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Q9BS16

- CENPK_HUMAN

UniProt

Q9BS16 - CENPK_HUMAN

Protein

Centromere protein K

Gene

CENPK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei96 – 972Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene

    GO - Biological processi

    1. CENP-A containing nucleosome assembly Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. nucleosome assembly Source: Reactome
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein K
    Short name:
    CENP-K
    Alternative name(s):
    Interphase centromere complex protein 37
    Protein AF-5alpha
    p33
    Gene namesi
    Name:CENPK
    Synonyms:ICEN37
    ORF Names:FKSG14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29479. CENPK.

    Subcellular locationi

    Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore
    Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

    Organism-specific databases

    PharmGKBiPA145149171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Centromere protein KPRO_0000249482Add
    BLAST

    Proteomic databases

    MaxQBiQ9BS16.
    PaxDbiQ9BS16.
    PRIDEiQ9BS16.

    PTM databases

    PhosphoSiteiQ9BS16.

    Expressioni

    Tissue specificityi

    Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ9BS16.
    BgeeiQ9BS16.
    CleanExiHS_CENPK.
    GenevestigatoriQ9BS16.

    Interactioni

    Subunit structurei

    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.3 Publications

    Protein-protein interaction databases

    BioGridi122063. 8 interactions.
    STRINGi9606.ENSP00000242872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BS16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili22 – 4221Sequence AnalysisAdd
    BLAST
    Coiled coili98 – 15154Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CENPK family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG46525.
    HOGENOMiHOG000111542.
    HOVERGENiHBG081084.
    InParanoidiQ9BS16.
    KOiK11503.
    OMAiSQWQKET.
    OrthoDBiEOG780RN0.
    PhylomeDBiQ9BS16.
    TreeFamiTF333264.

    Family and domain databases

    InterProiIPR020993. Centromere_CenpK.
    [Graphical view]
    PfamiPF11802. CENP-K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BS16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL    50
    TDSNAQLSLL IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL 100
    RQDLEMVLST KESKNEKLKE DLEREQRWLD EQQQIMESLN VLHSELKNKV 150
    ETFSESRIFN ELKTKMLNIK EYKEKLLSTL GEFLEDHFPL PDRSVKKKKK 200
    NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP PYVELLLRNG 250
    IALRHPEDPT RIRLEAFHQ 269
    Length:269
    Mass (Da):31,655
    Last modified:June 1, 2001 - v1
    Checksum:iD59737D32D221A84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451I → M in AAG31004. 1 PublicationCurated
    Sequence conflicti59 – 591L → W in AAG31004. 1 PublicationCurated
    Sequence conflicti66 – 661C → G in AAG31004. 1 PublicationCurated
    Sequence conflicti74 – 741W → G in AAG31004. 1 PublicationCurated
    Sequence conflicti81 – 811T → I in AAG31004. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033646 mRNA. Translation: AAK59382.1.
    AF315941 mRNA. Translation: AAL26880.1.
    AY009151 mRNA. Translation: AAG31004.1.
    BC005400 mRNA. Translation: AAH05400.1.
    BC008504 mRNA. Translation: AAH08504.1.
    CCDSiCCDS3984.1.
    RefSeqiNP_001253967.1. NM_001267038.1.
    NP_071428.2. NM_022145.4.
    UniGeneiHs.529778.

    Genome annotation databases

    EnsembliENST00000242872; ENSP00000242872; ENSG00000123219.
    ENST00000396679; ENSP00000379911; ENSG00000123219.
    ENST00000514814; ENSP00000422421; ENSG00000123219.
    GeneIDi64105.
    KEGGihsa:64105.
    UCSCiuc003jts.3. human.

    Polymorphism databases

    DMDMi74732954.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033646 mRNA. Translation: AAK59382.1 .
    AF315941 mRNA. Translation: AAL26880.1 .
    AY009151 mRNA. Translation: AAG31004.1 .
    BC005400 mRNA. Translation: AAH05400.1 .
    BC008504 mRNA. Translation: AAH08504.1 .
    CCDSi CCDS3984.1.
    RefSeqi NP_001253967.1. NM_001267038.1.
    NP_071428.2. NM_022145.4.
    UniGenei Hs.529778.

    3D structure databases

    ProteinModelPortali Q9BS16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122063. 8 interactions.
    STRINGi 9606.ENSP00000242872.

    PTM databases

    PhosphoSitei Q9BS16.

    Polymorphism databases

    DMDMi 74732954.

    Proteomic databases

    MaxQBi Q9BS16.
    PaxDbi Q9BS16.
    PRIDEi Q9BS16.

    Protocols and materials databases

    DNASUi 64105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242872 ; ENSP00000242872 ; ENSG00000123219 .
    ENST00000396679 ; ENSP00000379911 ; ENSG00000123219 .
    ENST00000514814 ; ENSP00000422421 ; ENSG00000123219 .
    GeneIDi 64105.
    KEGGi hsa:64105.
    UCSCi uc003jts.3. human.

    Organism-specific databases

    CTDi 64105.
    GeneCardsi GC05M064850.
    HGNCi HGNC:29479. CENPK.
    MIMi 611502. gene.
    neXtProti NX_Q9BS16.
    PharmGKBi PA145149171.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46525.
    HOGENOMi HOG000111542.
    HOVERGENi HBG081084.
    InParanoidi Q9BS16.
    KOi K11503.
    OMAi SQWQKET.
    OrthoDBi EOG780RN0.
    PhylomeDBi Q9BS16.
    TreeFami TF333264.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    GeneWikii CENPK.
    GenomeRNAii 64105.
    NextBioi 65948.
    PROi Q9BS16.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BS16.
    Bgeei Q9BS16.
    CleanExi HS_CENPK.
    Genevestigatori Q9BS16.

    Family and domain databases

    InterProi IPR020993. Centromere_CenpK.
    [Graphical view ]
    Pfami PF11802. CENP-K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia."
      Taki T., Hayashi Y., Taniwaki M., Seto M., Ueda R., Hanada R., Suzukawa K., Yokota J., Morishita K.
      Oncogene 13:2121-2130(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH KMT2A/MLL1, TISSUE SPECIFICITY.
    2. "Molecular cloning of human p33."
      Chang M.S., Yang Y.C.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning of FKSG14, a novel gene located on chromosome 5."
      Wang Y.-G.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Gall bladder.
    5. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
      Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
      Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
      Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
      Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPN; CENPO; CENPP; CENPQ; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPL; CENPO; CENPP; CENPQ; CENPR AND CENPS.
    8. "KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates."
      Cheeseman I.M., Hori T., Fukagawa T., Desai A.
      Mol. Biol. Cell 19:587-594(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "CENP-K and CENP-H may form coiled-coils in the kinetochores."
      Qiu S., Wang J., Yu C., He D.
      Sci. China, Ser. C, Life Sci. 52:352-359(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CENPH.

    Entry informationi

    Entry nameiCENPK_HUMAN
    AccessioniPrimary (citable) accession number: Q9BS16
    Secondary accession number(s): Q9H4L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3