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Protein

Protein pelota homolog

Gene

PELO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).By similarityCurated

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processCell cycle, Cell division
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pelota homolog (EC:3.1.-.-)
Gene namesi
Name:PELO
ORF Names:CGI-17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152684.10.
HGNCiHGNC:8829. PELO.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi53918.
OpenTargetsiENSG00000152684.
PharmGKBiPA33174.

Polymorphism and mutation databases

BioMutaiPELO.
DMDMi322510057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431881 – 385Protein pelota homologAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei374PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BRX2.
MaxQBiQ9BRX2.
PaxDbiQ9BRX2.
PeptideAtlasiQ9BRX2.
PRIDEiQ9BRX2.

PTM databases

iPTMnetiQ9BRX2.
PhosphoSitePlusiQ9BRX2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000152684.
CleanExiHS_PELO.
GenevisibleiQ9BRX2. HS.

Organism-specific databases

HPAiHPA031458.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HBS1LD9YZV03EBI-1043580,EBI-10297269

Protein-protein interaction databases

BioGridi119818. 33 interactors.
IntActiQ9BRX2. 24 interactors.
MINTiMINT-3372932.
STRINGi9606.ENSP00000274311.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi273 – 287Combined sources15
Helixi289 – 291Combined sources3
Beta strandi292 – 295Combined sources4
Helixi296 – 304Combined sources9
Beta strandi308 – 314Combined sources7
Helixi315 – 318Combined sources4
Helixi323 – 338Combined sources16
Beta strandi342 – 346Combined sources5
Beta strandi348 – 350Combined sources3
Helixi351 – 358Combined sources8
Turni359 – 361Combined sources3
Beta strandi362 – 368Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X52NMR-A261-371[»]
5EO3X-ray2.60A/B265-385[»]
5LZWelectron microscopy3.53ii1-385[»]
5LZXelectron microscopy3.67ii1-385[»]
5LZYelectron microscopy3.99ii1-385[»]
5LZZelectron microscopy3.47ii1-385[»]
ProteinModelPortaliQ9BRX2.
SMRiQ9BRX2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BRX2.

Family & Domainsi

Domaini

The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2869. Eukaryota.
COG1537. LUCA.
GeneTreeiENSGT00390000016326.
HOGENOMiHOG000184162.
HOVERGENiHBG053560.
InParanoidiQ9BRX2.
KOiK06965.
OMAiSDNLFRC.
OrthoDBiEOG091G0AVP.
PhylomeDBiQ9BRX2.
TreeFamiTF105733.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004405. Transl-rel_pelota.
PANTHERiPTHR10853. PTHR10853. 1 hit.
PfamiView protein in Pfam
PF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
SMARTiView protein in SMART
SM01194. eRF1_1. 1 hit.
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR00111. pelota. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BRX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVRKNIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH
110 120 130 140 150
TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHIC
160 170 180 190 200
LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHIHFD
210 220 230 240 250
VVKCILVASP GFVREQFCDY LFQQAVKTDN KLLLENRSKF LQVHASSGHK
260 270 280 290 300
YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
310 320 330 340 350
KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH
360 370 380
VSGEQLSQLT GVAAILRFPV PELSDQEGDS SSEED
Length:385
Mass (Da):43,359
Last modified:February 8, 2011 - v2
Checksum:i8A0D264202995B76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135A → D in AAG22574 (PubMed:11060452).Curated1
Sequence conflicti135A → D in AAG22575 (PubMed:11060452).Curated1
Sequence conflicti235E → G in AAD27726 (PubMed:10810093).Curated1
Sequence conflicti263 – 264AS → LA in AAD27726 (PubMed:10810093).Curated2
Sequence conflicti281F → S in AAD27726 (PubMed:10810093).Curated1
Sequence conflicti352S → Y in AAG22574 (PubMed:11060452).Curated1
Sequence conflicti352S → Y in AAG22575 (PubMed:11060452).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019777221L → M4 PublicationsCorresponds to variant dbSNP:rs1499280Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139828 mRNA. Translation: AAG22574.1.
AF143952 Genomic DNA. Translation: AAG22575.1.
AY117399 mRNA. Translation: AAM89414.1.
AF132951 mRNA. Translation: AAD27726.1.
AC026230 Genomic DNA. No translation available.
BC005889 mRNA. Translation: AAH05889.1.
BC007249 mRNA. Translation: AAH07249.1.
BC007650 mRNA. Translation: AAH07650.1.
BC022789 mRNA. Translation: AAH22789.1.
CCDSiCCDS3956.1.
RefSeqiNP_057030.3. NM_015946.4.
UniGeneiHs.644352.

Genome annotation databases

EnsembliENST00000274311; ENSP00000274311; ENSG00000152684.
GeneIDi53918.
KEGGihsa:53918.
UCSCiuc003jos.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPELO_HUMAN
AccessioniPrimary (citable) accession number: Q9BRX2
Secondary accession number(s): Q9GZS6, Q9Y306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 8, 2011
Last modified: October 25, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families