Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apoptosis-inducing factor 2

Gene

AIFM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.3 Publications

Cofactori

6-hydroxy-FAD1 PublicationNote: Binds 6-hydroxy-FAD non-covalently.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 5416-hydroxy-FADSequence analysis
Binding sitei82 – 8216-hydroxy-FAD; via amide nitrogen and carbonyl oxygenSequence analysis
Binding sitei285 – 28516-hydroxy-FADSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2256-hydroxy-FADSequence analysis

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • electron-transferring-flavoprotein dehydrogenase activity Source: UniProtKB
  • flavin adenine dinucleotide binding Source: UniProtKB

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB
  • regulation of apoptotic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

DNA-binding, FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-inducing factor 2 (EC:1.-.-.-)
Alternative name(s):
Apoptosis-inducing factor homologous mitochondrion-associated inducer of death
Apoptosis-inducing factor-like mitochondrion-associated inducer of death
p53-responsive gene 3 protein
Gene namesi
Name:AIFM2
Synonyms:AMID, PRG31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21411. AIFM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lipid particle Source: UniProtKB
  • mitochondrial outer membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376150.

Polymorphism and mutation databases

BioMutaiAIFM2.
DMDMi74752283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 373372Apoptosis-inducing factor 2PRO_0000238922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine2 Publications

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9BRQ8.
MaxQBiQ9BRQ8.
PaxDbiQ9BRQ8.
PeptideAtlasiQ9BRQ8.
PRIDEiQ9BRQ8.

PTM databases

iPTMnetiQ9BRQ8.
PhosphoSiteiQ9BRQ8.

Expressioni

Tissue specificityi

Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.1 Publication

Inductioni

Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human tumors.2 Publications

Gene expression databases

BgeeiQ9BRQ8.
CleanExiHS_AIFM2.
HS_PRG3.
GenevisibleiQ9BRQ8. HS.

Organism-specific databases

HPAiHPA042309.

Interactioni

Protein-protein interaction databases

BioGridi124325. 2 interactions.
IntActiQ9BRQ8. 2 interactions.
STRINGi9606.ENSP00000312370.

Structurei

3D structure databases

ProteinModelPortaliQ9BRQ8.
SMRiQ9BRQ8. Positions 11-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ9K. Eukaryota.
COG1252. LUCA.
GeneTreeiENSGT00390000004582.
HOGENOMiHOG000238788.
HOVERGENiHBG054912.
InParanoidiQ9BRQ8.
OMAiKINNSAY.
OrthoDBiEOG7J447T.
PhylomeDBiQ9BRQ8.
TreeFamiTF329369.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q9BRQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQVSVESG ALHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV
60 70 80 90 100
AALRASVETG FAKKTFISYS VTFKDNFRQG LVVGIDLKNQ MVLLQGGEAL
110 120 130 140 150
PFSHLILATG STGPFPGKFN EVSSQQAAIQ AYEDMVRQVQ RSRFIVVVGG
160 170 180 190 200
GSAGVEMAAE IKTEYPEKEV TLIHSQVALA DKELLPSVRQ EVKEILLRKG
210 220 230 240 250
VQLLLSERVS NLEELPLNEY REYIKVQTDK GTEVATNLVI LCTGIKINSS
260 270 280 290 300
AYRKAFESRL ASSGALRVNE HLQVEGHSNV YAIGDCADVR TPKMAYLAGL
310 320 330 340 350
HANIAVANIV NSVKQRPLQA YKPGALTFLL SMGRNDGVGQ ISGFYVGRLM
360 370
VRLTKSRDLF VSTSWKTMRQ SPP
Length:373
Mass (Da):40,527
Last modified:June 1, 2001 - v1
Checksum:i47F2E6F682D4C060
GO
Isoform 21 Publication (identifier: Q9BRQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-138: Missing.
     206-206: S → SLLG

Note: No experimental confirmation available.Curated
Show »
Length:336
Mass (Da):36,520
Checksum:i30E3D34AE9CE8EFA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351M → T.
Corresponds to variant rs10999147 [ dbSNP | Ensembl ].
VAR_050651
Natural varianti288 – 2881D → N.
Corresponds to variant rs2271694 [ dbSNP | Ensembl ].
VAR_050652

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 13840Missing in isoform 2. 2 PublicationsVSP_052047Add
BLAST
Alternative sequencei206 – 2061S → SLLG in isoform 2. 2 PublicationsVSP_052048

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337957 mRNA. Translation: AAL73229.1.
AF506757 mRNA. Translation: AAM77596.1.
AK027403 mRNA. Translation: BAB55089.1.
AK127353 mRNA. Translation: BAG54492.1.
AL731540 Genomic DNA. Translation: CAI13684.1.
CH471083 Genomic DNA. Translation: EAW54376.1.
BC006121 mRNA. Translation: AAH06121.1.
BC023601 mRNA. Translation: AAH23601.1.
BX537621 mRNA. Translation: CAH56481.1.
CCDSiCCDS7297.1. [Q9BRQ8-1]
RefSeqiNP_001185625.1. NM_001198696.1. [Q9BRQ8-1]
NP_116186.1. NM_032797.5. [Q9BRQ8-1]
UniGeneiHs.650680.

Genome annotation databases

EnsembliENST00000307864; ENSP00000312370; ENSG00000042286. [Q9BRQ8-1]
ENST00000373248; ENSP00000362345; ENSG00000042286. [Q9BRQ8-1]
ENST00000613322; ENSP00000478931; ENSG00000042286. [Q9BRQ8-1]
GeneIDi84883.
KEGGihsa:84883.
UCSCiuc001jqp.3. human. [Q9BRQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337957 mRNA. Translation: AAL73229.1.
AF506757 mRNA. Translation: AAM77596.1.
AK027403 mRNA. Translation: BAB55089.1.
AK127353 mRNA. Translation: BAG54492.1.
AL731540 Genomic DNA. Translation: CAI13684.1.
CH471083 Genomic DNA. Translation: EAW54376.1.
BC006121 mRNA. Translation: AAH06121.1.
BC023601 mRNA. Translation: AAH23601.1.
BX537621 mRNA. Translation: CAH56481.1.
CCDSiCCDS7297.1. [Q9BRQ8-1]
RefSeqiNP_001185625.1. NM_001198696.1. [Q9BRQ8-1]
NP_116186.1. NM_032797.5. [Q9BRQ8-1]
UniGeneiHs.650680.

3D structure databases

ProteinModelPortaliQ9BRQ8.
SMRiQ9BRQ8. Positions 11-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124325. 2 interactions.
IntActiQ9BRQ8. 2 interactions.
STRINGi9606.ENSP00000312370.

PTM databases

iPTMnetiQ9BRQ8.
PhosphoSiteiQ9BRQ8.

Polymorphism and mutation databases

BioMutaiAIFM2.
DMDMi74752283.

Proteomic databases

EPDiQ9BRQ8.
MaxQBiQ9BRQ8.
PaxDbiQ9BRQ8.
PeptideAtlasiQ9BRQ8.
PRIDEiQ9BRQ8.

Protocols and materials databases

DNASUi84883.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307864; ENSP00000312370; ENSG00000042286. [Q9BRQ8-1]
ENST00000373248; ENSP00000362345; ENSG00000042286. [Q9BRQ8-1]
ENST00000613322; ENSP00000478931; ENSG00000042286. [Q9BRQ8-1]
GeneIDi84883.
KEGGihsa:84883.
UCSCiuc001jqp.3. human. [Q9BRQ8-1]

Organism-specific databases

CTDi84883.
GeneCardsiAIFM2.
H-InvDBHIX0026110.
HGNCiHGNC:21411. AIFM2.
HPAiHPA042309.
MIMi605159. gene.
neXtProtiNX_Q9BRQ8.
PharmGKBiPA162376150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ9K. Eukaryota.
COG1252. LUCA.
GeneTreeiENSGT00390000004582.
HOGENOMiHOG000238788.
HOVERGENiHBG054912.
InParanoidiQ9BRQ8.
OMAiKINNSAY.
OrthoDBiEOG7J447T.
PhylomeDBiQ9BRQ8.
TreeFamiTF329369.

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Miscellaneous databases

ChiTaRSiAIFM2. human.
GeneWikiiAIFM2.
GenomeRNAii84883.
PROiQ9BRQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRQ8.
CleanExiHS_AIFM2.
HS_PRG3.
GenevisibleiQ9BRQ8. HS.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)."
    Ohiro Y., Garkavtsev I., Kobayashi S., Sreekumar K.R., Nantz R., Higashikubo B.T., Duffy S.L., Higashikubo R., Usheva A., Gius D., Kley N., Horikoshi N.
    FEBS Lett. 524:163-171(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  2. "AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis."
    Wu M., Xu L.-G., Li X., Zhai Z., Shu H.-B.
    J. Biol. Chem. 277:25617-25623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: KidneyImported and LungImported.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-373 (ISOFORM 2).
    Tissue: Esophageal carcinoma.
  8. "AMID is a p53-inducible gene downregulated in tumors."
    Wu M., Xu L.-G., Su T., Tian Y., Zhai Z., Shu H.-B.
    Oncogene 23:6815-6819(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity."
    Marshall K.R., Gong M., Wodke L., Lamb J.H., Jones D.J., Farmer P.B., Scrutton N.S., Munro A.W.
    J. Biol. Chem. 280:30735-30740(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR.
  10. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells."
    Thinon E., Serwa R.A., Broncel M., Brannigan J.A., Brassat U., Wright M.H., Heal W.P., Wilkinson A.J., Mann D.J., Tate E.W.
    Nat. Commun. 5:4919-4919(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAIFM2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ8
Secondary accession number(s): B3KXI0, Q63Z39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.