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Q9BRQ0

- PYGO2_HUMAN

UniProt

Q9BRQ0 - PYGO2_HUMAN

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Protein
Pygopus homolog 2
Gene
PYGO2, PP7910
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri327 – 38559PHD-type
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. canonical Wnt signaling pathway Source: Ensembl
  3. developmental growth Source: Ensembl
  4. in utero embryonic development Source: Ensembl
  5. kidney development Source: Ensembl
  6. lens development in camera-type eye Source: Ensembl
  7. mammary gland development Source: Ensembl
  8. palate development Source: Ensembl
  9. post-embryonic development Source: Ensembl
  10. regulation of histone H3-K4 methylation Source: Ensembl
  11. regulation of mammary gland epithelial cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200753. formation of the beta-catenin:TCF transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 2
Gene namesi
Name:PYGO2
ORF Names:PP7910
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30257. PYGO2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 406405Pygopus homolog 2
PRO_0000097123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei40 – 401Phosphoserine1 Publication
Modified residuei302 – 3021Phosphothreonine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BRQ0.
PaxDbiQ9BRQ0.
PRIDEiQ9BRQ0.

PTM databases

PhosphoSiteiQ9BRQ0.

Expressioni

Gene expression databases

ArrayExpressiQ9BRQ0.
BgeeiQ9BRQ0.
CleanExiHS_PYGO2.
GenevestigatoriQ9BRQ0.

Organism-specific databases

HPAiHPA023689.

Interactioni

Subunit structurei

Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL9O005122EBI-932471,EBI-533127

Protein-protein interaction databases

BioGridi124760. 13 interactions.
IntActiQ9BRQ0. 3 interactions.
MINTiMINT-8177751.
STRINGi9606.ENSP00000357442.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni331 – 3333
Beta strandi343 – 3453
Turni347 – 3504
Beta strandi353 – 3553
Helixi356 – 3583
Helixi363 – 3719
Beta strandi375 – 3773
Helixi380 – 3845
Turni385 – 3873

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C325-387[»]
ProteinModelPortaliQ9BRQ0.
SMRiQ9BRQ0. Positions 325-393.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 477Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 329324Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72798.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9BRQ0.
OMAiPGLVYPC.
OrthoDBiEOG79W952.
PhylomeDBiQ9BRQ0.
TreeFamiTF333020.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRQ0-1 [UniParc]FASTAAdd to Basket

« Hide

MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT    50
QGPAYSHLTE FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP 100
FGGFRVQGGM AGQVPPGYST GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ 150
GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG QMMPGPVGGF GPMISPTMGQ 200
PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN TSPFPGPDPG 250
FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG 300
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC 350
QKWFHRECTG MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL 400
VAANDG 406
Length:406
Mass (Da):41,244
Last modified:September 19, 2002 - v2
Checksum:iCA002A5447767CD9
GO

Sequence cautioni

The sequence AAL55782.1 differs from that shown. Reason: Sequencing errors.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571P → Q in AAL55782. 1 Publication
Sequence conflicti170 – 1701P → L in AAL55782. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF457208 mRNA. Translation: AAL91371.1.
BC006132 mRNA. Translation: AAH06132.2.
BC013725 mRNA. Translation: AAH13725.1.
BC032099 mRNA. Translation: AAH32099.1.
AF289598 mRNA. Translation: AAL55782.1. Sequence problems.
CCDSiCCDS1075.1.
RefSeqiNP_612157.1. NM_138300.3.
UniGeneiHs.533597.

Genome annotation databases

EnsembliENST00000368457; ENSP00000357442; ENSG00000163348.
GeneIDi90780.
KEGGihsa:90780.
UCSCiuc001fft.3. human.

Polymorphism databases

DMDMi23396825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF457208 mRNA. Translation: AAL91371.1 .
BC006132 mRNA. Translation: AAH06132.2 .
BC013725 mRNA. Translation: AAH13725.1 .
BC032099 mRNA. Translation: AAH32099.1 .
AF289598 mRNA. Translation: AAL55782.1 . Sequence problems.
CCDSi CCDS1075.1.
RefSeqi NP_612157.1. NM_138300.3.
UniGenei Hs.533597.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XB1 X-ray 1.90 A/C 325-387 [» ]
ProteinModelPortali Q9BRQ0.
SMRi Q9BRQ0. Positions 325-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124760. 13 interactions.
IntActi Q9BRQ0. 3 interactions.
MINTi MINT-8177751.
STRINGi 9606.ENSP00000357442.

PTM databases

PhosphoSitei Q9BRQ0.

Polymorphism databases

DMDMi 23396825.

Proteomic databases

MaxQBi Q9BRQ0.
PaxDbi Q9BRQ0.
PRIDEi Q9BRQ0.

Protocols and materials databases

DNASUi 90780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368457 ; ENSP00000357442 ; ENSG00000163348 .
GeneIDi 90780.
KEGGi hsa:90780.
UCSCi uc001fft.3. human.

Organism-specific databases

CTDi 90780.
GeneCardsi GC01M154929.
HGNCi HGNC:30257. PYGO2.
HPAi HPA023689.
MIMi 606903. gene.
neXtProti NX_Q9BRQ0.
PharmGKBi PA134881185.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72798.
HOGENOMi HOG000001580.
HOVERGENi HBG053774.
InParanoidi Q9BRQ0.
OMAi PGLVYPC.
OrthoDBi EOG79W952.
PhylomeDBi Q9BRQ0.
TreeFami TF333020.

Enzyme and pathway databases

Reactomei REACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200753. formation of the beta-catenin:TCF transactivating complex.

Miscellaneous databases

GeneWikii PYGO2.
GenomeRNAii 90780.
NextBioi 76956.
PROi Q9BRQ0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BRQ0.
Bgeei Q9BRQ0.
CleanExi HS_PYGO2.
Genevestigatori Q9BRQ0.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex."
    Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Zuellig S., Basler K.
    Cell 109:47-60(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-406.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPYGO2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ0
Secondary accession number(s): Q8WYZ4, Q96CY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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