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Q9BS18 (APC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaphase-promoting complex subunit 13

Short name=APC13
Alternative name(s):
Cyclosome subunit 13
Gene names
Name:ANAPC13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length74 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Ref.3 Ref.5

Pathway

Protein modification; protein ubiquitination.

Subunit structure

The APC/C is composed of at least 12 subunits. Ref.4

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the APC13 family.

Sequence caution

The sequence CAB43251.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
Ubl conjugation pathway
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

protein K11-linked ubiquitination

Inferred from direct assay Ref.5. Source: UniProtKB

   Cellular_componentanaphase-promoting complex

Inferred from direct assay Ref.4. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7474Anaphase-promoting complex subunit 13
PRO_0000253980

Experimental info

Sequence conflict81D → G in CAB43251. Ref.1
Sequence conflict671E → G in CAB43251. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BS18 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F3C52A7E3821CB3B

FASTA748,521
        10         20         30         40         50         60 
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL 

        70 
ALQYLHENVP PIGN 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27."
Schwickart M., Havlis J., Habermann B., Bogdanova A., Camasses A., Oelschlaegel T., Shevchenko A., Zachariae W.
Mol. Cell. Biol. 24:3562-3576(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE APC/C COMPLEX.
[5]"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE APC/C.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL050051 mRNA. Translation: CAB43251.1. Frameshift.
BC005398 mRNA. Translation: AAH05398.1.
CCDSCCDS3085.1.
PIRT08723.
RefSeqNP_001229303.1. NM_001242374.1.
NP_001229304.1. NM_001242375.1.
NP_056206.1. NM_015391.3.
UniGeneHs.106909.

3D structure databases

ProteinModelPortalQ9BS18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117372. 19 interactions.
IntActQ9BS18. 15 interactions.
STRING9606.ENSP00000346987.

PTM databases

PhosphoSiteQ9BS18.

Polymorphism databases

DMDM74732956.

Proteomic databases

MaxQBQ9BS18.
PRIDEQ9BS18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354910; ENSP00000346987; ENSG00000129055.
ENST00000510994; ENSP00000421842; ENSG00000129055.
ENST00000511751; ENSP00000421760; ENSG00000129055.
ENST00000514612; ENSP00000427327; ENSG00000129055.
GeneID25847.
KEGGhsa:25847.
UCSCuc003eqi.3. human.

Organism-specific databases

CTD25847.
GeneCardsGC03M134196.
HGNCHGNC:24540. ANAPC13.
HPAHPA046114.
MIM614484. gene.
neXtProtNX_Q9BS18.
PharmGKBPA134949652.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46843.
HOVERGENHBG079845.
InParanoidQ9BS18.
KOK12456.
OMARHTITEQ.
OrthoDBEOG7T1RDX.
PhylomeDBQ9BS18.
TreeFamTF105448.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ9BS18.
BgeeQ9BS18.
CleanExHS_ANAPC13.
GenevestigatorQ9BS18.

Family and domain databases

InterProIPR008401. Apc13p.
[Graphical view]
PfamPF05839. Apc13p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25847.
NextBio47182.
PROQ9BS18.
SOURCESearch...

Entry information

Entry nameAPC13_HUMAN
AccessionPrimary (citable) accession number: Q9BS18
Secondary accession number(s): Q9Y3V0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM