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Protein

ADP-dependent glucokinase

Gene

ADPGK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).By similarity

Catalytic activityi

ADP + D-glucose = AMP + D-glucose 6-phosphate.

Cofactori

Mg2+PROSITE-ProRule annotationNote: Binds 1 Mg2+ ion per subunit.PROSITE-ProRule annotation

Pathway:iglycolysis

This protein is involved in the pathway glycolysis, which is part of Carbohydrate degradation.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi297 – 2971MagnesiumPROSITE-ProRule annotation
Metal bindingi328 – 3281MagnesiumPROSITE-ProRule annotation
Active sitei481 – 4811Proton acceptorPROSITE-ProRule annotation
Metal bindingi481 – 4811MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent glucokinase (EC:2.7.1.147)
Short name:
ADP-GK
Short name:
ADPGK
Alternative name(s):
RbBP-35
Gene namesi
Name:ADPGK
ORF Names:PSEC0260
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25250. ADPGK.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: CACAO
  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971928.

Polymorphism and mutation databases

BioMutaiADPGK.
DMDMi62899887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 497475ADP-dependent glucokinasePRO_0000184776Add
BLAST

Proteomic databases

MaxQBiQ9BRR6.
PaxDbiQ9BRR6.
PRIDEiQ9BRR6.

PTM databases

PhosphoSiteiQ9BRR6.

Expressioni

Gene expression databases

BgeeiQ9BRR6.
CleanExiHS_ADPGK.
ExpressionAtlasiQ9BRR6. baseline and differential.
GenevisibleiQ9BRR6. HS.

Organism-specific databases

HPAiHPA045194.
HPA058525.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi123643. 11 interactions.
IntActiQ9BRR6. 5 interactions.
MINTiMINT-1404876.
STRINGi9606.ENSP00000312250.

Structurei

3D structure databases

ProteinModelPortaliQ9BRR6.
SMRiQ9BRR6. Positions 126-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 497446ADPKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ADP-dependent glucokinase family.Curated
Contains 1 ADPK (ADP-dependent kinase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4809.
GeneTreeiENSGT00390000017953.
HOGENOMiHOG000233731.
HOVERGENiHBG050461.
InParanoidiQ9BRR6.
KOiK08074.
OMAiSIVHQVF.
PhylomeDBiQ9BRR6.
TreeFamiTF313401.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR007666. ADP_PFK/GK.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR21208. PTHR21208. 1 hit.
PfamiPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS51255. ADPK. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP
60 70 80 90 100
VSPEGRLAAA WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP
110 120 130 140 150
GNGKDHSILH SRNDLEEAFI HFMGKGAAAE RFFSDKETFH DIAQVASEFP
160 170 180 190 200
GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP VGPKLHELLD DNVFVPPESL
210 220 230 240 250
QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM NMLEVFVSSL
260 270 280 290 300
EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS
310 320 330 340 350
MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP
360 370 380 390 400
DVGMVSDILF WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL
410 420 430 440 450
AAVAAGARVA GTQACATETI DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK
460 470 480 490
PVVEWHREGI SFHFTPVLVC KDPIRTVGLG DAISAEGLFY SEVHPHY
Length:497
Mass (Da):54,089
Last modified:June 1, 2001 - v1
Checksum:iB758E977CDA88F8F
GO
Isoform 2 (identifier: Q9BRR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-313: Missing.

Show »
Length:496
Mass (Da):53,961
Checksum:i5ACBE523E6EE8828
GO
Isoform 3 (identifier: Q9BRR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.

Show »
Length:258
Mass (Da):28,413
Checksum:i14A1E87AB18DDB1B
GO
Isoform 4 (identifier: Q9BRR6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     275-280: RKRLLE → MAASCR
     313-313: Missing.

Show »
Length:222
Mass (Da):24,130
Checksum:iF387E8FABA303003
GO
Isoform 5 (identifier: Q9BRR6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     404-469: AAGARVAGTQ...ISFHFTPVLV → LGSSCGWDTG...ILPLHTSIGV
     470-497: Missing.

Show »
Length:347
Mass (Da):38,254
Checksum:i6D5F512F495A60F6
GO
Isoform 6 (identifier: Q9BRR6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-497: Missing.

Note: No experimental confirmation available.
Show »
Length:78
Mass (Da):8,252
Checksum:iCE817CAB68D45EB9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841K → R.
Corresponds to variant rs8024644 [ dbSNP | Ensembl ].
VAR_060085

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 274274Missing in isoform 4. 2 PublicationsVSP_013550Add
BLAST
Alternative sequencei1 – 239239Missing in isoform 3. 1 PublicationVSP_013549Add
BLAST
Alternative sequencei1 – 122122Missing in isoform 5. 1 PublicationVSP_013548Add
BLAST
Alternative sequencei79 – 497419Missing in isoform 6. 1 PublicationVSP_035014Add
BLAST
Alternative sequencei275 – 2806RKRLLE → MAASCR in isoform 4. 2 PublicationsVSP_013551
Alternative sequencei313 – 3131Missing in isoform 2 and isoform 4. 3 PublicationsVSP_013552
Alternative sequencei404 – 46966AAGAR…TPVLV → LGSSCGWDTGLRHRNHRHQP SVSEGTPRVHDFPFGGRLQD CIKPKQASSRMAQRGNILPL HTSIGV in isoform 5. 1 PublicationVSP_013553Add
BLAST
Alternative sequencei470 – 49728Missing in isoform 5. 1 PublicationVSP_013554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204270 mRNA. Translation: AAL31473.1.
AL136873 mRNA. Translation: CAB66807.1.
AK055526 mRNA. Translation: BAB70941.1.
CR533447 mRNA. Translation: CAG38478.1.
AK075560 mRNA. Translation: BAC11699.1.
BC006112 mRNA. Translation: AAH06112.1.
BC018074 mRNA. Translation: AAH18074.1.
CCDSiCCDS42057.1. [Q9BRR6-2]
RefSeqiNP_112574.3. NM_031284.4. [Q9BRR6-2]
XP_006720775.1. XM_006720712.2. [Q9BRR6-1]
UniGeneiHs.654636.

Genome annotation databases

EnsembliENST00000311669; ENSP00000312250; ENSG00000159322. [Q9BRR6-2]
ENST00000456471; ENSP00000397694; ENSG00000159322. [Q9BRR6-4]
ENST00000562823; ENSP00000454367; ENSG00000159322. [Q9BRR6-6]
ENST00000567941; ENSP00000458102; ENSG00000159322. [Q9BRR6-6]
ENST00000569517; ENSP00000454304; ENSG00000159322. [Q9BRR6-6]
GeneIDi83440.
KEGGihsa:83440.
UCSCiuc002ave.4. human. [Q9BRR6-4]
uc002avf.4. human. [Q9BRR6-2]
uc002avg.4. human. [Q9BRR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204270 mRNA. Translation: AAL31473.1.
AL136873 mRNA. Translation: CAB66807.1.
AK055526 mRNA. Translation: BAB70941.1.
CR533447 mRNA. Translation: CAG38478.1.
AK075560 mRNA. Translation: BAC11699.1.
BC006112 mRNA. Translation: AAH06112.1.
BC018074 mRNA. Translation: AAH18074.1.
CCDSiCCDS42057.1. [Q9BRR6-2]
RefSeqiNP_112574.3. NM_031284.4. [Q9BRR6-2]
XP_006720775.1. XM_006720712.2. [Q9BRR6-1]
UniGeneiHs.654636.

3D structure databases

ProteinModelPortaliQ9BRR6.
SMRiQ9BRR6. Positions 126-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123643. 11 interactions.
IntActiQ9BRR6. 5 interactions.
MINTiMINT-1404876.
STRINGi9606.ENSP00000312250.

PTM databases

PhosphoSiteiQ9BRR6.

Polymorphism and mutation databases

BioMutaiADPGK.
DMDMi62899887.

Proteomic databases

MaxQBiQ9BRR6.
PaxDbiQ9BRR6.
PRIDEiQ9BRR6.

Protocols and materials databases

DNASUi83440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311669; ENSP00000312250; ENSG00000159322. [Q9BRR6-2]
ENST00000456471; ENSP00000397694; ENSG00000159322. [Q9BRR6-4]
ENST00000562823; ENSP00000454367; ENSG00000159322. [Q9BRR6-6]
ENST00000567941; ENSP00000458102; ENSG00000159322. [Q9BRR6-6]
ENST00000569517; ENSP00000454304; ENSG00000159322. [Q9BRR6-6]
GeneIDi83440.
KEGGihsa:83440.
UCSCiuc002ave.4. human. [Q9BRR6-4]
uc002avf.4. human. [Q9BRR6-2]
uc002avg.4. human. [Q9BRR6-1]

Organism-specific databases

CTDi83440.
GeneCardsiGC15M073043.
H-InvDBHIX0026868.
HGNCiHGNC:25250. ADPGK.
HPAiHPA045194.
HPA058525.
MIMi611861. gene.
neXtProtiNX_Q9BRR6.
PharmGKBiPA134971928.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4809.
GeneTreeiENSGT00390000017953.
HOGENOMiHOG000233731.
HOVERGENiHBG050461.
InParanoidiQ9BRR6.
KOiK08074.
OMAiSIVHQVF.
PhylomeDBiQ9BRR6.
TreeFamiTF313401.

Enzyme and pathway databases

UniPathwayiUPA00109.

Miscellaneous databases

ChiTaRSiADPGK. human.
GeneWikiiADP-specific_glucokinase.
GenomeRNAii83440.
NextBioi72318.
PROiQ9BRR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRR6.
CleanExiHS_ADPGK.
ExpressionAtlasiQ9BRR6. baseline and differential.
GenevisibleiQ9BRR6. HS.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR007666. ADP_PFK/GK.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR21208. PTHR21208. 1 hit.
PfamiPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RbBP-35 interacted with pRb."
    Fan Z.S., Ao S.Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Lymph node.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Tissue: Brain and Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADPGK_HUMAN
AccessioniPrimary (citable) accession number: Q9BRR6
Secondary accession number(s): Q49AU7
, Q8NBI1, Q8WZ90, Q96NF8, Q9H0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.