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Q9BS16 (CENPK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein K

Short name=CENP-K
Alternative name(s):
Interphase centromere complex protein 37
Protein AF-5alpha
p33
Gene names
Name:CENPK
Synonyms:ICEN37
ORF Names:FKSG14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. Ref.5 Ref.6 Ref.8

Subunit structure

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH. Ref.6 Ref.7 Ref.9

Subcellular location

Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore. Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. Ref.5 Ref.6

Tissue specificity

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. Ref.1

Involvement in disease

Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Sequence similarities

Belongs to the CENPK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Centromere protein K
PRO_0000249482

Regions

Coiled coil22 – 4221 Potential
Coiled coil98 – 15154 Potential

Sites

Site96 – 972Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene

Experimental info

Sequence conflict451I → M in AAG31004. Ref.3
Sequence conflict591L → W in AAG31004. Ref.3
Sequence conflict661C → G in AAG31004. Ref.3
Sequence conflict741W → G in AAG31004. Ref.3
Sequence conflict811T → I in AAG31004. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9BS16 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D59737D32D221A84

FASTA26931,655
        10         20         30         40         50         60 
MNQEDLDPDS TTDVGDVTNT EEELIRECEE MWKDMEECQN KLSLIGTETL TDSNAQLSLL 

        70         80         90        100        110        120 
IMQVKCLTAE LSQWQKKTPE TIPLTEDVLI TLGKEEFQKL RQDLEMVLST KESKNEKLKE 

       130        140        150        160        170        180 
DLEREQRWLD EQQQIMESLN VLHSELKNKV ETFSESRIFN ELKTKMLNIK EYKEKLLSTL 

       190        200        210        220        230        240 
GEFLEDHFPL PDRSVKKKKK NIQESSVNLI TLHEMLEILI NRLFDVPHDP YVKISDSFWP 

       250        260 
PYVELLLRNG IALRHPEDPT RIRLEAFHQ 

« Hide

References

« Hide 'large scale' references
[1]"Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia."
Taki T., Hayashi Y., Taniwaki M., Seto M., Ueda R., Hanada R., Suzukawa K., Yokota J., Morishita K.
Oncogene 13:2121-2130(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH KMT2A/MLL1, TISSUE SPECIFICITY.
[2]"Molecular cloning of human p33."
Chang M.S., Yang Y.C.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning of FKSG14, a novel gene located on chromosome 5."
Wang Y.-G.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Carcinoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Gall bladder.
[5]"Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPN; CENPO; CENPP; CENPQ; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
[7]"The human CENP-A centromeric nucleosome-associated complex."
Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R. III, Cleveland D.W.
Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPL; CENPO; CENPP; CENPQ; CENPR AND CENPS.
[8]"KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates."
Cheeseman I.M., Hori T., Fukagawa T., Desai A.
Mol. Biol. Cell 19:587-594(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"CENP-K and CENP-H may form coiled-coils in the kinetochores."
Qiu S., Wang J., Yu C., He D.
Sci. China, Ser. C, Life Sci. 52:352-359(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CENPH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY033646 mRNA. Translation: AAK59382.1.
AF315941 mRNA. Translation: AAL26880.1.
AY009151 mRNA. Translation: AAG31004.1.
BC005400 mRNA. Translation: AAH05400.1.
BC008504 mRNA. Translation: AAH08504.1.
RefSeqNP_001253967.1. NM_001267038.1.
NP_071428.2. NM_022145.4.
UniGeneHs.529778.

3D structure databases

ProteinModelPortalQ9BS16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122063. 8 interactions.
STRING9606.ENSP00000242872.

PTM databases

PhosphoSiteQ9BS16.

Polymorphism databases

DMDM74732954.

Proteomic databases

PaxDbQ9BS16.
PRIDEQ9BS16.

Protocols and materials databases

DNASU64105.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242872; ENSP00000242872; ENSG00000123219.
ENST00000396679; ENSP00000379911; ENSG00000123219.
ENST00000514814; ENSP00000422421; ENSG00000123219.
GeneID64105.
KEGGhsa:64105.
UCSCuc003jts.3. human.

Organism-specific databases

CTD64105.
GeneCardsGC05M064850.
HGNCHGNC:29479. CENPK.
MIM611502. gene.
neXtProtNX_Q9BS16.
PharmGKBPA145149171.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46525.
HOGENOMHOG000111542.
HOVERGENHBG081084.
InParanoidQ9BS16.
KOK11503.
OMASQWQKET.
OrthoDBEOG780RN0.
PhylomeDBQ9BS16.
TreeFamTF333264.

Enzyme and pathway databases

ReactomeREACT_115566. Cell Cycle.
REACT_21300. Mitotic M-M/G1 phases.

Gene expression databases

ArrayExpressQ9BS16.
BgeeQ9BS16.
CleanExHS_CENPK.
GenevestigatorQ9BS16.

Family and domain databases

InterProIPR020993. Centromere_CenpK.
[Graphical view]
PfamPF11802. CENP-K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCENPK.
GenomeRNAi64105.
NextBio65948.
PROQ9BS16.
SOURCESearch...

Entry information

Entry nameCENPK_HUMAN
AccessionPrimary (citable) accession number: Q9BS16
Secondary accession number(s): Q9H4L0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM