Q9BRS8 (LARP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
La-related protein 6

Alternative name(s):
Acheron
Short name=Achn
La ribonucleoprotein domain family member 6

Gene names

Name:

LARP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. Ref.6 Ref.7 Ref.8
Subunit structure	Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9. Ref.6 Ref.7 Ref.8
Subcellular location	Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.1
Tissue specificity	Expressed in numerous tissues. Ref.1
Domain	The RRM domain mediates the association with collagen mRNAs stem-loops.
Sequence similarities	Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Translation regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA ribonucleoprotein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BRS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BRS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     67-491: SGTTASGGEN...HGHERSRACV → RNRSSVNSRTMLASFIVSSAPSTAPST

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	La-related protein 6		PRO_0000281141
Regions
	Domain	86 – 177	92	HTH La-type RNA-binding
	Domain	184 – 296	113	RRM
	Motif	186 – 193	8	Nuclear export signal
	Motif	296 – 302	7	Nuclear localization signal
Natural variations
	Alternative sequence	67 – 491	425	SGTTA…SRACV → RNRSSVNSRTMLASFIVSSA PSTAPST in isoform 2.		VSP_042565
Experimental info
	Sequence conflict	103	1	Y → C in BAA92061. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2CF3AFFFD69BDD07	FASTA	491	54,737
	10 20 30 40 50 60 MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE 70 80 90 100 110 120 EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR 130 140 150 160 170 180 RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN 190 200 210 220 230 240 LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP 250 260 270 280 290 300 PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP 310 320 330 340 350 360 AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK 370 380 390 400 410 420 LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS 430 440 450 460 470 480 SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG 490 FHGHERSRAC V
	Isoform 2 [UniParc]. Checksum: 88CB7691294B6FD8	FASTA	93	9,773
	10 20 30 40 50 60 MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE 70 80 90 EPSRGHRNRS SVNSRTMLAS FIVSSAPSTA PST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Acheron, a novel member of the Lupus antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta." Valavanis C., Wang Z., Sun D., Vaine M., Schwartz L.M. Gene 393:101-109(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Hippocampus and Rhabdomyosarcoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Melanoma.
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adrenal cortex, Brain and Muscle.
[6]	"Nonmuscle myosin-dependent synthesis of type I collagen." Cai L., Fritz D., Stefanovic L., Stefanovic B. J. Mol. Biol. 401:564-578(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MYH10.
[7]	"A novel role of vimentin filaments: binding and stabilization of collagen mRNAs." Challa A.A., Stefanovic B. Mol. Cell. Biol. 31:3773-3789(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH VIM.
[8]	"A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs." Manojlovic Z., Stefanovic B. RNA 18:321-334(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DHX9.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF443828 mRNA. Translation: AAN76710.1. AF443829 mRNA. Translation: AAN76711.1. AK002058 mRNA. Translation: BAA92061.1. AL833876 mRNA. Translation: CAD38733.2. AC009269 Genomic DNA. No translation available. AC090868 Genomic DNA. No translation available. BC006082 mRNA. Translation: AAH06082.1. BC009446 mRNA. Translation: AAH09446.1. BC014018 mRNA. Translation: AAH14018.1. BC039153 mRNA. Translation: AAH39153.1.
IPI	IPI00377127. IPI00414661.
RefSeq	NP_060827.2. NM_018357.2. NP_932062.1. NM_197958.1.
UniGene	Hs.416755.
3D structure databases
HSSP	HSSP built from PDB template 1S7A based on UniProtKB P05455.
ProteinModelPortal	Q9BRS8.
SMR	Q9BRS8. Positions 84-174, 180-289.
ModBase	Search...
PTM databases
PhosphoSite	Q9BRS8.
Polymorphism databases
DMDM	74752287.
Proteomic databases
PaxDb	Q9BRS8.
PRIDE	Q9BRS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299213; ENSP00000299213; ENSG00000166173. ENST00000344870; ENSP00000343869; ENSG00000166173.
GeneID	55323.
KEGG	hsa:55323.
UCSC	uc002ass.3. human.
Organism-specific databases
CTD	55323.
GeneCards	GC15M071123.
HGNC	HGNC:24012. LARP6.
HPA	HPA020338.
MIM	611300. gene.
neXtProt	NX_Q9BRS8.
PharmGKB	PA142671568.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG239004.
HOGENOM	HOG000010108.
HOVERGEN	HBG070244.
InParanoid	Q9BRS8.
OMA	TSGGENE.
OrthoDB	EOG4NGGMP.
Gene expression databases
Bgee	Q9BRS8.
CleanEx	HS_LARP6.
Genevestigator	Q9BRS8.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.30.70.330. 1 hit.
InterPro	IPR002344. Lupus_La. IPR006630. Lupus_La_RNA-bd. IPR012677. Nucleotide-bd_a/b_plait. IPR024642. SUZ-C. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF05383. La. 1 hit. PF12901. SUZ-C. 1 hit. [Graphical view]
PRINTS	PR00302. LUPUSLA.
SMART	SM00715. LA. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LARP6. human.
GenomeRNAi	55323.
NextBio	59586.
SOURCE	Search...

Entry information

Entry name

LARP6_HUMAN

Accession

Primary (citable) accession number: Q9BRS8
Secondary accession number(s): Q5XKE4, Q8N3N2, Q9NUR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.