Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable UDP-sugar transporter protein SLC35A5

Gene

SLC35A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A5
Alternative name(s):
Solute carrier family 35 member A5
Gene namesi
Name:SLC35A5
ORF Names:UNQ164/PRO190
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20792. SLC35A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei94 – 116HelicalSequence analysisAdd BLAST23
Transmembranei120 – 142HelicalSequence analysisAdd BLAST23
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138459.
PharmGKBiPA134947136.

Polymorphism and mutation databases

DMDMi160358743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093551 – 424Probable UDP-sugar transporter protein SLC35A5Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Modified residuei394PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BS91.
MaxQBiQ9BS91.
PaxDbiQ9BS91.
PeptideAtlasiQ9BS91.
PRIDEiQ9BS91.

PTM databases

iPTMnetiQ9BS91.
PhosphoSitePlusiQ9BS91.

Expressioni

Gene expression databases

BgeeiENSG00000138459.
CleanExiHS_SLC35A5.
ExpressionAtlasiQ9BS91. baseline and differential.
GenevisibleiQ9BS91. HS.

Organism-specific databases

HPAiHPA035519.
HPA057964.

Interactioni

Protein-protein interaction databases

BioGridi120361. 8 interactors.
STRINGi9606.ENSP00000417654.

Structurei

3D structure databases

ProteinModelPortaliQ9BS91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154236.
HOVERGENiHBG056977.
InParanoidiQ9BS91.
KOiK15274.
OMAiLFRSECP.
OrthoDBiEOG091G08HH.
PhylomeDBiQ9BS91.
TreeFamiTF354304.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 2 hits.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BS91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL
60 70 80 90 100
PTTVNVCSEL VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP
110 120 130 140 150
AFLYFLDNLI VFYVLSYLQP AMAVIFSNFS IITTALLFRI VLKRRLNWIQ
160 170 180 190 200
WASLLTLFLS IVALTAGTKT LQHNLAGRGF HHDAFFSPSN SCLLFRSECP
210 220 230 240 250
RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC FISSMANIYN
260 270 280 290 300
EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY
310 320 330 340 350
GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV
360 370 380 390 400
FDFRPSLEFF LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER
410 420
SSGDGEELER LTKPKSDESD EDTF
Length:424
Mass (Da):48,500
Last modified:November 13, 2007 - v2
Checksum:i120D1E650D736F60
GO

Sequence cautioni

The sequence BAD18792 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036945247N → I.1 PublicationCorresponds to variant rs17849939dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA. Translation: AAQ89353.1.
AK000737 mRNA. Translation: BAA91350.1.
AK172825 mRNA. Translation: BAD18792.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79666.1.
CH471052 Genomic DNA. Translation: EAW79667.1.
BC005207 mRNA. Translation: AAH05207.1.
BC010307 mRNA. Translation: AAH10307.1.
BC013046 mRNA. Translation: AAH13046.1.
AL117531 mRNA. Translation: CAH10717.1.
CCDSiCCDS2967.1.
RefSeqiNP_060415.1. NM_017945.3.
XP_011511250.1. XM_011512948.1.
UniGeneiHs.237480.

Genome annotation databases

EnsembliENST00000492406; ENSP00000417654; ENSG00000138459.
GeneIDi55032.
KEGGihsa:55032.
UCSCiuc003dze.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA. Translation: AAQ89353.1.
AK000737 mRNA. Translation: BAA91350.1.
AK172825 mRNA. Translation: BAD18792.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79666.1.
CH471052 Genomic DNA. Translation: EAW79667.1.
BC005207 mRNA. Translation: AAH05207.1.
BC010307 mRNA. Translation: AAH10307.1.
BC013046 mRNA. Translation: AAH13046.1.
AL117531 mRNA. Translation: CAH10717.1.
CCDSiCCDS2967.1.
RefSeqiNP_060415.1. NM_017945.3.
XP_011511250.1. XM_011512948.1.
UniGeneiHs.237480.

3D structure databases

ProteinModelPortaliQ9BS91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120361. 8 interactors.
STRINGi9606.ENSP00000417654.

Protein family/group databases

TCDBi2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ9BS91.
PhosphoSitePlusiQ9BS91.

Polymorphism and mutation databases

DMDMi160358743.

Proteomic databases

EPDiQ9BS91.
MaxQBiQ9BS91.
PaxDbiQ9BS91.
PeptideAtlasiQ9BS91.
PRIDEiQ9BS91.

Protocols and materials databases

DNASUi55032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492406; ENSP00000417654; ENSG00000138459.
GeneIDi55032.
KEGGihsa:55032.
UCSCiuc003dze.5. human.

Organism-specific databases

CTDi55032.
GeneCardsiSLC35A5.
HGNCiHGNC:20792. SLC35A5.
HPAiHPA035519.
HPA057964.
neXtProtiNX_Q9BS91.
OpenTargetsiENSG00000138459.
PharmGKBiPA134947136.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154236.
HOVERGENiHBG056977.
InParanoidiQ9BS91.
KOiK15274.
OMAiLFRSECP.
OrthoDBiEOG091G08HH.
PhylomeDBiQ9BS91.
TreeFamiTF354304.

Miscellaneous databases

ChiTaRSiSLC35A5. human.
GenomeRNAii55032.
PROiQ9BS91.

Gene expression databases

BgeeiENSG00000138459.
CleanExiHS_SLC35A5.
ExpressionAtlasiQ9BS91. baseline and differential.
GenevisibleiQ9BS91. HS.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 2 hits.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A5_HUMAN
AccessioniPrimary (citable) accession number: Q9BS91
Secondary accession number(s): D3DN66
, Q69YY6, Q6ZMD6, Q9NWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.