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Protein

Zona pellucida-binding protein 1

Gene

ZPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be implicated in gamete interaction during fertilization.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 1
Alternative name(s):
Sp38
Gene namesi
Name:ZPBP
Synonyms:ZPBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15662. ZPBP.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38013.

Polymorphism and mutation databases

BioMutaiZPBP.
DMDMi54036652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence analysisAdd
BLAST
Chaini45 – 351307Zona pellucida-binding protein 1PRO_0000041598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BS86.
PRIDEiQ9BS86.

PTM databases

iPTMnetiQ9BS86.
PhosphoSiteiQ9BS86.

Expressioni

Gene expression databases

BgeeiQ9BS86.
CleanExiHS_ZPBP.
ExpressionAtlasiQ9BS86. baseline and differential.
GenevisibleiQ9BS86. HS.

Organism-specific databases

HPAiHPA058673.

Interactioni

Protein-protein interaction databases

BioGridi116240. 1 interaction.
IntActiQ9BS86. 1 interaction.
MINTiMINT-4723516.
STRINGi9606.ENSP00000046087.

Structurei

3D structure databases

ProteinModelPortaliQ9BS86.
SMRiQ9BS86. Positions 96-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG106672.
InParanoidiQ9BS86.
OMAiQCNSSLV.
OrthoDBiEOG7D2FF2.
PhylomeDBiQ9BS86.
TreeFamiTF335677.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BS86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP
60 70 80 90 100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF
110 120 130 140 150
QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE
160 170 180 190 200
IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK
210 220 230 240 250
LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD
260 270 280 290 300
HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
310 320 330 340 350
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC

L
Length:351
Mass (Da):40,142
Last modified:June 1, 2001 - v1
Checksum:i8B57027FBE12E7DB
GO
Isoform 2 (identifier: Q9BS86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-112: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,043
Checksum:i13D2B6ADB4408925
GO

Sequence cautioni

The sequence AAS07517.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801A → V in BAA04495 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei112 – 1121Missing in isoform 2. 1 PublicationVSP_045491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17570 mRNA. Translation: BAA04495.1.
BT006822 mRNA. Translation: AAP35468.1.
AK312799 mRNA. No translation available.
AC020743 Genomic DNA. No translation available.
AC034145 Genomic DNA. No translation available.
AC096568 Genomic DNA. Translation: AAS07517.1. Different initiation.
AC034148 Genomic DNA. Translation: AAS07558.1.
CH236955 Genomic DNA. Translation: EAL23903.1.
CH471128 Genomic DNA. Translation: EAW60984.1.
BC005223 mRNA. Translation: AAH05223.1.
CCDSiCCDS5509.1. [Q9BS86-1]
CCDS55110.1. [Q9BS86-2]
RefSeqiNP_001153350.1. NM_001159878.1. [Q9BS86-2]
NP_008940.2. NM_007009.2. [Q9BS86-1]
UniGeneiHs.388841.

Genome annotation databases

EnsembliENST00000046087; ENSP00000046087; ENSG00000042813. [Q9BS86-1]
ENST00000419417; ENSP00000402071; ENSG00000042813. [Q9BS86-2]
GeneIDi11055.
KEGGihsa:11055.
UCSCiuc003tou.4. human. [Q9BS86-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17570 mRNA. Translation: BAA04495.1.
BT006822 mRNA. Translation: AAP35468.1.
AK312799 mRNA. No translation available.
AC020743 Genomic DNA. No translation available.
AC034145 Genomic DNA. No translation available.
AC096568 Genomic DNA. Translation: AAS07517.1. Different initiation.
AC034148 Genomic DNA. Translation: AAS07558.1.
CH236955 Genomic DNA. Translation: EAL23903.1.
CH471128 Genomic DNA. Translation: EAW60984.1.
BC005223 mRNA. Translation: AAH05223.1.
CCDSiCCDS5509.1. [Q9BS86-1]
CCDS55110.1. [Q9BS86-2]
RefSeqiNP_001153350.1. NM_001159878.1. [Q9BS86-2]
NP_008940.2. NM_007009.2. [Q9BS86-1]
UniGeneiHs.388841.

3D structure databases

ProteinModelPortaliQ9BS86.
SMRiQ9BS86. Positions 96-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116240. 1 interaction.
IntActiQ9BS86. 1 interaction.
MINTiMINT-4723516.
STRINGi9606.ENSP00000046087.

PTM databases

iPTMnetiQ9BS86.
PhosphoSiteiQ9BS86.

Polymorphism and mutation databases

BioMutaiZPBP.
DMDMi54036652.

Proteomic databases

PaxDbiQ9BS86.
PRIDEiQ9BS86.

Protocols and materials databases

DNASUi11055.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000046087; ENSP00000046087; ENSG00000042813. [Q9BS86-1]
ENST00000419417; ENSP00000402071; ENSG00000042813. [Q9BS86-2]
GeneIDi11055.
KEGGihsa:11055.
UCSCiuc003tou.4. human. [Q9BS86-1]

Organism-specific databases

CTDi11055.
GeneCardsiZPBP.
HGNCiHGNC:15662. ZPBP.
HPAiHPA058673.
MIMi608498. gene.
neXtProtiNX_Q9BS86.
PharmGKBiPA38013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG106672.
InParanoidiQ9BS86.
OMAiQCNSSLV.
OrthoDBiEOG7D2FF2.
PhylomeDBiQ9BS86.
TreeFamiTF335677.

Miscellaneous databases

ChiTaRSiZPBP. human.
GenomeRNAii11055.
PROiQ9BS86.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BS86.
CleanExiHS_ZPBP.
ExpressionAtlasiQ9BS86. baseline and differential.
GenevisibleiQ9BS86. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the gene encoding zona-pellucida-binding protein, sp38, during spermatogenesis."
    Baba T., Mori E., Mori T., Kashiwabara S., Tanaka K.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  8. "Molecules involved in mammalian sperm-egg interaction."
    McLeskey S.B., Dowds C., Carballada R., White R.R., Saling P.M.
    Int. Rev. Cytol. 177:57-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiZPBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BS86
Secondary accession number(s): A4D253
, C9JPU1, Q15941, Q75KX9, Q75MI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.