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Protein

La-related protein 6

Gene

LARP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 6
Alternative name(s):
Acheron
Short name:
Achn
La ribonucleoprotein domain family member 6
Gene namesi
Name:LARP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24012. LARP6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55323.
OpenTargetsiENSG00000166173.
PharmGKBiPA142671568.

Polymorphism and mutation databases

BioMutaiLARP6.
DMDMi74752287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002811412 – 491La-related protein 6Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRS8.
MaxQBiQ9BRS8.
PaxDbiQ9BRS8.
PeptideAtlasiQ9BRS8.
PRIDEiQ9BRS8.

PTM databases

iPTMnetiQ9BRS8.
PhosphoSitePlusiQ9BRS8.

Expressioni

Tissue specificityi

Expressed in numerous tissues.1 Publication

Gene expression databases

BgeeiENSG00000166173.
CleanExiHS_LARP6.
ExpressionAtlasiQ9BRS8. baseline and differential.
GenevisibleiQ9BRS8. HS.

Organism-specific databases

HPAiHPA020338.
HPA049029.

Interactioni

Subunit structurei

Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9.3 Publications

Protein-protein interaction databases

BioGridi120604. 3 interactors.
STRINGi9606.ENSP00000299213.

Structurei

Secondary structure

1491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi78 – 80Combined sources3
Helixi90 – 103Combined sources14
Helixi106 – 109Combined sources4
Turni113 – 115Combined sources3
Helixi116 – 119Combined sources4
Beta strandi122 – 124Combined sources3
Helixi129 – 133Combined sources5
Turni136 – 140Combined sources5
Helixi145 – 153Combined sources9
Beta strandi157 – 159Combined sources3
Turni162 – 165Combined sources4
Turni177 – 179Combined sources3
Beta strandi185 – 189Combined sources5
Turni195 – 199Combined sources5
Helixi209 – 224Combined sources16
Beta strandi227 – 233Combined sources7
Turni235 – 237Combined sources3
Helixi241 – 246Combined sources6
Turni247 – 249Combined sources3
Beta strandi253 – 255Combined sources3
Beta strandi258 – 264Combined sources7
Helixi266 – 279Combined sources14
Turni280 – 284Combined sources5
Beta strandi287 – 291Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MTFNMR-A70-183[»]
2MTGNMR-A178-295[»]
ProteinModelPortaliQ9BRS8.
SMRiQ9BRS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 177HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini184 – 296RRMAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 193Nuclear export signal8
Motifi296 – 302Nuclear localization signal7

Domaini

The RRM domain mediates the association with collagen mRNAs stem-loops.

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1855. Eukaryota.
ENOG4110VUA. LUCA.
GeneTreeiENSGT00830000128323.
HOGENOMiHOG000010108.
HOVERGENiHBG070244.
InParanoidiQ9BRS8.
KOiK18733.
OMAiEEGGMRK.
OrthoDBiEOG091G09LP.
PhylomeDBiQ9BRS8.
TreeFamiTF326594.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR024642. SUZ-C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP
310 320 330 340 350
AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT
460 470 480 490
SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
Length:491
Mass (Da):54,737
Last modified:June 1, 2001 - v1
Checksum:i2CF3AFFFD69BDD07
GO
Isoform 2 (identifier: Q9BRS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-491: SGTTASGGEN...HGHERSRACV → RNRSSVNSRTMLASFIVSSAPSTAPST

Note: No experimental confirmation available.
Show »
Length:93
Mass (Da):9,773
Checksum:i88CB7691294B6FD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103Y → C in BAA92061 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04256567 – 491SGTTA…SRACV → RNRSSVNSRTMLASFIVSSA PSTAPST in isoform 2. 1 PublicationAdd BLAST425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443828 mRNA. Translation: AAN76710.1.
AF443829 mRNA. Translation: AAN76711.1.
AK002058 mRNA. Translation: BAA92061.1.
AL833876 mRNA. Translation: CAD38733.2.
AC009269 Genomic DNA. No translation available.
AC090868 Genomic DNA. No translation available.
BC006082 mRNA. Translation: AAH06082.1.
BC009446 mRNA. Translation: AAH09446.1.
BC014018 mRNA. Translation: AAH14018.1.
BC039153 mRNA. Translation: AAH39153.1.
CCDSiCCDS10236.1. [Q9BRS8-2]
CCDS32281.1. [Q9BRS8-1]
RefSeqiNP_001273608.1. NM_001286679.1.
NP_060827.2. NM_018357.3. [Q9BRS8-1]
NP_932062.1. NM_197958.2. [Q9BRS8-2]
UniGeneiHs.416755.

Genome annotation databases

EnsembliENST00000299213; ENSP00000299213; ENSG00000166173. [Q9BRS8-1]
ENST00000344870; ENSP00000343869; ENSG00000166173. [Q9BRS8-2]
GeneIDi55323.
KEGGihsa:55323.
UCSCiuc002ass.5. human. [Q9BRS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443828 mRNA. Translation: AAN76710.1.
AF443829 mRNA. Translation: AAN76711.1.
AK002058 mRNA. Translation: BAA92061.1.
AL833876 mRNA. Translation: CAD38733.2.
AC009269 Genomic DNA. No translation available.
AC090868 Genomic DNA. No translation available.
BC006082 mRNA. Translation: AAH06082.1.
BC009446 mRNA. Translation: AAH09446.1.
BC014018 mRNA. Translation: AAH14018.1.
BC039153 mRNA. Translation: AAH39153.1.
CCDSiCCDS10236.1. [Q9BRS8-2]
CCDS32281.1. [Q9BRS8-1]
RefSeqiNP_001273608.1. NM_001286679.1.
NP_060827.2. NM_018357.3. [Q9BRS8-1]
NP_932062.1. NM_197958.2. [Q9BRS8-2]
UniGeneiHs.416755.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MTFNMR-A70-183[»]
2MTGNMR-A178-295[»]
ProteinModelPortaliQ9BRS8.
SMRiQ9BRS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120604. 3 interactors.
STRINGi9606.ENSP00000299213.

PTM databases

iPTMnetiQ9BRS8.
PhosphoSitePlusiQ9BRS8.

Polymorphism and mutation databases

BioMutaiLARP6.
DMDMi74752287.

Proteomic databases

EPDiQ9BRS8.
MaxQBiQ9BRS8.
PaxDbiQ9BRS8.
PeptideAtlasiQ9BRS8.
PRIDEiQ9BRS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299213; ENSP00000299213; ENSG00000166173. [Q9BRS8-1]
ENST00000344870; ENSP00000343869; ENSG00000166173. [Q9BRS8-2]
GeneIDi55323.
KEGGihsa:55323.
UCSCiuc002ass.5. human. [Q9BRS8-1]

Organism-specific databases

CTDi55323.
DisGeNETi55323.
GeneCardsiLARP6.
HGNCiHGNC:24012. LARP6.
HPAiHPA020338.
HPA049029.
MIMi611300. gene.
neXtProtiNX_Q9BRS8.
OpenTargetsiENSG00000166173.
PharmGKBiPA142671568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1855. Eukaryota.
ENOG4110VUA. LUCA.
GeneTreeiENSGT00830000128323.
HOGENOMiHOG000010108.
HOVERGENiHBG070244.
InParanoidiQ9BRS8.
KOiK18733.
OMAiEEGGMRK.
OrthoDBiEOG091G09LP.
PhylomeDBiQ9BRS8.
TreeFamiTF326594.

Miscellaneous databases

ChiTaRSiLARP6. human.
GeneWikiiLARP6.
GenomeRNAii55323.
PROiQ9BRS8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166173.
CleanExiHS_LARP6.
ExpressionAtlasiQ9BRS8. baseline and differential.
GenevisibleiQ9BRS8. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR024642. SUZ-C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLARP6_HUMAN
AccessioniPrimary (citable) accession number: Q9BRS8
Secondary accession number(s): Q5XKE4, Q8N3N2, Q9NUR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.