Q9BRV3 (SWET1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sugar transporter SWEET1
Short name=HsSWEET1

Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Stromal cell protein

Gene names

Name:	SLC50A1
Synonyms:	RAG1AP1, SCP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. Ref.6
Subunit structure	Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation By similarity.
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: May also localize to the endoplasmic reticulum By similarity. Ref.6
Tissue specificity	Ubiquitously expressed with highest expression in oviduct, epididymis and intestine. Ref.6
Sequence similarities	Belongs to the SWEET sugar transporter family. Contains 2 MtN3/slv domains.
Sequence caution	Isoform 2: The sequence AAF17233.1 differs from that shown. Reason: Frameshift at positions 29 and 30.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell membrane Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: InterPro carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of gene expression, epigenetic Inferred from sequence or structural similarity PubMed 8630032. Source: HGNC
Cellular_component	Golgi apparatus Inferred from direct assay Ref.6. Source: UniProtKB Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endomembrane system Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred by curator PubMed 8630032. Source: HGNC plasma membrane Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	glucoside transmembrane transporter activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BRV3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BRV3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-94: GWLSYGALKG...LAYLHYCPRK → MRGLHPWHVL...VPALSHHGSQ

Isoform 3 (identifier: Q9BRV3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     95-148: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Sugar transporter SWEET1		PRO_0000345116
Regions
	Transmembrane	3 – 23	21	Helical; Name=1; Potential
	Transmembrane	42 – 62	21	Helical; Name=2; Potential
	Transmembrane	68 – 88	21	Helical; Name=3; Potential
	Transmembrane	96 – 116	21	Helical; Name=4; Potential
	Transmembrane	129 – 149	21	Helical; Name=5; Potential
	Transmembrane	160 – 180	21	Helical; Name=6; Potential
	Transmembrane	186 – 206	21	Helical; Name=7; Potential
	Domain	10 – 94	85	MtN3/slv 1
	Domain	127 – 212	86	MtN3/slv 2
	Region	149 – 221	73	Mediates interaction with TRPV2 By similarity
Natural variations
	Alternative sequence	1 – 55	55	Missing in isoform 2.		VSP_034916
	Alternative sequence	56 – 94	39	GWLSY…YCPRK → MRGLHPWHVLRRPLGPQAHA NDPECGQRPVPALSHHGSQ in isoform 2.		VSP_034917
	Alternative sequence	95 – 148	54	Missing in isoform 3.		VSP_034918
Experimental info
	Sequence conflict	43	1	Q → R in AAF17232. Ref.1
	Sequence conflict	130	1	G → A in CAG33429. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FEC35396C28EA9F0	FASTA	221	25,030
	10 20 30 40 50 60 MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY 70 80 90 100 110 120 GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ TATLLGVLLL GYGYFWLLVP 130 140 150 160 170 180 NPEARLQQLG LFCSVFTISM YLSPLADLAK VIQTKSTQCL SYPLTIATLL TSASWCLYGF 190 200 210 220 RLRDPYIMVS NFPGIVTSFI RFWLFWKYPQ EQDRNYWLLQ T
	Isoform 2 [UniParc]. Checksum: 04F7A714A75C3BDF	FASTA	166	19,050
	10 20 30 40 50 60 MRGLHPWHVL RRPLGPQAHA NDPECGQRPV PALSHHGSQR VVLLQTATLL GVLLLGYGYF 70 80 90 100 110 120 WLLVPNPEAR LQQLGLFCSV FTISMYLSPL ADLAKVIQTK STQCLSYPLT IATLLTSASW 130 140 150 160 CLYGFRLRDP YIMVSNFPGI VTSFIRFWLF WKYPQEQDRN YWLLQT
	Isoform 3 [UniParc]. Checksum: CCCDF3750BB71D12	FASTA	167	19,020
	10 20 30 40 50 60 MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY 70 80 90 100 110 120 GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKAKVIQT KSTQCLSYPL TIATLLTSAS 130 140 150 160 WCLYGFRLRD PYIMVSNFPG IVTSFIRFWL FWKYPQEQDR NYWLLQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adrenal gland.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain and Pancreas.
[6]	"Sugar transporters for intercellular exchange and nutrition of pathogens." Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q., Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G., White F.F., Somerville S.C., Mudgett M.B., Frommer W.B. Nature 468:527-532(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF126023 mRNA. Translation: AAF17232.1. AF126024 mRNA. Translation: AAF17233.1. Frameshift. AK289551 mRNA. Translation: BAF82240.1. CR457148 mRNA. Translation: CAG33429.1. AL691442 Genomic DNA. Translation: CAI15322.1. AL691442 Genomic DNA. Translation: CAI15323.1. AL691442 Genomic DNA. Translation: CAI15324.1. BC005943 mRNA. Translation: AAH05943.1. BC009621 mRNA. Translation: AAH09621.1.
IPI	IPI00060847. IPI00305185. IPI00514955.
RefSeq	NP_001116309.1. NM_001122837.1. NP_001116311.1. NM_001122839.1. NP_061333.2. NM_018845.3.
UniGene	Hs.292154.
3D structure databases
ProteinModelPortal	Q9BRV3.
ModBase	Search...
Protein family/group databases
TCDB	9.A.58.1.4. sweet, PQ-loop, saliva, MtN3 (Sweet) family.
PTM databases
PhosphoSite	Q9BRV3.
Polymorphism databases
DMDM	74752289.
Proteomic databases
PRIDE	Q9BRV3.
Protocols and materials databases
DNASU	55974.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303343; ENSP00000306146; ENSG00000169241. ENST00000368401; ENSP00000357386; ENSG00000169241. ENST00000368404; ENSP00000357389; ENSG00000169241.
GeneID	55974.
KEGG	hsa:55974.
UCSC	uc001fhj.4. human. uc001fhk.4. human. uc001fhl.4. human.
Organism-specific databases
CTD	55974.
GeneCards	GC01P155110.
H-InvDB	HIX0199799.
HGNC	HGNC:30657. SLC50A1.
HPA	HPA018095.
MIM	613683. gene.
neXtProt	NX_Q9BRV3.
PharmGKB	PA142671099.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG308353.
HOVERGEN	HBG055287.
InParanoid	Q9BRV3.
KO	K15382.
OMA	NTENTWA.
OrthoDB	EOG4D52ZX.
PhylomeDB	Q9BRV3.
Gene expression databases
ArrayExpress	Q9BRV3.
Bgee	Q9BRV3.
CleanEx	HS_RAG1AP1.
Genevestigator	Q9BRV3.
Family and domain databases
InterPro	IPR018180. Rag1ap1. IPR004316. SWEET_sugar_transpr. [Graphical view]
PANTHER	PTHR10791:SF7. PTHR10791:SF7. 1 hit.
Pfam	PF03083. MtN3_slv. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC50A1. human.
GenomeRNAi	55974.
NextBio	61425.
SOURCE	Search...

Entry information

Entry name

SWET1_HUMAN

Accession

Primary (citable) accession number: Q9BRV3
Secondary accession number(s): Q5SR64 , Q6IAK6, Q96DC5, Q9UHQ2, Q9UHQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.