Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Latexin

Gene

LXN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI47.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Latexin
Alternative name(s):
Endogenous carboxypeptidase inhibitor
Short name:
ECI
Protein MUM
Tissue carboxypeptidase inhibitor
Short name:
TCI
Gene namesi
Name:LXN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13347. LXN.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991999.

Polymorphism and mutation databases

BioMutaiLXN.
DMDMi146345452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222LatexinPRO_0000191343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BS40.
MaxQBiQ9BS40.
PaxDbiQ9BS40.
PeptideAtlasiQ9BS40.
PRIDEiQ9BS40.

PTM databases

iPTMnetiQ9BS40.
PhosphoSiteiQ9BS40.
SwissPalmiQ9BS40.

Expressioni

Tissue specificityi

Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.1 Publication

Gene expression databases

BgeeiENSG00000079257.
CleanExiHS_LXN.
ExpressionAtlasiQ9BS40. baseline and differential.
GenevisibleiQ9BS40. HS.

Organism-specific databases

HPAiCAB025128.
HPA014179.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPYDQ128823EBI-1044504,EBI-2839838
GSG1LQ6UXU43EBI-1044504,EBI-10297401
MAGEA8P433613EBI-1044504,EBI-10182930
TMEM14AQ9Y6G13EBI-1044504,EBI-2800360
TRIM39Q9HCM93EBI-1044504,EBI-739510
ZKSCAN4Q969J23EBI-1044504,EBI-2818641

Protein-protein interaction databases

BioGridi121252. 15 interactions.
IntActiQ9BS40. 6 interactions.
STRINGi9606.ENSP00000264265.

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2518Combined sources
Beta strandi32 – 4514Combined sources
Turni46 – 483Combined sources
Beta strandi49 – 6012Combined sources
Turni61 – 633Combined sources
Beta strandi67 – 7711Combined sources
Beta strandi86 – 938Combined sources
Helixi100 – 11213Combined sources
Beta strandi118 – 1236Combined sources
Helixi131 – 15121Combined sources
Beta strandi158 – 16912Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi176 – 18611Combined sources
Turni187 – 1893Combined sources
Beta strandi192 – 20211Combined sources
Turni203 – 2053Combined sources
Beta strandi206 – 2149Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BO9X-ray1.60B/D1-222[»]
ProteinModelPortaliQ9BS40.
SMRiQ9BS40. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BS40.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797Cystatin-like fold 1By similarityAdd
BLAST
Regioni98 – 11720Alpha-helical linkerBy similarityAdd
BLAST
Regioni118 – 222105Cystatin-like fold 2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHYK. Eukaryota.
ENOG4111KGW. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000113410.
HOVERGENiHBG052373.
InParanoidiQ9BS40.
OMAiCLKFSVE.
OrthoDBiEOG091G0I8X.
PhylomeDBiQ9BS40.
TreeFamiTF332787.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9BS40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH
60 70 80 90 100
KYHLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD
110 120 130 140 150
EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ
160 170 180 190 200
NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL
210 220
WHPQYGTKVK HNSRLPKEVQ LE
Length:222
Mass (Da):25,750
Last modified:May 1, 2007 - v2
Checksum:i7D557BEDA0E1F60C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531H → R.1 Publication
Corresponds to variant rs8455 [ dbSNP | Ensembl ].
VAR_019117
Natural varianti134 – 1341T → M.
Corresponds to variant rs59718588 [ dbSNP | Ensembl ].
VAR_062139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087851 mRNA. Translation: AAP97162.1.
AF282626 mRNA. Translation: AAF82807.1.
AF303587 Genomic DNA. Translation: AAL09331.1.
AF282594 mRNA. Translation: AAK69518.1.
AC025033 Genomic DNA. No translation available.
AC080013 Genomic DNA. No translation available.
BC005346 mRNA. Translation: AAH05346.1.
BC008438 mRNA. Translation: AAH08438.1.
CCDSiCCDS3183.1.
RefSeqiNP_064554.3. NM_020169.3.
UniGeneiHs.478067.

Genome annotation databases

EnsembliENST00000264265; ENSP00000264265; ENSG00000079257.
GeneIDi56925.
KEGGihsa:56925.
UCSCiuc003fch.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087851 mRNA. Translation: AAP97162.1.
AF282626 mRNA. Translation: AAF82807.1.
AF303587 Genomic DNA. Translation: AAL09331.1.
AF282594 mRNA. Translation: AAK69518.1.
AC025033 Genomic DNA. No translation available.
AC080013 Genomic DNA. No translation available.
BC005346 mRNA. Translation: AAH05346.1.
BC008438 mRNA. Translation: AAH08438.1.
CCDSiCCDS3183.1.
RefSeqiNP_064554.3. NM_020169.3.
UniGeneiHs.478067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BO9X-ray1.60B/D1-222[»]
ProteinModelPortaliQ9BS40.
SMRiQ9BS40. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121252. 15 interactions.
IntActiQ9BS40. 6 interactions.
STRINGi9606.ENSP00000264265.

Protein family/group databases

MEROPSiI47.001.

PTM databases

iPTMnetiQ9BS40.
PhosphoSiteiQ9BS40.
SwissPalmiQ9BS40.

Polymorphism and mutation databases

BioMutaiLXN.
DMDMi146345452.

Proteomic databases

EPDiQ9BS40.
MaxQBiQ9BS40.
PaxDbiQ9BS40.
PeptideAtlasiQ9BS40.
PRIDEiQ9BS40.

Protocols and materials databases

DNASUi56925.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264265; ENSP00000264265; ENSG00000079257.
GeneIDi56925.
KEGGihsa:56925.
UCSCiuc003fch.3. human.

Organism-specific databases

CTDi56925.
GeneCardsiLXN.
HGNCiHGNC:13347. LXN.
HPAiCAB025128.
HPA014179.
MIMi609305. gene.
neXtProtiNX_Q9BS40.
PharmGKBiPA134991999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYK. Eukaryota.
ENOG4111KGW. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000113410.
HOVERGENiHBG052373.
InParanoidiQ9BS40.
OMAiCLKFSVE.
OrthoDBiEOG091G0I8X.
PhylomeDBiQ9BS40.
TreeFamiTF332787.

Miscellaneous databases

EvolutionaryTraceiQ9BS40.
GenomeRNAii56925.
PROiQ9BS40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079257.
CleanExiHS_LXN.
ExpressionAtlasiQ9BS40. baseline and differential.
GenevisibleiQ9BS40. HS.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiLXN_HUMAN
AccessioniPrimary (citable) accession number: Q9BS40
Secondary accession number(s): Q96PN2, Q9NQS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.