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Protein

Centromere protein K

Gene

CENPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.3 Publications

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123219-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.
SIGNORiQ9BS16.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein K
Short name:
CENP-K
Alternative name(s):
Interphase centromere complex protein 37
Protein AF-5alpha
p33
Gene namesi
Name:CENPK
Synonyms:ICEN37
ORF Names:FKSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29479. CENPK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei96 – 97Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene2

Organism-specific databases

DisGeNETi64105.
OpenTargetsiENSG00000123219.
PharmGKBiPA145149171.

Polymorphism and mutation databases

BioMutaiCENPK.
DMDMi74732954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002494821 – 269Centromere protein KAdd BLAST269

Proteomic databases

EPDiQ9BS16.
MaxQBiQ9BS16.
PaxDbiQ9BS16.
PeptideAtlasiQ9BS16.
PRIDEiQ9BS16.

PTM databases

iPTMnetiQ9BS16.
PhosphoSitePlusiQ9BS16.

Expressioni

Tissue specificityi

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.1 Publication

Gene expression databases

BgeeiENSG00000123219.
CleanExiHS_CENPK.
ExpressionAtlasiQ9BS16. baseline and differential.
GenevisibleiQ9BS16. HS.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q86V283EBI-6871750,EBI-10259496
CENPHQ9H3R55EBI-6871750,EBI-1003700
MRFAP1L1Q96HT83EBI-6871750,EBI-748896

Protein-protein interaction databases

BioGridi122063. 17 interactors.
IntActiQ9BS16. 12 interactors.
STRINGi9606.ENSP00000242872.

Structurei

3D structure databases

ProteinModelPortaliQ9BS16.
SMRiQ9BS16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 42Sequence analysisAdd BLAST21
Coiled coili98 – 151Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the CENPK family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGKP. Eukaryota.
ENOG4111ZR6. LUCA.
GeneTreeiENSGT00390000006243.
HOGENOMiHOG000111542.
HOVERGENiHBG081084.
InParanoidiQ9BS16.
KOiK11503.
OMAiSQWQKET.
OrthoDBiEOG091G0LKB.
PhylomeDBiQ9BS16.
TreeFamiTF333264.

Family and domain databases

InterProiIPR020993. Centromere_CenpK.
[Graphical view]
PfamiPF11802. CENP-K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL
60 70 80 90 100
TDSNAQLSLL IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL
110 120 130 140 150
RQDLEMVLST KESKNEKLKE DLEREQRWLD EQQQIMESLN VLHSELKNKV
160 170 180 190 200
ETFSESRIFN ELKTKMLNIK EYKEKLLSTL GEFLEDHFPL PDRSVKKKKK
210 220 230 240 250
NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP PYVELLLRNG
260
IALRHPEDPT RIRLEAFHQ
Length:269
Mass (Da):31,655
Last modified:June 1, 2001 - v1
Checksum:iD59737D32D221A84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45I → M in AAG31004 (Ref. 3) Curated1
Sequence conflicti59L → W in AAG31004 (Ref. 3) Curated1
Sequence conflicti66C → G in AAG31004 (Ref. 3) Curated1
Sequence conflicti74W → G in AAG31004 (Ref. 3) Curated1
Sequence conflicti81T → I in AAG31004 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033646 mRNA. Translation: AAK59382.1.
AF315941 mRNA. Translation: AAL26880.1.
AY009151 mRNA. Translation: AAG31004.1.
BC005400 mRNA. Translation: AAH05400.1.
BC008504 mRNA. Translation: AAH08504.1.
CCDSiCCDS3984.1.
RefSeqiNP_001253967.1. NM_001267038.1.
NP_071428.2. NM_022145.4.
XP_011541838.1. XM_011543536.2.
XP_016865179.1. XM_017009690.1.
XP_016865180.1. XM_017009691.1.
XP_016865181.1. XM_017009692.1.
UniGeneiHs.529778.

Genome annotation databases

EnsembliENST00000242872; ENSP00000242872; ENSG00000123219.
ENST00000396679; ENSP00000379911; ENSG00000123219.
ENST00000514814; ENSP00000422421; ENSG00000123219.
GeneIDi64105.
KEGGihsa:64105.
UCSCiuc003jts.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033646 mRNA. Translation: AAK59382.1.
AF315941 mRNA. Translation: AAL26880.1.
AY009151 mRNA. Translation: AAG31004.1.
BC005400 mRNA. Translation: AAH05400.1.
BC008504 mRNA. Translation: AAH08504.1.
CCDSiCCDS3984.1.
RefSeqiNP_001253967.1. NM_001267038.1.
NP_071428.2. NM_022145.4.
XP_011541838.1. XM_011543536.2.
XP_016865179.1. XM_017009690.1.
XP_016865180.1. XM_017009691.1.
XP_016865181.1. XM_017009692.1.
UniGeneiHs.529778.

3D structure databases

ProteinModelPortaliQ9BS16.
SMRiQ9BS16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122063. 17 interactors.
IntActiQ9BS16. 12 interactors.
STRINGi9606.ENSP00000242872.

PTM databases

iPTMnetiQ9BS16.
PhosphoSitePlusiQ9BS16.

Polymorphism and mutation databases

BioMutaiCENPK.
DMDMi74732954.

Proteomic databases

EPDiQ9BS16.
MaxQBiQ9BS16.
PaxDbiQ9BS16.
PeptideAtlasiQ9BS16.
PRIDEiQ9BS16.

Protocols and materials databases

DNASUi64105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242872; ENSP00000242872; ENSG00000123219.
ENST00000396679; ENSP00000379911; ENSG00000123219.
ENST00000514814; ENSP00000422421; ENSG00000123219.
GeneIDi64105.
KEGGihsa:64105.
UCSCiuc003jts.4. human.

Organism-specific databases

CTDi64105.
DisGeNETi64105.
GeneCardsiCENPK.
HGNCiHGNC:29479. CENPK.
MIMi611502. gene.
neXtProtiNX_Q9BS16.
OpenTargetsiENSG00000123219.
PharmGKBiPA145149171.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGKP. Eukaryota.
ENOG4111ZR6. LUCA.
GeneTreeiENSGT00390000006243.
HOGENOMiHOG000111542.
HOVERGENiHBG081084.
InParanoidiQ9BS16.
KOiK11503.
OMAiSQWQKET.
OrthoDBiEOG091G0LKB.
PhylomeDBiQ9BS16.
TreeFamiTF333264.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123219-MONOMER.
ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.
SIGNORiQ9BS16.

Miscellaneous databases

GeneWikiiCENPK.
GenomeRNAii64105.
PROiQ9BS16.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123219.
CleanExiHS_CENPK.
ExpressionAtlasiQ9BS16. baseline and differential.
GenevisibleiQ9BS16. HS.

Family and domain databases

InterProiIPR020993. Centromere_CenpK.
[Graphical view]
PfamiPF11802. CENP-K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCENPK_HUMAN
AccessioniPrimary (citable) accession number: Q9BS16
Secondary accession number(s): Q9H4L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.