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Protein

Suppressor of IKBKE 1

Gene

SIKE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_25026. TRAF3-dependent IRF activation pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of IKBKE 1
Alternative name(s):
Suppressor of IKK-epsilon
Gene namesi
Name:SIKE1
Synonyms:SIKE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26119. SIKE1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165752371.

Polymorphism and mutation databases

BioMutaiSIKE1.
DMDMi74752290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Suppressor of IKBKE 1PRO_0000299050Add
BLAST

Proteomic databases

MaxQBiQ9BRV8.
PaxDbiQ9BRV8.
PRIDEiQ9BRV8.

PTM databases

PhosphoSiteiQ9BRV8.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).1 Publication

Gene expression databases

BgeeiQ9BRV8.
GenevisibleiQ9BRV8. HS.

Organism-specific databases

HPAiHPA024177.
HPA025726.

Interactioni

Subunit structurei

Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF3IP3Q9Y2282EBI-1773646,EBI-765817

Protein-protein interaction databases

BioGridi123136. 19 interactions.
IntActiQ9BRV8. 22 interactions.
STRINGi9606.ENSP00000358541.

Structurei

3D structure databases

ProteinModelPortaliQ9BRV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 10233Sequence AnalysisAdd
BLAST
Coiled coili162 – 19332Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SIKE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG72930.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ9BRV8.
KOiK12656.
OMAiDQYQEDA.
OrthoDBiEOG7BGHMV.
PhylomeDBiQ9BRV8.
TreeFamiTF324337.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 1 hit.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL
60 70 80 90 100
PDQYQEDASD MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA
110 120 130 140 150
LELIMSKYRK QMLQLMVAKK AVDAEPVLKA HQSHSAEIES QIDRICEMGE
160 170 180 190 200
VMRKAVQVDD DQFCKIQEKL AQLELENKEL RELLSISSES LQARKENSMD

TASQAIK
Length:207
Mass (Da):23,721
Last modified:June 1, 2001 - v1
Checksum:i4C5598612F032988
GO
Isoform 2 (identifier: Q9BRV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Q → QVRQR

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):24,261
Checksum:i555B830504AE0EB7
GO

Sequence cautioni

The sequence CAI18824.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271V → I in CAH18076 (PubMed:17974005).Curated
Sequence conflicti169 – 1691K → I in BAB15020 (PubMed:14702039).Curated
Sequence conflicti191 – 1911L → H in BAB15020 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 531Q → QVRQR in isoform 2. 1 PublicationVSP_027543

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024821 mRNA. Translation: BAB15020.1.
CR749219 mRNA. Translation: CAH18076.1.
AL096773 Genomic DNA. Translation: CAI18822.1.
AL096773 Genomic DNA. Translation: CAI18823.1.
AL096773 Genomic DNA. Translation: CAI18824.1. Sequence problems.
CH471122 Genomic DNA. Translation: EAW56620.1.
BC005934 mRNA. Translation: AAH05934.1.
CCDSiCCDS41371.1. [Q9BRV8-2]
CCDS878.1. [Q9BRV8-1]
RefSeqiNP_001095866.1. NM_001102396.1. [Q9BRV8-2]
NP_079349.2. NM_025073.2. [Q9BRV8-1]
UniGeneiHs.709277.

Genome annotation databases

EnsembliENST00000060969; ENSP00000060969; ENSG00000052723. [Q9BRV8-1]
ENST00000369528; ENSP00000358541; ENSG00000052723. [Q9BRV8-2]
GeneIDi80143.
KEGGihsa:80143.
UCSCiuc001efo.4. human. [Q9BRV8-1]
uc001efp.4. human. [Q9BRV8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024821 mRNA. Translation: BAB15020.1.
CR749219 mRNA. Translation: CAH18076.1.
AL096773 Genomic DNA. Translation: CAI18822.1.
AL096773 Genomic DNA. Translation: CAI18823.1.
AL096773 Genomic DNA. Translation: CAI18824.1. Sequence problems.
CH471122 Genomic DNA. Translation: EAW56620.1.
BC005934 mRNA. Translation: AAH05934.1.
CCDSiCCDS41371.1. [Q9BRV8-2]
CCDS878.1. [Q9BRV8-1]
RefSeqiNP_001095866.1. NM_001102396.1. [Q9BRV8-2]
NP_079349.2. NM_025073.2. [Q9BRV8-1]
UniGeneiHs.709277.

3D structure databases

ProteinModelPortaliQ9BRV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123136. 19 interactions.
IntActiQ9BRV8. 22 interactions.
STRINGi9606.ENSP00000358541.

PTM databases

PhosphoSiteiQ9BRV8.

Polymorphism and mutation databases

BioMutaiSIKE1.
DMDMi74752290.

Proteomic databases

MaxQBiQ9BRV8.
PaxDbiQ9BRV8.
PRIDEiQ9BRV8.

Protocols and materials databases

DNASUi80143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000060969; ENSP00000060969; ENSG00000052723. [Q9BRV8-1]
ENST00000369528; ENSP00000358541; ENSG00000052723. [Q9BRV8-2]
GeneIDi80143.
KEGGihsa:80143.
UCSCiuc001efo.4. human. [Q9BRV8-1]
uc001efp.4. human. [Q9BRV8-2]

Organism-specific databases

CTDi80143.
GeneCardsiGC01M115312.
HGNCiHGNC:26119. SIKE1.
HPAiHPA024177.
HPA025726.
MIMi611656. gene.
neXtProtiNX_Q9BRV8.
PharmGKBiPA165752371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72930.
GeneTreeiENSGT00390000018003.
HOGENOMiHOG000294110.
HOVERGENiHBG055808.
InParanoidiQ9BRV8.
KOiK12656.
OMAiDQYQEDA.
OrthoDBiEOG7BGHMV.
PhylomeDBiQ9BRV8.
TreeFamiTF324337.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_25026. TRAF3-dependent IRF activation pathway.

Miscellaneous databases

ChiTaRSiSIKE1. human.
GenomeRNAii80143.
NextBioi70409.
PROiQ9BRV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRV8.
GenevisibleiQ9BRV8. HS.

Family and domain databases

InterProiIPR008555. SIKE.
[Graphical view]
PANTHERiPTHR12186. PTHR12186. 1 hit.
PfamiPF05769. DUF837. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Smooth muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrial adenocarcinoma.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  6. "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways."
    Huang J., Liu T., Xu L.-G., Chen D., Zhai Z., Shu H.-B.
    EMBO J. 24:4018-4028(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH IKBKE AND TBK1.

Entry informationi

Entry nameiSIKE1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRV8
Secondary accession number(s): Q5TEZ7
, Q5TEZ9, Q68DZ4, Q9H778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.