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Protein

MICOS complex subunit MIC25

Gene

CHCHD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.1 Publication

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • cristae formation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC25
Alternative name(s):
Coiled-coil-helix cristae morphology protein 1
Coiled-coil-helix-coiled-coil-helix domain-containing protein 6
Gene namesi
Name:CHCHD6
Synonyms:CHCM1, MIC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28184. CHCHD6.

Subcellular locationi

GO - Cellular componenti

  • MICOS complex Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84303.
OpenTargetsiENSG00000159685.
PharmGKBiPA134899331.

Polymorphism and mutation databases

BioMutaiCHCHD6.
DMDMi62510505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00001291692 – 235MICOS complex subunit MIC25Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei13PhosphoserineCombined sources1
Modified residuei31PhosphoserineBy similarity1
Disulfide bondi197 ↔ 228PROSITE-ProRule annotation
Disulfide bondi207 ↔ 218PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9BRQ6.
MaxQBiQ9BRQ6.
PaxDbiQ9BRQ6.
PeptideAtlasiQ9BRQ6.
PRIDEiQ9BRQ6.

PTM databases

iPTMnetiQ9BRQ6.
PhosphoSitePlusiQ9BRQ6.

Expressioni

Inductioni

Down-regulated following genotoxic stress.1 Publication

Gene expression databases

BgeeiENSG00000159685.
CleanExiHS_CHCHD6.
ExpressionAtlasiQ9BRQ6. baseline and differential.
GenevisibleiQ9BRQ6. HS.

Organism-specific databases

HPAiHPA047673.
HPA051975.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:17624330, PubMed:22228767, PubMed:25781180, PubMed:25997101). Interacts with DISC1 (PubMed:22228767). Interacts with DISC1 (PubMed:22228767). Interacts with IMMT/MIC60 (PubMed:22228767, PubMed:25997101).4 Publications

Protein-protein interaction databases

BioGridi124029. 27 interactors.
IntActiQ9BRQ6. 16 interactors.
MINTiMINT-4830561.
STRINGi9606.ENSP00000290913.

Structurei

3D structure databases

ProteinModelPortaliQ9BRQ6.
SMRiQ9BRQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 235CHCHPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili129 – 176Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi197 – 207Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi218 – 228Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ9BRQ6.
KOiK17564.
PhylomeDBiQ9BRQ6.
TreeFamiTF326279.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS
60 70 80 90 100
STFGLQDGNL RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK
110 120 130 140 150
LFQVAKRERE AATKHSKASL PTGEGSISHE EQKSVRLARE LESREAELRR
160 170 180 190 200
RDTFYKEQLE RIERKNAEMY KLSSEQFHEA ASKMESTIKP RRVEPVCSGL
210 220 230
QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG
Length:235
Mass (Da):26,458
Last modified:June 1, 2001 - v1
Checksum:i674DE387557AF4F0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02441295A → S.Corresponds to variant rs2272487dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF264889 mRNA. Translation: AEA95848.1.
AC078867 Genomic DNA. No translation available.
AC092898 Genomic DNA. No translation available.
AC117450 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79352.1.
BC006123 mRNA. Translation: AAH06123.1.
CCDSiCCDS3041.1.
RefSeqiNP_001307539.1. NM_001320610.1.
NP_115719.1. NM_032343.2.
UniGeneiHs.518119.

Genome annotation databases

EnsembliENST00000290913; ENSP00000290913; ENSG00000159685.
GeneIDi84303.
KEGGihsa:84303.
UCSCiuc003ejf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF264889 mRNA. Translation: AEA95848.1.
AC078867 Genomic DNA. No translation available.
AC092898 Genomic DNA. No translation available.
AC117450 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79352.1.
BC006123 mRNA. Translation: AAH06123.1.
CCDSiCCDS3041.1.
RefSeqiNP_001307539.1. NM_001320610.1.
NP_115719.1. NM_032343.2.
UniGeneiHs.518119.

3D structure databases

ProteinModelPortaliQ9BRQ6.
SMRiQ9BRQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124029. 27 interactors.
IntActiQ9BRQ6. 16 interactors.
MINTiMINT-4830561.
STRINGi9606.ENSP00000290913.

PTM databases

iPTMnetiQ9BRQ6.
PhosphoSitePlusiQ9BRQ6.

Polymorphism and mutation databases

BioMutaiCHCHD6.
DMDMi62510505.

Proteomic databases

EPDiQ9BRQ6.
MaxQBiQ9BRQ6.
PaxDbiQ9BRQ6.
PeptideAtlasiQ9BRQ6.
PRIDEiQ9BRQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290913; ENSP00000290913; ENSG00000159685.
GeneIDi84303.
KEGGihsa:84303.
UCSCiuc003ejf.3. human.

Organism-specific databases

CTDi84303.
DisGeNETi84303.
GeneCardsiCHCHD6.
HGNCiHGNC:28184. CHCHD6.
HPAiHPA047673.
HPA051975.
MIMi615634. gene.
neXtProtiNX_Q9BRQ6.
OpenTargetsiENSG00000159685.
PharmGKBiPA134899331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ9BRQ6.
KOiK17564.
PhylomeDBiQ9BRQ6.
TreeFamiTF326279.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159685-MONOMER.

Miscellaneous databases

ChiTaRSiCHCHD6. human.
GenomeRNAii84303.
PROiQ9BRQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159685.
CleanExiHS_CHCHD6.
ExpressionAtlasiQ9BRQ6. baseline and differential.
GenevisibleiQ9BRQ6. HS.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIC25_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ6
Secondary accession number(s): D6R9U0, D6RIB4, H8Y0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.