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Protein

Centromere protein K

Gene

CENPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.3 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ9BS16

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein K
Short name:
CENP-K
Alternative name(s):
Interphase centromere complex protein 37
Protein AF-5alpha
p33
Gene namesi
Name:CENPK
Synonyms:ICEN37
ORF Names:FKSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000123219.12
HGNCiHGNC:29479 CENPK
MIMi611502 gene
neXtProtiNX_Q9BS16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei96 – 97Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene2

Organism-specific databases

DisGeNETi64105
OpenTargetsiENSG00000123219
PharmGKBiPA145149171

Polymorphism and mutation databases

BioMutaiCENPK
DMDMi74732954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002494821 – 269Centromere protein KAdd BLAST269

Proteomic databases

EPDiQ9BS16
MaxQBiQ9BS16
PaxDbiQ9BS16
PeptideAtlasiQ9BS16
PRIDEiQ9BS16

PTM databases

iPTMnetiQ9BS16
PhosphoSitePlusiQ9BS16

Expressioni

Tissue specificityi

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.1 Publication

Gene expression databases

BgeeiENSG00000123219
CleanExiHS_CENPK
ExpressionAtlasiQ9BS16 baseline and differential
GenevisibleiQ9BS16 HS

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122063, 21 interactors
CORUMiQ9BS16
IntActiQ9BS16, 14 interactors
STRINGi9606.ENSP00000242872

Structurei

3D structure databases

ProteinModelPortaliQ9BS16
SMRiQ9BS16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 42Sequence analysisAdd BLAST21
Coiled coili98 – 151Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the CENP-K/MCM22 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGKP Eukaryota
ENOG4111ZR6 LUCA
GeneTreeiENSGT00390000006243
HOGENOMiHOG000111542
HOVERGENiHBG081084
InParanoidiQ9BS16
KOiK11503
OMAiSQWQKET
OrthoDBiEOG091G0LKB
PhylomeDBiQ9BS16
TreeFamiTF333264

Family and domain databases

InterProiView protein in InterPro
IPR020993 Centromere_CenpK
PfamiView protein in Pfam
PF11802 CENP-K, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BS16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL
60 70 80 90 100
TDSNAQLSLL IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL
110 120 130 140 150
RQDLEMVLST KESKNEKLKE DLEREQRWLD EQQQIMESLN VLHSELKNKV
160 170 180 190 200
ETFSESRIFN ELKTKMLNIK EYKEKLLSTL GEFLEDHFPL PDRSVKKKKK
210 220 230 240 250
NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP PYVELLLRNG
260
IALRHPEDPT RIRLEAFHQ
Length:269
Mass (Da):31,655
Last modified:June 1, 2001 - v1
Checksum:iD59737D32D221A84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45I → M in AAG31004 (Ref. 3) Curated1
Sequence conflicti59L → W in AAG31004 (Ref. 3) Curated1
Sequence conflicti66C → G in AAG31004 (Ref. 3) Curated1
Sequence conflicti74W → G in AAG31004 (Ref. 3) Curated1
Sequence conflicti81T → I in AAG31004 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033646 mRNA Translation: AAK59382.1
AF315941 mRNA Translation: AAL26880.1
AY009151 mRNA Translation: AAG31004.1
BC005400 mRNA Translation: AAH05400.1
BC008504 mRNA Translation: AAH08504.1
CCDSiCCDS3984.1
RefSeqiNP_001253967.1, NM_001267038.1
NP_071428.2, NM_022145.4
XP_011541838.1, XM_011543536.2
XP_016865179.1, XM_017009690.1
XP_016865180.1, XM_017009691.1
XP_016865181.1, XM_017009692.1
UniGeneiHs.529778

Genome annotation databases

EnsembliENST00000242872; ENSP00000242872; ENSG00000123219
ENST00000396679; ENSP00000379911; ENSG00000123219
ENST00000514814; ENSP00000422421; ENSG00000123219
GeneIDi64105
KEGGihsa:64105
UCSCiuc003jts.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiCENPK_HUMAN
AccessioniPrimary (citable) accession number: Q9BS16
Secondary accession number(s): Q9H4L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health