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Q9BRV3

- SWET1_HUMAN

UniProt

Q9BRV3 - SWET1_HUMAN

Protein

Sugar transporter SWEET1

Gene

SLC50A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.1 Publication

    GO - Molecular functioni

    1. glucoside transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. DNA recombination Source: InterPro
    3. glucoside transport Source: GOC
    4. positive regulation of gene expression, epigenetic Source: HGNC

    Keywords - Biological processi

    Sugar transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transporter SWEET1
    Short name:
    HsSWEET1
    Alternative name(s):
    RAG1-activating protein 1
    Solute carrier family 50 member 1
    Stromal cell protein
    Gene namesi
    Name:SLC50A1
    Synonyms:RAG1AP1, SCP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30657. SLC50A1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: May also localize to the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. nucleus Source: HGNC
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671099.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Sugar transporter SWEET1PRO_0000345116Add
    BLAST

    Proteomic databases

    PRIDEiQ9BRV3.

    PTM databases

    PhosphoSiteiQ9BRV3.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ9BRV3.
    BgeeiQ9BRV3.
    CleanExiHS_RAG1AP1.
    GenevestigatoriQ9BRV3.

    Organism-specific databases

    HPAiHPA018095.

    Interactioni

    Subunit structurei

    Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.By similarity

    Protein-protein interaction databases

    BioGridi121020. 1 interaction.
    IntActiQ9BRV3. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 9485MtN3/slv 1Add
    BLAST
    Domaini127 – 21286MtN3/slv 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 22173Mediates interaction with TRPV2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SWEET sugar transporter family.Curated
    Contains 2 MtN3/slv domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308353.
    HOVERGENiHBG055287.
    InParanoidiQ9BRV3.
    KOiK15382.
    OMAiNTENTWA.
    PhylomeDBiQ9BRV3.
    TreeFamiTF313635.

    Family and domain databases

    InterProiIPR018180. SWEET1.
    [Graphical view]
    PANTHERiPTHR10791:SF24. PTHR10791:SF24. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRV3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT    50
    EVNNLGWLSY GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ 100
    TATLLGVLLL GYGYFWLLVP NPEARLQQLG LFCSVFTISM YLSPLADLAK 150
    VIQTKSTQCL SYPLTIATLL TSASWCLYGF RLRDPYIMVS NFPGIVTSFI 200
    RFWLFWKYPQ EQDRNYWLLQ T 221
    Length:221
    Mass (Da):25,030
    Last modified:June 1, 2001 - v1
    Checksum:iFEC35396C28EA9F0
    GO
    Isoform 2 (identifier: Q9BRV3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-55: Missing.
         56-94: GWLSYGALKG...LAYLHYCPRK → MRGLHPWHVL...VPALSHHGSQ

    Show »
    Length:166
    Mass (Da):19,050
    Checksum:i04F7A714A75C3BDF
    GO
    Isoform 3 (identifier: Q9BRV3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-148: Missing.

    Show »
    Length:167
    Mass (Da):19,020
    Checksum:iCCCDF3750BB71D12
    GO

    Sequence cautioni

    Isoform 2 : The sequence AAF17233.1 differs from that shown. Reason: Frameshift at positions 29 and 30.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431Q → R in AAF17232. (PubMed:10931946)Curated
    Sequence conflicti130 – 1301G → A in CAG33429. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_034916Add
    BLAST
    Alternative sequencei56 – 9439GWLSY…YCPRK → MRGLHPWHVLRRPLGPQAHA NDPECGQRPVPALSHHGSQ in isoform 2. 1 PublicationVSP_034917Add
    BLAST
    Alternative sequencei95 – 14854Missing in isoform 3. 1 PublicationVSP_034918Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126023 mRNA. Translation: AAF17232.1.
    AF126024 mRNA. Translation: AAF17233.1. Frameshift.
    AK289551 mRNA. Translation: BAF82240.1.
    CR457148 mRNA. Translation: CAG33429.1.
    AL691442 Genomic DNA. Translation: CAI15322.1.
    AL691442 Genomic DNA. Translation: CAI15323.1.
    AL691442 Genomic DNA. Translation: CAI15324.1.
    BC005943 mRNA. Translation: AAH05943.1.
    BC009621 mRNA. Translation: AAH09621.1.
    CCDSiCCDS1093.1. [Q9BRV3-1]
    CCDS44238.1. [Q9BRV3-3]
    CCDS44239.1. [Q9BRV3-2]
    RefSeqiNP_001116309.1. NM_001122837.1. [Q9BRV3-2]
    NP_001116311.1. NM_001122839.1. [Q9BRV3-3]
    NP_001274515.1. NM_001287586.1.
    NP_001274516.1. NM_001287587.1.
    NP_001274517.1. NM_001287588.1.
    NP_001274519.1. NM_001287590.1.
    NP_001274520.1. NM_001287591.1.
    NP_001274521.1. NM_001287592.1.
    NP_061333.2. NM_018845.3. [Q9BRV3-1]
    UniGeneiHs.292154.

    Genome annotation databases

    EnsembliENST00000303343; ENSP00000306146; ENSG00000169241. [Q9BRV3-3]
    ENST00000368401; ENSP00000357386; ENSG00000169241. [Q9BRV3-2]
    ENST00000368404; ENSP00000357389; ENSG00000169241. [Q9BRV3-1]
    GeneIDi55974.
    KEGGihsa:55974.
    UCSCiuc001fhj.4. human. [Q9BRV3-1]
    uc001fhk.4. human. [Q9BRV3-2]
    uc001fhl.4. human. [Q9BRV3-3]

    Polymorphism databases

    DMDMi74752289.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126023 mRNA. Translation: AAF17232.1 .
    AF126024 mRNA. Translation: AAF17233.1 . Frameshift.
    AK289551 mRNA. Translation: BAF82240.1 .
    CR457148 mRNA. Translation: CAG33429.1 .
    AL691442 Genomic DNA. Translation: CAI15322.1 .
    AL691442 Genomic DNA. Translation: CAI15323.1 .
    AL691442 Genomic DNA. Translation: CAI15324.1 .
    BC005943 mRNA. Translation: AAH05943.1 .
    BC009621 mRNA. Translation: AAH09621.1 .
    CCDSi CCDS1093.1. [Q9BRV3-1 ]
    CCDS44238.1. [Q9BRV3-3 ]
    CCDS44239.1. [Q9BRV3-2 ]
    RefSeqi NP_001116309.1. NM_001122837.1. [Q9BRV3-2 ]
    NP_001116311.1. NM_001122839.1. [Q9BRV3-3 ]
    NP_001274515.1. NM_001287586.1.
    NP_001274516.1. NM_001287587.1.
    NP_001274517.1. NM_001287588.1.
    NP_001274519.1. NM_001287590.1.
    NP_001274520.1. NM_001287591.1.
    NP_001274521.1. NM_001287592.1.
    NP_061333.2. NM_018845.3. [Q9BRV3-1 ]
    UniGenei Hs.292154.

    3D structure databases

    ProteinModelPortali Q9BRV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121020. 1 interaction.
    IntActi Q9BRV3. 2 interactions.

    PTM databases

    PhosphoSitei Q9BRV3.

    Polymorphism databases

    DMDMi 74752289.

    Proteomic databases

    PRIDEi Q9BRV3.

    Protocols and materials databases

    DNASUi 55974.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303343 ; ENSP00000306146 ; ENSG00000169241 . [Q9BRV3-3 ]
    ENST00000368401 ; ENSP00000357386 ; ENSG00000169241 . [Q9BRV3-2 ]
    ENST00000368404 ; ENSP00000357389 ; ENSG00000169241 . [Q9BRV3-1 ]
    GeneIDi 55974.
    KEGGi hsa:55974.
    UCSCi uc001fhj.4. human. [Q9BRV3-1 ]
    uc001fhk.4. human. [Q9BRV3-2 ]
    uc001fhl.4. human. [Q9BRV3-3 ]

    Organism-specific databases

    CTDi 55974.
    GeneCardsi GC01P155110.
    H-InvDB HIX0199799.
    HGNCi HGNC:30657. SLC50A1.
    HPAi HPA018095.
    MIMi 613683. gene.
    neXtProti NX_Q9BRV3.
    PharmGKBi PA142671099.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308353.
    HOVERGENi HBG055287.
    InParanoidi Q9BRV3.
    KOi K15382.
    OMAi NTENTWA.
    PhylomeDBi Q9BRV3.
    TreeFami TF313635.

    Miscellaneous databases

    ChiTaRSi SLC50A1. human.
    GenomeRNAii 55974.
    NextBioi 61425.
    PROi Q9BRV3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BRV3.
    Bgeei Q9BRV3.
    CleanExi HS_RAG1AP1.
    Genevestigatori Q9BRV3.

    Family and domain databases

    InterProi IPR018180. SWEET1.
    [Graphical view ]
    PANTHERi PTHR10791:SF24. PTHR10791:SF24. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adrenal gland.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Pancreas.
    6. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSWET1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRV3
    Secondary accession number(s): Q5SR64
    , Q6IAK6, Q96DC5, Q9UHQ2, Q9UHQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3