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Q9BRV3 (SWET1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sugar transporter SWEET1

Short name=HsSWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Stromal cell protein
Gene names
Name:SLC50A1
Synonyms:RAG1AP1, SCP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. Ref.6

Subunit structure

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: May also localize to the endoplasmic reticulum By similarity. Ref.6

Tissue specificity

Ubiquitously expressed with highest expression in oviduct, epididymis and intestine. Ref.6

Sequence similarities

Belongs to the SWEET sugar transporter family.

Contains 2 MtN3/slv domains.

Sequence caution

Isoform 2: The sequence AAF17233.1 differs from that shown. Reason: Frameshift at positions 29 and 30.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BRV3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BRV3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-94: GWLSYGALKG...LAYLHYCPRK → MRGLHPWHVL...VPALSHHGSQ
Isoform 3 (identifier: Q9BRV3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     95-148: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Sugar transporter SWEET1
PRO_0000345116

Regions

Transmembrane3 – 2321Helical; Name=1; Potential
Transmembrane42 – 6221Helical; Name=2; Potential
Transmembrane68 – 8821Helical; Name=3; Potential
Transmembrane96 – 11621Helical; Name=4; Potential
Transmembrane129 – 14921Helical; Name=5; Potential
Transmembrane160 – 18021Helical; Name=6; Potential
Transmembrane186 – 20621Helical; Name=7; Potential
Domain10 – 9485MtN3/slv 1
Domain127 – 21286MtN3/slv 2
Region149 – 22173Mediates interaction with TRPV2 By similarity

Natural variations

Alternative sequence1 – 5555Missing in isoform 2.
VSP_034916
Alternative sequence56 – 9439GWLSY…YCPRK → MRGLHPWHVLRRPLGPQAHA NDPECGQRPVPALSHHGSQ in isoform 2.
VSP_034917
Alternative sequence95 – 14854Missing in isoform 3.
VSP_034918

Experimental info

Sequence conflict431Q → R in AAF17232. Ref.1
Sequence conflict1301G → A in CAG33429. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FEC35396C28EA9F0

FASTA22125,030
        10         20         30         40         50         60 
MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY 

        70         80         90        100        110        120 
GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ TATLLGVLLL GYGYFWLLVP 

       130        140        150        160        170        180 
NPEARLQQLG LFCSVFTISM YLSPLADLAK VIQTKSTQCL SYPLTIATLL TSASWCLYGF 

       190        200        210        220 
RLRDPYIMVS NFPGIVTSFI RFWLFWKYPQ EQDRNYWLLQ T 

« Hide

Isoform 2 [UniParc].

Checksum: 04F7A714A75C3BDF
Show »

FASTA16619,050
Isoform 3 [UniParc].

Checksum: CCCDF3750BB71D12
Show »

FASTA16719,020

References

« Hide 'large scale' references
[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Adrenal gland.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cerebellum.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain and Pancreas.
[6]"Sugar transporters for intercellular exchange and nutrition of pathogens."
Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q., Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G., White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.
Nature 468:527-532(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF126023 mRNA. Translation: AAF17232.1.
AF126024 mRNA. Translation: AAF17233.1. Frameshift.
AK289551 mRNA. Translation: BAF82240.1.
CR457148 mRNA. Translation: CAG33429.1.
AL691442 Genomic DNA. Translation: CAI15322.1.
AL691442 Genomic DNA. Translation: CAI15323.1.
AL691442 Genomic DNA. Translation: CAI15324.1.
BC005943 mRNA. Translation: AAH05943.1.
BC009621 mRNA. Translation: AAH09621.1.
CCDSCCDS1093.1. [Q9BRV3-1]
CCDS44238.1. [Q9BRV3-3]
CCDS44239.1. [Q9BRV3-2]
RefSeqNP_001116309.1. NM_001122837.1. [Q9BRV3-2]
NP_001116311.1. NM_001122839.1. [Q9BRV3-3]
NP_001274515.1. NM_001287586.1.
NP_001274516.1. NM_001287587.1.
NP_001274517.1. NM_001287588.1.
NP_001274519.1. NM_001287590.1.
NP_001274520.1. NM_001287591.1.
NP_001274521.1. NM_001287592.1.
NP_061333.2. NM_018845.3. [Q9BRV3-1]
UniGeneHs.292154.

3D structure databases

ProteinModelPortalQ9BRV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121020. 1 interaction.
IntActQ9BRV3. 1 interaction.

PTM databases

PhosphoSiteQ9BRV3.

Polymorphism databases

DMDM74752289.

Proteomic databases

PRIDEQ9BRV3.

Protocols and materials databases

DNASU55974.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303343; ENSP00000306146; ENSG00000169241. [Q9BRV3-3]
ENST00000368401; ENSP00000357386; ENSG00000169241. [Q9BRV3-2]
ENST00000368404; ENSP00000357389; ENSG00000169241. [Q9BRV3-1]
GeneID55974.
KEGGhsa:55974.
UCSCuc001fhj.4. human. [Q9BRV3-1]
uc001fhk.4. human. [Q9BRV3-2]
uc001fhl.4. human. [Q9BRV3-3]

Organism-specific databases

CTD55974.
GeneCardsGC01P155110.
H-InvDBHIX0199799.
HGNCHGNC:30657. SLC50A1.
HPAHPA018095.
MIM613683. gene.
neXtProtNX_Q9BRV3.
PharmGKBPA142671099.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308353.
HOVERGENHBG055287.
InParanoidQ9BRV3.
KOK15382.
OMANTENTWA.
PhylomeDBQ9BRV3.
TreeFamTF313635.

Gene expression databases

ArrayExpressQ9BRV3.
BgeeQ9BRV3.
CleanExHS_RAG1AP1.
GenevestigatorQ9BRV3.

Family and domain databases

InterProIPR018180. SWEET1.
[Graphical view]
PANTHERPTHR10791:SF24. PTHR10791:SF24. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC50A1. human.
GenomeRNAi55974.
NextBio61425.
PROQ9BRV3.
SOURCESearch...

Entry information

Entry nameSWET1_HUMAN
AccessionPrimary (citable) accession number: Q9BRV3
Secondary accession number(s): Q5SR64 expand/collapse secondary AC list , Q6IAK6, Q96DC5, Q9UHQ2, Q9UHQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM