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Protein

Protein LLP homolog

Gene

LLPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LLP homolog
Alternative name(s):
Protein LAPS18-like
Gene namesi
Name:LLPH
Synonyms:C12orf31, cPERP-G1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139233.6
HGNCiHGNC:28229 LLPH
MIMi616998 gene
neXtProtiNX_Q9BRT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139233
PharmGKBiPA164722116

Polymorphism and mutation databases

BioMutaiLLPH
DMDMi74732927

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743461 – 129Protein LLP homologAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9BRT6
MaxQBiQ9BRT6
PaxDbiQ9BRT6
PeptideAtlasiQ9BRT6
PRIDEiQ9BRT6

PTM databases

iPTMnetiQ9BRT6
PhosphoSitePlusiQ9BRT6

Expressioni

Gene expression databases

BgeeiENSG00000139233
CleanExiHS_LLPH
ExpressionAtlasiQ9BRT6 baseline and differential
GenevisibleiQ9BRT6 HS

Organism-specific databases

HPAiHPA048920
HPA058786

Interactioni

Subunit structurei

Interacts with CTCF, MYO1C and with the transcriptional machinery, including RNA polymerase II and TBP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124024, 18 interactors
IntActiQ9BRT6, 5 interactors
STRINGi9606.ENSP00000266604

Structurei

3D structure databases

ProteinModelPortaliQ9BRT6
SMRiQ9BRT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 125Lys-richAdd BLAST123

Sequence similaritiesi

Belongs to the learning-associated protein family.Curated

Phylogenomic databases

eggNOGiKOG4811 Eukaryota
ENOG4111VT9 LUCA
GeneTreeiENSGT00390000012979
HOGENOMiHOG000004847
HOVERGENiHBG081232
InParanoidiQ9BRT6
OMAiVWMNQRQ
OrthoDBiEOG091G159Q
PhylomeDBiQ9BRT6
TreeFamiTF314654

Family and domain databases

InterProiView protein in InterPro
IPR018784 LAPS18-like
PANTHERiPTHR34253 PTHR34253, 1 hit
PfamiView protein in Pfam
PF10169 Laps, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BRT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSLRSKWK RKMRAEKRKK NAPKEASRLK SILKLDGDVL MKDVQEIATV
60 70 80 90 100
VVPKPKHCQE KMQCEVKDEK DDMKMETDIK RNKKTLLDQH GQYPIWMNQR
110 120
QRKRLKAKRE KRKGKSKAKA VKVAKGLAW
Length:129
Mass (Da):15,225
Last modified:June 1, 2001 - v1
Checksum:i71C2CE6F79B63E4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76E → G in AAI07781 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091568 mRNA Translation: BAC03699.1
BC006002 mRNA Translation: AAH06002.1
BC070232 mRNA Translation: AAH70232.1
BC107780 mRNA Translation: AAI07781.1
CCDSiCCDS8974.1
RefSeqiNP_115714.1, NM_032338.3
UniGeneiHs.504820

Genome annotation databases

EnsembliENST00000266604; ENSP00000266604; ENSG00000139233
ENST00000446587; ENSP00000437372; ENSG00000139233
GeneIDi84298
KEGGihsa:84298
UCSCiuc010ssw.3 human

Similar proteinsi

Entry informationi

Entry nameiLLPH_HUMAN
AccessioniPrimary (citable) accession number: Q9BRT6
Secondary accession number(s): Q3B766
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health