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Protein

Pygopus homolog 2

Gene

PYGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 385PHD-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163348-MONOMER.
ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 2
Gene namesi
Name:PYGO2
ORF Names:PP7910
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30257. PYGO2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90780.
OpenTargetsiENSG00000163348.
PharmGKBiPA134881185.

Polymorphism and mutation databases

BioMutaiPYGO2.
DMDMi23396825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000971232 – 406Pygopus homolog 2Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei302PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRQ0.
MaxQBiQ9BRQ0.
PaxDbiQ9BRQ0.
PeptideAtlasiQ9BRQ0.
PRIDEiQ9BRQ0.

PTM databases

iPTMnetiQ9BRQ0.
PhosphoSitePlusiQ9BRQ0.

Expressioni

Gene expression databases

BgeeiENSG00000163348.
CleanExiHS_PYGO2.
ExpressionAtlasiQ9BRQ0. baseline and differential.
GenevisibleiQ9BRQ0. HS.

Organism-specific databases

HPAiHPA023689.

Interactioni

Subunit structurei

Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL9O005122EBI-932471,EBI-533127

Protein-protein interaction databases

BioGridi124760. 21 interactors.
IntActiQ9BRQ0. 4 interactors.
MINTiMINT-8177751.
STRINGi9606.ENSP00000357442.

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni331 – 333Combined sources3
Beta strandi343 – 346Combined sources4
Turni347 – 350Combined sources4
Beta strandi353 – 355Combined sources3
Helixi356 – 358Combined sources3
Helixi363 – 371Combined sources9
Beta strandi375 – 377Combined sources3
Helixi380 – 384Combined sources5
Turni385 – 387Combined sources3
Beta strandi392 – 394Combined sources3
Helixi396 – 403Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C325-387[»]
4UP0X-ray1.28A327-387[»]
4UP5X-ray1.65A327-387[»]
ProteinModelPortaliQ9BRQ0.
SMRiQ9BRQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 47Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 329Pro-richAdd BLAST324

Sequence similaritiesi

Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 385PHD-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKQ3. Eukaryota.
ENOG41128HN. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9BRQ0.
OMAiNQQNNTP.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9BRQ0.
TreeFamiTF333020.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT
60 70 80 90 100
QGPAYSHLTE FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP
110 120 130 140 150
FGGFRVQGGM AGQVPPGYST GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ
160 170 180 190 200
GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG QMMPGPVGGF GPMISPTMGQ
210 220 230 240 250
PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN TSPFPGPDPG
260 270 280 290 300
FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG
310 320 330 340 350
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC
360 370 380 390 400
QKWFHRECTG MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL

VAANDG
Length:406
Mass (Da):41,244
Last modified:September 19, 2002 - v2
Checksum:iCA002A5447767CD9
GO

Sequence cautioni

The sequence AAL55782 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157P → Q in AAL55782 (PubMed:15498874).Curated1
Sequence conflicti170P → L in AAL55782 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457208 mRNA. Translation: AAL91371.1.
BC006132 mRNA. Translation: AAH06132.2.
BC013725 mRNA. Translation: AAH13725.1.
BC032099 mRNA. Translation: AAH32099.1.
AF289598 mRNA. Translation: AAL55782.1. Sequence problems.
CCDSiCCDS1075.1.
RefSeqiNP_612157.1. NM_138300.3.
UniGeneiHs.533597.

Genome annotation databases

EnsembliENST00000368457; ENSP00000357442; ENSG00000163348.
GeneIDi90780.
KEGGihsa:90780.
UCSCiuc001fft.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457208 mRNA. Translation: AAL91371.1.
BC006132 mRNA. Translation: AAH06132.2.
BC013725 mRNA. Translation: AAH13725.1.
BC032099 mRNA. Translation: AAH32099.1.
AF289598 mRNA. Translation: AAL55782.1. Sequence problems.
CCDSiCCDS1075.1.
RefSeqiNP_612157.1. NM_138300.3.
UniGeneiHs.533597.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C325-387[»]
4UP0X-ray1.28A327-387[»]
4UP5X-ray1.65A327-387[»]
ProteinModelPortaliQ9BRQ0.
SMRiQ9BRQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124760. 21 interactors.
IntActiQ9BRQ0. 4 interactors.
MINTiMINT-8177751.
STRINGi9606.ENSP00000357442.

PTM databases

iPTMnetiQ9BRQ0.
PhosphoSitePlusiQ9BRQ0.

Polymorphism and mutation databases

BioMutaiPYGO2.
DMDMi23396825.

Proteomic databases

EPDiQ9BRQ0.
MaxQBiQ9BRQ0.
PaxDbiQ9BRQ0.
PeptideAtlasiQ9BRQ0.
PRIDEiQ9BRQ0.

Protocols and materials databases

DNASUi90780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368457; ENSP00000357442; ENSG00000163348.
GeneIDi90780.
KEGGihsa:90780.
UCSCiuc001fft.4. human.

Organism-specific databases

CTDi90780.
DisGeNETi90780.
GeneCardsiPYGO2.
HGNCiHGNC:30257. PYGO2.
HPAiHPA023689.
MIMi606903. gene.
neXtProtiNX_Q9BRQ0.
OpenTargetsiENSG00000163348.
PharmGKBiPA134881185.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQ3. Eukaryota.
ENOG41128HN. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9BRQ0.
OMAiNQQNNTP.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9BRQ0.
TreeFamiTF333020.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163348-MONOMER.
ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

ChiTaRSiPYGO2. human.
GeneWikiiPYGO2.
GenomeRNAii90780.
PROiQ9BRQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163348.
CleanExiHS_PYGO2.
ExpressionAtlasiQ9BRQ0. baseline and differential.
GenevisibleiQ9BRQ0. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYGO2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ0
Secondary accession number(s): Q8WYZ4, Q96CY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.