Reviewed,
UniProtKB/Swiss-Prot Q9BRR9 (RHG09_HUMAN)
Last modified
November 24, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Rho GTPase-activating protein 9 Alternative name(s): Rho-type GTPase-activating protein 9 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 750 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Ref.1 |
| Tissue specificity | Predominantly expressed in peripheral blood leukocytes, spleen, and thymus. Ref.1 |
| Sequence similarities | Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain. Contains 1 WW domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | SH3 domain |
| Molecular function | GTPase activation |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | signal transduction Inferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9BRR9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9BRR9-2) The sequence of this isoform differs from the canonical sequence as follows: 438-456: Missing. | ||||||
| Isoform 3 (identifier: Q9BRR9-3) The sequence of this isoform differs from the canonical sequence as follows: 1-184: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||
Molecule processing | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 750 | 750 | Rho GTPase-activating protein 9 | PRO_0000056712 | |||||||||||||||||||
Regions | |||||||||||||||||||||||
| Domain | 22 – 88 | 67 | SH3 | ||||||||||||||||||||
| Domain | 213 – 247 | 35 | WW | ||||||||||||||||||||
| Domain | 322 – 435 | 114 | PH | ||||||||||||||||||||
| Domain | 542 – 749 | 208 | Rho-GAP | ||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||
| Modified residue | 475 | 1 | Phosphoserine Ref.5 | ||||||||||||||||||||
Natural variations | |||||||||||||||||||||||
| Alternative sequence | 1 – 184 | 184 | Missing in isoform 3. | VSP_010340 | |||||||||||||||||||
| Alternative sequence | 438 – 456 | 19 | Missing in isoform 2. | VSP_010325 | |||||||||||||||||||
| Natural variant | 50 | 1 | R → G: dbSNP rs33927108. | VAR_055830 | |||||||||||||||||||
| Natural variant | 137 | 1 | R → C: dbSNP rs3802989. | VAR_055831 | |||||||||||||||||||
| Natural variant | 370 | 1 | S → A: dbSNP rs11544238. Ref.2 | VAR_055832 | |||||||||||||||||||
Experimental info | |||||||||||||||||||||||
| Sequence conflict | 152 | 1 | L → F in AAH06107. Ref.2 | ||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||
| Beta strand | 322 – 336 | 15 | |||||||||||||||||||||
| Beta strand | 346 – 361 | 16 | |||||||||||||||||||||
| Beta strand | 380 – 384 | 5 | |||||||||||||||||||||
| Beta strand | 389 – 392 | 4 | |||||||||||||||||||||
| Beta strand | 398 – 406 | 9 | |||||||||||||||||||||
| Beta strand | 412 – 416 | 5 | |||||||||||||||||||||
| Helix | 420 – 439 | 20 | |||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein." Furukawa Y., Kawasoe T., Daigo Y., Nishiwaki T., Ishiguro H., Takahashi M., Kitayama J., Nakamura Y. Biochem. Biophys. Res. Commun. 284:643-649(2001) [PubMed: 11396949] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-370. Tissue: Lymph and Muscle. |
| [3] | "Isolation, mapping, and characterization of a novel member of human rho-GAP family." Kawasoe T., Furukawa Y., Daigo Y., Nishiwaki T., Ishiguro H., Fujita M., Ogawa M., Nakamura Y. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). |
| [4] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 384-750 (ISOFORM 2). Tissue: Lymph node. |
| [5] | "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475, MASS SPECTROMETRY. Tissue: T-cell. |
| [6] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475, MASS SPECTROMETRY. Tissue: T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AB051853 mRNA. Translation: BAB56159.1. BC006107 mRNA. Translation: AAH06107.1. BC011820 mRNA. Translation: AAH11820.1. AB030239 mRNA. Translation: BAB83128.1. AL713803 mRNA. Translation: CAD28552.1. | |||||||||||||||||||||||||
| IPI | IPI00414939. IPI00442053. IPI00747804. | ||||||||||||||||||||||||
| PIR | JC7701. | ||||||||||||||||||||||||
| RefSeq | NP_001073625.1. NP_001073626.1. NP_115885.2. | ||||||||||||||||||||||||
| UniGene | Hs.437126 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | Q9BRR9. 2 interactions. | ||||||||||||||||||||||||
| STRING | Q9BRR9. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | Q9BRR9. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | Q9BRR9. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000356411; ENSP00000348782; ENSG00000123329; Homo sapiens. [Genome view] ENST00000393797; ENSP00000377386; ENSG00000123329; Homo sapiens. [Genome view] | ||||||||||||||||||||||||
| GeneID | 64333. | ||||||||||||||||||||||||
| KEGG | hsa:64333. | ||||||||||||||||||||||||
| UCSC | uc001snz.1. human. uc001soc.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 64333. | ||||||||||||||||||||||||
| GeneCards | GC12M056152. | ||||||||||||||||||||||||
| H-InvDB | HIX0010768. | ||||||||||||||||||||||||
| HGNC | HGNC:14130. ARHGAP9. | ||||||||||||||||||||||||
| MIM | 610576. gene. | ||||||||||||||||||||||||
| PharmGKB | PA24962. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOVERGEN | Q9BRR9. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Reactome | REACT_11044. Signaling by Rho GTPases. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q9BRR9. | ||||||||||||||||||||||||
| Bgee | Q9BRR9. | ||||||||||||||||||||||||
| CleanEx | HS_ARHGAP9. | ||||||||||||||||||||||||
| Genevestigator | Q9BRR9. | ||||||||||||||||||||||||
| GermOnline | ENSG00000123329. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR015767. Rho_GTPase_activating. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP. IPR001452. SH3_domain. IPR001202. WW_Rsp5_WWP. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.10.555.10. RhoGAP. 1 hit. | ||||||||||||||||||||||||
| PANTHER | PTHR23181. Rho_GTPase_activating. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00169. PH. 1 hit. PF00620. RhoGAP. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. SM00326. SH3. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. PS50002. SH3. 1 hit. PS01159. WW_DOMAIN_1. False negative. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 66267. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | RHG09_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BRR9 Secondary accession number(s): Q8TCJ3 Q96S74 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


