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Q9BRR6 (ADPGK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-dependent glucokinase

Short name=ADP-GK
Short name=ADPGK
EC=2.7.1.147
Alternative name(s):
RbBP-35
Gene names
Name:ADPGK
ORF Names:PSEC0260
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency By similarity.

Catalytic activity

ADP + D-glucose = AMP + D-glucose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Carbohydrate degradation; glycolysis.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the ADP-dependent glucokinase family.

Contains 1 ADPK (ADP-dependent kinase) domain.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandMagnesium
Metal-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionADP-specific glucokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BRR6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BRR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     313-313: Missing.
Isoform 3 (identifier: Q9BRR6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
Isoform 4 (identifier: Q9BRR6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     275-280: RKRLLE → MAASCR
     313-313: Missing.
Isoform 5 (identifier: Q9BRR6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     404-469: AAGARVAGTQ...ISFHFTPVLV → LGSSCGWDTG...ILPLHTSIGV
     470-497: Missing.
Isoform 6 (identifier: Q9BRR6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     79-497: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 497475ADP-dependent glucokinase
PRO_0000184776

Regions

Domain52 – 497446ADPK

Sites

Active site4811Proton acceptor By similarity
Metal binding2971Magnesium By similarity
Metal binding3281Magnesium By similarity
Metal binding4811Magnesium By similarity

Natural variations

Alternative sequence1 – 274274Missing in isoform 4.
VSP_013550
Alternative sequence1 – 239239Missing in isoform 3.
VSP_013549
Alternative sequence1 – 122122Missing in isoform 5.
VSP_013548
Alternative sequence79 – 497419Missing in isoform 6.
VSP_035014
Alternative sequence275 – 2806RKRLLE → MAASCR in isoform 4.
VSP_013551
Alternative sequence3131Missing in isoform 2 and isoform 4.
VSP_013552
Alternative sequence404 – 46966AAGAR…TPVLV → LGSSCGWDTGLRHRNHRHQP SVSEGTPRVHDFPFGGRLQD CIKPKQASSRMAQRGNILPL HTSIGV in isoform 5.
VSP_013553
Alternative sequence470 – 49728Missing in isoform 5.
VSP_013554
Natural variant1841K → R.
Corresponds to variant rs8024644 [ dbSNP | Ensembl ].
VAR_060085

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B758E977CDA88F8F

FASTA49754,089
        10         20         30         40         50         60 
MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP VSPEGRLAAA 

        70         80         90        100        110        120 
WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSILH SRNDLEEAFI 

       130        140        150        160        170        180 
HFMGKGAAAE RFFSDKETFH DIAQVASEFP GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP 

       190        200        210        220        230        240 
VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM 

       250        260        270        280        290        300 
NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS 

       310        320        330        340        350        360 
MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP DVGMVSDILF 

       370        380        390        400        410        420 
WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL AAVAAGARVA GTQACATETI 

       430        440        450        460        470        480 
DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK PVVEWHREGI SFHFTPVLVC KDPIRTVGLG 

       490 
DAISAEGLFY SEVHPHY 

« Hide

Isoform 2 [UniParc].

Checksum: 5ACBE523E6EE8828
Show »

FASTA49653,961
Isoform 3 [UniParc].

Checksum: 14A1E87AB18DDB1B
Show »

FASTA25828,413
Isoform 4 [UniParc].

Checksum: F387E8FABA303003
Show »

FASTA22224,130
Isoform 5 [UniParc].

Checksum: 6D5F512F495A60F6
Show »

FASTA34738,254
Isoform 6 [UniParc].

Checksum: CE817CAB68D45EB9
Show »

FASTA788,252

References

« Hide 'large scale' references
[1]"RbBP-35 interacted with pRb."
Fan Z.S., Ao S.Z.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
Tissue: Lymph node.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Heart.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[5]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Teratocarcinoma.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
Tissue: Brain and Kidney.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF204270 mRNA. Translation: AAL31473.1.
AL136873 mRNA. Translation: CAB66807.1.
AK055526 mRNA. Translation: BAB70941.1.
CR533447 mRNA. Translation: CAG38478.1.
AK075560 mRNA. Translation: BAC11699.1.
BC006112 mRNA. Translation: AAH06112.1.
BC018074 mRNA. Translation: AAH18074.1.
RefSeqNP_112574.3. NM_031284.4.
UniGeneHs.654636.

3D structure databases

ProteinModelPortalQ9BRR6.
SMRQ9BRR6. Positions 126-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123643. 3 interactions.
IntActQ9BRR6. 5 interactions.
MINTMINT-1404876.
STRING9606.ENSP00000312250.

PTM databases

PhosphoSiteQ9BRR6.

Polymorphism databases

DMDM62899887.

Proteomic databases

PaxDbQ9BRR6.
PRIDEQ9BRR6.

Protocols and materials databases

DNASU83440.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311669; ENSP00000312250; ENSG00000159322. [Q9BRR6-2]
ENST00000456471; ENSP00000397694; ENSG00000159322. [Q9BRR6-4]
ENST00000562823; ENSP00000454367; ENSG00000159322. [Q9BRR6-6]
ENST00000567941; ENSP00000458102; ENSG00000159322. [Q9BRR6-6]
ENST00000569517; ENSP00000454304; ENSG00000159322. [Q9BRR6-6]
GeneID83440.
KEGGhsa:83440.
UCSCuc002ave.4. human. [Q9BRR6-4]
uc002avf.4. human. [Q9BRR6-2]
uc002avg.4. human. [Q9BRR6-1]

Organism-specific databases

CTD83440.
GeneCardsGC15M073043.
H-InvDBHIX0026868.
HGNCHGNC:25250. ADPGK.
HPAHPA045194.
MIM611861. gene.
neXtProtNX_Q9BRR6.
PharmGKBPA134971928.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4809.
HOGENOMHOG000233731.
HOVERGENHBG050461.
InParanoidQ9BRR6.
KOK08074.
OMAAVGVNAC.
PhylomeDBQ9BRR6.
TreeFamTF313401.

Enzyme and pathway databases

UniPathwayUPA00109.

Gene expression databases

ArrayExpressQ9BRR6.
BgeeQ9BRR6.
CleanExHS_ADPGK.
GenevestigatorQ9BRR6.

Family and domain databases

InterProIPR007666. ADP_PFK/GK.
[Graphical view]
PANTHERPTHR21208. PTHR21208. 1 hit.
PfamPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PROSITEPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADP-specific_glucokinase.
GenomeRNAi83440.
NextBio72318.
PROQ9BRR6.
SOURCESearch...

Entry information

Entry nameADPGK_HUMAN
AccessionPrimary (citable) accession number: Q9BRR6
Secondary accession number(s): Q49AU7 expand/collapse secondary AC list , Q8NBI1, Q8WZ90, Q96NF8, Q9H0A7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM