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Q9BSA9

- TM175_HUMAN

UniProt

Q9BSA9 - TM175_HUMAN

Protein

Transmembrane protein 175

Gene

TMEM175

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 175
    Gene namesi
    Name:TMEM175
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:28709. TMEM175.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Transmembrane protein 175PRO_0000282588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BSA9.
    PaxDbiQ9BSA9.
    PRIDEiQ9BSA9.

    PTM databases

    PhosphoSiteiQ9BSA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BSA9.
    BgeeiQ9BSA9.
    CleanExiHS_TMEM175.
    GenevestigatoriQ9BSA9.

    Organism-specific databases

    HPAiHPA023327.

    Interactioni

    Protein-protein interaction databases

    BioGridi124013. 2 interactions.
    STRINGi9606.ENSP00000264771.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BSA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM175 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82925.
    HOGENOMiHOG000154616.
    HOVERGENiHBG059914.
    InParanoidiQ9BSA9.
    OMAiYAFHFPH.
    PhylomeDBiQ9BSA9.
    TreeFamiTF328838.

    Family and domain databases

    InterProiIPR010617. DUF1211_TMEM175.
    [Graphical view]
    PfamiPF06736. DUF1211. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BSA9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV    50
    MILPVTHTEI SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ 100
    VVGKTDDTLA LLNLACMMTI TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI 150
    GVVQALIVGY AFHFPHLLSP QIQRSAHRAL YRRHVLGIVL QGPALCFAAA 200
    IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP SAHPVEVFSF 250
    DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV 300
    AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA 350
    FVGGLPLAYQ QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH 400
    QAETLQPSVW FGGREHVLMF AKLALYPCAS LLAFASTCLL SRFSVGIFHL 450
    MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA RPEHPPPAPT GQDDPQSQLL 500
    PAPC 504
    Length:504
    Mass (Da):55,615
    Last modified:June 1, 2001 - v1
    Checksum:i7FEE4C22CA248094
    GO
    Isoform 2 (identifier: Q9BSA9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Show »
    Length:388
    Mass (Da):42,847
    Checksum:i179ED37576BCB367
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651Q → P.
    Corresponds to variant rs34884217 [ dbSNP | Ensembl ].
    VAR_053873
    Natural varianti393 – 3931M → T.
    Corresponds to variant rs34311866 [ dbSNP | Ensembl ].
    VAR_053874

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_024213Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834199 mRNA. Translation: CAD38888.1.
    CH471131 Genomic DNA. Translation: EAW82633.1.
    CH471131 Genomic DNA. Translation: EAW82638.1.
    BC005158 mRNA. Translation: AAH05158.1.
    CCDSiCCDS3341.1. [Q9BSA9-1]
    RefSeqiNP_115702.1. NM_032326.2. [Q9BSA9-1]
    XP_005272361.1. XM_005272304.1. [Q9BSA9-2]
    XP_005272362.1. XM_005272305.2. [Q9BSA9-2]
    XP_005272363.1. XM_005272306.2. [Q9BSA9-2]
    UniGeneiHs.478936.

    Genome annotation databases

    EnsembliENST00000264771; ENSP00000264771; ENSG00000127419. [Q9BSA9-1]
    ENST00000515740; ENSP00000427039; ENSG00000127419. [Q9BSA9-2]
    GeneIDi84286.
    KEGGihsa:84286.
    UCSCiuc003gbq.3. human. [Q9BSA9-1]

    Polymorphism databases

    DMDMi74732981.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834199 mRNA. Translation: CAD38888.1 .
    CH471131 Genomic DNA. Translation: EAW82633.1 .
    CH471131 Genomic DNA. Translation: EAW82638.1 .
    BC005158 mRNA. Translation: AAH05158.1 .
    CCDSi CCDS3341.1. [Q9BSA9-1 ]
    RefSeqi NP_115702.1. NM_032326.2. [Q9BSA9-1 ]
    XP_005272361.1. XM_005272304.1. [Q9BSA9-2 ]
    XP_005272362.1. XM_005272305.2. [Q9BSA9-2 ]
    XP_005272363.1. XM_005272306.2. [Q9BSA9-2 ]
    UniGenei Hs.478936.

    3D structure databases

    ProteinModelPortali Q9BSA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124013. 2 interactions.
    STRINGi 9606.ENSP00000264771.

    PTM databases

    PhosphoSitei Q9BSA9.

    Polymorphism databases

    DMDMi 74732981.

    Proteomic databases

    MaxQBi Q9BSA9.
    PaxDbi Q9BSA9.
    PRIDEi Q9BSA9.

    Protocols and materials databases

    DNASUi 84286.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264771 ; ENSP00000264771 ; ENSG00000127419 . [Q9BSA9-1 ]
    ENST00000515740 ; ENSP00000427039 ; ENSG00000127419 . [Q9BSA9-2 ]
    GeneIDi 84286.
    KEGGi hsa:84286.
    UCSCi uc003gbq.3. human. [Q9BSA9-1 ]

    Organism-specific databases

    CTDi 84286.
    GeneCardsi GC04P000917.
    H-InvDB HIX0004008.
    HGNCi HGNC:28709. TMEM175.
    HPAi HPA023327.
    neXtProti NX_Q9BSA9.
    PharmGKBi PA162405946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82925.
    HOGENOMi HOG000154616.
    HOVERGENi HBG059914.
    InParanoidi Q9BSA9.
    OMAi YAFHFPH.
    PhylomeDBi Q9BSA9.
    TreeFami TF328838.

    Miscellaneous databases

    ChiTaRSi TMEM175. human.
    GenomeRNAii 84286.
    NextBioi 73901.
    PROi Q9BSA9.

    Gene expression databases

    ArrayExpressi Q9BSA9.
    Bgeei Q9BSA9.
    CleanExi HS_TMEM175.
    Genevestigatori Q9BSA9.

    Family and domain databases

    InterProi IPR010617. DUF1211_TMEM175.
    [Graphical view ]
    Pfami PF06736. DUF1211. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTM175_HUMAN
    AccessioniPrimary (citable) accession number: Q9BSA9
    Secondary accession number(s): D3DVN4, Q8ND13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3