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Q9BS91

- S35A5_HUMAN

UniProt

Q9BS91 - S35A5_HUMAN

Protein

Probable UDP-sugar transporter protein SLC35A5

Gene

SLC35A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleotide-sugar transmembrane transporter activity Source: InterPro
    2. sugar:proton symporter activity Source: InterPro

    GO - Biological processi

    1. nucleotide-sugar transport Source: InterPro

    Keywords - Biological processi

    Sugar transport, Transport

    Protein family/group databases

    TCDBi2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A5
    Alternative name(s):
    Solute carrier family 35 member A5
    Gene namesi
    Name:SLC35A5
    ORF Names:UNQ164/PRO190
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:20792. SLC35A5.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134947136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Probable UDP-sugar transporter protein SLC35A5PRO_0000309355Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Modified residuei416 – 4161Phosphoserine1 Publication
    Modified residuei419 – 4191Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9BS91.
    PRIDEiQ9BS91.

    PTM databases

    PhosphoSiteiQ9BS91.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BS91.
    BgeeiQ9BS91.
    CleanExiHS_SLC35A5.
    GenevestigatoriQ9BS91.

    Organism-specific databases

    HPAiHPA035519.

    Interactioni

    Protein-protein interaction databases

    BioGridi120361. 2 interactions.
    STRINGi9606.ENSP00000417654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BS91.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    HOGENOMiHOG000154236.
    HOVERGENiHBG056977.
    InParanoidiQ9BS91.
    KOiK15274.
    OMAiQNSKLYF.
    PhylomeDBiQ9BS91.
    TreeFamiTF354304.

    Family and domain databases

    InterProiIPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view]
    PANTHERiPTHR10231. PTHR10231. 1 hit.
    PfamiPF04142. Nuc_sug_transp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsiTIGR00803. nst. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BS91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL    50
    PTTVNVCSEL VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP 100
    AFLYFLDNLI VFYVLSYLQP AMAVIFSNFS IITTALLFRI VLKRRLNWIQ 150
    WASLLTLFLS IVALTAGTKT LQHNLAGRGF HHDAFFSPSN SCLLFRSECP 200
    RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC FISSMANIYN 250
    EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY 300
    GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV 350
    FDFRPSLEFF LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER 400
    SSGDGEELER LTKPKSDESD EDTF 424
    Length:424
    Mass (Da):48,500
    Last modified:November 13, 2007 - v2
    Checksum:i120D1E650D736F60
    GO

    Sequence cautioni

    The sequence BAD18792.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471N → I.1 Publication
    Corresponds to variant rs17849939 [ dbSNP | Ensembl ].
    VAR_036945

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358994 mRNA. Translation: AAQ89353.1.
    AK000737 mRNA. Translation: BAA91350.1.
    AK172825 mRNA. Translation: BAD18792.1. Different initiation.
    CH471052 Genomic DNA. Translation: EAW79666.1.
    CH471052 Genomic DNA. Translation: EAW79667.1.
    BC005207 mRNA. Translation: AAH05207.1.
    BC010307 mRNA. Translation: AAH10307.1.
    BC013046 mRNA. Translation: AAH13046.1.
    AL117531 mRNA. Translation: CAH10717.1.
    CCDSiCCDS2967.1.
    RefSeqiNP_060415.1. NM_017945.3.
    UniGeneiHs.237480.

    Genome annotation databases

    EnsembliENST00000492406; ENSP00000417654; ENSG00000138459.
    GeneIDi55032.
    KEGGihsa:55032.
    UCSCiuc003dze.4. human.

    Polymorphism databases

    DMDMi160358743.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358994 mRNA. Translation: AAQ89353.1 .
    AK000737 mRNA. Translation: BAA91350.1 .
    AK172825 mRNA. Translation: BAD18792.1 . Different initiation.
    CH471052 Genomic DNA. Translation: EAW79666.1 .
    CH471052 Genomic DNA. Translation: EAW79667.1 .
    BC005207 mRNA. Translation: AAH05207.1 .
    BC010307 mRNA. Translation: AAH10307.1 .
    BC013046 mRNA. Translation: AAH13046.1 .
    AL117531 mRNA. Translation: CAH10717.1 .
    CCDSi CCDS2967.1.
    RefSeqi NP_060415.1. NM_017945.3.
    UniGenei Hs.237480.

    3D structure databases

    ProteinModelPortali Q9BS91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120361. 2 interactions.
    STRINGi 9606.ENSP00000417654.

    Protein family/group databases

    TCDBi 2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q9BS91.

    Polymorphism databases

    DMDMi 160358743.

    Proteomic databases

    PaxDbi Q9BS91.
    PRIDEi Q9BS91.

    Protocols and materials databases

    DNASUi 55032.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000492406 ; ENSP00000417654 ; ENSG00000138459 .
    GeneIDi 55032.
    KEGGi hsa:55032.
    UCSCi uc003dze.4. human.

    Organism-specific databases

    CTDi 55032.
    GeneCardsi GC03P112281.
    HGNCi HGNC:20792. SLC35A5.
    HPAi HPA035519.
    neXtProti NX_Q9BS91.
    PharmGKBi PA134947136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0697.
    HOGENOMi HOG000154236.
    HOVERGENi HBG056977.
    InParanoidi Q9BS91.
    KOi K15274.
    OMAi QNSKLYF.
    PhylomeDBi Q9BS91.
    TreeFami TF354304.

    Miscellaneous databases

    ChiTaRSi SLC35A5. human.
    GenomeRNAii 55032.
    NextBioi 58451.
    PROi Q9BS91.

    Gene expression databases

    ArrayExpressi Q9BS91.
    Bgeei Q9BS91.
    CleanExi HS_SLC35A5.
    Genevestigatori Q9BS91.

    Family and domain databases

    InterProi IPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view ]
    PANTHERi PTHR10231. PTHR10231. 1 hit.
    Pfami PF04142. Nuc_sug_transp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsi TIGR00803. nst. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-247.
      Tissue: Choriocarcinoma, Kidney and Retina.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-424.
      Tissue: Testis.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416 AND SER-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiS35A5_HUMAN
    AccessioniPrimary (citable) accession number: Q9BS91
    Secondary accession number(s): D3DN66
    , Q69YY6, Q6ZMD6, Q9NWM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3