Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription elongation factor A protein-like 7

Gene

TCEAL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 7
Short name:
TCEA-like protein 7
Alternative name(s):
Transcription elongation factor S-II protein-like 7
Gene namesi
Name:TCEAL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182916.7
HGNCiHGNC:28336 TCEAL7
MIMi300771 gene
neXtProtiNX_Q9BRU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56849
OpenTargetsiENSG00000182916
PharmGKBiPA134936264

Polymorphism and mutation databases

BioMutaiTCEAL7
DMDMi74761221

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392141 – 100Transcription elongation factor A protein-like 7Add BLAST100

Proteomic databases

MaxQBiQ9BRU2
PaxDbiQ9BRU2
PeptideAtlasiQ9BRU2
PRIDEiQ9BRU2

Expressioni

Tissue specificityi

Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.1 Publication

Gene expression databases

BgeeiENSG00000182916
CleanExiHS_TCEAL7
GenevisibleiQ9BRU2 HS

Organism-specific databases

HPAiHPA051507
HPA065080

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1212091 interactor.
IntActiQ9BRU2 1 interactor.
MINTiQ9BRU2
STRINGi9606.ENSP00000329794

Structurei

3D structure databases

ProteinModelPortaliQ9BRU2
SMRiQ9BRU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 88Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYJC Eukaryota
ENOG41117ES LUCA
GeneTreeiENSGT00730000111091
HOGENOMiHOG000231343
HOVERGENiHBG098559
InParanoidiQ9BRU2
OMAiMQKSCKE
OrthoDBiEOG091G13IU
PhylomeDBiQ9BRU2

Family and domain databases

InterProiView protein in InterPro
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BRU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKPCKENEG KPKCSVPKRE EKRPYGEFER QQTEGNFRQR LLQSLEEFKE
60 70 80 90 100
DIDYRHFKDE EMTREGDEME RCLEEIRGLR KKFRALHSNH RHSRDRPYPI
Length:100
Mass (Da):12,324
Last modified:March 1, 2004 - v2
Checksum:i84AF23BD169606D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094400 mRNA Translation: BAG52864.1
Z92846 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54714.1
BC005988 mRNA Translation: AAH05988.2
BC016786 mRNA Translation: AAH16786.1
CCDSiCCDS14506.1
RefSeqiNP_001335187.1, NM_001348258.1
NP_689491.1, NM_152278.4
UniGeneiHs.21861

Genome annotation databases

EnsembliENST00000332431; ENSP00000329794; ENSG00000182916
ENST00000372666; ENSP00000361751; ENSG00000182916
GeneIDi56849
KEGGihsa:56849
UCSCiuc004ekc.3 human

Similar proteinsi

Entry informationi

Entry nameiTCAL7_HUMAN
AccessioniPrimary (citable) accession number: Q9BRU2
Secondary accession number(s): B3KSV2, Q96AT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2004
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome