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Q9BS34

- ZN670_HUMAN

UniProt

Q9BS34 - ZN670_HUMAN

Protein

Zinc finger protein 670

Gene

ZNF670

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri141 – 16323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 670
    Gene namesi
    Name:ZNF670
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28167. ZNF670.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Zinc finger protein 670PRO_0000233989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BS34.
    PaxDbiQ9BS34.
    PRIDEiQ9BS34.

    PTM databases

    PhosphoSiteiQ9BS34.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BS34.
    BgeeiQ9BS34.
    CleanExiHS_ZNF670.
    GenevestigatoriQ9BS34.

    Organism-specific databases

    HPAiHPA003142.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H1O434632EBI-745276,EBI-349968

    Protein-protein interaction databases

    BioGridi125029. 5 interactions.
    IntActiQ9BS34. 5 interactions.
    MINTiMINT-1472382.
    STRINGi9606.ENSP00000355459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BS34.
    SMRiQ9BS34. Positions 4-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 9087KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri141 – 16323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9BS34.
    KOiK09228.
    OMAiCEECPEK.
    PhylomeDBiQ9BS34.
    TreeFamiTF338854.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BS34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSVSFEDVA VAFTQEEWAL LDPSQKNLYR DVMQEIFRNL ASVGNKSEDQ    50
    NIQDDFKNPG RNLSSHVVER LFEIKEGSQY GETFSQDSNL NLNKKVSTGV 100
    KPCECSVCGK VFICHSALHR HILSHIGNKL FECEECPEKL YHCKQCGKAF 150
    ISLTSVDRHM VTHTSNGPYK GPVYEKPFDF PSVFQMPQST YTGEKTYKCK 200
    HCDKAFNYSS YLREHERTHT GEKPYACKKC GKSFTFSSSL RQHERSHTGE 250
    KPYECKECGK AFSRSTYLGI HERTHTGEKP YECIKCGKAF RCSRVLRVHE 300
    RTHSGEKPYE CKQCGKAFKY SSNLCEHERT HTGVKPYGCK ECGKSFTSSS 350
    ALRSHERTHT GEKPYECKKC GKAFSCSSSL RKHERAYMW 389
    Length:389
    Mass (Da):44,603
    Last modified:June 1, 2001 - v1
    Checksum:iE0828F813293C098
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074774 mRNA. Translation: BAC11200.1.
    AL512637, AL627095 Genomic DNA. Translation: CAI15616.1.
    AL627095, AL512637 Genomic DNA. Translation: CAH70012.1.
    BC005360 mRNA. Translation: AAH05360.1.
    CCDSiCCDS31087.1.
    RefSeqiNP_149990.1. NM_033213.4.
    UniGeneiHs.732305.

    Genome annotation databases

    EnsembliENST00000366503; ENSP00000355459; ENSG00000135747.
    GeneIDi93474.
    KEGGihsa:93474.
    UCSCiuc001icd.2. human.

    Polymorphism databases

    DMDMi74761228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074774 mRNA. Translation: BAC11200.1 .
    AL512637 , AL627095 Genomic DNA. Translation: CAI15616.1 .
    AL627095 , AL512637 Genomic DNA. Translation: CAH70012.1 .
    BC005360 mRNA. Translation: AAH05360.1 .
    CCDSi CCDS31087.1.
    RefSeqi NP_149990.1. NM_033213.4.
    UniGenei Hs.732305.

    3D structure databases

    ProteinModelPortali Q9BS34.
    SMRi Q9BS34. Positions 4-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125029. 5 interactions.
    IntActi Q9BS34. 5 interactions.
    MINTi MINT-1472382.
    STRINGi 9606.ENSP00000355459.

    PTM databases

    PhosphoSitei Q9BS34.

    Polymorphism databases

    DMDMi 74761228.

    Proteomic databases

    MaxQBi Q9BS34.
    PaxDbi Q9BS34.
    PRIDEi Q9BS34.

    Protocols and materials databases

    DNASUi 93474.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366503 ; ENSP00000355459 ; ENSG00000135747 .
    GeneIDi 93474.
    KEGGi hsa:93474.
    UCSCi uc001icd.2. human.

    Organism-specific databases

    CTDi 93474.
    GeneCardsi GC01M247112.
    GC01M247114.
    HGNCi HGNC:28167. ZNF670.
    HPAi HPA003142.
    neXtProti NX_Q9BS34.
    PharmGKBi PA142670517.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9BS34.
    KOi K09228.
    OMAi CEECPEK.
    PhylomeDBi Q9BS34.
    TreeFami TF338854.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 93474.
    NextBioi 78096.
    PROi Q9BS34.

    Gene expression databases

    ArrayExpressi Q9BS34.
    Bgeei Q9BS34.
    CleanExi HS_ZNF670.
    Genevestigatori Q9BS34.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gall bladder.
    4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN670_HUMAN
    AccessioniPrimary (citable) accession number: Q9BS34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3