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Protein

Protein orai-3

Gene

ORAI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi1.A.52.1.2. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:ORAI3
Synonyms:TMEM142C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28185. ORAI3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398465.

Polymorphism and mutation databases

BioMutaiORAI3.
DMDMi74732916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Protein orai-3PRO_0000234395Add
BLAST

Proteomic databases

PaxDbiQ9BRQ5.
PRIDEiQ9BRQ5.

PTM databases

PhosphoSiteiQ9BRQ5.

Expressioni

Gene expression databases

BgeeiQ9BRQ5.
CleanExiHS_ORAI3.
ExpressionAtlasiQ9BRQ5. baseline.
GenevisibleiQ9BRQ5. HS.

Organism-specific databases

HPAiHPA015022.

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ORAI1Q96D313EBI-4279484,EBI-2291476

Protein-protein interaction databases

DIPiDIP-48945N.
IntActiQ9BRQ5. 2 interactions.
STRINGi9606.ENSP00000322249.

Structurei

3D structure databases

ProteinModelPortaliQ9BRQ5.
SMRiQ9BRQ5. Positions 49-174, 243-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ9BRQ5.
KOiK16058.
OMAiEPSEACP.
OrthoDBiEOG7G1V73.
PhylomeDBiQ9BRQ5.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF6. PTHR31501:SF6. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP LDTPTPMVPT SRVPGTLAPV
210 220 230 240 250
ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP GWQAAMASTA
260 270 280 290
IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAV
Length:295
Mass (Da):31,499
Last modified:June 1, 2002 - v2
Checksum:iDC44C8AE7EEF238D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006126 mRNA. Translation: AAH06126.2.
BC015555 mRNA. Translation: AAH15555.1.
BC022786 mRNA. Translation: AAH22786.1.
CCDSiCCDS10697.1.
RefSeqiNP_689501.1. NM_152288.2.
UniGeneiHs.745104.

Genome annotation databases

EnsembliENST00000318663; ENSP00000322249; ENSG00000175938.
GeneIDi93129.
KEGGihsa:93129.
UCSCiuc002eac.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006126 mRNA. Translation: AAH06126.2.
BC015555 mRNA. Translation: AAH15555.1.
BC022786 mRNA. Translation: AAH22786.1.
CCDSiCCDS10697.1.
RefSeqiNP_689501.1. NM_152288.2.
UniGeneiHs.745104.

3D structure databases

ProteinModelPortaliQ9BRQ5.
SMRiQ9BRQ5. Positions 49-174, 243-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48945N.
IntActiQ9BRQ5. 2 interactions.
STRINGi9606.ENSP00000322249.

Chemistry

ChEMBLiCHEMBL3038476.

Protein family/group databases

TCDBi1.A.52.1.2. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

PTM databases

PhosphoSiteiQ9BRQ5.

Polymorphism and mutation databases

BioMutaiORAI3.
DMDMi74732916.

Proteomic databases

PaxDbiQ9BRQ5.
PRIDEiQ9BRQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318663; ENSP00000322249; ENSG00000175938.
GeneIDi93129.
KEGGihsa:93129.
UCSCiuc002eac.3. human.

Organism-specific databases

CTDi93129.
GeneCardsiGC16P030960.
HGNCiHGNC:28185. ORAI3.
HPAiHPA015022.
MIMi610930. gene.
neXtProtiNX_Q9BRQ5.
PharmGKBiPA162398465.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ9BRQ5.
KOiK16058.
OMAiEPSEACP.
OrthoDBiEOG7G1V73.
PhylomeDBiQ9BRQ5.
TreeFamiTF313576.

Miscellaneous databases

ChiTaRSiORAI3. human.
GenomeRNAii93129.
NextBioi77996.
PROiQ9BRQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRQ5.
CleanExiHS_ORAI3.
ExpressionAtlasiQ9BRQ5. baseline.
GenevisibleiQ9BRQ5. HS.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF6. PTHR31501:SF6. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  2. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
    Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
    Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
    Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
    Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRACR2A.

Entry informationi

Entry nameiORAI3_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ5
Secondary accession number(s): Q96BI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.