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Protein

Zona pellucida-binding protein 1

Gene

ZPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 1
Alternative name(s):
Inner acrosomal membrane IAM38By similarity
Sp38
Gene namesi
Name:ZPBP
Synonyms:ZPBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15662. ZPBP.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicleacrosome membrane By similarity; Peripheral membrane protein By similarity
  • Secreted Curated

  • Note: First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.By similarity

GO - Cellular componenti

  • acrosomal membrane Source: UniProtKB-SubCell
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000042813.
PharmGKBiPA38013.

Polymorphism and mutation databases

BioMutaiZPBP.
DMDMi54036652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000004159845 – 351Zona pellucida-binding protein 1Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BS86.
PeptideAtlasiQ9BS86.
PRIDEiQ9BS86.

PTM databases

iPTMnetiQ9BS86.
PhosphoSitePlusiQ9BS86.

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000042813.
CleanExiHS_ZPBP.
ExpressionAtlasiQ9BS86. baseline and differential.
GenevisibleiQ9BS86. HS.

Organism-specific databases

HPAiHPA058673.

Interactioni

Protein-protein interaction databases

BioGridi116240. 1 interactor.
IntActiQ9BS86. 1 interactor.
MINTiMINT-4723516.
STRINGi9606.ENSP00000046087.

Structurei

3D structure databases

ProteinModelPortaliQ9BS86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG106672.
InParanoidiQ9BS86.
OMAiQCNSSLV.
OrthoDBiEOG091G0D27.
PhylomeDBiQ9BS86.
TreeFamiTF335677.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BS86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP
60 70 80 90 100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF
110 120 130 140 150
QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE
160 170 180 190 200
IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK
210 220 230 240 250
LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD
260 270 280 290 300
HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
310 320 330 340 350
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC

L
Length:351
Mass (Da):40,142
Last modified:June 1, 2001 - v1
Checksum:i8B57027FBE12E7DB
GO
Isoform 2 (identifier: Q9BS86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-112: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,043
Checksum:i13D2B6ADB4408925
GO

Sequence cautioni

The sequence AAS07517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180A → V in BAA04495 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07682617R → P.1 PublicationCorresponds to variant rs202231065dbSNPEnsembl.1
Natural variantiVAR_07682725R → P.1 PublicationCorresponds to variant rs6169422dbSNPEnsembl.1
Natural variantiVAR_076828184S → G Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076829217H → L Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076830225G → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076831252N → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076832287I → T Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045491112Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17570 mRNA. Translation: BAA04495.1.
BT006822 mRNA. Translation: AAP35468.1.
AK312799 mRNA. No translation available.
AC020743 Genomic DNA. No translation available.
AC034145 Genomic DNA. No translation available.
AC096568 Genomic DNA. Translation: AAS07517.1. Different initiation.
AC034148 Genomic DNA. Translation: AAS07558.1.
CH236955 Genomic DNA. Translation: EAL23903.1.
CH471128 Genomic DNA. Translation: EAW60984.1.
BC005223 mRNA. Translation: AAH05223.1.
CCDSiCCDS5509.1. [Q9BS86-1]
CCDS55110.1. [Q9BS86-2]
RefSeqiNP_001153350.1. NM_001159878.1. [Q9BS86-2]
NP_008940.2. NM_007009.2. [Q9BS86-1]
UniGeneiHs.388841.

Genome annotation databases

EnsembliENST00000046087; ENSP00000046087; ENSG00000042813. [Q9BS86-1]
ENST00000419417; ENSP00000402071; ENSG00000042813. [Q9BS86-2]
GeneIDi11055.
KEGGihsa:11055.
UCSCiuc003tou.4. human. [Q9BS86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17570 mRNA. Translation: BAA04495.1.
BT006822 mRNA. Translation: AAP35468.1.
AK312799 mRNA. No translation available.
AC020743 Genomic DNA. No translation available.
AC034145 Genomic DNA. No translation available.
AC096568 Genomic DNA. Translation: AAS07517.1. Different initiation.
AC034148 Genomic DNA. Translation: AAS07558.1.
CH236955 Genomic DNA. Translation: EAL23903.1.
CH471128 Genomic DNA. Translation: EAW60984.1.
BC005223 mRNA. Translation: AAH05223.1.
CCDSiCCDS5509.1. [Q9BS86-1]
CCDS55110.1. [Q9BS86-2]
RefSeqiNP_001153350.1. NM_001159878.1. [Q9BS86-2]
NP_008940.2. NM_007009.2. [Q9BS86-1]
UniGeneiHs.388841.

3D structure databases

ProteinModelPortaliQ9BS86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116240. 1 interactor.
IntActiQ9BS86. 1 interactor.
MINTiMINT-4723516.
STRINGi9606.ENSP00000046087.

PTM databases

iPTMnetiQ9BS86.
PhosphoSitePlusiQ9BS86.

Polymorphism and mutation databases

BioMutaiZPBP.
DMDMi54036652.

Proteomic databases

PaxDbiQ9BS86.
PeptideAtlasiQ9BS86.
PRIDEiQ9BS86.

Protocols and materials databases

DNASUi11055.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000046087; ENSP00000046087; ENSG00000042813. [Q9BS86-1]
ENST00000419417; ENSP00000402071; ENSG00000042813. [Q9BS86-2]
GeneIDi11055.
KEGGihsa:11055.
UCSCiuc003tou.4. human. [Q9BS86-1]

Organism-specific databases

CTDi11055.
GeneCardsiZPBP.
HGNCiHGNC:15662. ZPBP.
HPAiHPA058673.
MIMi608498. gene.
neXtProtiNX_Q9BS86.
OpenTargetsiENSG00000042813.
PharmGKBiPA38013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
GeneTreeiENSGT00520000055647.
HOGENOMiHOG000230972.
HOVERGENiHBG106672.
InParanoidiQ9BS86.
OMAiQCNSSLV.
OrthoDBiEOG091G0D27.
PhylomeDBiQ9BS86.
TreeFamiTF335677.

Miscellaneous databases

ChiTaRSiZPBP. human.
GenomeRNAii11055.
PROiQ9BS86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000042813.
CleanExiHS_ZPBP.
ExpressionAtlasiQ9BS86. baseline and differential.
GenevisibleiQ9BS86. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZPBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BS86
Secondary accession number(s): A4D253
, C9JPU1, Q15941, Q75KX9, Q75MI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.