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Protein

rRNA-processing protein UTP23 homolog

Gene

UTP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in rRNA-processing and ribosome biogenesis.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein UTP23 homolog
Gene namesi
Name:UTP23
Synonyms:C8orf53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28224. UTP23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408778.

Polymorphism and mutation databases

BioMutaiUTP23.
DMDMi296452859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249rRNA-processing protein UTP23 homologPRO_0000285634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BRU9.
MaxQBiQ9BRU9.
PaxDbiQ9BRU9.
PeptideAtlasiQ9BRU9.
PRIDEiQ9BRU9.

PTM databases

iPTMnetiQ9BRU9.
PhosphoSiteiQ9BRU9.

Expressioni

Gene expression databases

BgeeiQ9BRU9.
CleanExiHS_UTP23.
ExpressionAtlasiQ9BRU9. baseline and differential.
GenevisibleiQ9BRU9. HS.

Organism-specific databases

HPAiHPA044418.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-5457544,EBI-948001
KRT40Q6A1623EBI-5457544,EBI-10171697
KRTAP10-5P603703EBI-5457544,EBI-10172150
KRTAP10-8P604103EBI-5457544,EBI-10171774
KRTAP10-9P604113EBI-5457544,EBI-10172052
MID2Q9UJV3-23EBI-5457544,EBI-10172526
NOTCH2NLQ7Z3S93EBI-5457544,EBI-945833
PDE9AO760833EBI-5457544,EBI-742764
TCF4P158843EBI-5457544,EBI-533224
TRIM23P364063EBI-5457544,EBI-740098
TRIM27P143733EBI-5457544,EBI-719493

Protein-protein interaction databases

BioGridi124021. 37 interactions.
IntActiQ9BRU9. 20 interactions.
MINTiMINT-3060846.
STRINGi9606.ENSP00000308332.

Structurei

3D structure databases

ProteinModelPortaliQ9BRU9.
SMRiQ9BRU9. Positions 5-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi209 – 2135Poly-Lys

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. UTP23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3164. Eukaryota.
COG1412. LUCA.
GeneTreeiENSGT00550000074848.
HOGENOMiHOG000239062.
HOVERGENiHBG054456.
InParanoidiQ9BRU9.
KOiK14773.
OMAiGLVKNPE.
OrthoDBiEOG7GJ6FP.
PhylomeDBiQ9BRU9.
TreeFamiTF105804.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR006984. Fcf1/Utp23.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF04900. Fcf1. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKITRQKHAK KHLGFFRNNF GVREPYQILL DGTFCQAALR GRIQLREQLP
60 70 80 90 100
RYLMGETQLC TTRCVLKELE TLGKDLYGAK LIAQKCQVRN CPHFKNAVSG
110 120 130 140 150
SECLLSMVEE GNPHHYFVAT QDQNLSVKVK KKPGVPLMFI IQNTMVLDKP
160 170 180 190 200
SPKTIAFVKA VESGQLVSVH EKESIKHLKE EQGLVKNTEQ SRRKKRKKIS
210 220 230 240
GPNPLSCLKK KKKAPDTQSS ASEKKRKRKR IRNRSNPKVL SEKQNAEGE
Length:249
Mass (Da):28,402
Last modified:May 18, 2010 - v2
Checksum:i5DBFD9D7D64D96EE
GO
Isoform 2 (identifier: Q9BRU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-145: DQNLSVKVKKKPGVPLMFIIQNTM → YIPRMYTFCTNYGGQQYVIDALIG
     146-249: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):16,680
Checksum:iF26E100DD5996164
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251K → R in AAH05955 (PubMed:15489334).Curated
Sequence conflicti225 – 2251K → R in AAH22441 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701H → R.
Corresponds to variant rs16888722 [ dbSNP | Ensembl ].
VAR_032031
Natural varianti195 – 1951K → Q.
Corresponds to variant rs1133950 [ dbSNP | Ensembl ].
VAR_032032
Natural varianti215 – 2151P → L.
Corresponds to variant rs16888728 [ dbSNP | Ensembl ].
VAR_032033

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 14524DQNLS…IQNTM → YIPRMYTFCTNYGGQQYVID ALIG in isoform 2. 1 PublicationVSP_024874Add
BLAST
Alternative sequencei146 – 249104Missing in isoform 2. 1 PublicationVSP_024875Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055279 mRNA. Translation: BAB70896.1.
AK315770 mRNA. Translation: BAG38122.1.
AC087350 Genomic DNA. No translation available.
AP002905 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91960.1.
BC005955 mRNA. Translation: AAH05955.1.
BC022441 mRNA. Translation: AAH22441.1.
CCDSiCCDS6320.1. [Q9BRU9-1]
RefSeqiNP_115710.2. NM_032334.2. [Q9BRU9-1]
UniGeneiHs.86970.

Genome annotation databases

EnsembliENST00000309822; ENSP00000308332; ENSG00000147679. [Q9BRU9-1]
GeneIDi84294.
KEGGihsa:84294.
UCSCiuc003yoc.4. human. [Q9BRU9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055279 mRNA. Translation: BAB70896.1.
AK315770 mRNA. Translation: BAG38122.1.
AC087350 Genomic DNA. No translation available.
AP002905 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91960.1.
BC005955 mRNA. Translation: AAH05955.1.
BC022441 mRNA. Translation: AAH22441.1.
CCDSiCCDS6320.1. [Q9BRU9-1]
RefSeqiNP_115710.2. NM_032334.2. [Q9BRU9-1]
UniGeneiHs.86970.

3D structure databases

ProteinModelPortaliQ9BRU9.
SMRiQ9BRU9. Positions 5-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124021. 37 interactions.
IntActiQ9BRU9. 20 interactions.
MINTiMINT-3060846.
STRINGi9606.ENSP00000308332.

PTM databases

iPTMnetiQ9BRU9.
PhosphoSiteiQ9BRU9.

Polymorphism and mutation databases

BioMutaiUTP23.
DMDMi296452859.

Proteomic databases

EPDiQ9BRU9.
MaxQBiQ9BRU9.
PaxDbiQ9BRU9.
PeptideAtlasiQ9BRU9.
PRIDEiQ9BRU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309822; ENSP00000308332; ENSG00000147679. [Q9BRU9-1]
GeneIDi84294.
KEGGihsa:84294.
UCSCiuc003yoc.4. human. [Q9BRU9-1]

Organism-specific databases

CTDi84294.
GeneCardsiUTP23.
HGNCiHGNC:28224. UTP23.
HPAiHPA044418.
neXtProtiNX_Q9BRU9.
PharmGKBiPA162408778.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3164. Eukaryota.
COG1412. LUCA.
GeneTreeiENSGT00550000074848.
HOGENOMiHOG000239062.
HOVERGENiHBG054456.
InParanoidiQ9BRU9.
KOiK14773.
OMAiGLVKNPE.
OrthoDBiEOG7GJ6FP.
PhylomeDBiQ9BRU9.
TreeFamiTF105804.

Miscellaneous databases

ChiTaRSiUTP23. human.
GenomeRNAii84294.
PROiQ9BRU9.

Gene expression databases

BgeeiQ9BRU9.
CleanExiHS_UTP23.
ExpressionAtlasiQ9BRU9. baseline and differential.
GenevisibleiQ9BRU9. HS.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR006984. Fcf1/Utp23.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF04900. Fcf1. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Trachea.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiUTP23_HUMAN
AccessioniPrimary (citable) accession number: Q9BRU9
Secondary accession number(s): B2RE25, Q96NJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.