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Protein

Nucleoside diphosphate-linked moiety X motif 22

Gene

NUDT22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 22
Short name:
Nudix motif 22
Gene namesi
Name:NUDT22
ORF Names:PP11246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28189. NUDT22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671240.

Polymorphism and mutation databases

DMDMi317373407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Nucleoside diphosphate-linked moiety X motif 22PRO_0000263731Add
BLAST

Proteomic databases

MaxQBiQ9BRQ3.
PaxDbiQ9BRQ3.
PRIDEiQ9BRQ3.

PTM databases

iPTMnetiQ9BRQ3.
PhosphoSiteiQ9BRQ3.

Expressioni

Gene expression databases

BgeeiQ9BRQ3.
CleanExiHS_NUDT22.
ExpressionAtlasiQ9BRQ3. baseline and differential.
GenevisibleiQ9BRQ3. HS.

Organism-specific databases

HPAiHPA039334.
HPA053464.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-10297093,EBI-717810

Protein-protein interaction databases

BioGridi124030. 2 interactions.
IntActiQ9BRQ3. 1 interaction.
STRINGi9606.ENSP00000279206.

Structurei

3D structure databases

ProteinModelPortaliQ9BRQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 285168Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Domaini

Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IENM. Eukaryota.
ENOG410YWU8. LUCA.
GeneTreeiENSGT00390000017869.
HOGENOMiHOG000241166.
HOVERGENiHBG059597.
InParanoidiQ9BRQ3.
PhylomeDBiQ9BRQ3.
TreeFamiTF106357.

Family and domain databases

InterProiIPR000086. NUDIX_hydrolase_dom.
[Graphical view]
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPEVTLLLQ CPGGGLPQEQ IQAELSPAHD RRPLPGGDEA ITAIWETRLK
60 70 80 90 100
AQPWLFDAPK FRLHSATLAP IGSRGPQLLL RLGLTSYRDF LGTNWSSSAA
110 120 130 140 150
WLRQQGATDW GDTQAYLADP LGVGAALATA DDFLVFLRRS RQVAEAPGLV
160 170 180 190 200
DVPGGHPEPQ ALCPGGSPQH QDLAGQLVVH ELFSSVLQEI CDEVNLPLLT
210 220 230 240 250
LSQPLLLGIA RNETSAGRAS AEFYVQCSLT SEQVRKHYLS GGPEAHESTG
260 270 280 290 300
IFFVETQNVQ RLLETEMWAE LCPSAKGAII LYNRVQGSPT GAALGSPALL

PPL
Length:303
Mass (Da):32,580
Last modified:January 11, 2011 - v3
Checksum:iC26958E8BB90B02F
GO
Isoform 2 (identifier: Q9BRQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-303: ALCPGGSPQH...LGSPALLPPL → VRFQAGHKDP...LLRAVHLPPH

Show »
Length:213
Mass (Da):23,116
Checksum:iD560BB85585CCAF8
GO
Isoform 3 (identifier: Q9BRQ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-193: QALCPGGSPQHQDLAGQLVVHELFSSVLQEICDE → Q

Note: No experimental confirmation.
Show »
Length:270
Mass (Da):29,077
Checksum:iFDC501D9C6EB0B7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → V in AAQ15238 (PubMed:15498874).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361G → C.
Corresponds to variant rs2286612 [ dbSNP | Ensembl ].
VAR_029616
Natural varianti129 – 1291T → R.
Corresponds to variant rs34448455 [ dbSNP | Ensembl ].
VAR_050414
Natural varianti260 – 2601Q → R.1 Publication
Corresponds to variant rs633561 [ dbSNP | Ensembl ].
VAR_029617
Natural varianti263 – 2631L → P.1 Publication
Corresponds to variant rs633557 [ dbSNP | Ensembl ].
VAR_029618

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 19334QALCP…EICDE → Q in isoform 3. CuratedVSP_053790Add
BLAST
Alternative sequencei161 – 303143ALCPG…LLPPL → VRFQAGHKDPDSSRELQLST LPILPALVSPSLKGKLAWYF SGSLLRAVHLPPH in isoform 2. 1 PublicationVSP_021884Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370402 mRNA. Translation: AAQ15238.1.
AP001453 Genomic DNA. No translation available.
AP006334 Genomic DNA. No translation available.
BC006129 mRNA. Translation: AAH06129.1.
CCDSiCCDS44640.1. [Q9BRQ3-3]
CCDS8061.1. [Q9BRQ3-1]
RefSeqiNP_001122084.1. NM_001128612.2.
NP_001122085.1. NM_001128613.2.
NP_001258760.1. NM_001271831.1.
NP_115720.1. NM_032344.3.
UniGeneiHs.656074.
Hs.744098.

Genome annotation databases

EnsembliENST00000279206; ENSP00000279206; ENSG00000149761. [Q9BRQ3-1]
ENST00000441250; ENSP00000407970; ENSG00000149761. [Q9BRQ3-3]
GeneIDi84304.
KEGGihsa:84304.
UCSCiuc001nyp.6. human. [Q9BRQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370402 mRNA. Translation: AAQ15238.1.
AP001453 Genomic DNA. No translation available.
AP006334 Genomic DNA. No translation available.
BC006129 mRNA. Translation: AAH06129.1.
CCDSiCCDS44640.1. [Q9BRQ3-3]
CCDS8061.1. [Q9BRQ3-1]
RefSeqiNP_001122084.1. NM_001128612.2.
NP_001122085.1. NM_001128613.2.
NP_001258760.1. NM_001271831.1.
NP_115720.1. NM_032344.3.
UniGeneiHs.656074.
Hs.744098.

3D structure databases

ProteinModelPortaliQ9BRQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124030. 2 interactions.
IntActiQ9BRQ3. 1 interaction.
STRINGi9606.ENSP00000279206.

PTM databases

iPTMnetiQ9BRQ3.
PhosphoSiteiQ9BRQ3.

Polymorphism and mutation databases

DMDMi317373407.

Proteomic databases

MaxQBiQ9BRQ3.
PaxDbiQ9BRQ3.
PRIDEiQ9BRQ3.

Protocols and materials databases

DNASUi84304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279206; ENSP00000279206; ENSG00000149761. [Q9BRQ3-1]
ENST00000441250; ENSP00000407970; ENSG00000149761. [Q9BRQ3-3]
GeneIDi84304.
KEGGihsa:84304.
UCSCiuc001nyp.6. human. [Q9BRQ3-1]

Organism-specific databases

CTDi84304.
GeneCardsiNUDT22.
HGNCiHGNC:28189. NUDT22.
HPAiHPA039334.
HPA053464.
neXtProtiNX_Q9BRQ3.
PharmGKBiPA142671240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENM. Eukaryota.
ENOG410YWU8. LUCA.
GeneTreeiENSGT00390000017869.
HOGENOMiHOG000241166.
HOVERGENiHBG059597.
InParanoidiQ9BRQ3.
PhylomeDBiQ9BRQ3.
TreeFamiTF106357.

Miscellaneous databases

ChiTaRSiNUDT22. human.
GenomeRNAii84304.
NextBioi35488253.
PROiQ9BRQ3.

Gene expression databases

BgeeiQ9BRQ3.
CleanExiHS_NUDT22.
ExpressionAtlasiQ9BRQ3. baseline and differential.
GenevisibleiQ9BRQ3. HS.

Family and domain databases

InterProiIPR000086. NUDIX_hydrolase_dom.
[Graphical view]
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-260 AND PRO-263.
    Tissue: Uterus.

Entry informationi

Entry nameiNUD22_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ3
Secondary accession number(s): C9JY06, Q71RD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: March 16, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.