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Protein

Phospholipase A(2)

Gene

PLA2G1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.UniRule annotation

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processLipid metabolismUniRule annotation
LigandCalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A(2)UniRule annotation (EC:3.1.1.4UniRule annotation)
Gene namesi
Name:PLA2G1BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000170890.13.
HGNCiHGNC:9030. PLA2G1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170890.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000170890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69PA2cInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the phospholipase A2 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000152136.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiView protein in InterPro
IPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR036444. PLipase_A2_dom_sf.
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiView protein in Pfam
PF00068. Phospholip_A2_1. 1 hit.
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiView protein in SMART
SM00085. PA2c. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BS22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP FLEYNNYGCY
60 70
CGLGGSGTPV DELDKQKQRV
Length:70
Mass (Da):7,633
Last modified:June 1, 2001 - v1
Checksum:i6AB5E4153E6204B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003982 Genomic DNA. No translation available.
BC005386 mRNA. Translation: AAH05386.1.
UniGeneiHs.992.

Genome annotation databases

EnsembliENST00000423423; ENSP00000413594; ENSG00000170890.
UCSCiuc009zwx.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ9BS22_HUMAN
AccessioniPrimary (citable) accession number: Q9BS22
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported