Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9BS16

- CENPK_HUMAN

UniProt

Q9BS16 - CENPK_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Centromere protein K

Gene

CENPK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei96 – 972Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene

GO - Biological processi

  1. CENP-A containing nucleosome assembly Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. nucleosome assembly Source: Reactome
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein K
Short name:
CENP-K
Alternative name(s):
Interphase centromere complex protein 37
Protein AF-5alpha
p33
Gene namesi
Name:CENPK
Synonyms:ICEN37
ORF Names:FKSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:29479. CENPK.

Subcellular locationi

Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. kinetochore Source: UniProtKB-KW
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Organism-specific databases

PharmGKBiPA145149171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Centromere protein KPRO_0000249482Add
BLAST

Proteomic databases

MaxQBiQ9BS16.
PaxDbiQ9BS16.
PRIDEiQ9BS16.

PTM databases

PhosphoSiteiQ9BS16.

Expressioni

Tissue specificityi

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.1 Publication

Gene expression databases

BgeeiQ9BS16.
CleanExiHS_CENPK.
ExpressionAtlasiQ9BS16. baseline and differential.
GenevestigatoriQ9BS16.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.3 Publications

Protein-protein interaction databases

BioGridi122063. 8 interactions.
STRINGi9606.ENSP00000242872.

Structurei

3D structure databases

ProteinModelPortaliQ9BS16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili22 – 4221Sequence AnalysisAdd
BLAST
Coiled coili98 – 15154Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CENPK family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46525.
GeneTreeiENSGT00390000006243.
HOGENOMiHOG000111542.
HOVERGENiHBG081084.
InParanoidiQ9BS16.
KOiK11503.
OMAiSQWQKET.
OrthoDBiEOG780RN0.
PhylomeDBiQ9BS16.
TreeFamiTF333264.

Family and domain databases

InterProiIPR020993. Centromere_CenpK.
[Graphical view]
PfamiPF11802. CENP-K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BS16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL
60 70 80 90 100
TDSNAQLSLL IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL
110 120 130 140 150
RQDLEMVLST KESKNEKLKE DLEREQRWLD EQQQIMESLN VLHSELKNKV
160 170 180 190 200
ETFSESRIFN ELKTKMLNIK EYKEKLLSTL GEFLEDHFPL PDRSVKKKKK
210 220 230 240 250
NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP PYVELLLRNG
260
IALRHPEDPT RIRLEAFHQ
Length:269
Mass (Da):31,655
Last modified:June 1, 2001 - v1
Checksum:iD59737D32D221A84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451I → M in AAG31004. 1 PublicationCurated
Sequence conflicti59 – 591L → W in AAG31004. 1 PublicationCurated
Sequence conflicti66 – 661C → G in AAG31004. 1 PublicationCurated
Sequence conflicti74 – 741W → G in AAG31004. 1 PublicationCurated
Sequence conflicti81 – 811T → I in AAG31004. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033646 mRNA. Translation: AAK59382.1.
AF315941 mRNA. Translation: AAL26880.1.
AY009151 mRNA. Translation: AAG31004.1.
BC005400 mRNA. Translation: AAH05400.1.
BC008504 mRNA. Translation: AAH08504.1.
CCDSiCCDS3984.1.
RefSeqiNP_001253967.1. NM_001267038.1.
NP_071428.2. NM_022145.4.
UniGeneiHs.529778.

Genome annotation databases

EnsembliENST00000242872; ENSP00000242872; ENSG00000123219.
ENST00000396679; ENSP00000379911; ENSG00000123219.
ENST00000514814; ENSP00000422421; ENSG00000123219.
GeneIDi64105.
KEGGihsa:64105.
UCSCiuc003jts.3. human.

Polymorphism databases

DMDMi74732954.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033646 mRNA. Translation: AAK59382.1 .
AF315941 mRNA. Translation: AAL26880.1 .
AY009151 mRNA. Translation: AAG31004.1 .
BC005400 mRNA. Translation: AAH05400.1 .
BC008504 mRNA. Translation: AAH08504.1 .
CCDSi CCDS3984.1.
RefSeqi NP_001253967.1. NM_001267038.1.
NP_071428.2. NM_022145.4.
UniGenei Hs.529778.

3D structure databases

ProteinModelPortali Q9BS16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122063. 8 interactions.
STRINGi 9606.ENSP00000242872.

PTM databases

PhosphoSitei Q9BS16.

Polymorphism databases

DMDMi 74732954.

Proteomic databases

MaxQBi Q9BS16.
PaxDbi Q9BS16.
PRIDEi Q9BS16.

Protocols and materials databases

DNASUi 64105.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000242872 ; ENSP00000242872 ; ENSG00000123219 .
ENST00000396679 ; ENSP00000379911 ; ENSG00000123219 .
ENST00000514814 ; ENSP00000422421 ; ENSG00000123219 .
GeneIDi 64105.
KEGGi hsa:64105.
UCSCi uc003jts.3. human.

Organism-specific databases

CTDi 64105.
GeneCardsi GC05M064850.
HGNCi HGNC:29479. CENPK.
MIMi 611502. gene.
neXtProti NX_Q9BS16.
PharmGKBi PA145149171.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46525.
GeneTreei ENSGT00390000006243.
HOGENOMi HOG000111542.
HOVERGENi HBG081084.
InParanoidi Q9BS16.
KOi K11503.
OMAi SQWQKET.
OrthoDBi EOG780RN0.
PhylomeDBi Q9BS16.
TreeFami TF333264.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

GeneWikii CENPK.
GenomeRNAii 64105.
NextBioi 65948.
PROi Q9BS16.
SOURCEi Search...

Gene expression databases

Bgeei Q9BS16.
CleanExi HS_CENPK.
ExpressionAtlasi Q9BS16. baseline and differential.
Genevestigatori Q9BS16.

Family and domain databases

InterProi IPR020993. Centromere_CenpK.
[Graphical view ]
Pfami PF11802. CENP-K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia."
    Taki T., Hayashi Y., Taniwaki M., Seto M., Ueda R., Hanada R., Suzukawa K., Yokota J., Morishita K.
    Oncogene 13:2121-2130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH KMT2A/MLL1, TISSUE SPECIFICITY.
  2. "Molecular cloning of human p33."
    Chang M.S., Yang Y.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning of FKSG14, a novel gene located on chromosome 5."
    Wang Y.-G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Gall bladder.
  5. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
    Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
    Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPN; CENPO; CENPP; CENPQ; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPL; CENPO; CENPP; CENPQ; CENPR AND CENPS.
  8. "KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates."
    Cheeseman I.M., Hori T., Fukagawa T., Desai A.
    Mol. Biol. Cell 19:587-594(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "CENP-K and CENP-H may form coiled-coils in the kinetochores."
    Qiu S., Wang J., Yu C., He D.
    Sci. China, Ser. C, Life Sci. 52:352-359(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CENPH.

Entry informationi

Entry nameiCENPK_HUMAN
AccessioniPrimary (citable) accession number: Q9BS16
Secondary accession number(s): Q9H4L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3