Q9BS91 (S35A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable UDP-sugar transporter protein SLC35A5

Alternative name(s):
Solute carrier family 35 member A5

Gene names

Name:	SLC35A5
ORF Names:	UNQ164/PRO190

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Sequence caution	The sequence BAD18792.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide-sugar transport Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide-sugar transmembrane transporter activity Inferred from electronic annotation. Source: InterPro sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Probable UDP-sugar transporter protein SLC35A5		PRO_0000309355
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	54 – 74	21	Helical; Potential
	Transmembrane	94 – 116	23	Helical; Potential
	Transmembrane	120 – 142	23	Helical; Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Transmembrane	229 – 249	21	Helical; Potential
	Transmembrane	264 – 284	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Transmembrane	331 – 351	21	Helical; Potential
	Transmembrane	355 – 375	21	Helical; Potential
Amino acid modifications
	Modified residue	416	1	Phosphoserine Ref.6
	Modified residue	419	1	Phosphoserine Ref.6
	Glycosylation	204	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	247	1	N → I. Ref.4 Corresponds to variant rs17849939 [ dbSNP | Ensembl ].		VAR_036945

Sequences

	Sequence		Length	Mass (Da)
	Q9BS91 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 120D1E650D736F60	FASTA	424	48,500
	10 20 30 40 50 60 MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL PTTVNVCSEL 70 80 90 100 110 120 VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP AFLYFLDNLI VFYVLSYLQP 130 140 150 160 170 180 AMAVIFSNFS IITTALLFRI VLKRRLNWIQ WASLLTLFLS IVALTAGTKT LQHNLAGRGF 190 200 210 220 230 240 HHDAFFSPSN SCLLFRSECP RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC 250 260 270 280 290 300 FISSMANIYN EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY 310 320 330 340 350 360 GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV FDFRPSLEFF 370 380 390 400 410 420 LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER SSGDGEELER LTKPKSDESD EDTF

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-247. Tissue: Choriocarcinoma, Kidney and Retina.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-424. Tissue: Testis.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416 AND SER-419, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358994 mRNA. Translation: AAQ89353.1. AK000737 mRNA. Translation: BAA91350.1. AK172825 mRNA. Translation: BAD18792.1. Different initiation. CH471052 Genomic DNA. Translation: EAW79666.1. CH471052 Genomic DNA. Translation: EAW79667.1. BC005207 mRNA. Translation: AAH05207.1. BC010307 mRNA. Translation: AAH10307.1. BC013046 mRNA. Translation: AAH13046.1. AL117531 mRNA. Translation: CAH10717.1.
IPI	IPI00305218.
RefSeq	NP_060415.1. NM_017945.3.
UniGene	Hs.237480.
3D structure databases
ProteinModelPortal	Q9BS91.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000417654.
PTM databases
PhosphoSite	Q9BS91.
Polymorphism databases
DMDM	160358743.
Proteomic databases
PaxDb	Q9BS91.
PRIDE	Q9BS91.
Protocols and materials databases
DNASU	55032.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000492406; ENSP00000417654; ENSG00000138459.
GeneID	55032.
KEGG	hsa:55032.
UCSC	uc003dze.3. human.
Organism-specific databases
CTD	55032.
GeneCards	GC03P112281.
HGNC	HGNC:20792. SLC35A5.
HPA	HPA035519.
neXtProt	NX_Q9BS91.
PharmGKB	PA134947136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000154236.
HOVERGEN	HBG056977.
InParanoid	Q9BS91.
KO	K15274.
OMA	FCVLVSF.
PhylomeDB	Q9BS91.
Gene expression databases
ArrayExpress	Q9BS91.
Bgee	Q9BS91.
CleanEx	HS_SLC35A5.
Genevestigator	Q9BS91.
Family and domain databases
InterPro	IPR007271. Nuc_sug_transpt. IPR021189. UDP/CMP-sugar_transptr. IPR004689. UDPgal_transpt. [Graphical view]
PANTHER	PTHR10231. PTHR10231. 1 hit.
Pfam	PF04142. Nuc_sug_transp. 1 hit. [Graphical view]
PIRSF	PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMs	TIGR00803. nst. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC35A5. human.
GenomeRNAi	55032.
NextBio	58451.

Entry information

Entry name

S35A5_HUMAN

Accession

Primary (citable) accession number: Q9BS91
Secondary accession number(s): D3DN66 , Q69YY6, Q6ZMD6, Q9NWM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.