 250 260 270 280 290 300 LAYQQTSAFA RQPRDELERV RVSCTIIFLA SIFQLAMWTT ALLHQAETLQ PSVWFGGREH 310 320 330 340 350 360 VLMFAKLALY PCASLLAFAS TCLLSRFSVG IFHLMQIAVP CAFLLLRLLV GLALATLRVL 370 380 RGLARPEHPP PAPTGQDDPQ SQLLPAPC

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[4]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL834199 mRNA. Translation: CAD38888.1. CH471131 Genomic DNA. Translation: EAW82633.1. CH471131 Genomic DNA. Translation: EAW82638.1. BC005158 mRNA. Translation: AAH05158.1.
IPI	IPI00031572. IPI00844314.
RefSeq	NP_115702.1. NM_032326.2.
UniGene	Hs.478936.
3D structure databases
ProteinModelPortal	Q9BSA9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264771.
PTM databases
PhosphoSite	Q9BSA9.
Polymorphism databases
DMDM	74732981.
Proteomic databases
PaxDb	Q9BSA9.
PRIDE	Q9BSA9.
Protocols and materials databases
DNASU	84286.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264771; ENSP00000264771; ENSG00000127419. ENST00000515740; ENSP00000427039; ENSG00000127419.
GeneID	84286.
KEGG	hsa:84286.
UCSC	uc003gbq.3. human.
Organism-specific databases
CTD	84286.
GeneCards	GC04P000917.
H-InvDB	HIX0004008.
HGNC	HGNC:28709. TMEM175.
HPA	HPA023327.
neXtProt	NX_Q9BSA9.
PharmGKB	PA162405946.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82925.
HOGENOM	HOG000154616.
HOVERGEN	HBG059914.
InParanoid	Q9BSA9.
OMA	LITFLPY.
OrthoDB	EOG4FFD1V.
PhylomeDB	Q9BSA9.
Gene expression databases
ArrayExpress	Q9BSA9.
Bgee	Q9BSA9.
CleanEx	HS_TMEM175.
Genevestigator	Q9BSA9.
Family and domain databases
InterPro	IPR010617. DUF1211_TMEM175. [Graphical view]
Pfam	PF06736. DUF1211. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM175. human.
GenomeRNAi	84286.
NextBio	73901.

Entry information

Entry name

TM175_HUMAN

Accession

Primary (citable) accession number: Q9BSA9
Secondary accession number(s): D3DVN4, Q8ND13

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.