Q9BRS8 (LARP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
La-related protein 6

Alternative name(s):
Acheron
Short name=Achn
La ribonucleoprotein domain family member 6

Gene names

Name:

LARP6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.1
Tissue specificity	Expressed in numerous tissues. Ref.1
Sequence similarities	Contains 1 HTH La-type RNA-binding domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA ribonucleoprotein complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 491	490	La-related protein 6		PRO_0000281141
Regions
	Domain	86 – 177	92	HTH La-type RNA-binding
	Motif	186 – 193	8	Nuclear export signal
	Motif	296 – 302	7	Nuclear localization signal
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.6
	Modified residue	56	1	Phosphoserine Ref.5
	Modified residue	58	1	Phosphoserine Ref.5
	Modified residue	447	1	Phosphoserine Ref.5 Ref.6
	Modified residue	451	1	Phosphoserine Ref.5 Ref.6
Experimental info
	Sequence conflict	103	1	Y → C in BAA92061. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9BRS8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2CF3AFFFD69BDD07	FASTA	491	54,737
	10 20 30 40 50 60 MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE 70 80 90 100 110 120 EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR 130 140 150 160 170 180 RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN 190 200 210 220 230 240 LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP 250 260 270 280 290 300 PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP 310 320 330 340 350 360 AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK 370 380 390 400 410 420 LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS 430 440 450 460 470 480 SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG 490 FHGHERSRAC V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Acheron, a novel member of the Lupus antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta." Valavanis C., Wang Z., Sun D., Vaine M., Schwartz L.M. Gene 393:101-109(2007) [PubMed: 17383118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Hippocampus and Rhabdomyosarcoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Melanoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Muscle.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-58; SER-447 AND SER-451, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447 AND SER-451, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF443828 mRNA. Translation: AAN76710.1. AF443829 mRNA. Translation: AAN76711.1. AK002058 mRNA. Translation: BAA92061.1. AL833876 mRNA. Translation: CAD38733.2. BC006082 mRNA. Translation: AAH06082.1. BC009446 mRNA. Translation: AAH09446.1. BC014018 mRNA. Translation: AAH14018.1.
IPI	IPI00414661.
RefSeq	NP_060827.2. NM_018357.2. NP_932062.1. NM_197958.1.
UniGene	Hs.416755.
3D structure databases
HSSP	HSSP built from PDB template 1S7A based on UniProtKB P05455.
ProteinModelPortal	Q9BRS8.
SMR	Q9BRS8. Positions 84-174, 180-289.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BRS8.
PTM databases
PhosphoSite	Q9BRS8.
Polymorphism databases
DMDM	74752287.
Proteomic databases
PRIDE	Q9BRS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299213; ENSP00000299213; ENSG00000166173.
GeneID	55323.
KEGG	hsa:55323.
UCSC	uc002ass.1. human.
Organism-specific databases
CTD	55323.
GeneCards	GC15M071123.
H-InvDB	HIX0012396.
HGNC	HGNC:24012. LARP6.
HPA	HPA020338.
MIM	611300. gene.
neXtProt	NX_Q9BRS8.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000048191.
HOGENOM	HBG443790.
HOVERGEN	HBG070244.
InParanoid	Q9BRS8.
OMA	TSGGENE.
OrthoDB	EOG4NGGMP.
PhylomeDB	Q9BRS8.
Gene expression databases
ArrayExpress	Q9BRS8.
Bgee	Q9BRS8.
CleanEx	HS_LARP6.
Genevestigator	Q9BRS8.
Family and domain databases
InterPro	IPR002344. Lupus_La. IPR006630. Lupus_La_RNA-bd. IPR012677. Nucleotide-bd_a/b_plait. IPR024642. SUZ-C. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF05383. La. 1 hit. PF12901. SUZ-C. 1 hit. [Graphical view]
PRINTS	PR00302. LUPUSLA.
SMART	SM00715. LA. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	59586.
SOURCE	Search...

Entry information

Entry name

LARP6_HUMAN

Accession

Primary (citable) accession number: Q9BRS8
Secondary accession number(s): Q8N3N2, Q9NUR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.