Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BRQ5

- ORAI3_HUMAN

UniProt

Q9BRQ5 - ORAI3_HUMAN

Protein

Protein orai-3

Gene

ORAI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Protein family/group databases

    TCDBi1.A.52.1.2. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein orai-3
    Alternative name(s):
    Transmembrane protein 142C
    Gene namesi
    Name:ORAI3
    Synonyms:TMEM142C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28185. ORAI3.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162398465.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Protein orai-3PRO_0000234395Add
    BLAST

    Proteomic databases

    PaxDbiQ9BRQ5.
    PRIDEiQ9BRQ5.

    PTM databases

    PhosphoSiteiQ9BRQ5.

    Expressioni

    Gene expression databases

    BgeeiQ9BRQ5.
    CleanExiHS_ORAI3.
    GenevestigatoriQ9BRQ5.

    Organism-specific databases

    HPAiHPA015022.

    Interactioni

    Subunit structurei

    Interacts with CRACR2A/EFCAB4B.1 Publication

    Protein-protein interaction databases

    BioGridi125004. 1 interaction.
    DIPiDIP-48945N.
    IntActiQ9BRQ5. 1 interaction.
    STRINGi9606.ENSP00000322249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRQ5.
    SMRiQ9BRQ5. Positions 49-174, 243-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Orai family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263788.
    HOGENOMiHOG000246925.
    HOVERGENiHBG081343.
    InParanoidiQ9BRQ5.
    KOiK16058.
    OMAiEPSEACP.
    OrthoDBiEOG7G1V73.
    PhylomeDBiQ9BRQ5.
    TreeFamiTF313576.

    Family and domain databases

    InterProiIPR012446. CRAC_channel.
    [Graphical view]
    PfamiPF07856. Orai-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BRQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS    50
    WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA 100
    CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA 150
    WGFSTALGTF LFLAEVVLVG WVKFVPIGAP LDTPTPMVPT SRVPGTLAPV 200
    ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP GWQAAMASTA 250
    IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAV 295
    Length:295
    Mass (Da):31,499
    Last modified:June 1, 2002 - v2
    Checksum:iDC44C8AE7EEF238D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC006126 mRNA. Translation: AAH06126.2.
    BC015555 mRNA. Translation: AAH15555.1.
    BC022786 mRNA. Translation: AAH22786.1.
    CCDSiCCDS10697.1.
    RefSeqiNP_689501.1. NM_152288.2.
    UniGeneiHs.745104.

    Genome annotation databases

    EnsembliENST00000318663; ENSP00000322249; ENSG00000175938.
    GeneIDi93129.
    KEGGihsa:93129.
    UCSCiuc002eac.3. human.

    Polymorphism databases

    DMDMi74732916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC006126 mRNA. Translation: AAH06126.2 .
    BC015555 mRNA. Translation: AAH15555.1 .
    BC022786 mRNA. Translation: AAH22786.1 .
    CCDSi CCDS10697.1.
    RefSeqi NP_689501.1. NM_152288.2.
    UniGenei Hs.745104.

    3D structure databases

    ProteinModelPortali Q9BRQ5.
    SMRi Q9BRQ5. Positions 49-174, 243-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125004. 1 interaction.
    DIPi DIP-48945N.
    IntActi Q9BRQ5. 1 interaction.
    STRINGi 9606.ENSP00000322249.

    Chemistry

    ChEMBLi CHEMBL3038476.

    Protein family/group databases

    TCDBi 1.A.52.1.2. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    PTM databases

    PhosphoSitei Q9BRQ5.

    Polymorphism databases

    DMDMi 74732916.

    Proteomic databases

    PaxDbi Q9BRQ5.
    PRIDEi Q9BRQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318663 ; ENSP00000322249 ; ENSG00000175938 .
    GeneIDi 93129.
    KEGGi hsa:93129.
    UCSCi uc002eac.3. human.

    Organism-specific databases

    CTDi 93129.
    GeneCardsi GC16P030960.
    HGNCi HGNC:28185. ORAI3.
    HPAi HPA015022.
    MIMi 610930. gene.
    neXtProti NX_Q9BRQ5.
    PharmGKBi PA162398465.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263788.
    HOGENOMi HOG000246925.
    HOVERGENi HBG081343.
    InParanoidi Q9BRQ5.
    KOi K16058.
    OMAi EPSEACP.
    OrthoDBi EOG7G1V73.
    PhylomeDBi Q9BRQ5.
    TreeFami TF313576.

    Miscellaneous databases

    ChiTaRSi ORAI3. human.
    GenomeRNAii 93129.
    NextBioi 77996.
    PROi Q9BRQ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BRQ5.
    CleanExi HS_ORAI3.
    Genevestigatori Q9BRQ5.

    Family and domain databases

    InterProi IPR012446. CRAC_channel.
    [Graphical view ]
    Pfami PF07856. Orai-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    2. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
      Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
      Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
      Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
      Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRACR2A.

    Entry informationi

    Entry nameiORAI3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRQ5
    Secondary accession number(s): Q96BI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3