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Q9BRV3

- SWET1_HUMAN

UniProt

Q9BRV3 - SWET1_HUMAN

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Protein

Sugar transporter SWEET1

Gene

SLC50A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.1 Publication

GO - Molecular functioni

  1. glucoside transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. DNA recombination Source: InterPro
  3. glucoside transport Source: GOC
  4. positive regulation of gene expression, epigenetic Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Short name:
HsSWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Stromal cell protein
Gene namesi
Name:SLC50A1
Synonyms:RAG1AP1, SCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30657. SLC50A1.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: May also localize to the endoplasmic reticulum.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=7Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: HGNC
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Sugar transporter SWEET1PRO_0000345116Add
BLAST

Proteomic databases

PRIDEiQ9BRV3.

PTM databases

PhosphoSiteiQ9BRV3.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.1 Publication

Gene expression databases

BgeeiQ9BRV3.
CleanExiHS_RAG1AP1.
ExpressionAtlasiQ9BRV3. baseline and differential.
GenevestigatoriQ9BRV3.

Organism-specific databases

HPAiHPA018095.

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.By similarity

Protein-protein interaction databases

BioGridi121020. 1 interaction.
IntActiQ9BRV3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9BRV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9485MtN3/slv 1Add
BLAST
Domaini127 – 21286MtN3/slv 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 22173Mediates interaction with TRPV2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated
Contains 2 MtN3/slv domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308353.
GeneTreeiENSGT00390000007801.
HOVERGENiHBG055287.
InParanoidiQ9BRV3.
KOiK15382.
OMAiNTENTWA.
PhylomeDBiQ9BRV3.
TreeFamiTF313635.

Family and domain databases

InterProiIPR018180. SWEET1.
[Graphical view]
PANTHERiPTHR10791:SF24. PTHR10791:SF24. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRV3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT
60 70 80 90 100
EVNNLGWLSY GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ
110 120 130 140 150
TATLLGVLLL GYGYFWLLVP NPEARLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
VIQTKSTQCL SYPLTIATLL TSASWCLYGF RLRDPYIMVS NFPGIVTSFI
210 220
RFWLFWKYPQ EQDRNYWLLQ T
Length:221
Mass (Da):25,030
Last modified:June 1, 2001 - v1
Checksum:iFEC35396C28EA9F0
GO
Isoform 2 (identifier: Q9BRV3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-94: GWLSYGALKG...LAYLHYCPRK → MRGLHPWHVL...VPALSHHGSQ

Show »
Length:166
Mass (Da):19,050
Checksum:i04F7A714A75C3BDF
GO
Isoform 3 (identifier: Q9BRV3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-148: Missing.

Show »
Length:167
Mass (Da):19,020
Checksum:iCCCDF3750BB71D12
GO

Sequence cautioni

Isoform 2 : The sequence AAF17233.1 differs from that shown. Reason: Frameshift at positions 29 and 30. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431Q → R in AAF17232. (PubMed:10931946)Curated
Sequence conflicti130 – 1301G → A in CAG33429. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_034916Add
BLAST
Alternative sequencei56 – 9439GWLSY…YCPRK → MRGLHPWHVLRRPLGPQAHA NDPECGQRPVPALSHHGSQ in isoform 2. 1 PublicationVSP_034917Add
BLAST
Alternative sequencei95 – 14854Missing in isoform 3. 1 PublicationVSP_034918Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126023 mRNA. Translation: AAF17232.1.
AF126024 mRNA. Translation: AAF17233.1. Frameshift.
AK289551 mRNA. Translation: BAF82240.1.
CR457148 mRNA. Translation: CAG33429.1.
AL691442 Genomic DNA. Translation: CAI15322.1.
AL691442 Genomic DNA. Translation: CAI15323.1.
AL691442 Genomic DNA. Translation: CAI15324.1.
BC005943 mRNA. Translation: AAH05943.1.
BC009621 mRNA. Translation: AAH09621.1.
CCDSiCCDS1093.1. [Q9BRV3-1]
CCDS44238.1. [Q9BRV3-3]
CCDS44239.1. [Q9BRV3-2]
RefSeqiNP_001116309.1. NM_001122837.1. [Q9BRV3-2]
NP_001116311.1. NM_001122839.1. [Q9BRV3-3]
NP_001274515.1. NM_001287586.1.
NP_001274516.1. NM_001287587.1.
NP_001274517.1. NM_001287588.1.
NP_001274519.1. NM_001287590.1.
NP_001274520.1. NM_001287591.1.
NP_001274521.1. NM_001287592.1.
NP_061333.2. NM_018845.3. [Q9BRV3-1]
UniGeneiHs.292154.

Genome annotation databases

EnsembliENST00000303343; ENSP00000306146; ENSG00000169241. [Q9BRV3-3]
ENST00000368401; ENSP00000357386; ENSG00000169241. [Q9BRV3-2]
ENST00000368404; ENSP00000357389; ENSG00000169241. [Q9BRV3-1]
GeneIDi55974.
KEGGihsa:55974.
UCSCiuc001fhj.4. human. [Q9BRV3-1]
uc001fhk.4. human. [Q9BRV3-2]
uc001fhl.4. human. [Q9BRV3-3]

Polymorphism databases

DMDMi74752289.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126023 mRNA. Translation: AAF17232.1 .
AF126024 mRNA. Translation: AAF17233.1 . Frameshift.
AK289551 mRNA. Translation: BAF82240.1 .
CR457148 mRNA. Translation: CAG33429.1 .
AL691442 Genomic DNA. Translation: CAI15322.1 .
AL691442 Genomic DNA. Translation: CAI15323.1 .
AL691442 Genomic DNA. Translation: CAI15324.1 .
BC005943 mRNA. Translation: AAH05943.1 .
BC009621 mRNA. Translation: AAH09621.1 .
CCDSi CCDS1093.1. [Q9BRV3-1 ]
CCDS44238.1. [Q9BRV3-3 ]
CCDS44239.1. [Q9BRV3-2 ]
RefSeqi NP_001116309.1. NM_001122837.1. [Q9BRV3-2 ]
NP_001116311.1. NM_001122839.1. [Q9BRV3-3 ]
NP_001274515.1. NM_001287586.1.
NP_001274516.1. NM_001287587.1.
NP_001274517.1. NM_001287588.1.
NP_001274519.1. NM_001287590.1.
NP_001274520.1. NM_001287591.1.
NP_001274521.1. NM_001287592.1.
NP_061333.2. NM_018845.3. [Q9BRV3-1 ]
UniGenei Hs.292154.

3D structure databases

ProteinModelPortali Q9BRV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121020. 1 interaction.
IntActi Q9BRV3. 2 interactions.

PTM databases

PhosphoSitei Q9BRV3.

Polymorphism databases

DMDMi 74752289.

Proteomic databases

PRIDEi Q9BRV3.

Protocols and materials databases

DNASUi 55974.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303343 ; ENSP00000306146 ; ENSG00000169241 . [Q9BRV3-3 ]
ENST00000368401 ; ENSP00000357386 ; ENSG00000169241 . [Q9BRV3-2 ]
ENST00000368404 ; ENSP00000357389 ; ENSG00000169241 . [Q9BRV3-1 ]
GeneIDi 55974.
KEGGi hsa:55974.
UCSCi uc001fhj.4. human. [Q9BRV3-1 ]
uc001fhk.4. human. [Q9BRV3-2 ]
uc001fhl.4. human. [Q9BRV3-3 ]

Organism-specific databases

CTDi 55974.
GeneCardsi GC01P155110.
H-InvDB HIX0199799.
HGNCi HGNC:30657. SLC50A1.
HPAi HPA018095.
MIMi 613683. gene.
neXtProti NX_Q9BRV3.
PharmGKBi PA142671099.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308353.
GeneTreei ENSGT00390000007801.
HOVERGENi HBG055287.
InParanoidi Q9BRV3.
KOi K15382.
OMAi NTENTWA.
PhylomeDBi Q9BRV3.
TreeFami TF313635.

Miscellaneous databases

ChiTaRSi SLC50A1. human.
GenomeRNAii 55974.
NextBioi 61425.
PROi Q9BRV3.
SOURCEi Search...

Gene expression databases

Bgeei Q9BRV3.
CleanExi HS_RAG1AP1.
ExpressionAtlasi Q9BRV3. baseline and differential.
Genevestigatori Q9BRV3.

Family and domain databases

InterProi IPR018180. SWEET1.
[Graphical view ]
PANTHERi PTHR10791:SF24. PTHR10791:SF24. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal gland.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Pancreas.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSWET1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRV3
Secondary accession number(s): Q5SR64
, Q6IAK6, Q96DC5, Q9UHQ2, Q9UHQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3