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Q9BS18

- APC13_HUMAN

UniProt

Q9BS18 - APC13_HUMAN

Protein

Anaphase-promoting complex subunit 13

Gene

ANAPC13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.2 Publications

    Pathwayi

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. protein K11-linked ubiquitination Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaphase-promoting complex subunit 13
    Short name:
    APC13
    Alternative name(s):
    Cyclosome subunit 13
    Gene namesi
    Name:ANAPC13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24540. ANAPC13.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134949652.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7474Anaphase-promoting complex subunit 13PRO_0000253980Add
    BLAST

    Proteomic databases

    MaxQBiQ9BS18.
    PRIDEiQ9BS18.

    PTM databases

    PhosphoSiteiQ9BS18.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BS18.
    BgeeiQ9BS18.
    CleanExiHS_ANAPC13.
    GenevestigatoriQ9BS18.

    Organism-specific databases

    HPAiHPA046114.

    Interactioni

    Subunit structurei

    The APC/C is composed of at least 12 subunits.1 Publication

    Protein-protein interaction databases

    BioGridi117372. 19 interactions.
    IntActiQ9BS18. 15 interactions.
    STRINGi9606.ENSP00000346987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BS18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the APC13 family.Curated

    Phylogenomic databases

    eggNOGiNOG46843.
    HOVERGENiHBG079845.
    InParanoidiQ9BS18.
    KOiK12456.
    OMAiRHTITEQ.
    OrthoDBiEOG7T1RDX.
    PhylomeDBiQ9BS18.
    TreeFamiTF105448.

    Family and domain databases

    InterProiIPR008401. Apc13p.
    [Graphical view]
    PfamiPF05839. Apc13p. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BS18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV   50
    KEQEMKWTDL ALQYLHENVP PIGN 74
    Length:74
    Mass (Da):8,521
    Last modified:June 1, 2001 - v1
    Checksum:iF3C52A7E3821CB3B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81D → G in CAB43251. (PubMed:17974005)Curated
    Sequence conflicti67 – 671E → G in CAB43251. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL050051 mRNA. Translation: CAB43251.1. Frameshift.
    BC005398 mRNA. Translation: AAH05398.1.
    CCDSiCCDS3085.1.
    PIRiT08723.
    RefSeqiNP_001229303.1. NM_001242374.1.
    NP_001229304.1. NM_001242375.1.
    NP_056206.1. NM_015391.3.
    UniGeneiHs.106909.

    Genome annotation databases

    EnsembliENST00000354910; ENSP00000346987; ENSG00000129055.
    ENST00000510994; ENSP00000421842; ENSG00000129055.
    ENST00000511751; ENSP00000421760; ENSG00000129055.
    ENST00000514612; ENSP00000427327; ENSG00000129055.
    GeneIDi25847.
    KEGGihsa:25847.
    UCSCiuc003eqi.3. human.

    Polymorphism databases

    DMDMi74732956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL050051 mRNA. Translation: CAB43251.1 . Frameshift.
    BC005398 mRNA. Translation: AAH05398.1 .
    CCDSi CCDS3085.1.
    PIRi T08723.
    RefSeqi NP_001229303.1. NM_001242374.1.
    NP_001229304.1. NM_001242375.1.
    NP_056206.1. NM_015391.3.
    UniGenei Hs.106909.

    3D structure databases

    ProteinModelPortali Q9BS18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117372. 19 interactions.
    IntActi Q9BS18. 15 interactions.
    STRINGi 9606.ENSP00000346987.

    PTM databases

    PhosphoSitei Q9BS18.

    Polymorphism databases

    DMDMi 74732956.

    Proteomic databases

    MaxQBi Q9BS18.
    PRIDEi Q9BS18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354910 ; ENSP00000346987 ; ENSG00000129055 .
    ENST00000510994 ; ENSP00000421842 ; ENSG00000129055 .
    ENST00000511751 ; ENSP00000421760 ; ENSG00000129055 .
    ENST00000514612 ; ENSP00000427327 ; ENSG00000129055 .
    GeneIDi 25847.
    KEGGi hsa:25847.
    UCSCi uc003eqi.3. human.

    Organism-specific databases

    CTDi 25847.
    GeneCardsi GC03M134196.
    HGNCi HGNC:24540. ANAPC13.
    HPAi HPA046114.
    MIMi 614484. gene.
    neXtProti NX_Q9BS18.
    PharmGKBi PA134949652.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46843.
    HOVERGENi HBG079845.
    InParanoidi Q9BS18.
    KOi K12456.
    OMAi RHTITEQ.
    OrthoDBi EOG7T1RDX.
    PhylomeDBi Q9BS18.
    TreeFami TF105448.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 25847.
    NextBioi 47182.
    PROi Q9BS18.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BS18.
    Bgeei Q9BS18.
    CleanExi HS_ANAPC13.
    Genevestigatori Q9BS18.

    Family and domain databases

    InterProi IPR008401. Apc13p.
    [Graphical view ]
    Pfami PF05839. Apc13p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27."
      Schwickart M., Havlis J., Habermann B., Bogdanova A., Camasses A., Oelschlaegel T., Shevchenko A., Zachariae W.
      Mol. Cell. Biol. 24:3562-3576(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
      Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
      Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE APC/C COMPLEX.
    5. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
      Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
      Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE APC/C.

    Entry informationi

    Entry nameiAPC13_HUMAN
    AccessioniPrimary (citable) accession number: Q9BS18
    Secondary accession number(s): Q9Y3V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3