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Protein

Protein orai-3

Gene

ORAI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

TCDBi1.A.52.1.2 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:ORAI3
Synonyms:TMEM142C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000175938.6
HGNCiHGNC:28185 ORAI3
MIMi610930 gene
neXtProtiNX_Q9BRQ5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi93129
OpenTargetsiENSG00000175938
PharmGKBiPA162398465

Chemistry databases

ChEMBLiCHEMBL3038476

Polymorphism and mutation databases

BioMutaiORAI3
DMDMi74732916

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343951 – 295Protein orai-3Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BRQ5
PeptideAtlasiQ9BRQ5
PRIDEiQ9BRQ5

PTM databases

iPTMnetiQ9BRQ5
PhosphoSitePlusiQ9BRQ5

Expressioni

Gene expression databases

BgeeiENSG00000175938
CleanExiHS_ORAI3
ExpressionAtlasiQ9BRQ5 baseline and differential
GenevisibleiQ9BRQ5 HS

Organism-specific databases

HPAiHPA015022

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ORAI1Q96D314EBI-4279484,EBI-2291476

Protein-protein interaction databases

DIPiDIP-48945N
IntActiQ9BRQ5, 4 interactors
STRINGi9606.ENSP00000322249

Structurei

3D structure databases

ProteinModelPortaliQ9BRQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ9BRQ5
KOiK16058
OMAiMASTVIM
OrthoDBiEOG091G0E4P
PhylomeDBiQ9BRQ5
TreeFamiTF313576

Family and domain databases

Gene3Di1.20.140.140, 2 hits
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030032 Orai-3
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF6 PTHR31501:SF6, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BRQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP LDTPTPMVPT SRVPGTLAPV
210 220 230 240 250
ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP GWQAAMASTA
260 270 280 290
IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAV
Length:295
Mass (Da):31,499
Last modified:June 1, 2002 - v2
Checksum:iDC44C8AE7EEF238D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006126 mRNA Translation: AAH06126.2
BC015555 mRNA Translation: AAH15555.1
BC022786 mRNA Translation: AAH22786.1
CCDSiCCDS10697.1
RefSeqiNP_689501.1, NM_152288.2
UniGeneiHs.745104

Genome annotation databases

EnsembliENST00000318663; ENSP00000322249; ENSG00000175938
GeneIDi93129
KEGGihsa:93129
UCSCiuc002eac.4 human

Similar proteinsi

Entry informationi

Entry nameiORAI3_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ5
Secondary accession number(s): Q96BI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health