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Protein

Nucleoside diphosphate-linked moiety X motif 22

Gene

NUDT22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 22
Short name:
Nudix motif 22
Gene namesi
Name:NUDT22
ORF Names:PP11246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149761.8.
HGNCiHGNC:28189. NUDT22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149761.
PharmGKBiPA142671240.

Polymorphism and mutation databases

DMDMi317373407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637311 – 303Nucleoside diphosphate-linked moiety X motif 22Add BLAST303

Proteomic databases

MaxQBiQ9BRQ3.
PaxDbiQ9BRQ3.
PeptideAtlasiQ9BRQ3.
PRIDEiQ9BRQ3.

PTM databases

iPTMnetiQ9BRQ3.
PhosphoSitePlusiQ9BRQ3.

Expressioni

Gene expression databases

BgeeiENSG00000149761.
CleanExiHS_NUDT22.
ExpressionAtlasiQ9BRQ3. baseline and differential.
GenevisibleiQ9BRQ3. HS.

Organism-specific databases

HPAiHPA039334.
HPA053464.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-10297093,EBI-717810

Protein-protein interaction databases

BioGridi124030. 2 interactors.
IntActiQ9BRQ3. 19 interactors.
STRINGi9606.ENSP00000279206.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi18 – 20Combined sources3
Beta strandi21 – 25Combined sources5
Helixi27 – 29Combined sources3
Helixi39 – 51Combined sources13
Beta strandi59 – 68Combined sources10
Beta strandi77 – 86Combined sources10
Helixi87 – 92Combined sources6
Turni93 – 95Combined sources3
Helixi99 – 110Combined sources12
Turni113 – 116Combined sources4
Beta strandi122 – 128Combined sources7
Beta strandi132 – 138Combined sources7
Beta strandi143 – 146Combined sources4
Beta strandi153 – 155Combined sources3
Helixi159 – 161Combined sources3
Beta strandi165 – 167Combined sources3
Helixi170 – 172Combined sources3
Helixi174 – 193Combined sources20
Helixi198 – 200Combined sources3
Beta strandi205 – 212Combined sources8
Helixi213 – 215Combined sources3
Beta strandi219 – 229Combined sources11
Helixi231 – 239Combined sources9
Helixi243 – 245Combined sources3
Beta strandi247 – 255Combined sources9
Helixi256 – 259Combined sources4
Helixi262 – 264Combined sources3
Helixi268 – 270Combined sources3
Helixi273 – 285Combined sources13
Helixi293 – 295Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LF9X-ray1.45A1-303[»]
5LORX-ray2.19A/B1-303[»]
5LOUX-ray1.80A/B1-303[»]
ProteinModelPortaliQ9BRQ3.
SMRiQ9BRQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 285Nudix hydrolasePROSITE-ProRule annotationAdd BLAST168

Domaini

Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IENM. Eukaryota.
ENOG410YWU8. LUCA.
GeneTreeiENSGT00390000017869.
HOGENOMiHOG000241166.
HOVERGENiHBG059597.
InParanoidiQ9BRQ3.
OMAiGHPEPQA.
OrthoDBiEOG091G0R1B.
PhylomeDBiQ9BRQ3.
TreeFamiTF106357.

Family and domain databases

InterProiView protein in InterPro
IPR000086. NUDIX_hydrolase_dom.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPEVTLLLQ CPGGGLPQEQ IQAELSPAHD RRPLPGGDEA ITAIWETRLK
60 70 80 90 100
AQPWLFDAPK FRLHSATLAP IGSRGPQLLL RLGLTSYRDF LGTNWSSSAA
110 120 130 140 150
WLRQQGATDW GDTQAYLADP LGVGAALATA DDFLVFLRRS RQVAEAPGLV
160 170 180 190 200
DVPGGHPEPQ ALCPGGSPQH QDLAGQLVVH ELFSSVLQEI CDEVNLPLLT
210 220 230 240 250
LSQPLLLGIA RNETSAGRAS AEFYVQCSLT SEQVRKHYLS GGPEAHESTG
260 270 280 290 300
IFFVETQNVQ RLLETEMWAE LCPSAKGAII LYNRVQGSPT GAALGSPALL

PPL
Length:303
Mass (Da):32,580
Last modified:January 11, 2011 - v3
Checksum:iC26958E8BB90B02F
GO
Isoform 2 (identifier: Q9BRQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-303: ALCPGGSPQH...LGSPALLPPL → VRFQAGHKDP...LLRAVHLPPH

Show »
Length:213
Mass (Da):23,116
Checksum:iD560BB85585CCAF8
GO
Isoform 3 (identifier: Q9BRQ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-193: QALCPGGSPQHQDLAGQLVVHELFSSVLQEICDE → Q

Note: No experimental confirmation.
Show »
Length:270
Mass (Da):29,077
Checksum:iFDC501D9C6EB0B7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → V in AAQ15238 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02961636G → C. Corresponds to variant dbSNP:rs2286612Ensembl.1
Natural variantiVAR_050414129T → R. Corresponds to variant dbSNP:rs34448455Ensembl.1
Natural variantiVAR_029617260Q → R1 PublicationCorresponds to variant dbSNP:rs633561Ensembl.1
Natural variantiVAR_029618263L → P1 PublicationCorresponds to variant dbSNP:rs633557Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053790160 – 193QALCP…EICDE → Q in isoform 3. CuratedAdd BLAST34
Alternative sequenceiVSP_021884161 – 303ALCPG…LLPPL → VRFQAGHKDPDSSRELQLST LPILPALVSPSLKGKLAWYF SGSLLRAVHLPPH in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370402 mRNA. Translation: AAQ15238.1.
AP001453 Genomic DNA. No translation available.
AP006334 Genomic DNA. No translation available.
BC006129 mRNA. Translation: AAH06129.1.
CCDSiCCDS44640.1. [Q9BRQ3-3]
CCDS8061.1. [Q9BRQ3-1]
RefSeqiNP_001122084.1. NM_001128612.2.
NP_001122085.1. NM_001128613.2.
NP_001258760.1. NM_001271831.1.
NP_115720.1. NM_032344.3.
UniGeneiHs.656074.
Hs.744098.

Genome annotation databases

EnsembliENST00000279206; ENSP00000279206; ENSG00000149761. [Q9BRQ3-1]
ENST00000441250; ENSP00000407970; ENSG00000149761. [Q9BRQ3-3]
GeneIDi84304.
KEGGihsa:84304.
UCSCiuc001nyp.6. human. [Q9BRQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUD22_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ3
Secondary accession number(s): C9JY06, Q71RD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: November 22, 2017
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families