Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaphase-promoting complex subunit 13

Gene

ANAPC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.2 Publications

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • protein K11-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 13
Short name:
APC13
Alternative name(s):
Cyclosome subunit 13
Gene namesi
Name:ANAPC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24540. ANAPC13.

Subcellular locationi

GO - Cellular componenti

  • anaphase-promoting complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949652.

Polymorphism and mutation databases

BioMutaiANAPC13.
DMDMi74732956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Anaphase-promoting complex subunit 13PRO_0000253980Add
BLAST

Proteomic databases

MaxQBiQ9BS18.
PRIDEiQ9BS18.

PTM databases

PhosphoSiteiQ9BS18.

Expressioni

Gene expression databases

BgeeiQ9BS18.
CleanExiHS_ANAPC13.
ExpressionAtlasiQ9BS18. baseline and differential.
GenevisibleiQ9BS18. HS.

Organism-specific databases

HPAiHPA046114.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.2 Publications

Protein-protein interaction databases

BioGridi117372. 15 interactions.
DIPiDIP-56455N.
IntActiQ9BS18. 15 interactions.
STRINGi9606.ENSP00000346987.

Structurei

3D structure databases

ProteinModelPortaliQ9BS18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APC13 family.Curated

Phylogenomic databases

eggNOGiNOG46843.
GeneTreeiENSGT00390000008673.
HOVERGENiHBG079845.
InParanoidiQ9BS18.
KOiK12456.
OMAiLHENTPN.
OrthoDBiEOG7T1RDX.
PhylomeDBiQ9BS18.
TreeFamiTF105448.

Family and domain databases

InterProiIPR008401. Apc13p.
[Graphical view]
PfamiPF05839. Apc13p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV
60 70
KEQEMKWTDL ALQYLHENVP PIGN
Length:74
Mass (Da):8,521
Last modified:June 1, 2001 - v1
Checksum:iF3C52A7E3821CB3B
GO

Sequence cautioni

The sequence CAB43251.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81D → G in CAB43251 (PubMed:17974005).Curated
Sequence conflicti67 – 671E → G in CAB43251 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050051 mRNA. Translation: CAB43251.1. Frameshift.
BC005398 mRNA. Translation: AAH05398.1.
CCDSiCCDS3085.1.
PIRiT08723.
RefSeqiNP_001229303.1. NM_001242374.1.
NP_001229304.1. NM_001242375.1.
NP_056206.1. NM_015391.3.
UniGeneiHs.106909.

Genome annotation databases

EnsembliENST00000354910; ENSP00000346987; ENSG00000129055.
ENST00000510994; ENSP00000421842; ENSG00000129055.
ENST00000511751; ENSP00000421760; ENSG00000129055.
ENST00000514612; ENSP00000427327; ENSG00000129055.
GeneIDi25847.
KEGGihsa:25847.
UCSCiuc003eqi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050051 mRNA. Translation: CAB43251.1. Frameshift.
BC005398 mRNA. Translation: AAH05398.1.
CCDSiCCDS3085.1.
PIRiT08723.
RefSeqiNP_001229303.1. NM_001242374.1.
NP_001229304.1. NM_001242375.1.
NP_056206.1. NM_015391.3.
UniGeneiHs.106909.

3D structure databases

ProteinModelPortaliQ9BS18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117372. 15 interactions.
DIPiDIP-56455N.
IntActiQ9BS18. 15 interactions.
STRINGi9606.ENSP00000346987.

PTM databases

PhosphoSiteiQ9BS18.

Polymorphism and mutation databases

BioMutaiANAPC13.
DMDMi74732956.

Proteomic databases

MaxQBiQ9BS18.
PRIDEiQ9BS18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354910; ENSP00000346987; ENSG00000129055.
ENST00000510994; ENSP00000421842; ENSG00000129055.
ENST00000511751; ENSP00000421760; ENSG00000129055.
ENST00000514612; ENSP00000427327; ENSG00000129055.
GeneIDi25847.
KEGGihsa:25847.
UCSCiuc003eqi.3. human.

Organism-specific databases

CTDi25847.
GeneCardsiGC03M134196.
HGNCiHGNC:24540. ANAPC13.
HPAiHPA046114.
MIMi614484. gene.
neXtProtiNX_Q9BS18.
PharmGKBiPA134949652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46843.
GeneTreeiENSGT00390000008673.
HOVERGENiHBG079845.
InParanoidiQ9BS18.
KOiK12456.
OMAiLHENTPN.
OrthoDBiEOG7T1RDX.
PhylomeDBiQ9BS18.
TreeFamiTF105448.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiANAPC13. human.
GenomeRNAii25847.
NextBioi47182.
PROiQ9BS18.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BS18.
CleanExiHS_ANAPC13.
ExpressionAtlasiQ9BS18. baseline and differential.
GenevisibleiQ9BS18. HS.

Family and domain databases

InterProiIPR008401. Apc13p.
[Graphical view]
PfamiPF05839. Apc13p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27."
    Schwickart M., Havlis J., Habermann B., Bogdanova A., Camasses A., Oelschlaegel T., Shevchenko A., Zachariae W.
    Mol. Cell. Biol. 24:3562-3576(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."
    Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H.
    Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE APC/C COMPLEX.
  5. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
    Jin L., Williamson A., Banerjee S., Philipp I., Rape M.
    Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE APC/C.
  6. "Molecular architecture and mechanism of the anaphase-promoting complex."
    Chang L., Zhang Z., Yang J., McLaughlin S.H., Barford D.
    Nature 513:388-393(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE APC/C, SUBUNIT.

Entry informationi

Entry nameiAPC13_HUMAN
AccessioniPrimary (citable) accession number: Q9BS18
Secondary accession number(s): Q9Y3V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.