Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat domain-containing protein 83

Gene

WDR83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.By similarity

GO - Biological processi

  • MAPK cascade Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing, via transesterification reactions Source: UniProtKB

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-5674135. MAP2K and MAPK activation.
SignaLinkiQ9BRX9.
SIGNORiQ9BRX9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:WDR83
Synonyms:MORG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000123154.11.
HGNCiHGNC:32672. WDR83.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi84292.
OpenTargetsiENSG00000123154.
PharmGKBiPA165394765.

Polymorphism and mutation databases

BioMutaiWDR83.
DMDMi74761224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352631 – 315WD repeat domain-containing protein 83Add BLAST315

Proteomic databases

EPDiQ9BRX9.
MaxQBiQ9BRX9.
PaxDbiQ9BRX9.
PeptideAtlasiQ9BRX9.
PRIDEiQ9BRX9.

PTM databases

iPTMnetiQ9BRX9.
PhosphoSitePlusiQ9BRX9.

Expressioni

Gene expression databases

BgeeiENSG00000123154.
ExpressionAtlasiQ9BRX9. baseline and differential.
GenevisibleiQ9BRX9. HS.

Organism-specific databases

HPAiHPA042629.
HPA042838.

Interactioni

Subunit structurei

Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124019. 136 interactors.
CORUMiQ9BRX9.
IntActiQ9BRX9. 61 interactors.
MINTiMINT-4776445.
STRINGi9606.ENSP00000242796.

Structurei

3D structure databases

ProteinModelPortaliQ9BRX9.
SMRiQ9BRX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 62WD 1Add BLAST40
Repeati65 – 104WD 2Add BLAST40
Repeati107 – 146WD 3Add BLAST40
Repeati151 – 188WD 4Add BLAST38
Repeati190 – 228WD 5Add BLAST39
Repeati231 – 272WD 6Add BLAST42
Repeati275 – 313WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
GeneTreeiENSGT00890000139369.
HOGENOMiHOG000091642.
HOVERGENiHBG105288.
InParanoidiQ9BRX9.
KOiK13124.
OMAiMCWDIRT.
OrthoDBiEOG091G0G62.
PhylomeDBiQ9BRX9.
TreeFamiTF314828.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BRX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSIRCWDCRS RRPEPVQTLD
160 170 180 190 200
EARDGVSSVK VSDHEILAGS VDGRVRRYDL RMGQLFSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV
310
QCWREEAYEA EDGAG
Length:315
Mass (Da):34,343
Last modified:June 1, 2001 - v1
Checksum:iCF5F59C1FAA432FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162S → L in BAD96915 (Ref. 2) Curated1
Sequence conflicti278G → D in BAD96915 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053410278G → S. Corresponds to variant dbSNP:rs34373915Ensembl.1
Natural variantiVAR_053411304R → Q. Corresponds to variant dbSNP:rs35092999Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA. Translation: BAD96915.1.
AK314164 mRNA. Translation: BAG36848.1.
CH471106 Genomic DNA. Translation: EAW84282.1.
BC005870 mRNA. Translation: AAH05870.1.
CCDSiCCDS12275.1.
RefSeqiNP_001093207.1. NM_001099737.2.
NP_115708.1. NM_032332.3.
UniGeneiHs.657204.

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154.
GeneIDi84292.
KEGGihsa:84292.
UCSCiuc002mue.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR83_HUMAN
AccessioniPrimary (citable) accession number: Q9BRX9
Secondary accession number(s): B2RAF1, Q53FT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families