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Q9BS18

- APC13_HUMAN

UniProt

Q9BS18 - APC13_HUMAN

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Protein

Anaphase-promoting complex subunit 13

Gene

ANAPC13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.2 Publications

Pathwayi

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. protein K11-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 13
Short name:
APC13
Alternative name(s):
Cyclosome subunit 13
Gene namesi
Name:ANAPC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24540. ANAPC13.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. anaphase-promoting complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Anaphase-promoting complex subunit 13PRO_0000253980Add
BLAST

Proteomic databases

MaxQBiQ9BS18.
PRIDEiQ9BS18.

PTM databases

PhosphoSiteiQ9BS18.

Expressioni

Gene expression databases

BgeeiQ9BS18.
CleanExiHS_ANAPC13.
ExpressionAtlasiQ9BS18. baseline and differential.
GenevestigatoriQ9BS18.

Organism-specific databases

HPAiHPA046114.

Interactioni

Subunit structurei

The APC/C is composed of at least 12 subunits.1 Publication

Protein-protein interaction databases

BioGridi117372. 19 interactions.
IntActiQ9BS18. 15 interactions.
STRINGi9606.ENSP00000346987.

Structurei

3D structure databases

ProteinModelPortaliQ9BS18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APC13 family.Curated

Phylogenomic databases

eggNOGiNOG46843.
GeneTreeiENSGT00390000008673.
HOVERGENiHBG079845.
InParanoidiQ9BS18.
KOiK12456.
OMAiRHTITEQ.
OrthoDBiEOG7T1RDX.
PhylomeDBiQ9BS18.
TreeFamiTF105448.

Family and domain databases

InterProiIPR008401. Apc13p.
[Graphical view]
PfamiPF05839. Apc13p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS18 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV
60 70
KEQEMKWTDL ALQYLHENVP PIGN
Length:74
Mass (Da):8,521
Last modified:June 1, 2001 - v1
Checksum:iF3C52A7E3821CB3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81D → G in CAB43251. (PubMed:17974005)Curated
Sequence conflicti67 – 671E → G in CAB43251. (PubMed:17974005)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL050051 mRNA. Translation: CAB43251.1. Frameshift.
BC005398 mRNA. Translation: AAH05398.1.
CCDSiCCDS3085.1.
PIRiT08723.
RefSeqiNP_001229303.1. NM_001242374.1.
NP_001229304.1. NM_001242375.1.
NP_056206.1. NM_015391.3.
UniGeneiHs.106909.

Genome annotation databases

EnsembliENST00000354910; ENSP00000346987; ENSG00000129055.
ENST00000510994; ENSP00000421842; ENSG00000129055.
ENST00000511751; ENSP00000421760; ENSG00000129055.
ENST00000514612; ENSP00000427327; ENSG00000129055.
GeneIDi25847.
KEGGihsa:25847.
UCSCiuc003eqi.3. human.

Polymorphism databases

DMDMi74732956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL050051 mRNA. Translation: CAB43251.1 . Frameshift.
BC005398 mRNA. Translation: AAH05398.1 .
CCDSi CCDS3085.1.
PIRi T08723.
RefSeqi NP_001229303.1. NM_001242374.1.
NP_001229304.1. NM_001242375.1.
NP_056206.1. NM_015391.3.
UniGenei Hs.106909.

3D structure databases

ProteinModelPortali Q9BS18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117372. 19 interactions.
IntActi Q9BS18. 15 interactions.
STRINGi 9606.ENSP00000346987.

PTM databases

PhosphoSitei Q9BS18.

Polymorphism databases

DMDMi 74732956.

Proteomic databases

MaxQBi Q9BS18.
PRIDEi Q9BS18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354910 ; ENSP00000346987 ; ENSG00000129055 .
ENST00000510994 ; ENSP00000421842 ; ENSG00000129055 .
ENST00000511751 ; ENSP00000421760 ; ENSG00000129055 .
ENST00000514612 ; ENSP00000427327 ; ENSG00000129055 .
GeneIDi 25847.
KEGGi hsa:25847.
UCSCi uc003eqi.3. human.

Organism-specific databases

CTDi 25847.
GeneCardsi GC03M134196.
HGNCi HGNC:24540. ANAPC13.
HPAi HPA046114.
MIMi 614484. gene.
neXtProti NX_Q9BS18.
PharmGKBi PA134949652.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46843.
GeneTreei ENSGT00390000008673.
HOVERGENi HBG079845.
InParanoidi Q9BS18.
KOi K12456.
OMAi RHTITEQ.
OrthoDBi EOG7T1RDX.
PhylomeDBi Q9BS18.
TreeFami TF105448.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii 25847.
NextBioi 47182.
PROi Q9BS18.
SOURCEi Search...

Gene expression databases

Bgeei Q9BS18.
CleanExi HS_ANAPC13.
ExpressionAtlasi Q9BS18. baseline and differential.
Genevestigatori Q9BS18.

Family and domain databases

InterProi IPR008401. Apc13p.
[Graphical view ]
Pfami PF05839. Apc13p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27."
    Schwickart M., Havlis J., Habermann B., Bogdanova A., Camasses A., Oelschlaegel T., Shevchenko A., Zachariae W.
    Mol. Cell. Biol. 24:3562-3576(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
    Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
    Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE APC/C COMPLEX.
  5. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
    Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
    Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE APC/C.

Entry informationi

Entry nameiAPC13_HUMAN
AccessioniPrimary (citable) accession number: Q9BS18
Secondary accession number(s): Q9Y3V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3