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Q9BRR0

- ZKSC3_HUMAN

UniProt

Q9BRR0 - ZKSC3_HUMAN

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Protein

Zinc finger protein with KRAB and SCAN domains 3

Gene
ZKSCAN3, ZFP47, ZNF306, ZNF309, ZSCAN13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri314 – 33623C2H2-type 1Add
BLAST
Zinc fingeri342 – 36423C2H2-type 2Add
BLAST
Zinc fingeri370 – 39223C2H2-type 3Add
BLAST
Zinc fingeri398 – 42023C2H2-type 4Add
BLAST
Zinc fingeri426 – 44823C2H2-type 5Add
BLAST
Zinc fingeri480 – 50223C2H2-type 6Add
BLAST
Zinc fingeri508 – 53023C2H2-type 7Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. lysosome organization Source: UniProtKB
  3. negative regulation of autophagy Source: UniProtKB
  4. negative regulation of cellular senescence Source: UniProtKB
  5. negative regulation of transcription, DNA-templated Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Autophagy, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 3
Alternative name(s):
Zinc finger and SCAN domain-containing protein 13
Zinc finger protein 306
Zinc finger protein 309
Zinc finger protein 47 homolog
Short name:
Zf47
Short name:
Zfp-47
Gene namesi
Name:ZKSCAN3
Synonyms:ZFP47, ZNF306, ZNF309, ZSCAN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13853. ZKSCAN3.

Subcellular locationi

Nucleus. Cytoplasm
Note: Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Zinc finger protein with KRAB and SCAN domains 3PRO_0000047524Add
BLAST

Proteomic databases

MaxQBiQ9BRR0.
PaxDbiQ9BRR0.
PRIDEiQ9BRR0.

PTM databases

PhosphoSiteiQ9BRR0.

Expressioni

Inductioni

Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).3 Publications

Gene expression databases

BgeeiQ9BRR0.
CleanExiHS_ZKSCAN3.
GenevestigatoriQ9BRR0.

Organism-specific databases

HPAiHPA009637.

Interactioni

Protein-protein interaction databases

IntActiQ9BRR0. 1 interaction.
STRINGi9606.ENSP00000252211.

Structurei

3D structure databases

ProteinModelPortaliQ9BRR0.
SMRiQ9BRR0. Positions 37-129, 289-533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12883SCAN boxAdd
BLAST
Domaini214 – 27461KRABAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.
Contains 1 SCAN box domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9BRR0.
KOiK09229.
OMAiQGEAWKS.
OrthoDBiEOG79GT5W.
PhylomeDBiQ9BRR0.
TreeFamiTF350830.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRR0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARELSESTA LDAQSTEDQM ELLVIKVEEE EAGFPSSPDL GSEGSRERFR    50
GFRYPEAAGP REALSRLREL CRQWLQPEMH SKEQILELLV LEQFLTILPG 100
NLQSWVREQH PESGEEVVVL LEYLERQLDE PAPQVSGVDQ GQELLCCKMA 150
LLTPAPGSQS SQFQLMKALL KHESVGSQPL QDRVLQVPVL AHGGCCREDK 200
VVASRLTPES QGLLKVEDVA LTLTPEWTQQ DSSQGNLCRD EKQENHGSLV 250
SLGDEKQTKS RDLPPAEELP EKEHGKISCH LREDIAQIPT CAEAGEQEGR 300
LQRKQKNATG GRRHICHECG KSFAQSSGLS KHRRIHTGEK PYECEECGKA 350
FIGSSALVIH QRVHTGEKPY ECEECGKAFS HSSDLIKHQR THTGEKPYEC 400
DDCGKTFSQS CSLLEHHRIH TGEKPYQCSM CGKAFRRSSH LLRHQRIHTG 450
DKNVQEPEQG EAWKSRMESQ LENVETPMSY KCNECERSFT QNTGLIEHQK 500
IHTGEKPYQC NACGKGFTRI SYLVQHQRSH VGKNILSQ 538
Length:538
Mass (Da):60,641
Last modified:October 17, 2006 - v2
Checksum:i0D8F706F1B2F888F
GO
Isoform 2 (identifier: Q9BRR0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.

Note: No experimental confirmation available.

Show »
Length:390
Mass (Da):43,793
Checksum:iBE2B599E4BE6A684
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31R → T.
Corresponds to variant rs733743 [ dbSNP | Ensembl ].
VAR_024208
Natural varianti33 – 331G → V.
Corresponds to variant rs3857554 [ dbSNP | Ensembl ].
VAR_028313
Natural varianti34 – 341F → L.
Corresponds to variant rs3857555 [ dbSNP | Ensembl ].
VAR_028314
Natural varianti189 – 1891V → M.1 Publication
Corresponds to variant rs17856167 [ dbSNP | Ensembl ].
VAR_028315
Natural varianti200 – 2001K → A Requires 2 nucleotide substitutions. 3 Publications
Corresponds to variant rs13201752 [ dbSNP | Ensembl ].
VAR_059950
Natural varianti200 – 2001K → E.1 Publication
Corresponds to variant rs45505399 [ dbSNP | Ensembl ].
VAR_028316
Natural varianti200 – 2001K → T.
Corresponds to variant rs13201753 [ dbSNP | Ensembl ].
VAR_028317
Natural varianti246 – 2461H → Q.
Corresponds to variant rs213227 [ dbSNP | Ensembl ].
VAR_028318

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 148148Missing in isoform 2. VSP_045908Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2072LT → IP in AAB16813. 1 Publication
Sequence conflicti348 – 3503GKA → AKP in AAB16813. 1 Publication
Sequence conflicti437 – 4371R → D in AAB16813. 1 Publication
Sequence conflicti459 – 47921QGEAW…ETPMS → TGRGWKVGWKASWKMLKLPC P in AAB16813. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT007427 mRNA. Translation: AAP36095.1.
AK122790 mRNA. Translation: BAG53732.1.
AK313532 mRNA. Translation: BAG36309.1.
AL358785, AL021997 Genomic DNA. Translation: CAH71668.1.
AL021997, AL358785 Genomic DNA. Translation: CAI23088.1.
CH471081 Genomic DNA. Translation: EAX03157.1.
BC006118 mRNA. Translation: AAH06118.1.
U71601 mRNA. Translation: AAB16813.1.
CCDSiCCDS4650.1. [Q9BRR0-1]
CCDS56408.1. [Q9BRR0-2]
RefSeqiNP_001229823.1. NM_001242894.1. [Q9BRR0-1]
NP_001229824.1. NM_001242895.1. [Q9BRR0-2]
NP_077819.2. NM_024493.3. [Q9BRR0-1]
XP_005249481.1. XM_005249424.1. [Q9BRR0-2]
XP_006715278.1. XM_006715215.1. [Q9BRR0-1]
XP_006715281.1. XM_006715218.1. [Q9BRR0-2]
XP_006715282.1. XM_006715219.1. [Q9BRR0-2]
UniGeneiHs.380930.
Hs.485004.

Genome annotation databases

EnsembliENST00000252211; ENSP00000252211; ENSG00000189298. [Q9BRR0-1]
ENST00000341464; ENSP00000341883; ENSG00000189298. [Q9BRR0-2]
ENST00000377255; ENSP00000366465; ENSG00000189298. [Q9BRR0-1]
GeneIDi80317.
KEGGihsa:80317.
UCSCiuc003nle.4. human. [Q9BRR0-1]

Polymorphism databases

DMDMi116242859.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT007427 mRNA. Translation: AAP36095.1 .
AK122790 mRNA. Translation: BAG53732.1 .
AK313532 mRNA. Translation: BAG36309.1 .
AL358785 , AL021997 Genomic DNA. Translation: CAH71668.1 .
AL021997 , AL358785 Genomic DNA. Translation: CAI23088.1 .
CH471081 Genomic DNA. Translation: EAX03157.1 .
BC006118 mRNA. Translation: AAH06118.1 .
U71601 mRNA. Translation: AAB16813.1 .
CCDSi CCDS4650.1. [Q9BRR0-1 ]
CCDS56408.1. [Q9BRR0-2 ]
RefSeqi NP_001229823.1. NM_001242894.1. [Q9BRR0-1 ]
NP_001229824.1. NM_001242895.1. [Q9BRR0-2 ]
NP_077819.2. NM_024493.3. [Q9BRR0-1 ]
XP_005249481.1. XM_005249424.1. [Q9BRR0-2 ]
XP_006715278.1. XM_006715215.1. [Q9BRR0-1 ]
XP_006715281.1. XM_006715218.1. [Q9BRR0-2 ]
XP_006715282.1. XM_006715219.1. [Q9BRR0-2 ]
UniGenei Hs.380930.
Hs.485004.

3D structure databases

ProteinModelPortali Q9BRR0.
SMRi Q9BRR0. Positions 37-129, 289-533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9BRR0. 1 interaction.
STRINGi 9606.ENSP00000252211.

PTM databases

PhosphoSitei Q9BRR0.

Polymorphism databases

DMDMi 116242859.

Proteomic databases

MaxQBi Q9BRR0.
PaxDbi Q9BRR0.
PRIDEi Q9BRR0.

Protocols and materials databases

DNASUi 80317.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252211 ; ENSP00000252211 ; ENSG00000189298 . [Q9BRR0-1 ]
ENST00000341464 ; ENSP00000341883 ; ENSG00000189298 . [Q9BRR0-2 ]
ENST00000377255 ; ENSP00000366465 ; ENSG00000189298 . [Q9BRR0-1 ]
GeneIDi 80317.
KEGGi hsa:80317.
UCSCi uc003nle.4. human. [Q9BRR0-1 ]

Organism-specific databases

CTDi 80317.
GeneCardsi GC06P028317.
HGNCi HGNC:13853. ZKSCAN3.
HPAi HPA009637.
MIMi 612791. gene.
neXtProti NX_Q9BRR0.
PharmGKBi PA37821.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi Q9BRR0.
KOi K09229.
OMAi QGEAWKS.
OrthoDBi EOG79GT5W.
PhylomeDBi Q9BRR0.
TreeFami TF350830.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 80317.
NextBioi 70823.
PROi Q9BRR0.
SOURCEi Search...

Gene expression databases

Bgeei Q9BRR0.
CleanExi HS_ZKSCAN3.
Genevestigatori Q9BRR0.

Family and domain databases

Gene3Di 3.30.160.60. 7 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-189 AND ALA-200.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-200 AND GLU-200.
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-200.
    Tissue: Placenta.
  6. "Computer sequence analysis of human highly conserved zinc finger modules."
    Petroni D., Bartolini E., Chiaramonte R., Ottolenghi S., Comi P.
    DNA Seq. 9:163-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 206-538 (ISOFORM 1/2).
  7. "The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression."
    Yang L., Hamilton S.R., Sood A., Kuwai T., Ellis L., Sanguino A., Lopez-Berestein G., Boyd D.D.
    Cancer Res. 68:4321-4330(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets."
    Yang L., Zhang L., Wu Q., Boyd D.D.
    J. Biol. Chem. 283:35295-35304(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, INDUCTION.
  9. "Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma."
    Yang L., Wang H., Kornblau S.M., Graber D.A., Zhang N., Matthews J.A., Wang M., Weber D.M., Thomas S.K., Shah J.J., Zhang L., Lu G., Zhao M., Muddasani R., Yoo S.Y., Baggerly K.A., Orlowski R.Z.
    Oncogene 30:1329-1340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration."
    Zhang X., Jing Y., Qin Y., Hunsucker S., Meng H., Sui J., Jiang Y., Gao L., An G., Yang N., Orlowski R.Z., Yang L.
    Int. J. Biochem. Cell Biol. 44:1166-1173(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  11. "ZKSCAN3 is a master transcriptional repressor of autophagy."
    Chauhan S., Goodwin J.G., Chauhan S., Manyam G., Wang J., Kamat A.M., Boyd D.D.
    Mol. Cell 50:16-28(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZKSC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BRR0
Secondary accession number(s): B2R8W2
, B3KVC0, H7BXX1, Q5VXH3, Q92972, Q9H4T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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