Pygopus homolog 2 - Homo sapiens (Human)

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Q9BRQ0 (PYGO2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Pygopus homolog 2

Gene names

Name:	PYGO2
ORF Names:	PP7910

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in signal transduction through the Wnt pathway.
Subunit structure	Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 PHD-type zinc finger.
Sequence caution	The sequence AAL55782.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara developmental growth Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara lens development in camera-type eye Inferred from electronic annotation. Source: Compara mammary gland development Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara post-embryonic development Inferred from electronic annotation. Source: Compara regulation of histone H3-K4 methylation Inferred from electronic annotation. Source: Compara regulation of mammary gland epithelial cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 406

406

Pygopus homolog 2

PRO_0000097123

Regions

Zinc finger

327 – 385

PHD-type

Motif

41 – 47

Nuclear localization signal Potential

Compositional bias

6 – 329

324

Pro-rich

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

302

Phosphothreonine Ref.4 Ref.5

Experimental info

Sequence conflict

157

P → Q in AAL55782. Ref.3

Sequence conflict

170

P → L in AAL55782. Ref.3

Secondary structure

406

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9BRQ0 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: CA002A5447767CD9
Show »

FASTA

406

41,244

        10         20         30         40         50         60 
MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT QGPAYSHLTE 

        70         80         90        100        110        120 
FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP FGGFRVQGGM AGQVPPGYST 

       130        140        150        160        170        180 
GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG 

       190        200        210        220        230        240 
QMMPGPVGGF GPMISPTMGQ PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN 

       250        260        270        280        290        300 
TSPFPGPDPG FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG 

       310        320        330        340        350        360 
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC QKWFHRECTG 

       370        380        390        400 
MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL VAANDG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex." Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Zuellig S., Basler K. Cell 109:47-60(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-406.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF457208 mRNA. Translation: AAL91371.1.
BC006132 mRNA. Translation: AAH06132.2.
BC013725 mRNA. Translation: AAH13725.1.
BC032099 mRNA. Translation: AAH32099.1.
AF289598 mRNA. Translation: AAL55782.1. Sequence problems.

IPI

IPI00042099.

RefSeq

NP_612157.1. NM_138300.3.

UniGene

Hs.533597.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XB1	X-ray	1.90	A/C	325-387	[»]

ProteinModelPortal

Q9BRQ0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BRQ0. 2 interactions.

STRING

9606.ENSP00000357442.

PTM databases

PhosphoSite

Q9BRQ0.

Polymorphism databases

DMDM

23396825.

Proteomic databases

PaxDb

Q9BRQ0.

PRIDE

Q9BRQ0.

Protocols and materials databases

DNASU

90780.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000368457; ENSP00000357442; ENSG00000163348.

GeneID

90780.

KEGG

hsa:90780.

UCSC

uc001fft.3. human.

Organism-specific databases

CTD

90780.

GeneCards

GC01M154929.

HGNC

HGNC:30257. PYGO2.

HPA

HPA023689.

MIM

606903. gene.

neXtProt

NX_Q9BRQ0.

PharmGKB

PA134881185.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG72798.

HOGENOM

HOG000001580.

HOVERGEN

HBG053774.

InParanoid

Q9BRQ0.

OMA

PGLVYPC.

OrthoDB

EOG4QZ7MB.

PhylomeDB

Q9BRQ0.

Gene expression databases

ArrayExpress

Q9BRQ0.

Bgee

Q9BRQ0.

CleanEx

HS_PYGO2.

Genevestigator

Q9BRQ0.

GermOnline

ENSG00000163348. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00628. PHD. 1 hit.
[Graphical view]

SMART

SM00249. PHD. 1 hit.
[Graphical view]

SUPFAM

SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

90780.

NextBio

76956.

SOURCE

Search...

Entry information

Entry name

PYGO2_HUMAN

Accession

Primary (citable) accession number: Q9BRQ0
Secondary accession number(s): Q8WYZ4, Q96CY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	September 19, 2002
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents