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Q9BRR6

- ADPGK_HUMAN

UniProt

Q9BRR6 - ADPGK_HUMAN

Protein

ADP-dependent glucokinase

Gene

ADPGK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency By similarity.By similarity

    Catalytic activityi

    ADP + D-glucose = AMP + D-glucose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi297 – 2971MagnesiumPROSITE-ProRule annotation
    Metal bindingi328 – 3281MagnesiumPROSITE-ProRule annotation
    Active sitei481 – 4811Proton acceptorPROSITE-ProRule annotation
    Metal bindingi481 – 4811MagnesiumPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ADP-specific glucokinase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-dependent glucokinase (EC:2.7.1.147)
    Short name:
    ADP-GK
    Short name:
    ADPGK
    Alternative name(s):
    RbBP-35
    Gene namesi
    Name:ADPGK
    ORF Names:PSEC0260
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:25250. ADPGK.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134971928.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 497475ADP-dependent glucokinasePRO_0000184776Add
    BLAST

    Proteomic databases

    MaxQBiQ9BRR6.
    PaxDbiQ9BRR6.
    PRIDEiQ9BRR6.

    PTM databases

    PhosphoSiteiQ9BRR6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BRR6.
    BgeeiQ9BRR6.
    CleanExiHS_ADPGK.
    GenevestigatoriQ9BRR6.

    Organism-specific databases

    HPAiHPA045194.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi123643. 5 interactions.
    IntActiQ9BRR6. 5 interactions.
    MINTiMINT-1404876.
    STRINGi9606.ENSP00000312250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRR6.
    SMRiQ9BRR6. Positions 126-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 497446ADPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ADP-dependent glucokinase family.Curated
    Contains 1 ADPK (ADP-dependent kinase) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4809.
    HOGENOMiHOG000233731.
    HOVERGENiHBG050461.
    InParanoidiQ9BRR6.
    KOiK08074.
    OMAiGVNACVD.
    PhylomeDBiQ9BRR6.
    TreeFamiTF313401.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR007666. ADP_PFK/GK.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PANTHERiPTHR21208. PTHR21208. 1 hit.
    PfamiPF04587. ADP_PFK_GK. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    PROSITEiPS51255. ADPK. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRR6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP    50
    VSPEGRLAAA WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP 100
    GNGKDHSILH SRNDLEEAFI HFMGKGAAAE RFFSDKETFH DIAQVASEFP 150
    GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP VGPKLHELLD DNVFVPPESL 200
    QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM NMLEVFVSSL 250
    EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS 300
    MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP 350
    DVGMVSDILF WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL 400
    AAVAAGARVA GTQACATETI DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK 450
    PVVEWHREGI SFHFTPVLVC KDPIRTVGLG DAISAEGLFY SEVHPHY 497
    Length:497
    Mass (Da):54,089
    Last modified:June 1, 2001 - v1
    Checksum:iB758E977CDA88F8F
    GO
    Isoform 2 (identifier: Q9BRR6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         313-313: Missing.

    Show »
    Length:496
    Mass (Da):53,961
    Checksum:i5ACBE523E6EE8828
    GO
    Isoform 3 (identifier: Q9BRR6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-239: Missing.

    Show »
    Length:258
    Mass (Da):28,413
    Checksum:i14A1E87AB18DDB1B
    GO
    Isoform 4 (identifier: Q9BRR6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-274: Missing.
         275-280: RKRLLE → MAASCR
         313-313: Missing.

    Show »
    Length:222
    Mass (Da):24,130
    Checksum:iF387E8FABA303003
    GO
    Isoform 5 (identifier: Q9BRR6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.
         404-469: AAGARVAGTQ...ISFHFTPVLV → LGSSCGWDTG...ILPLHTSIGV
         470-497: Missing.

    Show »
    Length:347
    Mass (Da):38,254
    Checksum:i6D5F512F495A60F6
    GO
    Isoform 6 (identifier: Q9BRR6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-497: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:78
    Mass (Da):8,252
    Checksum:iCE817CAB68D45EB9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841K → R.
    Corresponds to variant rs8024644 [ dbSNP | Ensembl ].
    VAR_060085

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 274274Missing in isoform 4. 2 PublicationsVSP_013550Add
    BLAST
    Alternative sequencei1 – 239239Missing in isoform 3. 1 PublicationVSP_013549Add
    BLAST
    Alternative sequencei1 – 122122Missing in isoform 5. 1 PublicationVSP_013548Add
    BLAST
    Alternative sequencei79 – 497419Missing in isoform 6. 1 PublicationVSP_035014Add
    BLAST
    Alternative sequencei275 – 2806RKRLLE → MAASCR in isoform 4. 2 PublicationsVSP_013551
    Alternative sequencei313 – 3131Missing in isoform 2 and isoform 4. 3 PublicationsVSP_013552
    Alternative sequencei404 – 46966AAGAR…TPVLV → LGSSCGWDTGLRHRNHRHQP SVSEGTPRVHDFPFGGRLQD CIKPKQASSRMAQRGNILPL HTSIGV in isoform 5. 1 PublicationVSP_013553Add
    BLAST
    Alternative sequencei470 – 49728Missing in isoform 5. 1 PublicationVSP_013554Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204270 mRNA. Translation: AAL31473.1.
    AL136873 mRNA. Translation: CAB66807.1.
    AK055526 mRNA. Translation: BAB70941.1.
    CR533447 mRNA. Translation: CAG38478.1.
    AK075560 mRNA. Translation: BAC11699.1.
    BC006112 mRNA. Translation: AAH06112.1.
    BC018074 mRNA. Translation: AAH18074.1.
    CCDSiCCDS42057.1. [Q9BRR6-2]
    RefSeqiNP_112574.3. NM_031284.4. [Q9BRR6-2]
    XP_006720775.1. XM_006720712.1. [Q9BRR6-1]
    XP_006720778.1. XM_006720715.1. [Q9BRR6-3]
    UniGeneiHs.654636.

    Genome annotation databases

    EnsembliENST00000311669; ENSP00000312250; ENSG00000159322. [Q9BRR6-2]
    ENST00000456471; ENSP00000397694; ENSG00000159322. [Q9BRR6-4]
    ENST00000562823; ENSP00000454367; ENSG00000159322. [Q9BRR6-6]
    ENST00000567941; ENSP00000458102; ENSG00000159322. [Q9BRR6-6]
    ENST00000569517; ENSP00000454304; ENSG00000159322. [Q9BRR6-6]
    GeneIDi83440.
    KEGGihsa:83440.
    UCSCiuc002ave.4. human. [Q9BRR6-4]
    uc002avf.4. human. [Q9BRR6-2]
    uc002avg.4. human. [Q9BRR6-1]

    Polymorphism databases

    DMDMi62899887.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204270 mRNA. Translation: AAL31473.1 .
    AL136873 mRNA. Translation: CAB66807.1 .
    AK055526 mRNA. Translation: BAB70941.1 .
    CR533447 mRNA. Translation: CAG38478.1 .
    AK075560 mRNA. Translation: BAC11699.1 .
    BC006112 mRNA. Translation: AAH06112.1 .
    BC018074 mRNA. Translation: AAH18074.1 .
    CCDSi CCDS42057.1. [Q9BRR6-2 ]
    RefSeqi NP_112574.3. NM_031284.4. [Q9BRR6-2 ]
    XP_006720775.1. XM_006720712.1. [Q9BRR6-1 ]
    XP_006720778.1. XM_006720715.1. [Q9BRR6-3 ]
    UniGenei Hs.654636.

    3D structure databases

    ProteinModelPortali Q9BRR6.
    SMRi Q9BRR6. Positions 126-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123643. 5 interactions.
    IntActi Q9BRR6. 5 interactions.
    MINTi MINT-1404876.
    STRINGi 9606.ENSP00000312250.

    PTM databases

    PhosphoSitei Q9BRR6.

    Polymorphism databases

    DMDMi 62899887.

    Proteomic databases

    MaxQBi Q9BRR6.
    PaxDbi Q9BRR6.
    PRIDEi Q9BRR6.

    Protocols and materials databases

    DNASUi 83440.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311669 ; ENSP00000312250 ; ENSG00000159322 . [Q9BRR6-2 ]
    ENST00000456471 ; ENSP00000397694 ; ENSG00000159322 . [Q9BRR6-4 ]
    ENST00000562823 ; ENSP00000454367 ; ENSG00000159322 . [Q9BRR6-6 ]
    ENST00000567941 ; ENSP00000458102 ; ENSG00000159322 . [Q9BRR6-6 ]
    ENST00000569517 ; ENSP00000454304 ; ENSG00000159322 . [Q9BRR6-6 ]
    GeneIDi 83440.
    KEGGi hsa:83440.
    UCSCi uc002ave.4. human. [Q9BRR6-4 ]
    uc002avf.4. human. [Q9BRR6-2 ]
    uc002avg.4. human. [Q9BRR6-1 ]

    Organism-specific databases

    CTDi 83440.
    GeneCardsi GC15M073043.
    H-InvDB HIX0026868.
    HGNCi HGNC:25250. ADPGK.
    HPAi HPA045194.
    MIMi 611861. gene.
    neXtProti NX_Q9BRR6.
    PharmGKBi PA134971928.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4809.
    HOGENOMi HOG000233731.
    HOVERGENi HBG050461.
    InParanoidi Q9BRR6.
    KOi K08074.
    OMAi GVNACVD.
    PhylomeDBi Q9BRR6.
    TreeFami TF313401.

    Enzyme and pathway databases

    UniPathwayi UPA00109 .

    Miscellaneous databases

    GeneWikii ADP-specific_glucokinase.
    GenomeRNAii 83440.
    NextBioi 72318.
    PROi Q9BRR6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BRR6.
    Bgeei Q9BRR6.
    CleanExi HS_ADPGK.
    Genevestigatori Q9BRR6.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR007666. ADP_PFK/GK.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    PANTHERi PTHR21208. PTHR21208. 1 hit.
    Pfami PF04587. ADP_PFK_GK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    PROSITEi PS51255. ADPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RbBP-35 interacted with pRb."
      Fan Z.S., Ao S.Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Tissue: Lymph node.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Heart.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Teratocarcinoma.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
      Tissue: Brain and Kidney.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADPGK_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRR6
    Secondary accession number(s): Q49AU7
    , Q8NBI1, Q8WZ90, Q96NF8, Q9H0A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3