Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BRQ5 (ORAI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene names
Name:ORAI3
Synonyms:TMEM142C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import By similarity.

Subunit structure

Interacts with EFCAB4B/CRACR2A. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Orai family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Protein orai-3
PRO_0000234395

Regions

Transmembrane63 – 8220Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9BRQ5 [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: DC44C8AE7EEF238D

FASTA29531,499
        10         20         30         40         50         60 
MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS WRRLYLSRAK 

        70         80         90        100        110        120 
LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA CTTVLVAVHL FALMVSTCLL 

       130        140        150        160        170        180 
PHIEAVSNIH NLNSVHQSPH QRLHRYVELA WGFSTALGTF LFLAEVVLVG WVKFVPIGAP 

       190        200        210        220        230        240 
LDTPTPMVPT SRVPGTLAPV ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP 

       250        260        270        280        290 
GWQAAMASTA IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Uterus.
[2]"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EFCAB4B.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC006126 mRNA. Translation: AAH06126.2.
BC015555 mRNA. Translation: AAH15555.1.
BC022786 mRNA. Translation: AAH22786.1.
CCDSCCDS10697.1.
RefSeqNP_689501.1. NM_152288.2.
UniGeneHs.745104.

3D structure databases

ProteinModelPortalQ9BRQ5.
SMRQ9BRQ5. Positions 49-174, 243-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125004. 1 interaction.
DIPDIP-48945N.
IntActQ9BRQ5. 1 interaction.
STRING9606.ENSP00000322249.

Chemistry

ChEMBLCHEMBL3038476.

Protein family/group databases

TCDB1.A.52.1.2. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

PTM databases

PhosphoSiteQ9BRQ5.

Polymorphism databases

DMDM74732916.

Proteomic databases

PaxDbQ9BRQ5.
PRIDEQ9BRQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318663; ENSP00000322249; ENSG00000175938.
GeneID93129.
KEGGhsa:93129.
UCSCuc002eac.3. human.

Organism-specific databases

CTD93129.
GeneCardsGC16P030960.
HGNCHGNC:28185. ORAI3.
HPAHPA015022.
MIM610930. gene.
neXtProtNX_Q9BRQ5.
PharmGKBPA162398465.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263788.
HOGENOMHOG000246925.
HOVERGENHBG081343.
InParanoidQ9BRQ5.
KOK16058.
OMAEPSEACP.
OrthoDBEOG7G1V73.
PhylomeDBQ9BRQ5.
TreeFamTF313576.

Gene expression databases

BgeeQ9BRQ5.
CleanExHS_ORAI3.
GenevestigatorQ9BRQ5.

Family and domain databases

InterProIPR012446. CRAC_channel.
[Graphical view]
PfamPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSORAI3. human.
GenomeRNAi93129.
NextBio77996.
PROQ9BRQ5.
SOURCESearch...

Entry information

Entry nameORAI3_HUMAN
AccessionPrimary (citable) accession number: Q9BRQ5
Secondary accession number(s): Q96BI8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM