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Protein

Redox-regulatory protein FAM213A

Gene

FAM213A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Redox-activeBy similarity
Active sitei88 – 881Redox-activeBy similarity

GO - Molecular functioni

  • antioxidant activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
  • regulation of osteoclast differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Redox-regulatory protein FAM213A
Alternative name(s):
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
Short name:
Protein PAMM
Gene namesi
Name:FAM213A
Synonyms:C10orf58, PAMM
ORF Names:PRO2290, PSEC0139, UNQ611/PRO1198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28651. FAM213A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi85 – 851C → G: Decrease of about 38% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation. 1 Publication
Mutagenesisi88 – 881C → G: Decrease of about 125% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation. 1 Publication

Organism-specific databases

PharmGKBiPA134969403.

Polymorphism and mutation databases

BioMutaiFAM213A.
DMDMi73620080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Redox-regulatory protein FAM213APRO_0000019550Add
BLAST

Proteomic databases

EPDiQ9BRX8.
MaxQBiQ9BRX8.
PaxDbiQ9BRX8.
PeptideAtlasiQ9BRX8.
PRIDEiQ9BRX8.

PTM databases

iPTMnetiQ9BRX8.
PhosphoSiteiQ9BRX8.
SwissPalmiQ9BRX8.

Expressioni

Tissue specificityi

Expressed in CSF1 and TNFSF11-stimulated CD14+ peripheral blood mononuclear cells (PBMCs).1 Publication

Inductioni

By CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11.

Gene expression databases

BgeeiENSG00000122378.
CleanExiHS_C10orf58.
GenevisibleiQ9BRX8. HS.

Organism-specific databases

HPAiHPA009025.
HPA024565.

Interactioni

Protein-protein interaction databases

BioGridi124020. 21 interactions.
IntActiQ9BRX8. 1 interaction.
STRINGi9606.ENSP00000361254.

Structurei

3D structure databases

ProteinModelPortaliQ9BRX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 11299Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG4498. Eukaryota.
ENOG410YFY9. LUCA.
GeneTreeiENSGT00530000063724.
HOGENOMiHOG000293175.
HOVERGENiHBG060239.
InParanoidiQ9BRX8.
OMAiCFLCREE.
OrthoDBiEOG091G0NNK.
PhylomeDBiQ9BRX8.
TreeFamiTF313804.

Family and domain databases

InterProiIPR032802. FAM213.
IPR032801. FAM213/AAED1.
[Graphical view]
PANTHERiPTHR28630. PTHR28630. 1 hit.
PTHR28630:SF2. PTHR28630:SF2. 1 hit.
PfamiPF13911. AhpC-TSA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE
60 70 80 90 100
DIDLKTLEKE PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS
110 120 130 140 150
MLDQLGVPLY AVVKEHIRTE VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF
160 170 180 190 200
MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI LGGVFVVGSG KQGILLEHRE
210 220
KEFGDKVNLL SVLEAAKMIK PQTLASEKK
Length:229
Mass (Da):25,764
Last modified:November 23, 2004 - v3
Checksum:i9ECE72DEF6C338D7
GO
Isoform 2 (identifier: Q9BRX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:218
Mass (Da):24,463
Checksum:iC07A4C051DD19488
GO

Sequence cautioni

The sequence AAK55527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37828 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011K → N in BAC11108 (PubMed:14702039).Curated
Sequence conflicti206 – 2061K → R in BAC11627 (PubMed:16303743).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_042229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359059 mRNA. Translation: AAQ89418.1.
AK315440 mRNA. Translation: BAG37828.1. Different initiation.
AK074643 mRNA. Translation: BAC11108.1.
AK075447 mRNA. Translation: BAC11627.1.
AC021028 Genomic DNA. No translation available.
BC005871 mRNA. Translation: AAH05871.3.
AF305824 mRNA. Translation: AAK55527.1. Different initiation.
CCDSiCCDS58089.1. [Q9BRX8-2]
CCDS7368.1. [Q9BRX8-1]
RefSeqiNP_001230707.1. NM_001243778.1. [Q9BRX8-1]
NP_001230708.1. NM_001243779.1. [Q9BRX8-1]
NP_001230709.1. NM_001243780.1. [Q9BRX8-1]
NP_001230710.1. NM_001243781.1. [Q9BRX8-2]
NP_001230711.1. NM_001243782.1.
NP_115709.3. NM_032333.4. [Q9BRX8-1]
XP_011538567.1. XM_011540265.2. [Q9BRX8-1]
XP_011538568.1. XM_011540266.2. [Q9BRX8-1]
UniGeneiHs.500333.
Hs.718589.

Genome annotation databases

EnsembliENST00000372181; ENSP00000361254; ENSG00000122378. [Q9BRX8-1]
ENST00000372185; ENSP00000361259; ENSG00000122378. [Q9BRX8-2]
ENST00000372187; ENSP00000361261; ENSG00000122378. [Q9BRX8-1]
ENST00000372188; ENSP00000361262; ENSG00000122378. [Q9BRX8-1]
ENST00000606162; ENSP00000482445; ENSG00000122378. [Q9BRX8-1]
ENST00000615554; ENSP00000478152; ENSG00000122378. [Q9BRX8-1]
GeneIDi84293.
KEGGihsa:84293.
UCSCiuc001kcc.5. human. [Q9BRX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359059 mRNA. Translation: AAQ89418.1.
AK315440 mRNA. Translation: BAG37828.1. Different initiation.
AK074643 mRNA. Translation: BAC11108.1.
AK075447 mRNA. Translation: BAC11627.1.
AC021028 Genomic DNA. No translation available.
BC005871 mRNA. Translation: AAH05871.3.
AF305824 mRNA. Translation: AAK55527.1. Different initiation.
CCDSiCCDS58089.1. [Q9BRX8-2]
CCDS7368.1. [Q9BRX8-1]
RefSeqiNP_001230707.1. NM_001243778.1. [Q9BRX8-1]
NP_001230708.1. NM_001243779.1. [Q9BRX8-1]
NP_001230709.1. NM_001243780.1. [Q9BRX8-1]
NP_001230710.1. NM_001243781.1. [Q9BRX8-2]
NP_001230711.1. NM_001243782.1.
NP_115709.3. NM_032333.4. [Q9BRX8-1]
XP_011538567.1. XM_011540265.2. [Q9BRX8-1]
XP_011538568.1. XM_011540266.2. [Q9BRX8-1]
UniGeneiHs.500333.
Hs.718589.

3D structure databases

ProteinModelPortaliQ9BRX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124020. 21 interactions.
IntActiQ9BRX8. 1 interaction.
STRINGi9606.ENSP00000361254.

PTM databases

iPTMnetiQ9BRX8.
PhosphoSiteiQ9BRX8.
SwissPalmiQ9BRX8.

Polymorphism and mutation databases

BioMutaiFAM213A.
DMDMi73620080.

Proteomic databases

EPDiQ9BRX8.
MaxQBiQ9BRX8.
PaxDbiQ9BRX8.
PeptideAtlasiQ9BRX8.
PRIDEiQ9BRX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372181; ENSP00000361254; ENSG00000122378. [Q9BRX8-1]
ENST00000372185; ENSP00000361259; ENSG00000122378. [Q9BRX8-2]
ENST00000372187; ENSP00000361261; ENSG00000122378. [Q9BRX8-1]
ENST00000372188; ENSP00000361262; ENSG00000122378. [Q9BRX8-1]
ENST00000606162; ENSP00000482445; ENSG00000122378. [Q9BRX8-1]
ENST00000615554; ENSP00000478152; ENSG00000122378. [Q9BRX8-1]
GeneIDi84293.
KEGGihsa:84293.
UCSCiuc001kcc.5. human. [Q9BRX8-1]

Organism-specific databases

CTDi84293.
GeneCardsiFAM213A.
H-InvDBHIX0008980.
HIX0170428.
HGNCiHGNC:28651. FAM213A.
HPAiHPA009025.
HPA024565.
neXtProtiNX_Q9BRX8.
PharmGKBiPA134969403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4498. Eukaryota.
ENOG410YFY9. LUCA.
GeneTreeiENSGT00530000063724.
HOGENOMiHOG000293175.
HOVERGENiHBG060239.
InParanoidiQ9BRX8.
OMAiCFLCREE.
OrthoDBiEOG091G0NNK.
PhylomeDBiQ9BRX8.
TreeFamiTF313804.

Miscellaneous databases

GeneWikiiC10orf58.
GenomeRNAii84293.
PROiQ9BRX8.

Gene expression databases

BgeeiENSG00000122378.
CleanExiHS_C10orf58.
GenevisibleiQ9BRX8. HS.

Family and domain databases

InterProiIPR032802. FAM213.
IPR032801. FAM213/AAED1.
[Graphical view]
PANTHERiPTHR28630. PTHR28630. 1 hit.
PTHR28630:SF2. PTHR28630:SF2. 1 hit.
PfamiPF13911. AhpC-TSA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF213A_HUMAN
AccessioniPrimary (citable) accession number: Q9BRX8
Secondary accession number(s): B2RD81
, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.