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Q9BRR6

- ADPGK_HUMAN

UniProt

Q9BRR6 - ADPGK_HUMAN

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Protein
ADP-dependent glucokinase
Gene
ADPGK, PSEC0260
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency By similarity.

Catalytic activityi

ADP + D-glucose = AMP + D-glucose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi297 – 2971Magnesium By similarity
Metal bindingi328 – 3281Magnesium By similarity
Active sitei481 – 4811Proton acceptor By similarity
Metal bindingi481 – 4811Magnesium By similarity

GO - Molecular functioni

  1. ADP-specific glucokinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent glucokinase (EC:2.7.1.147)
Short name:
ADP-GK
Short name:
ADPGK
Alternative name(s):
RbBP-35
Gene namesi
Name:ADPGK
ORF Names:PSEC0260
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:25250. ADPGK.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 497475ADP-dependent glucokinase
PRO_0000184776Add
BLAST

Proteomic databases

MaxQBiQ9BRR6.
PaxDbiQ9BRR6.
PRIDEiQ9BRR6.

PTM databases

PhosphoSiteiQ9BRR6.

Expressioni

Gene expression databases

ArrayExpressiQ9BRR6.
BgeeiQ9BRR6.
CleanExiHS_ADPGK.
GenevestigatoriQ9BRR6.

Organism-specific databases

HPAiHPA045194.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi123643. 5 interactions.
IntActiQ9BRR6. 5 interactions.
MINTiMINT-1404876.
STRINGi9606.ENSP00000312250.

Structurei

3D structure databases

ProteinModelPortaliQ9BRR6.
SMRiQ9BRR6. Positions 126-492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 497446ADPK
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4809.
HOGENOMiHOG000233731.
HOVERGENiHBG050461.
InParanoidiQ9BRR6.
KOiK08074.
OMAiGVNACVD.
PhylomeDBiQ9BRR6.
TreeFamiTF313401.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR007666. ADP_PFK/GK.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR21208. PTHR21208. 1 hit.
PfamiPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS51255. ADPK. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRR6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP    50
VSPEGRLAAA WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP 100
GNGKDHSILH SRNDLEEAFI HFMGKGAAAE RFFSDKETFH DIAQVASEFP 150
GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP VGPKLHELLD DNVFVPPESL 200
QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM NMLEVFVSSL 250
EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS 300
MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP 350
DVGMVSDILF WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL 400
AAVAAGARVA GTQACATETI DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK 450
PVVEWHREGI SFHFTPVLVC KDPIRTVGLG DAISAEGLFY SEVHPHY 497
Length:497
Mass (Da):54,089
Last modified:June 1, 2001 - v1
Checksum:iB758E977CDA88F8F
GO
Isoform 2 (identifier: Q9BRR6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-313: Missing.

Show »
Length:496
Mass (Da):53,961
Checksum:i5ACBE523E6EE8828
GO
Isoform 3 (identifier: Q9BRR6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.

Show »
Length:258
Mass (Da):28,413
Checksum:i14A1E87AB18DDB1B
GO
Isoform 4 (identifier: Q9BRR6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     275-280: RKRLLE → MAASCR
     313-313: Missing.

Show »
Length:222
Mass (Da):24,130
Checksum:iF387E8FABA303003
GO
Isoform 5 (identifier: Q9BRR6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     404-469: AAGARVAGTQ...ISFHFTPVLV → LGSSCGWDTG...ILPLHTSIGV
     470-497: Missing.

Show »
Length:347
Mass (Da):38,254
Checksum:i6D5F512F495A60F6
GO
Isoform 6 (identifier: Q9BRR6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-497: Missing.

Note: No experimental confirmation available.

Show »
Length:78
Mass (Da):8,252
Checksum:iCE817CAB68D45EB9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841K → R.
Corresponds to variant rs8024644 [ dbSNP | Ensembl ].
VAR_060085

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 274274Missing in isoform 4.
VSP_013550Add
BLAST
Alternative sequencei1 – 239239Missing in isoform 3.
VSP_013549Add
BLAST
Alternative sequencei1 – 122122Missing in isoform 5.
VSP_013548Add
BLAST
Alternative sequencei79 – 497419Missing in isoform 6.
VSP_035014Add
BLAST
Alternative sequencei275 – 2806RKRLLE → MAASCR in isoform 4.
VSP_013551
Alternative sequencei313 – 3131Missing in isoform 2 and isoform 4.
VSP_013552
Alternative sequencei404 – 46966AAGAR…TPVLV → LGSSCGWDTGLRHRNHRHQP SVSEGTPRVHDFPFGGRLQD CIKPKQASSRMAQRGNILPL HTSIGV in isoform 5.
VSP_013553Add
BLAST
Alternative sequencei470 – 49728Missing in isoform 5.
VSP_013554Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204270 mRNA. Translation: AAL31473.1.
AL136873 mRNA. Translation: CAB66807.1.
AK055526 mRNA. Translation: BAB70941.1.
CR533447 mRNA. Translation: CAG38478.1.
AK075560 mRNA. Translation: BAC11699.1.
BC006112 mRNA. Translation: AAH06112.1.
BC018074 mRNA. Translation: AAH18074.1.
CCDSiCCDS42057.1. [Q9BRR6-2]
RefSeqiNP_112574.3. NM_031284.4. [Q9BRR6-2]
XP_006720775.1. XM_006720712.1. [Q9BRR6-1]
XP_006720778.1. XM_006720715.1. [Q9BRR6-3]
UniGeneiHs.654636.

Genome annotation databases

EnsembliENST00000311669; ENSP00000312250; ENSG00000159322. [Q9BRR6-2]
ENST00000456471; ENSP00000397694; ENSG00000159322. [Q9BRR6-4]
ENST00000562823; ENSP00000454367; ENSG00000159322. [Q9BRR6-6]
ENST00000567941; ENSP00000458102; ENSG00000159322. [Q9BRR6-6]
ENST00000569517; ENSP00000454304; ENSG00000159322. [Q9BRR6-6]
GeneIDi83440.
KEGGihsa:83440.
UCSCiuc002ave.4. human. [Q9BRR6-4]
uc002avf.4. human. [Q9BRR6-2]
uc002avg.4. human. [Q9BRR6-1]

Polymorphism databases

DMDMi62899887.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204270 mRNA. Translation: AAL31473.1 .
AL136873 mRNA. Translation: CAB66807.1 .
AK055526 mRNA. Translation: BAB70941.1 .
CR533447 mRNA. Translation: CAG38478.1 .
AK075560 mRNA. Translation: BAC11699.1 .
BC006112 mRNA. Translation: AAH06112.1 .
BC018074 mRNA. Translation: AAH18074.1 .
CCDSi CCDS42057.1. [Q9BRR6-2 ]
RefSeqi NP_112574.3. NM_031284.4. [Q9BRR6-2 ]
XP_006720775.1. XM_006720712.1. [Q9BRR6-1 ]
XP_006720778.1. XM_006720715.1. [Q9BRR6-3 ]
UniGenei Hs.654636.

3D structure databases

ProteinModelPortali Q9BRR6.
SMRi Q9BRR6. Positions 126-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123643. 5 interactions.
IntActi Q9BRR6. 5 interactions.
MINTi MINT-1404876.
STRINGi 9606.ENSP00000312250.

PTM databases

PhosphoSitei Q9BRR6.

Polymorphism databases

DMDMi 62899887.

Proteomic databases

MaxQBi Q9BRR6.
PaxDbi Q9BRR6.
PRIDEi Q9BRR6.

Protocols and materials databases

DNASUi 83440.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311669 ; ENSP00000312250 ; ENSG00000159322 . [Q9BRR6-2 ]
ENST00000456471 ; ENSP00000397694 ; ENSG00000159322 . [Q9BRR6-4 ]
ENST00000562823 ; ENSP00000454367 ; ENSG00000159322 . [Q9BRR6-6 ]
ENST00000567941 ; ENSP00000458102 ; ENSG00000159322 . [Q9BRR6-6 ]
ENST00000569517 ; ENSP00000454304 ; ENSG00000159322 . [Q9BRR6-6 ]
GeneIDi 83440.
KEGGi hsa:83440.
UCSCi uc002ave.4. human. [Q9BRR6-4 ]
uc002avf.4. human. [Q9BRR6-2 ]
uc002avg.4. human. [Q9BRR6-1 ]

Organism-specific databases

CTDi 83440.
GeneCardsi GC15M073043.
H-InvDB HIX0026868.
HGNCi HGNC:25250. ADPGK.
HPAi HPA045194.
MIMi 611861. gene.
neXtProti NX_Q9BRR6.
PharmGKBi PA134971928.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4809.
HOGENOMi HOG000233731.
HOVERGENi HBG050461.
InParanoidi Q9BRR6.
KOi K08074.
OMAi GVNACVD.
PhylomeDBi Q9BRR6.
TreeFami TF313401.

Enzyme and pathway databases

UniPathwayi UPA00109 .

Miscellaneous databases

GeneWikii ADP-specific_glucokinase.
GenomeRNAii 83440.
NextBioi 72318.
PROi Q9BRR6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BRR6.
Bgeei Q9BRR6.
CleanExi HS_ADPGK.
Genevestigatori Q9BRR6.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR007666. ADP_PFK/GK.
IPR029056. Ribokinase-like.
[Graphical view ]
PANTHERi PTHR21208. PTHR21208. 1 hit.
Pfami PF04587. ADP_PFK_GK. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
PROSITEi PS51255. ADPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RbBP-35 interacted with pRb."
    Fan Z.S., Ao S.Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Lymph node.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Tissue: Brain and Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADPGK_HUMAN
AccessioniPrimary (citable) accession number: Q9BRR6
Secondary accession number(s): Q49AU7
, Q8NBI1, Q8WZ90, Q96NF8, Q9H0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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