Reviewed, UniProtKB/Swiss-Prot Q9BS40 (LXN_HUMAN)

Names and origin

Protein names

Recommended name:
    Latexin
Alternative name(s):
    Endogenous carboxypeptidase inhibitor
      Short name=ECI
    Tissue carboxypeptidase inhibitor
      Short name=TCI
    MUM

Gene names

Name:

LXN

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 By similarity.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain. Ref.1
Sequence similarities	Belongs to the protease inhibitor I47 (latexin) family. [View classification]

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Metalloenzyme inhibitor Metalloprotease inhibitor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CIRBP	Q14011	1	EBI-1044504,EBI-538850
MAGEB2	O15479	1	EBI-1044504,EBI-1057615
PANK2	Q9BZ23	1	EBI-1044504,EBI-1058434
PPM1A	P35813	1	EBI-1044504,EBI-989143
THRAP3	Q9Y2W1	1	EBI-1044504,EBI-352039

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 222

222

Latexin

PRO_0000191343

Natural variations

Natural variant

53

1

H → R: dbSNP rs8455. Ref.1

VAR_019117

Natural variant

134

1

T → M: dbSNP rs59718588.

VAR_062139

Secondary structure

1

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222

Helix Strand Turn

Details...

Helix

8 – 24

17

Beta strand

32 – 43

12

Beta strand

51 – 60

10

Turn

61 – 63

3

Beta strand

67 – 75

9

Beta strand

86 – 91

6

Helix

100 – 112

13

Beta strand

118 – 123

6

Helix

131 – 143

13

Helix

147 – 151

5

Beta strand

158 – 169

12

Beta strand

172 – 174

3

Beta strand

176 – 186

11

Turn

187 – 189

3

Beta strand

192 – 201

10

Beta strand

208 – 214

7

Sequences

	Sequence		Length	Mass (Da)
	Q9BS40-1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 7D557BEDA0E1F60C	FASTA	222	25,750
	10 20 30 40 50 60 MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYHLKFAVEE 70 80 90 100 110 120 IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD EEDNTFYQRL KSMKEPLEAQ 130 140 150 160 170 180 NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY 190 200 210 220 TILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor." Liu Q., Yu L., Gao J., Fu Q., Zhang J., Zhang P., Chen J., Zhao S. Mol. Biol. Rep. 27:241-246(2000) [PubMed: 11455960] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-53, TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"1G10 and gastric cancer." Ke Y., Ning T., Lu Z., Guo M., Zhao H. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Urinary bladder.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin." Pallares I., Bonet R., Garcia-Castellanos R., Ventura S., Aviles F.X., Vendrell J., Gomis-Rueth F.-X. Proc. Natl. Acad. Sci. U.S.A. 102:3978-3983(2005) [PubMed: 15738388] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH CPA4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF087851 mRNA. Translation: AAP97162.1.
AF282626 mRNA. Translation: AAF82807.1.
AF303587 Genomic DNA. Translation: AAL09331.1.
AF282594 mRNA. Translation: AAK69518.1.
AC025033 Genomic DNA. No translation available.
AC080013 Genomic DNA. No translation available.
BC005346 mRNA. Translation: AAH05346.1.
BC008438 mRNA. Translation: AAH08438.1.

IPI

IPI00106687.

RefSeq

NP_064554.3.

UniGene

Hs.478067

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BO9	X-ray	1.60	B/D	1-222	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BS40. 10 interactions.

STRING

Q9BS40.

Protein family/group databases

MEROPS

I47.001.

Proteomic databases

PRIDE

Q9BS40.

Genome annotation databases

Ensembl

ENST00000264265; ENSP00000264265; ENSG00000079257; Homo sapiens. [Genome view]

GeneID

56925.

KEGG

hsa:56925.

UCSC

uc003fch.1. human.

Organism-specific databases

CTD

56925.

GeneCards

GC03M159866.

H-InvDB

HIX0003807.

HGNC

HGNC:13347. LXN.

HPA

CAB025128.
HPA014179.

MIM

609305. gene.

PharmGKB

PA134991999.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16307.

HOGENOM

HBG280530.

HOVERGEN

Q9BS40.

InParanoid

Q9BS40.

OMA

EPLEAQN.

OrthoDB

EOG912PRD.

PhylomeDB

Q9BS40.

Gene expression databases

ArrayExpress

Q9BS40.

Bgee

Q9BS40.

CleanEx

HS_LXN.

Genevestigator

Q9BS40.

GermOnline

ENSG00000079257. Homo sapiens.

Family and domain databases

InterPro

IPR009684. Prot_inh_latexin.
[Graphical view]

Pfam

PF06907. Latexin. 1 hit.
[Graphical view]

PIRSF

PIRSF011132. Prot_inh_latexin. 1 hit.

ProDom

PD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other Resources

NextBio

62440.

SOURCE

Search...

Entry information

Entry name

LXN_HUMAN

Accession

Primary (citable) accession number: Q9BS40
Secondary accession number(s): Q96PN2, Q9NQS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	May 1, 2007
Last modified:	January 19, 2010
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.