Q9BS18 (APC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaphase-promoting complex subunit 13
Short name=APC13

Alternative name(s):
Cyclosome subunit 13

Gene names

Name:

ANAPC13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Ref.3 Ref.5
Pathway	Protein modification; protein ubiquitination.
Subunit structure	The APC/C is composed of at least 12 subunits. Ref.4
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the APC13 family.
Sequence caution	The sequence CAB43251.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein K11-linked ubiquitination Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	anaphase-promoting complex Inferred from direct assay Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 74	74	Anaphase-promoting complex subunit 13		PRO_0000253980
Experimental info
	Sequence conflict	8	1	D → G in CAB43251. Ref.1
	Sequence conflict	67	1	E → G in CAB43251. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BS18 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F3C52A7E3821CB3B	FASTA	74	8,521
	10 20 30 40 50 60 MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL 70 ALQYLHENVP PIGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27." Schwickart M., Havlis J., Habermann B., Bogdanova A., Camasses A., Oelschlaegel T., Shevchenko A., Zachariae W. Mol. Cell. Biol. 24:3562-3576(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C." Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H. Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE APC/C COMPLEX.
[5]	"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex." Jin L., Williamson A., Banerjee S., Philipp I., Rape M. Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION OF THE APC/C.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL050051 mRNA. Translation: CAB43251.1. Frameshift. BC005398 mRNA. Translation: AAH05398.1.
IPI	IPI00029244.
PIR	T08723.
RefSeq	NP_001229303.1. NM_001242374.1. NP_001229304.1. NM_001242375.1. NP_056206.1. NM_015391.3.
UniGene	Hs.106909.
3D structure databases
ProteinModelPortal	Q9BS18.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BS18. 15 interactions.
STRING	9606.ENSP00000346987.
PTM databases
PhosphoSite	Q9BS18.
Polymorphism databases
DMDM	74732956.
Proteomic databases
PRIDE	Q9BS18.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354910; ENSP00000346987; ENSG00000129055. ENST00000510994; ENSP00000421842; ENSG00000129055. ENST00000511751; ENSP00000421760; ENSG00000129055. ENST00000514612; ENSP00000427327; ENSG00000129055.
GeneID	25847.
KEGG	hsa:25847.
UCSC	uc003eqi.3. human.
Organism-specific databases
CTD	25847.
GeneCards	GC03M134196.
HGNC	HGNC:24540. ANAPC13.
HPA	HPA046114.
MIM	614484. gene.
neXtProt	NX_Q9BS18.
PharmGKB	PA134949652.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46843.
HOVERGEN	HBG079845.
InParanoid	Q9BS18.
KO	K12456.
OMA	EQDNGGS.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9BS18.
Bgee	Q9BS18.
CleanEx	HS_ANAPC13.
Genevestigator	Q9BS18.
GermOnline	ENSG00000129055. Homo sapiens.
Family and domain databases
InterPro	IPR008401. Apc13p. [Graphical view]
Pfam	PF05839. Apc13p. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25847.
NextBio	47182.
SOURCE	Search...

Entry information

Entry name

APC13_HUMAN

Accession

Primary (citable) accession number: Q9BS18
Secondary accession number(s): Q9Y3V0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.