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Protein

Zinc finger protein 649

Gene

ZNF649

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 649
Gene namesi
Name:ZNF649
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198093.10
HGNCiHGNC:25741 ZNF649
MIMi611903 gene
neXtProtiNX_Q9BS31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198093
PharmGKBiPA143485678

Polymorphism and mutation databases

BioMutaiZNF649
DMDMi74761227

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512241 – 505Zinc finger protein 649Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9BS31
PaxDbiQ9BS31
PeptideAtlasiQ9BS31
PRIDEiQ9BS31

PTM databases

iPTMnetiQ9BS31
PhosphoSitePlusiQ9BS31

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.1 Publication

Developmental stagei

Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000198093
CleanExiHS_ZNF649
ExpressionAtlasiQ9BS31 baseline and differential
GenevisibleiQ9BS31 HS

Organism-specific databases

HPAiHPA026541

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-4395789,EBI-349968

Protein-protein interaction databases

BioGridi122414, 3 interactors
IntActiQ9BS31, 2 interactors
MINTiQ9BS31
STRINGi9606.ENSP00000347043

Structurei

3D structure databases

ProteinModelPortaliQ9BS31
SMRiQ9BS31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Domaini

The KRAB domain is required for transcriptional repression.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133760
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BS31
KOiK09228
OMAiEPAEFNG
OrthoDBiEOG091G02KC
PhylomeDBiQ9BS31
TreeFamiTF340593

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q9BS31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVSVGYQ
60 70 80 90 100
AGKPDALTKL EQGEPLWTLE DEIHSPAHPE IEKADDHLQQ PLQNQKILKR
110 120 130 140 150
TGQRYEHGRT LKSYLGLTNQ SRRYNRKEPA EFNGDGAFLH DNHEQMPTEI
160 170 180 190 200
EFPESRKPIS TKSQFLKHQQ THNIEKAHEC TDCGKAFLKK SQLTEHKRIH
210 220 230 240 250
TGKKPHVCSL CGKAFYKKYR LTEHERAHRG EKPHGCSLCG KAFYKRYRLT
260 270 280 290 300
EHERAHKGEK PYGCSECGKA FPRKSELTEH QRIHTGIKPH QCSECGRAFS
310 320 330 340 350
RKSLLVVHQR THTGEKPHTC SECGKGFIQK GNLNIHQRTH TGEKPYGCID
360 370 380 390 400
CGKAFSQKSC LVAHQRYHTG KTPFVCPECG QPCSQKSGLI RHQKIHSGEK
410 420 430 440 450
PYKCSDCGKA FLTKTMLIVH HRTHTGERPY GCDECEKAYF YMSCLVKHKR
460 470 480 490 500
IHSREKRGDS VKVENPSTAS HSLSPSEHVQ GKSPVNMVTV AMVAGQCEFA

HILHS
Length:505
Mass (Da):57,683
Last modified:June 1, 2001 - v1
Checksum:iEC1A70DCA8E01613
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → V in BAB14191 (PubMed:14702039).Curated1
Sequence conflicti314G → E in BAB14191 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027668352G → D. Corresponds to variant dbSNP:rs6509593Ensembl.1
Natural variantiVAR_027669469A → T. Corresponds to variant dbSNP:rs1433083Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022706 mRNA Translation: BAB14191.1
AK315487 mRNA Translation: BAG37871.1
AL713677 mRNA Translation: CAD28482.1
AC011460 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72050.1
BC005368 mRNA Translation: AAH05368.1
CCDSiCCDS12843.1
RefSeqiNP_075562.2, NM_023074.3
UniGeneiHs.148322

Genome annotation databases

EnsembliENST00000354957; ENSP00000347043; ENSG00000198093
GeneIDi65251
KEGGihsa:65251
UCSCiuc002pxy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN649_HUMAN
AccessioniPrimary (citable) accession number: Q9BS31
Secondary accession number(s): A8MYJ5, B2RDC4, Q9H9N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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