Q9BS86 (ZPBP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zona pellucida-binding protein 1

Alternative name(s):
Sp38

Gene names

Name:	ZPBP
Synonyms:	ZPBP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be implicated in gamete interaction during fertilization.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the zona pellucida-binding protein Sp38 family.
Sequence caution	The sequence AAS07517.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acrosome assembly Inferred from electronic annotation. Source: Compara binding of sperm to zona pellucida Inferred from electronic annotation. Source: InterPro
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BS86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BS86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     112-112: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 44	44	Potential
	Chain	45 – 351	307	Zona pellucida-binding protein 1		PRO_0000041598
Amino acid modifications
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	112	1	Missing in isoform 2.		VSP_045491
Experimental info
	Sequence conflict	180	1	A → V in BAA04495. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 8B57027FBE12E7DB	FASTA	351	40,142
	10 20 30 40 50 60 MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV 70 80 90 100 110 120 KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SVENRTAQIT 130 140 150 160 170 180 STGSLVFQNF EESMSGIYTC FLEYKPTVEE IVKRLQLKYA IYAYREPHYY YQFTARYHAA 190 200 210 220 230 240 PCNSIYNISF EKKLLQILSK LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD 250 260 270 280 290 300 TEKGPKRCTD HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN 310 320 330 340 350 RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC L
	Isoform 2 [UniParc]. Checksum: 13D2B6ADB4408925	FASTA	350	40,043
	10 20 30 40 50 60 MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV 70 80 90 100 110 120 KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SENRTAQITS 130 140 150 160 170 180 TGSLVFQNFE ESMSGIYTCF LEYKPTVEEI VKRLQLKYAI YAYREPHYYY QFTARYHAAP 190 200 210 220 230 240 CNSIYNISFE KKLLQILSKL LLDLSCEISL LKSECHRVKM QRAGLQNELF FAFSVSSLDT 250 260 270 280 290 300 EKGPKRCTDH NCEPYKRLFK AKNLIERFFN QQVEILGRRA EQLPQIYYIE GTLQMVWINR 310 320 330 340 350 CFPGYGMNVQ QHPKCPECCV ICSPGSYNPR DGIHCLQCNS SLVYGAKTCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the gene encoding zona-pellucida-binding protein, sp38, during spermatogenesis." Baba T., Mori E., Mori T., Kashiwabara S., Tanaka K. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[8]	"Molecules involved in mammalian sperm-egg interaction." McLeskey S.B., Dowds C., Carballada R., White R.R., Saling P.M. Int. Rev. Cytol. 177:57-113(1998) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D17570 mRNA. Translation: BAA04495.1. BT006822 mRNA. Translation: AAP35468.1. AK312799 mRNA. No translation available. AC020743 Genomic DNA. No translation available. AC034145 Genomic DNA. No translation available. AC096568 Genomic DNA. Translation: AAS07517.1. Different initiation. AC034148 Genomic DNA. Translation: AAS07558.1. CH236955 Genomic DNA. Translation: EAL23903.1. CH471128 Genomic DNA. Translation: EAW60984.1. BC005223 mRNA. Translation: AAH05223.1.
IPI	IPI00013006. IPI00926275.
RefSeq	NP_001153350.1. NM_001159878.1. NP_008940.2. NM_007009.2.
UniGene	Hs.388841.
3D structure databases
ProteinModelPortal	Q9BS86.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BS86. 1 interaction.
STRING	9606.ENSP00000046087.
PTM databases
PhosphoSite	Q9BS86.
Polymorphism databases
DMDM	54036652.
Proteomic databases
PaxDb	Q9BS86.
PRIDE	Q9BS86.
Protocols and materials databases
DNASU	11055.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000046087; ENSP00000046087; ENSG00000042813. ENST00000419417; ENSP00000402071; ENSG00000042813.
GeneID	11055.
KEGG	hsa:11055.
UCSC	uc003tou.3. human.
Organism-specific databases
CTD	11055.
GeneCards	GC07M049947.
HGNC	HGNC:15662. ZPBP.
MIM	608498. gene.
neXtProt	NX_Q9BS86.
PharmGKB	PA38013.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41092.
HOGENOM	HOG000230972.
HOVERGEN	HBG106672.
InParanoid	Q9BS86.
OMA	CNSSLVY.
OrthoDB	EOG4ZW5BG.
PhylomeDB	Q9BS86.
Gene expression databases
ArrayExpress	Q9BS86.
Bgee	Q9BS86.
CleanEx	HS_ZPBP.
Genevestigator	Q9BS86.
GermOnline	ENSG00000042813. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR010857. Sp38-bd. [Graphical view]
PANTHER	PTHR15443. PTHR15443. 1 hit.
Pfam	PF07354. Sp38. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11055.
NextBio	42003.
SOURCE	Search...

Entry information

Entry name

ZPBP1_HUMAN

Accession

Primary (citable) accession number: Q9BS86
Secondary accession number(s): A4D253 , C9JPU1, Q15941, Q75KX9, Q75MI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.