Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BS91 (S35A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable UDP-sugar transporter protein SLC35A5
Alternative name(s):
Solute carrier family 35 member A5
Gene names
Name:SLC35A5
ORF Names:UNQ164/PRO190
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Sequence caution

The sequence BAD18792.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Probable UDP-sugar transporter protein SLC35A5
PRO_0000309355

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane54 – 7421Helical; Potential
Transmembrane94 – 11623Helical; Potential
Transmembrane120 – 14223Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane355 – 37521Helical; Potential

Amino acid modifications

Modified residue4161Phosphoserine Ref.6
Modified residue4191Phosphoserine Ref.6
Glycosylation2041N-linked (GlcNAc...) Potential

Natural variations

Natural variant2471N → I. Ref.4
Corresponds to variant rs17849939 [ dbSNP | Ensembl ].
VAR_036945

Sequences

Sequence LengthMass (Da)Tools
Q9BS91 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 120D1E650D736F60

FASTA42448,500
        10         20         30         40         50         60 
MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL PTTVNVCSEL 

        70         80         90        100        110        120 
VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP AFLYFLDNLI VFYVLSYLQP 

       130        140        150        160        170        180 
AMAVIFSNFS IITTALLFRI VLKRRLNWIQ WASLLTLFLS IVALTAGTKT LQHNLAGRGF 

       190        200        210        220        230        240 
HHDAFFSPSN SCLLFRSECP RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC 

       250        260        270        280        290        300 
FISSMANIYN EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY 

       310        320        330        340        350        360 
GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV FDFRPSLEFF 

       370        380        390        400        410        420 
LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER SSGDGEELER LTKPKSDESD 


EDTF 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-247.
Tissue: Choriocarcinoma, Kidney and Retina.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-424.
Tissue: Testis.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416 AND SER-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358994 mRNA. Translation: AAQ89353.1.
AK000737 mRNA. Translation: BAA91350.1.
AK172825 mRNA. Translation: BAD18792.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79666.1.
CH471052 Genomic DNA. Translation: EAW79667.1.
BC005207 mRNA. Translation: AAH05207.1.
BC010307 mRNA. Translation: AAH10307.1.
BC013046 mRNA. Translation: AAH13046.1.
AL117531 mRNA. Translation: CAH10717.1.
RefSeqNP_060415.1. NM_017945.3.
UniGeneHs.237480.

3D structure databases

ProteinModelPortalQ9BS91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120361. 2 interactions.
STRING9606.ENSP00000417654.

Protein family/group databases

TCDB2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ9BS91.

Polymorphism databases

DMDM160358743.

Proteomic databases

PaxDbQ9BS91.
PRIDEQ9BS91.

Protocols and materials databases

DNASU55032.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000492406; ENSP00000417654; ENSG00000138459.
GeneID55032.
KEGGhsa:55032.
UCSCuc003dze.4. human.

Organism-specific databases

CTD55032.
GeneCardsGC03P112281.
HGNCHGNC:20792. SLC35A5.
HPAHPA035519.
neXtProtNX_Q9BS91.
PharmGKBPA134947136.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0697.
HOGENOMHOG000154236.
HOVERGENHBG056977.
InParanoidQ9BS91.
KOK15274.
OMAQNSKLYF.
PhylomeDBQ9BS91.
TreeFamTF354304.

Gene expression databases

ArrayExpressQ9BS91.
BgeeQ9BS91.
CleanExHS_SLC35A5.
GenevestigatorQ9BS91.

Family and domain databases

InterProIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERPTHR10231. PTHR10231. 1 hit.
PfamPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsTIGR00803. nst. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC35A5. human.
GenomeRNAi55032.
NextBio58451.
PROQ9BS91.

Entry information

Entry nameS35A5_HUMAN
AccessionPrimary (citable) accession number: Q9BS91
Secondary accession number(s): D3DN66 expand/collapse secondary AC list , Q69YY6, Q6ZMD6, Q9NWM9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM