Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 670

Gene

ZNF670

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135747-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 670
Gene namesi
Name:ZNF670
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28167. ZNF670.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000277462.
PharmGKBiPA142670517.

Polymorphism and mutation databases

BioMutaiZNF670.
DMDMi74761228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339891 – 389Zinc finger protein 670Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BS34.
MaxQBiQ9BS34.
PaxDbiQ9BS34.
PeptideAtlasiQ9BS34.
PRIDEiQ9BS34.

PTM databases

iPTMnetiQ9BS34.
PhosphoSitePlusiQ9BS34.

Expressioni

Gene expression databases

BgeeiENSG00000135747.
CleanExiHS_ZNF670.
GenevisibleiQ9BS34. HS.

Organism-specific databases

HPAiHPA003142.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952735EBI-745276,EBI-748961
KRTAP10-5P603703EBI-745276,EBI-10172150
KRTAP10-7P604093EBI-745276,EBI-10172290
MDFIQ997504EBI-745276,EBI-724076
MTUS2Q5JR593EBI-745276,EBI-742948
OPTNQ96CV95EBI-745276,EBI-748974
SUV39H1O434632EBI-745276,EBI-349968
TRIM41Q8WV443EBI-745276,EBI-725997
TSGA10Q9BZW73EBI-745276,EBI-744794

Protein-protein interaction databases

BioGridi125029. 13 interactors.
IntActiQ9BS34. 14 interactors.
MINTiMINT-1472382.
STRINGi9606.ENSP00000355459.

Structurei

3D structure databases

ProteinModelPortaliQ9BS34.
SMRiQ9BS34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 90KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BS34.
KOiK09228.
OMAiCEECPEK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BS34.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVSFEDVA VAFTQEEWAL LDPSQKNLYR DVMQEIFRNL ASVGNKSEDQ
60 70 80 90 100
NIQDDFKNPG RNLSSHVVER LFEIKEGSQY GETFSQDSNL NLNKKVSTGV
110 120 130 140 150
KPCECSVCGK VFICHSALHR HILSHIGNKL FECEECPEKL YHCKQCGKAF
160 170 180 190 200
ISLTSVDRHM VTHTSNGPYK GPVYEKPFDF PSVFQMPQST YTGEKTYKCK
210 220 230 240 250
HCDKAFNYSS YLREHERTHT GEKPYACKKC GKSFTFSSSL RQHERSHTGE
260 270 280 290 300
KPYECKECGK AFSRSTYLGI HERTHTGEKP YECIKCGKAF RCSRVLRVHE
310 320 330 340 350
RTHSGEKPYE CKQCGKAFKY SSNLCEHERT HTGVKPYGCK ECGKSFTSSS
360 370 380
ALRSHERTHT GEKPYECKKC GKAFSCSSSL RKHERAYMW
Length:389
Mass (Da):44,603
Last modified:June 1, 2001 - v1
Checksum:iE0828F813293C098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074774 mRNA. Translation: BAC11200.1.
AL512637, AL627095 Genomic DNA. Translation: CAI15616.1.
AL627095, AL512637 Genomic DNA. Translation: CAH70012.1.
BC005360 mRNA. Translation: AAH05360.1.
CCDSiCCDS31087.1.
RefSeqiNP_149990.1. NM_033213.4.
UniGeneiHs.732305.

Genome annotation databases

EnsembliENST00000366503; ENSP00000355459; ENSG00000277462.
GeneIDi93474.
KEGGihsa:93474.
UCSCiuc001icd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074774 mRNA. Translation: BAC11200.1.
AL512637, AL627095 Genomic DNA. Translation: CAI15616.1.
AL627095, AL512637 Genomic DNA. Translation: CAH70012.1.
BC005360 mRNA. Translation: AAH05360.1.
CCDSiCCDS31087.1.
RefSeqiNP_149990.1. NM_033213.4.
UniGeneiHs.732305.

3D structure databases

ProteinModelPortaliQ9BS34.
SMRiQ9BS34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125029. 13 interactors.
IntActiQ9BS34. 14 interactors.
MINTiMINT-1472382.
STRINGi9606.ENSP00000355459.

PTM databases

iPTMnetiQ9BS34.
PhosphoSitePlusiQ9BS34.

Polymorphism and mutation databases

BioMutaiZNF670.
DMDMi74761228.

Proteomic databases

EPDiQ9BS34.
MaxQBiQ9BS34.
PaxDbiQ9BS34.
PeptideAtlasiQ9BS34.
PRIDEiQ9BS34.

Protocols and materials databases

DNASUi93474.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366503; ENSP00000355459; ENSG00000277462.
GeneIDi93474.
KEGGihsa:93474.
UCSCiuc001icd.3. human.

Organism-specific databases

CTDi93474.
GeneCardsiZNF670.
HGNCiHGNC:28167. ZNF670.
HPAiHPA003142.
neXtProtiNX_Q9BS34.
OpenTargetsiENSG00000277462.
PharmGKBiPA142670517.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BS34.
KOiK09228.
OMAiCEECPEK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9BS34.
TreeFamiTF338854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135747-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii93474.
PROiQ9BS34.

Gene expression databases

BgeeiENSG00000135747.
CleanExiHS_ZNF670.
GenevisibleiQ9BS34. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN670_HUMAN
AccessioniPrimary (citable) accession number: Q9BS34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.