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Q9BRV8

- SIKE1_HUMAN

UniProt

Q9BRV8 - SIKE1_HUMAN

Protein

Suppressor of IKBKE 1

Gene

SIKE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. innate immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_25026. TRAF3-dependent IRF activation pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor of IKBKE 1
    Alternative name(s):
    Suppressor of IKK-epsilon
    Gene namesi
    Name:SIKE1
    Synonyms:SIKE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26119. SIKE1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165752371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Suppressor of IKBKE 1PRO_0000299050Add
    BLAST

    Proteomic databases

    MaxQBiQ9BRV8.
    PaxDbiQ9BRV8.
    PRIDEiQ9BRV8.

    PTM databases

    PhosphoSiteiQ9BRV8.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9BRV8.
    GenevestigatoriQ9BRV8.

    Organism-specific databases

    HPAiHPA024177.
    HPA025726.

    Interactioni

    Subunit structurei

    Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRAF3IP3Q9Y2282EBI-1773646,EBI-765817

    Protein-protein interaction databases

    BioGridi123136. 19 interactions.
    IntActiQ9BRV8. 22 interactions.
    STRINGi9606.ENSP00000358541.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 10233Sequence AnalysisAdd
    BLAST
    Coiled coili162 – 19332Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SIKE family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG72930.
    HOGENOMiHOG000294110.
    HOVERGENiHBG055808.
    KOiK12656.
    OMAiDQYQEDA.
    OrthoDBiEOG7BGHMV.
    PhylomeDBiQ9BRV8.
    TreeFamiTF324337.

    Family and domain databases

    InterProiIPR008555. SIKE.
    [Graphical view]
    PANTHERiPTHR12186. PTHR12186. 1 hit.
    PfamiPF05769. DUF837. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRV8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL    50
    PDQYQEDASD MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA 100
    LELIMSKYRK QMLQLMVAKK AVDAEPVLKA HQSHSAEIES QIDRICEMGE 150
    VMRKAVQVDD DQFCKIQEKL AQLELENKEL RELLSISSES LQARKENSMD 200
    TASQAIK 207
    Length:207
    Mass (Da):23,721
    Last modified:June 1, 2001 - v1
    Checksum:i4C5598612F032988
    GO
    Isoform 2 (identifier: Q9BRV8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-53: Q → QVRQR

    Note: No experimental confirmation available.

    Show »
    Length:211
    Mass (Da):24,261
    Checksum:i555B830504AE0EB7
    GO

    Sequence cautioni

    The sequence CAI18824.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271V → I in CAH18076. (PubMed:17974005)Curated
    Sequence conflicti169 – 1691K → I in BAB15020. (PubMed:14702039)Curated
    Sequence conflicti191 – 1911L → H in BAB15020. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei53 – 531Q → QVRQR in isoform 2. 1 PublicationVSP_027543

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024821 mRNA. Translation: BAB15020.1.
    CR749219 mRNA. Translation: CAH18076.1.
    AL096773 Genomic DNA. Translation: CAI18822.1.
    AL096773 Genomic DNA. Translation: CAI18823.1.
    AL096773 Genomic DNA. Translation: CAI18824.1. Sequence problems.
    CH471122 Genomic DNA. Translation: EAW56620.1.
    BC005934 mRNA. Translation: AAH05934.1.
    CCDSiCCDS41371.1. [Q9BRV8-2]
    CCDS878.1. [Q9BRV8-1]
    RefSeqiNP_001095866.1. NM_001102396.1. [Q9BRV8-2]
    NP_079349.2. NM_025073.2. [Q9BRV8-1]
    UniGeneiHs.709277.

    Genome annotation databases

    EnsembliENST00000060969; ENSP00000060969; ENSG00000052723. [Q9BRV8-1]
    ENST00000369528; ENSP00000358541; ENSG00000052723. [Q9BRV8-2]
    GeneIDi80143.
    KEGGihsa:80143.
    UCSCiuc001efo.4. human. [Q9BRV8-1]
    uc001efp.4. human. [Q9BRV8-2]

    Polymorphism databases

    DMDMi74752290.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024821 mRNA. Translation: BAB15020.1 .
    CR749219 mRNA. Translation: CAH18076.1 .
    AL096773 Genomic DNA. Translation: CAI18822.1 .
    AL096773 Genomic DNA. Translation: CAI18823.1 .
    AL096773 Genomic DNA. Translation: CAI18824.1 . Sequence problems.
    CH471122 Genomic DNA. Translation: EAW56620.1 .
    BC005934 mRNA. Translation: AAH05934.1 .
    CCDSi CCDS41371.1. [Q9BRV8-2 ]
    CCDS878.1. [Q9BRV8-1 ]
    RefSeqi NP_001095866.1. NM_001102396.1. [Q9BRV8-2 ]
    NP_079349.2. NM_025073.2. [Q9BRV8-1 ]
    UniGenei Hs.709277.

    3D structure databases

    ProteinModelPortali Q9BRV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123136. 19 interactions.
    IntActi Q9BRV8. 22 interactions.
    STRINGi 9606.ENSP00000358541.

    PTM databases

    PhosphoSitei Q9BRV8.

    Polymorphism databases

    DMDMi 74752290.

    Proteomic databases

    MaxQBi Q9BRV8.
    PaxDbi Q9BRV8.
    PRIDEi Q9BRV8.

    Protocols and materials databases

    DNASUi 80143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000060969 ; ENSP00000060969 ; ENSG00000052723 . [Q9BRV8-1 ]
    ENST00000369528 ; ENSP00000358541 ; ENSG00000052723 . [Q9BRV8-2 ]
    GeneIDi 80143.
    KEGGi hsa:80143.
    UCSCi uc001efo.4. human. [Q9BRV8-1 ]
    uc001efp.4. human. [Q9BRV8-2 ]

    Organism-specific databases

    CTDi 80143.
    GeneCardsi GC01M115312.
    HGNCi HGNC:26119. SIKE1.
    HPAi HPA024177.
    HPA025726.
    MIMi 611656. gene.
    neXtProti NX_Q9BRV8.
    PharmGKBi PA165752371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72930.
    HOGENOMi HOG000294110.
    HOVERGENi HBG055808.
    KOi K12656.
    OMAi DQYQEDA.
    OrthoDBi EOG7BGHMV.
    PhylomeDBi Q9BRV8.
    TreeFami TF324337.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_25026. TRAF3-dependent IRF activation pathway.

    Miscellaneous databases

    ChiTaRSi SIKE1. human.
    GenomeRNAii 80143.
    NextBioi 70409.
    PROi Q9BRV8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BRV8.
    Genevestigatori Q9BRV8.

    Family and domain databases

    InterProi IPR008555. SIKE.
    [Graphical view ]
    PANTHERi PTHR12186. PTHR12186. 1 hit.
    Pfami PF05769. DUF837. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Smooth muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endometrial adenocarcinoma.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    6. "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways."
      Huang J., Liu T., Xu L.-G., Chen D., Zhai Z., Shu H.-B.
      EMBO J. 24:4018-4028(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH IKBKE AND TBK1.

    Entry informationi

    Entry nameiSIKE1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRV8
    Secondary accession number(s): Q5TEZ7
    , Q5TEZ9, Q68DZ4, Q9H778
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3