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Protein

COBW domain-containing protein 1

Gene

CBWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 1
Alternative name(s):
Cobalamin synthase W domain-containing protein 1
Short name:
COBP
NPC-A-6 COBW domain-containing protein 1
Short name:
NPC-A-6
Gene namesi
Name:CBWD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000172785.18
HGNCiHGNC:17134 CBWD1
MIMi611078 gene
neXtProtiNX_Q9BRT8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172785
PharmGKBiPA26124

Polymorphism and mutation databases

BioMutaiCBWD1
DMDMi74752288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455231 – 395COBW domain-containing protein 1Add BLAST395

Proteomic databases

EPDiQ9BRT8
MaxQBiQ9BRT8
PaxDbiQ9BRT8
PeptideAtlasiQ9BRT8
PRIDEiQ9BRT8

PTM databases

iPTMnetiQ9BRT8
PhosphoSitePlusiQ9BRT8

Expressioni

Tissue specificityi

Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine.1 Publication

Inductioni

Increased expression in response to dopamine treatment. Down-regulated by ZNF658 in response to zinc.2 Publications

Gene expression databases

BgeeiENSG00000172785
ExpressionAtlasiQ9BRT8 baseline and differential
GenevisibleiQ9BRT8 HS

Organism-specific databases

HPAiHPA042759
HPA042813

Interactioni

Protein-protein interaction databases

BioGridi120970, 104 interactors
IntActiQ9BRT8, 8 interactors
STRINGi9606.ENSP00000348915

Structurei

3D structure databases

ProteinModelPortaliQ9BRT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 377CobW C-terminalAdd BLAST104

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2743 Eukaryota
COG0523 LUCA
GeneTreeiENSGT00640000091523
HOVERGENiHBG056297
InParanoidiQ9BRT8
OMAiLTERHGH
OrthoDBiEOG091G0JUI
PhylomeDBiQ9BRT8
TreeFamiTF332679

Family and domain databases

Gene3Di3.30.1220.10, 1 hit
InterProiView protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDSGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT
Length:395
Mass (Da):44,068
Last modified:June 1, 2001 - v1
Checksum:iA3E04537A6698C6E
GO
Isoform 2 (identifier: Q9BRT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-51: GLGAKIPVTIITGYL → MYFKRAARAFPVLLT

Show »
Length:359
Mass (Da):40,420
Checksum:i9928D6FBA10020A9
GO
Isoform 3 (identifier: Q9BRT8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-254: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):42,015
Checksum:iCA0A21FFE9F924F4
GO
Isoform 4 (identifier: Q9BRT8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-395: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,172
Checksum:i52695BDF92C6CFD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25I → M in AAF68990 (PubMed:11489251).Curated1
Sequence conflicti25I → M in AAK14935 (PubMed:10931946).Curated1
Sequence conflicti115S → N in AAF68990 (PubMed:11489251).Curated1
Sequence conflicti387 – 389RFQ → HFK in AAK14935 (PubMed:10931946).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0269798A → V2 PublicationsCorresponds to variant dbSNP:rs16925054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197311 – 36Missing in isoform 2. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_01973237 – 51GLGAK…ITGYL → MYFKRAARAFPVLLT in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_019733114 – 395Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_019734236 – 254Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257330 mRNA Translation: AAF68990.2
AY343911 mRNA Translation: AAQ76869.1
AY320414 mRNA Translation: AAP73813.1
AF212253 mRNA Translation: AAK14935.1
AK315855 mRNA Translation: BAF98746.1
AK290648 mRNA Translation: BAF83337.1
AL356244 Genomic DNA No translation available.
AL449043 Genomic DNA No translation available.
BC005996 mRNA Translation: AAH05996.1
BC009573 mRNA Translation: AAH09573.1
BC013432 mRNA Translation: AAH13432.1
BC132759 mRNA Translation: AAI32760.1
CCDSiCCDS47947.1 [Q9BRT8-3]
CCDS47948.1 [Q9BRT8-2]
CCDS6438.1 [Q9BRT8-1]
RefSeqiNP_001138827.1, NM_001145355.1 [Q9BRT8-2]
NP_001138828.1, NM_001145356.1 [Q9BRT8-3]
NP_060961.3, NM_018491.3 [Q9BRT8-1]
UniGeneiHs.531330
Hs.567539
Hs.645337

Genome annotation databases

EnsembliENST00000314367; ENSP00000323433; ENSG00000172785 [Q9BRT8-2]
ENST00000356521; ENSP00000348915; ENSG00000172785 [Q9BRT8-1]
ENST00000377400; ENSP00000366617; ENSG00000172785 [Q9BRT8-1]
ENST00000382393; ENSP00000371830; ENSG00000172785 [Q9BRT8-4]
ENST00000382447; ENSP00000371885; ENSG00000172785 [Q9BRT8-3]
GeneIDi55871
KEGGihsa:55871
UCSCiuc003zga.5 human [Q9BRT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCBWD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRT8
Secondary accession number(s): A2RU55
, A8K3N3, B0AZR4, Q49AJ1, Q5VVK2, Q6VBU6, Q7Z5Z0, Q7Z652, Q9BY38, Q9NYD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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