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Protein

Zinc finger protein 649

Gene

ZNF649

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 20023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 649
Gene namesi
Name:ZNF649
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25741. ZNF649.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485678.

Polymorphism and mutation databases

BioMutaiZNF649.
DMDMi74761227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Zinc finger protein 649PRO_0000251224Add
BLAST

Proteomic databases

MaxQBiQ9BS31.
PaxDbiQ9BS31.
PRIDEiQ9BS31.

PTM databases

PhosphoSiteiQ9BS31.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.1 Publication

Developmental stagei

Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.1 Publication

Gene expression databases

BgeeiQ9BS31.
CleanExiHS_ZNF649.
ExpressionAtlasiQ9BS31. baseline and differential.
GenevisibleiQ9BS31. HS.

Organism-specific databases

HPAiHPA026541.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-4395789,EBI-349968

Protein-protein interaction databases

BioGridi122414. 3 interactions.
IntActiQ9BS31. 2 interactions.
MINTiMINT-4719207.
STRINGi9606.ENSP00000347043.

Structurei

3D structure databases

ProteinModelPortaliQ9BS31.
SMRiQ9BS31. Positions 2-49, 160-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

The KRAB domain is required for transcriptional repression.

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 20023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000123017.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BS31.
KOiK09228.
OMAiEPAEFNG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BS31.
TreeFamiTF340593.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVSVGYQ
60 70 80 90 100
AGKPDALTKL EQGEPLWTLE DEIHSPAHPE IEKADDHLQQ PLQNQKILKR
110 120 130 140 150
TGQRYEHGRT LKSYLGLTNQ SRRYNRKEPA EFNGDGAFLH DNHEQMPTEI
160 170 180 190 200
EFPESRKPIS TKSQFLKHQQ THNIEKAHEC TDCGKAFLKK SQLTEHKRIH
210 220 230 240 250
TGKKPHVCSL CGKAFYKKYR LTEHERAHRG EKPHGCSLCG KAFYKRYRLT
260 270 280 290 300
EHERAHKGEK PYGCSECGKA FPRKSELTEH QRIHTGIKPH QCSECGRAFS
310 320 330 340 350
RKSLLVVHQR THTGEKPHTC SECGKGFIQK GNLNIHQRTH TGEKPYGCID
360 370 380 390 400
CGKAFSQKSC LVAHQRYHTG KTPFVCPECG QPCSQKSGLI RHQKIHSGEK
410 420 430 440 450
PYKCSDCGKA FLTKTMLIVH HRTHTGERPY GCDECEKAYF YMSCLVKHKR
460 470 480 490 500
IHSREKRGDS VKVENPSTAS HSLSPSEHVQ GKSPVNMVTV AMVAGQCEFA

HILHS
Length:505
Mass (Da):57,683
Last modified:June 1, 2001 - v1
Checksum:iEC1A70DCA8E01613
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81L → V in BAB14191 (PubMed:14702039).Curated
Sequence conflicti314 – 3141G → E in BAB14191 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti352 – 3521G → D.
Corresponds to variant rs6509593 [ dbSNP | Ensembl ].
VAR_027668
Natural varianti469 – 4691A → T.
Corresponds to variant rs1433083 [ dbSNP | Ensembl ].
VAR_027669

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022706 mRNA. Translation: BAB14191.1.
AK315487 mRNA. Translation: BAG37871.1.
AL713677 mRNA. Translation: CAD28482.1.
AC011460 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72050.1.
BC005368 mRNA. Translation: AAH05368.1.
CCDSiCCDS12843.1.
RefSeqiNP_075562.2. NM_023074.3.
UniGeneiHs.148322.

Genome annotation databases

EnsembliENST00000354957; ENSP00000347043; ENSG00000198093.
GeneIDi65251.
KEGGihsa:65251.
UCSCiuc002pxy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022706 mRNA. Translation: BAB14191.1.
AK315487 mRNA. Translation: BAG37871.1.
AL713677 mRNA. Translation: CAD28482.1.
AC011460 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72050.1.
BC005368 mRNA. Translation: AAH05368.1.
CCDSiCCDS12843.1.
RefSeqiNP_075562.2. NM_023074.3.
UniGeneiHs.148322.

3D structure databases

ProteinModelPortaliQ9BS31.
SMRiQ9BS31. Positions 2-49, 160-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122414. 3 interactions.
IntActiQ9BS31. 2 interactions.
MINTiMINT-4719207.
STRINGi9606.ENSP00000347043.

PTM databases

PhosphoSiteiQ9BS31.

Polymorphism and mutation databases

BioMutaiZNF649.
DMDMi74761227.

Proteomic databases

MaxQBiQ9BS31.
PaxDbiQ9BS31.
PRIDEiQ9BS31.

Protocols and materials databases

DNASUi65251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354957; ENSP00000347043; ENSG00000198093.
GeneIDi65251.
KEGGihsa:65251.
UCSCiuc002pxy.3. human.

Organism-specific databases

CTDi65251.
GeneCardsiGC19M052392.
HGNCiHGNC:25741. ZNF649.
HPAiHPA026541.
MIMi611903. gene.
neXtProtiNX_Q9BS31.
PharmGKBiPA143485678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000123017.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BS31.
KOiK09228.
OMAiEPAEFNG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BS31.
TreeFamiTF340593.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF649. human.
GeneWikiiZNF649.
GenomeRNAii65251.
NextBioi67374.
PROiQ9BS31.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BS31.
CleanExiHS_ZNF649.
ExpressionAtlasiQ9BS31. baseline and differential.
GenevisibleiQ9BS31. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor."
    Yang H., Yuan W., Wang Y., Zhu C., Liu B., Wang Y., Yang D., Li Y., Wang C., Wu X., Liu M.
    Biochem. Biophys. Res. Commun. 333:206-215(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN649_HUMAN
AccessioniPrimary (citable) accession number: Q9BS31
Secondary accession number(s): A8MYJ5, B2RDC4, Q9H9N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.