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Protein

WD repeat domain-containing protein 83

Gene

WDR83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.By similarity

GO - Biological processi

  • MAPK cascade Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing, via transesterification reactions Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123154-MONOMER.
ReactomeiR-HSA-5674135. MAP2K and MAPK activation.
SignaLinkiQ9BRX9.
SIGNORiQ9BRX9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:WDR83
Synonyms:MORG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32672. WDR83.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic. Partially nuclear.By similarity

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • endosome membrane Source: Reactome
  • spliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi84292.
OpenTargetsiENSG00000123154.
PharmGKBiPA165394765.

Polymorphism and mutation databases

BioMutaiWDR83.
DMDMi74761224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352631 – 315WD repeat domain-containing protein 83Add BLAST315

Proteomic databases

EPDiQ9BRX9.
MaxQBiQ9BRX9.
PaxDbiQ9BRX9.
PeptideAtlasiQ9BRX9.
PRIDEiQ9BRX9.

PTM databases

iPTMnetiQ9BRX9.
PhosphoSitePlusiQ9BRX9.

Expressioni

Gene expression databases

BgeeiENSG00000123154.
ExpressionAtlasiQ9BRX9. baseline and differential.
GenevisibleiQ9BRX9. HS.

Organism-specific databases

HPAiHPA042629.
HPA042838.

Interactioni

Subunit structurei

Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KEAP1Q141455EBI-7705033,EBI-751001
PPIL1Q9Y3C62EBI-7705033,EBI-2557649
PRPF8Q6P2Q92EBI-7705033,EBI-538479
SF3B4Q154272EBI-7705033,EBI-348469
SNRPCP092342EBI-7705033,EBI-766589
UBL5Q9BZL12EBI-7705033,EBI-607755

Protein-protein interaction databases

BioGridi124019. 134 interactors.
IntActiQ9BRX9. 51 interactors.
MINTiMINT-4776445.
STRINGi9606.ENSP00000242796.

Structurei

3D structure databases

ProteinModelPortaliQ9BRX9.
SMRiQ9BRX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 62WD 1Add BLAST40
Repeati65 – 104WD 2Add BLAST40
Repeati107 – 146WD 3Add BLAST40
Repeati151 – 188WD 4Add BLAST38
Repeati190 – 228WD 5Add BLAST39
Repeati231 – 272WD 6Add BLAST42
Repeati275 – 313WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
GeneTreeiENSGT00860000133801.
HOGENOMiHOG000091642.
HOVERGENiHBG105288.
InParanoidiQ9BRX9.
KOiK13124.
OMAiFGHGEAS.
OrthoDBiEOG091G0G62.
PhylomeDBiQ9BRX9.
TreeFamiTF314828.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSIRCWDCRS RRPEPVQTLD
160 170 180 190 200
EARDGVSSVK VSDHEILAGS VDGRVRRYDL RMGQLFSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV
310
QCWREEAYEA EDGAG
Length:315
Mass (Da):34,343
Last modified:June 1, 2001 - v1
Checksum:iCF5F59C1FAA432FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162S → L in BAD96915 (Ref. 2) Curated1
Sequence conflicti278G → D in BAD96915 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053410278G → S.Corresponds to variant rs34373915dbSNPEnsembl.1
Natural variantiVAR_053411304R → Q.Corresponds to variant rs35092999dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA. Translation: BAD96915.1.
AK314164 mRNA. Translation: BAG36848.1.
CH471106 Genomic DNA. Translation: EAW84282.1.
BC005870 mRNA. Translation: AAH05870.1.
CCDSiCCDS12275.1.
RefSeqiNP_001093207.1. NM_001099737.2.
NP_115708.1. NM_032332.3.
UniGeneiHs.657204.

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154.
GeneIDi84292.
KEGGihsa:84292.
UCSCiuc002mue.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA. Translation: BAD96915.1.
AK314164 mRNA. Translation: BAG36848.1.
CH471106 Genomic DNA. Translation: EAW84282.1.
BC005870 mRNA. Translation: AAH05870.1.
CCDSiCCDS12275.1.
RefSeqiNP_001093207.1. NM_001099737.2.
NP_115708.1. NM_032332.3.
UniGeneiHs.657204.

3D structure databases

ProteinModelPortaliQ9BRX9.
SMRiQ9BRX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124019. 134 interactors.
IntActiQ9BRX9. 51 interactors.
MINTiMINT-4776445.
STRINGi9606.ENSP00000242796.

PTM databases

iPTMnetiQ9BRX9.
PhosphoSitePlusiQ9BRX9.

Polymorphism and mutation databases

BioMutaiWDR83.
DMDMi74761224.

Proteomic databases

EPDiQ9BRX9.
MaxQBiQ9BRX9.
PaxDbiQ9BRX9.
PeptideAtlasiQ9BRX9.
PRIDEiQ9BRX9.

Protocols and materials databases

DNASUi84292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154.
GeneIDi84292.
KEGGihsa:84292.
UCSCiuc002mue.5. human.

Organism-specific databases

CTDi84292.
DisGeNETi84292.
GeneCardsiWDR83.
HGNCiHGNC:32672. WDR83.
HPAiHPA042629.
HPA042838.
neXtProtiNX_Q9BRX9.
OpenTargetsiENSG00000123154.
PharmGKBiPA165394765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
GeneTreeiENSGT00860000133801.
HOGENOMiHOG000091642.
HOVERGENiHBG105288.
InParanoidiQ9BRX9.
KOiK13124.
OMAiFGHGEAS.
OrthoDBiEOG091G0G62.
PhylomeDBiQ9BRX9.
TreeFamiTF314828.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123154-MONOMER.
ReactomeiR-HSA-5674135. MAP2K and MAPK activation.
SignaLinkiQ9BRX9.
SIGNORiQ9BRX9.

Miscellaneous databases

ChiTaRSiWDR83. human.
GenomeRNAii84292.
PROiQ9BRX9.

Gene expression databases

BgeeiENSG00000123154.
ExpressionAtlasiQ9BRX9. baseline and differential.
GenevisibleiQ9BRX9. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR83_HUMAN
AccessioniPrimary (citable) accession number: Q9BRX9
Secondary accession number(s): B2RAF1, Q53FT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.