Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BS31

- ZN649_HUMAN

UniProt

Q9BS31 - ZN649_HUMAN

Protein

Zinc finger protein 649

Gene

ZNF649

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri178 – 20023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri206 – 22823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 649
    Gene namesi
    Name:ZNF649
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25741. ZNF649.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485678.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Zinc finger protein 649PRO_0000251224Add
    BLAST

    Proteomic databases

    MaxQBiQ9BS31.
    PaxDbiQ9BS31.
    PRIDEiQ9BS31.

    PTM databases

    PhosphoSiteiQ9BS31.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.1 Publication

    Developmental stagei

    Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9BS31.
    BgeeiQ9BS31.
    CleanExiHS_ZNF649.
    GenevestigatoriQ9BS31.

    Organism-specific databases

    HPAiHPA026541.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H1O434632EBI-4395789,EBI-349968

    Protein-protein interaction databases

    BioGridi122414. 3 interactions.
    IntActiQ9BS31. 2 interactions.
    MINTiMINT-4719207.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BS31.
    SMRiQ9BS31. Positions 2-49, 160-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The KRAB domain is required for transcriptional repression.

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri178 – 20023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri206 – 22823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9BS31.
    KOiK09228.
    OMAiKTMLIVH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9BS31.
    TreeFamiTF340593.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BS31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVSVGYQ    50
    AGKPDALTKL EQGEPLWTLE DEIHSPAHPE IEKADDHLQQ PLQNQKILKR 100
    TGQRYEHGRT LKSYLGLTNQ SRRYNRKEPA EFNGDGAFLH DNHEQMPTEI 150
    EFPESRKPIS TKSQFLKHQQ THNIEKAHEC TDCGKAFLKK SQLTEHKRIH 200
    TGKKPHVCSL CGKAFYKKYR LTEHERAHRG EKPHGCSLCG KAFYKRYRLT 250
    EHERAHKGEK PYGCSECGKA FPRKSELTEH QRIHTGIKPH QCSECGRAFS 300
    RKSLLVVHQR THTGEKPHTC SECGKGFIQK GNLNIHQRTH TGEKPYGCID 350
    CGKAFSQKSC LVAHQRYHTG KTPFVCPECG QPCSQKSGLI RHQKIHSGEK 400
    PYKCSDCGKA FLTKTMLIVH HRTHTGERPY GCDECEKAYF YMSCLVKHKR 450
    IHSREKRGDS VKVENPSTAS HSLSPSEHVQ GKSPVNMVTV AMVAGQCEFA 500
    HILHS 505
    Length:505
    Mass (Da):57,683
    Last modified:June 1, 2001 - v1
    Checksum:iEC1A70DCA8E01613
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81L → V in BAB14191. (PubMed:14702039)Curated
    Sequence conflicti314 – 3141G → E in BAB14191. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti352 – 3521G → D.
    Corresponds to variant rs6509593 [ dbSNP | Ensembl ].
    VAR_027668
    Natural varianti469 – 4691A → T.
    Corresponds to variant rs1433083 [ dbSNP | Ensembl ].
    VAR_027669

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022706 mRNA. Translation: BAB14191.1.
    AK315487 mRNA. Translation: BAG37871.1.
    AL713677 mRNA. Translation: CAD28482.1.
    AC011460 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72050.1.
    BC005368 mRNA. Translation: AAH05368.1.
    CCDSiCCDS12843.1.
    RefSeqiNP_075562.2. NM_023074.3.
    UniGeneiHs.148322.

    Genome annotation databases

    EnsembliENST00000354957; ENSP00000347043; ENSG00000198093.
    GeneIDi65251.
    KEGGihsa:65251.
    UCSCiuc002pxy.3. human.

    Polymorphism databases

    DMDMi74761227.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022706 mRNA. Translation: BAB14191.1 .
    AK315487 mRNA. Translation: BAG37871.1 .
    AL713677 mRNA. Translation: CAD28482.1 .
    AC011460 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72050.1 .
    BC005368 mRNA. Translation: AAH05368.1 .
    CCDSi CCDS12843.1.
    RefSeqi NP_075562.2. NM_023074.3.
    UniGenei Hs.148322.

    3D structure databases

    ProteinModelPortali Q9BS31.
    SMRi Q9BS31. Positions 2-49, 160-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122414. 3 interactions.
    IntActi Q9BS31. 2 interactions.
    MINTi MINT-4719207.

    PTM databases

    PhosphoSitei Q9BS31.

    Polymorphism databases

    DMDMi 74761227.

    Proteomic databases

    MaxQBi Q9BS31.
    PaxDbi Q9BS31.
    PRIDEi Q9BS31.

    Protocols and materials databases

    DNASUi 65251.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354957 ; ENSP00000347043 ; ENSG00000198093 .
    GeneIDi 65251.
    KEGGi hsa:65251.
    UCSCi uc002pxy.3. human.

    Organism-specific databases

    CTDi 65251.
    GeneCardsi GC19M052392.
    HGNCi HGNC:25741. ZNF649.
    HPAi HPA026541.
    MIMi 611903. gene.
    neXtProti NX_Q9BS31.
    PharmGKBi PA143485678.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9BS31.
    KOi K09228.
    OMAi KTMLIVH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9BS31.
    TreeFami TF340593.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF649. human.
    GeneWikii ZNF649.
    GenomeRNAii 65251.
    NextBioi 67374.
    PROi Q9BS31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BS31.
    Bgeei Q9BS31.
    CleanExi HS_ZNF649.
    Genevestigatori Q9BS31.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor."
      Yang H., Yuan W., Wang Y., Zhu C., Liu B., Wang Y., Yang D., Li Y., Wang C., Wu X., Liu M.
      Biochem. Biophys. Res. Commun. 333:206-215(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiZN649_HUMAN
    AccessioniPrimary (citable) accession number: Q9BS31
    Secondary accession number(s): A8MYJ5, B2RDC4, Q9H9N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3