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Q9BRQ0 (PYGO2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pygopus homolog 2
Gene names
Name:PYGO2
ORF Names:PP7910
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in signal transduction through the Wnt pathway.

Subunit structure

Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 PHD-type zinc finger.

Sequence caution

The sequence AAL55782.1 differs from that shown. Reason: Sequencing errors.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BCL9O005122EBI-932471,EBI-533127

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 406405Pygopus homolog 2
PRO_0000097123

Regions

Zinc finger327 – 38559PHD-type
Motif41 – 477Nuclear localization signal Potential
Compositional bias6 – 329324Pro-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.5
Modified residue401Phosphoserine Ref.7
Modified residue3021Phosphothreonine Ref.4 Ref.6

Experimental info

Sequence conflict1571P → Q in AAL55782. Ref.3
Sequence conflict1701P → L in AAL55782. Ref.3

Secondary structure

................. 406
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9BRQ0 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: CA002A5447767CD9

FASTA40641,244
        10         20         30         40         50         60 
MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT QGPAYSHLTE 

        70         80         90        100        110        120 
FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP FGGFRVQGGM AGQVPPGYST 

       130        140        150        160        170        180 
GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG 

       190        200        210        220        230        240 
QMMPGPVGGF GPMISPTMGQ PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN 

       250        260        270        280        290        300 
TSPFPGPDPG FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG 

       310        320        330        340        350        360 
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC QKWFHRECTG 

       370        380        390        400 
MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL VAANDG 

« Hide

References

« Hide 'large scale' references
[1]"Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex."
Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Zuellig S., Basler K.
Cell 109:47-60(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Ovary.
[3]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-406.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF457208 mRNA. Translation: AAL91371.1.
BC006132 mRNA. Translation: AAH06132.2.
BC013725 mRNA. Translation: AAH13725.1.
BC032099 mRNA. Translation: AAH32099.1.
AF289598 mRNA. Translation: AAL55782.1. Sequence problems.
CCDSCCDS1075.1.
RefSeqNP_612157.1. NM_138300.3.
UniGeneHs.533597.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C325-387[»]
ProteinModelPortalQ9BRQ0.
SMRQ9BRQ0. Positions 325-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124760. 13 interactions.
IntActQ9BRQ0. 3 interactions.
MINTMINT-8177751.
STRING9606.ENSP00000357442.

PTM databases

PhosphoSiteQ9BRQ0.

Polymorphism databases

DMDM23396825.

Proteomic databases

MaxQBQ9BRQ0.
PaxDbQ9BRQ0.
PRIDEQ9BRQ0.

Protocols and materials databases

DNASU90780.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368457; ENSP00000357442; ENSG00000163348.
GeneID90780.
KEGGhsa:90780.
UCSCuc001fft.3. human.

Organism-specific databases

CTD90780.
GeneCardsGC01M154929.
HGNCHGNC:30257. PYGO2.
HPAHPA023689.
MIM606903. gene.
neXtProtNX_Q9BRQ0.
PharmGKBPA134881185.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72798.
HOGENOMHOG000001580.
HOVERGENHBG053774.
InParanoidQ9BRQ0.
OMAPGLVYPC.
OrthoDBEOG79W952.
PhylomeDBQ9BRQ0.
TreeFamTF333020.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9BRQ0.
BgeeQ9BRQ0.
CleanExHS_PYGO2.
GenevestigatorQ9BRQ0.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPYGO2.
GenomeRNAi90780.
NextBio76956.
PROQ9BRQ0.
SOURCESearch...

Entry information

Entry namePYGO2_HUMAN
AccessionPrimary (citable) accession number: Q9BRQ0
Secondary accession number(s): Q8WYZ4, Q96CY2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM