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Q9BS91

- S35A5_HUMAN

UniProt

Q9BS91 - S35A5_HUMAN

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Protein

Probable UDP-sugar transporter protein SLC35A5

Gene

SLC35A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleotide-sugar transmembrane transporter activity Source: InterPro
  2. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. nucleotide-sugar transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A5
Alternative name(s):
Solute carrier family 35 member A5
Gene namesi
Name:SLC35A5
ORF Names:UNQ164/PRO190
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:20792. SLC35A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11623HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14223HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Probable UDP-sugar transporter protein SLC35A5PRO_0000309355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Modified residuei416 – 4161Phosphoserine1 Publication
Modified residuei419 – 4191Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9BS91.
PaxDbiQ9BS91.
PRIDEiQ9BS91.

PTM databases

PhosphoSiteiQ9BS91.

Expressioni

Gene expression databases

BgeeiQ9BS91.
CleanExiHS_SLC35A5.
ExpressionAtlasiQ9BS91. baseline and differential.
GenevestigatoriQ9BS91.

Organism-specific databases

HPAiHPA035519.

Interactioni

Protein-protein interaction databases

BioGridi120361. 9 interactions.
STRINGi9606.ENSP00000417654.

Structurei

3D structure databases

ProteinModelPortaliQ9BS91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154236.
HOVERGENiHBG056977.
InParanoidiQ9BS91.
KOiK15274.
OMAiQNSKLYF.
PhylomeDBiQ9BS91.
TreeFamiTF354304.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BS91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL
60 70 80 90 100
PTTVNVCSEL VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP
110 120 130 140 150
AFLYFLDNLI VFYVLSYLQP AMAVIFSNFS IITTALLFRI VLKRRLNWIQ
160 170 180 190 200
WASLLTLFLS IVALTAGTKT LQHNLAGRGF HHDAFFSPSN SCLLFRSECP
210 220 230 240 250
RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC FISSMANIYN
260 270 280 290 300
EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY
310 320 330 340 350
GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV
360 370 380 390 400
FDFRPSLEFF LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER
410 420
SSGDGEELER LTKPKSDESD EDTF
Length:424
Mass (Da):48,500
Last modified:November 13, 2007 - v2
Checksum:i120D1E650D736F60
GO

Sequence cautioni

The sequence BAD18792.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471N → I.1 Publication
Corresponds to variant rs17849939 [ dbSNP | Ensembl ].
VAR_036945

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA. Translation: AAQ89353.1.
AK000737 mRNA. Translation: BAA91350.1.
AK172825 mRNA. Translation: BAD18792.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79666.1.
CH471052 Genomic DNA. Translation: EAW79667.1.
BC005207 mRNA. Translation: AAH05207.1.
BC010307 mRNA. Translation: AAH10307.1.
BC013046 mRNA. Translation: AAH13046.1.
AL117531 mRNA. Translation: CAH10717.1.
CCDSiCCDS2967.1.
RefSeqiNP_060415.1. NM_017945.3.
UniGeneiHs.237480.

Genome annotation databases

EnsembliENST00000492406; ENSP00000417654; ENSG00000138459.
GeneIDi55032.
KEGGihsa:55032.
UCSCiuc003dze.4. human.

Polymorphism databases

DMDMi160358743.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA. Translation: AAQ89353.1 .
AK000737 mRNA. Translation: BAA91350.1 .
AK172825 mRNA. Translation: BAD18792.1 . Different initiation.
CH471052 Genomic DNA. Translation: EAW79666.1 .
CH471052 Genomic DNA. Translation: EAW79667.1 .
BC005207 mRNA. Translation: AAH05207.1 .
BC010307 mRNA. Translation: AAH10307.1 .
BC013046 mRNA. Translation: AAH13046.1 .
AL117531 mRNA. Translation: CAH10717.1 .
CCDSi CCDS2967.1.
RefSeqi NP_060415.1. NM_017945.3.
UniGenei Hs.237480.

3D structure databases

ProteinModelPortali Q9BS91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120361. 9 interactions.
STRINGi 9606.ENSP00000417654.

Protein family/group databases

TCDBi 2.A.7.12.14. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q9BS91.

Polymorphism databases

DMDMi 160358743.

Proteomic databases

MaxQBi Q9BS91.
PaxDbi Q9BS91.
PRIDEi Q9BS91.

Protocols and materials databases

DNASUi 55032.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000492406 ; ENSP00000417654 ; ENSG00000138459 .
GeneIDi 55032.
KEGGi hsa:55032.
UCSCi uc003dze.4. human.

Organism-specific databases

CTDi 55032.
GeneCardsi GC03P112281.
HGNCi HGNC:20792. SLC35A5.
HPAi HPA035519.
neXtProti NX_Q9BS91.
PharmGKBi PA134947136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00550000074563.
HOGENOMi HOG000154236.
HOVERGENi HBG056977.
InParanoidi Q9BS91.
KOi K15274.
OMAi QNSKLYF.
PhylomeDBi Q9BS91.
TreeFami TF354304.

Miscellaneous databases

ChiTaRSi SLC35A5. human.
GenomeRNAii 55032.
NextBioi 58451.
PROi Q9BS91.

Gene expression databases

Bgeei Q9BS91.
CleanExi HS_SLC35A5.
ExpressionAtlasi Q9BS91. baseline and differential.
Genevestigatori Q9BS91.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsi TIGR00803. nst. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-247.
    Tissue: Choriocarcinoma, Kidney and Retina.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-424.
    Tissue: Testis.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416 AND SER-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiS35A5_HUMAN
AccessioniPrimary (citable) accession number: Q9BS91
Secondary accession number(s): D3DN66
, Q69YY6, Q6ZMD6, Q9NWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3