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Q9BRR0

- ZKSC3_HUMAN

UniProt

Q9BRR0 - ZKSC3_HUMAN

Protein

Zinc finger protein with KRAB and SCAN domains 3

Gene

ZKSCAN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri314 – 33623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. DNA binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. lysosome organization Source: UniProtKB
    3. negative regulation of autophagy Source: UniProtKB
    4. negative regulation of cellular senescence Source: UniProtKB
    5. negative regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of transcription, DNA-templated Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Autophagy, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 3
    Alternative name(s):
    Zinc finger and SCAN domain-containing protein 13
    Zinc finger protein 306
    Zinc finger protein 309
    Zinc finger protein 47 homolog
    Short name:
    Zf47
    Short name:
    Zfp-47
    Gene namesi
    Name:ZKSCAN3
    Synonyms:ZFP47, ZNF306, ZNF309, ZSCAN13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13853. ZKSCAN3.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37821.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Zinc finger protein with KRAB and SCAN domains 3PRO_0000047524Add
    BLAST

    Proteomic databases

    MaxQBiQ9BRR0.
    PaxDbiQ9BRR0.
    PRIDEiQ9BRR0.

    PTM databases

    PhosphoSiteiQ9BRR0.

    Expressioni

    Inductioni

    Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).3 Publications

    Gene expression databases

    BgeeiQ9BRR0.
    CleanExiHS_ZKSCAN3.
    GenevestigatoriQ9BRR0.

    Organism-specific databases

    HPAiHPA009637.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BRR0. 1 interaction.
    STRINGi9606.ENSP00000252211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRR0.
    SMRiQ9BRR0. Positions 37-129, 289-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 12883SCAN boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini214 – 27461KRABAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.Curated
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri314 – 33623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ9BRR0.
    KOiK09229.
    OMAiQGEAWKS.
    OrthoDBiEOG79GT5W.
    PhylomeDBiQ9BRR0.
    TreeFamiTF350830.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARELSESTA LDAQSTEDQM ELLVIKVEEE EAGFPSSPDL GSEGSRERFR    50
    GFRYPEAAGP REALSRLREL CRQWLQPEMH SKEQILELLV LEQFLTILPG 100
    NLQSWVREQH PESGEEVVVL LEYLERQLDE PAPQVSGVDQ GQELLCCKMA 150
    LLTPAPGSQS SQFQLMKALL KHESVGSQPL QDRVLQVPVL AHGGCCREDK 200
    VVASRLTPES QGLLKVEDVA LTLTPEWTQQ DSSQGNLCRD EKQENHGSLV 250
    SLGDEKQTKS RDLPPAEELP EKEHGKISCH LREDIAQIPT CAEAGEQEGR 300
    LQRKQKNATG GRRHICHECG KSFAQSSGLS KHRRIHTGEK PYECEECGKA 350
    FIGSSALVIH QRVHTGEKPY ECEECGKAFS HSSDLIKHQR THTGEKPYEC 400
    DDCGKTFSQS CSLLEHHRIH TGEKPYQCSM CGKAFRRSSH LLRHQRIHTG 450
    DKNVQEPEQG EAWKSRMESQ LENVETPMSY KCNECERSFT QNTGLIEHQK 500
    IHTGEKPYQC NACGKGFTRI SYLVQHQRSH VGKNILSQ 538
    Length:538
    Mass (Da):60,641
    Last modified:October 17, 2006 - v2
    Checksum:i0D8F706F1B2F888F
    GO
    Isoform 2 (identifier: Q9BRR0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-148: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:390
    Mass (Da):43,793
    Checksum:iBE2B599E4BE6A684
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2072LT → IP in AAB16813. (PubMed:10520746)Curated
    Sequence conflicti348 – 3503GKA → AKP in AAB16813. (PubMed:10520746)Curated
    Sequence conflicti437 – 4371R → D in AAB16813. (PubMed:10520746)Curated
    Sequence conflicti459 – 47921QGEAW…ETPMS → TGRGWKVGWKASWKMLKLPC P in AAB16813. (PubMed:10520746)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31R → T.
    Corresponds to variant rs733743 [ dbSNP | Ensembl ].
    VAR_024208
    Natural varianti33 – 331G → V.
    Corresponds to variant rs3857554 [ dbSNP | Ensembl ].
    VAR_028313
    Natural varianti34 – 341F → L.
    Corresponds to variant rs3857555 [ dbSNP | Ensembl ].
    VAR_028314
    Natural varianti189 – 1891V → M.1 Publication
    Corresponds to variant rs17856167 [ dbSNP | Ensembl ].
    VAR_028315
    Natural varianti200 – 2001K → A Requires 2 nucleotide substitutions. 3 Publications
    Corresponds to variant rs13201752 [ dbSNP | Ensembl ].
    VAR_059950
    Natural varianti200 – 2001K → E.1 Publication
    Corresponds to variant rs45505399 [ dbSNP | Ensembl ].
    VAR_028316
    Natural varianti200 – 2001K → T.
    Corresponds to variant rs13201753 [ dbSNP | Ensembl ].
    VAR_028317
    Natural varianti246 – 2461H → Q.
    Corresponds to variant rs213227 [ dbSNP | Ensembl ].
    VAR_028318

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 148148Missing in isoform 2. 1 PublicationVSP_045908Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT007427 mRNA. Translation: AAP36095.1.
    AK122790 mRNA. Translation: BAG53732.1.
    AK313532 mRNA. Translation: BAG36309.1.
    AL358785, AL021997 Genomic DNA. Translation: CAH71668.1.
    AL021997, AL358785 Genomic DNA. Translation: CAI23088.1.
    CH471081 Genomic DNA. Translation: EAX03157.1.
    BC006118 mRNA. Translation: AAH06118.1.
    U71601 mRNA. Translation: AAB16813.1.
    CCDSiCCDS4650.1. [Q9BRR0-1]
    CCDS56408.1. [Q9BRR0-2]
    RefSeqiNP_001229823.1. NM_001242894.1. [Q9BRR0-1]
    NP_001229824.1. NM_001242895.1. [Q9BRR0-2]
    NP_077819.2. NM_024493.3. [Q9BRR0-1]
    XP_005249481.1. XM_005249424.1. [Q9BRR0-2]
    XP_006715278.1. XM_006715215.1. [Q9BRR0-1]
    XP_006715281.1. XM_006715218.1. [Q9BRR0-2]
    XP_006715282.1. XM_006715219.1. [Q9BRR0-2]
    UniGeneiHs.380930.
    Hs.485004.

    Genome annotation databases

    EnsembliENST00000252211; ENSP00000252211; ENSG00000189298. [Q9BRR0-1]
    ENST00000341464; ENSP00000341883; ENSG00000189298. [Q9BRR0-2]
    ENST00000377255; ENSP00000366465; ENSG00000189298. [Q9BRR0-1]
    GeneIDi80317.
    KEGGihsa:80317.
    UCSCiuc003nle.4. human. [Q9BRR0-1]

    Polymorphism databases

    DMDMi116242859.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT007427 mRNA. Translation: AAP36095.1 .
    AK122790 mRNA. Translation: BAG53732.1 .
    AK313532 mRNA. Translation: BAG36309.1 .
    AL358785 , AL021997 Genomic DNA. Translation: CAH71668.1 .
    AL021997 , AL358785 Genomic DNA. Translation: CAI23088.1 .
    CH471081 Genomic DNA. Translation: EAX03157.1 .
    BC006118 mRNA. Translation: AAH06118.1 .
    U71601 mRNA. Translation: AAB16813.1 .
    CCDSi CCDS4650.1. [Q9BRR0-1 ]
    CCDS56408.1. [Q9BRR0-2 ]
    RefSeqi NP_001229823.1. NM_001242894.1. [Q9BRR0-1 ]
    NP_001229824.1. NM_001242895.1. [Q9BRR0-2 ]
    NP_077819.2. NM_024493.3. [Q9BRR0-1 ]
    XP_005249481.1. XM_005249424.1. [Q9BRR0-2 ]
    XP_006715278.1. XM_006715215.1. [Q9BRR0-1 ]
    XP_006715281.1. XM_006715218.1. [Q9BRR0-2 ]
    XP_006715282.1. XM_006715219.1. [Q9BRR0-2 ]
    UniGenei Hs.380930.
    Hs.485004.

    3D structure databases

    ProteinModelPortali Q9BRR0.
    SMRi Q9BRR0. Positions 37-129, 289-533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BRR0. 1 interaction.
    STRINGi 9606.ENSP00000252211.

    PTM databases

    PhosphoSitei Q9BRR0.

    Polymorphism databases

    DMDMi 116242859.

    Proteomic databases

    MaxQBi Q9BRR0.
    PaxDbi Q9BRR0.
    PRIDEi Q9BRR0.

    Protocols and materials databases

    DNASUi 80317.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252211 ; ENSP00000252211 ; ENSG00000189298 . [Q9BRR0-1 ]
    ENST00000341464 ; ENSP00000341883 ; ENSG00000189298 . [Q9BRR0-2 ]
    ENST00000377255 ; ENSP00000366465 ; ENSG00000189298 . [Q9BRR0-1 ]
    GeneIDi 80317.
    KEGGi hsa:80317.
    UCSCi uc003nle.4. human. [Q9BRR0-1 ]

    Organism-specific databases

    CTDi 80317.
    GeneCardsi GC06P028317.
    HGNCi HGNC:13853. ZKSCAN3.
    HPAi HPA009637.
    MIMi 612791. gene.
    neXtProti NX_Q9BRR0.
    PharmGKBi PA37821.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q9BRR0.
    KOi K09229.
    OMAi QGEAWKS.
    OrthoDBi EOG79GT5W.
    PhylomeDBi Q9BRR0.
    TreeFami TF350830.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 80317.
    NextBioi 70823.
    PROi Q9BRR0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BRR0.
    CleanExi HS_ZKSCAN3.
    Genevestigatori Q9BRR0.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-189 AND ALA-200.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-200 AND GLU-200.
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-200.
      Tissue: Placenta.
    6. "Computer sequence analysis of human highly conserved zinc finger modules."
      Petroni D., Bartolini E., Chiaramonte R., Ottolenghi S., Comi P.
      DNA Seq. 9:163-169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 206-538 (ISOFORM 1/2).
    7. "The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression."
      Yang L., Hamilton S.R., Sood A., Kuwai T., Ellis L., Sanguino A., Lopez-Berestein G., Boyd D.D.
      Cancer Res. 68:4321-4330(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets."
      Yang L., Zhang L., Wu Q., Boyd D.D.
      J. Biol. Chem. 283:35295-35304(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, INDUCTION.
    9. "Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma."
      Yang L., Wang H., Kornblau S.M., Graber D.A., Zhang N., Matthews J.A., Wang M., Weber D.M., Thomas S.K., Shah J.J., Zhang L., Lu G., Zhao M., Muddasani R., Yoo S.Y., Baggerly K.A., Orlowski R.Z.
      Oncogene 30:1329-1340(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration."
      Zhang X., Jing Y., Qin Y., Hunsucker S., Meng H., Sui J., Jiang Y., Gao L., An G., Yang N., Orlowski R.Z., Yang L.
      Int. J. Biochem. Cell Biol. 44:1166-1173(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    11. "ZKSCAN3 is a master transcriptional repressor of autophagy."
      Chauhan S., Goodwin J.G., Chauhan S., Manyam G., Wang J., Kamat A.M., Boyd D.D.
      Mol. Cell 50:16-28(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiZKSC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRR0
    Secondary accession number(s): B2R8W2
    , B3KVC0, H7BXX1, Q5VXH3, Q92972, Q9H4T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3