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Q9BRP8

- WIBG_HUMAN

UniProt

Q9BRP8 - WIBG_HUMAN

Protein

Partner of Y14 and mago

Gene

WIBG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. ribosome binding Source: UniProtKB

    GO - Biological processi

    1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
    2. positive regulation of translation Source: UniProtKB

    Keywords - Biological processi

    Nonsense-mediated mRNA decay, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Partner of Y14 and mago
    Alternative name(s):
    Protein wibg homolog
    Gene namesi
    Name:WIBG
    Synonyms:PYM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30258. WIBG.

    Subcellular locationi

    Cytoplasm. Nucleusnucleolus. Nucleusnucleoplasm
    Note: Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exon-exon junction complex Source: UniProtKB
    3. nucleolus Source: UniProtKB-SubCell
    4. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670574.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Partner of Y14 and magoPRO_0000287285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Modified residuei6 – 61Phosphoserine1 Publication
    Modified residuei64 – 641Phosphoserine1 Publication
    Modified residuei72 – 721Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BRP8.
    PaxDbiQ9BRP8.
    PRIDEiQ9BRP8.

    PTM databases

    PhosphoSiteiQ9BRP8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BRP8.
    BgeeiQ9BRP8.
    CleanExiHS_WIBG.
    GenevestigatoriQ9BRP8.

    Organism-specific databases

    HPAiHPA046200.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORF57Q2HR754EBI-2352802,EBI-6884751From a different organism.

    Protein-protein interaction databases

    BioGridi124031. 50 interactions.
    DIPiDIP-48413N.
    IntActiQ9BRP8. 10 interactions.
    MINTiMINT-3060675.
    STRINGi9606.ENSP00000386156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRP8.
    SMRiQ9BRP8. Positions 6-38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3333Required for interaction with MAGOH and RBM8AAdd
    BLAST
    Regioni152 – 20453eIF2A-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili82 – 11635Sequence AnalysisAdd
    BLAST
    Coiled coili145 – 20460Sequence AnalysisAdd
    BLAST

    Domaini

    The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal subunit and the 48S preinitiation complex.1 Publication

    Sequence similaritiesi

    Belongs to the wibg family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG114683.
    HOGENOMiHOG000215176.
    HOVERGENiHBG097451.
    InParanoidiQ9BRP8.
    KOiK14294.
    OMAiQQKIPGC.
    OrthoDBiEOG7HMS3N.
    PhylomeDBiQ9BRP8.
    TreeFamiTF324615.

    Family and domain databases

    InterProiIPR015362. EJC_Pym.
    [Graphical view]
    PfamiPF09282. Mago-bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF101931. SSF101931. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRP8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAAGSPAAT ETGKYIASTQ RPDGTWRKQR RVKEGYVPQE EVPVYENKYV    50
    KFFKSKPELP PGLSPEATAP VTPSRPEGGE PGLSKTAKRN LKRKEKRRQQ 100
    QEKGEAEALS RTLDKVSLEE TAQLPSAPQG SRAAPTAASD QPDSAATTEK 150
    AKKIKNLKKK LRQVEELQQR IQAGEVSQPS KEQLEKLARR RALEEELEDL 200
    ELGL 204
    Length:204
    Mass (Da):22,656
    Last modified:June 1, 2001 - v1
    Checksum:i087B901279007C05
    GO
    Isoform 2 (identifier: Q9BRP8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MEAAGSPAATET → MATPYVTDETG

    Show »
    Length:203
    Mass (Da):22,705
    Checksum:i67BA3B0E86D8C581
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471T → S in CAD30677. (PubMed:12438415)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661E → Q.
    Corresponds to variant rs3802998 [ dbSNP | Ensembl ].
    VAR_032297

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212MEAAG…AATET → MATPYVTDETG in isoform 2. 1 PublicationVSP_025430Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459406 mRNA. Translation: CAD30677.1.
    AK096922 mRNA. Translation: BAC04897.1.
    AC023055 Genomic DNA. No translation available.
    AC025162 Genomic DNA. No translation available.
    BC006135 mRNA. Translation: AAH06135.1.
    BC014976 mRNA. Translation: AAH14976.1.
    CCDSiCCDS41795.1. [Q9BRP8-1]
    CCDS44916.1. [Q9BRP8-2]
    RefSeqiNP_001137325.1. NM_001143853.1. [Q9BRP8-2]
    NP_115721.1. NM_032345.2. [Q9BRP8-1]
    UniGeneiHs.505687.
    Hs.524488.

    Genome annotation databases

    EnsembliENST00000398213; ENSP00000381271; ENSG00000170473. [Q9BRP8-2]
    ENST00000408946; ENSP00000386156; ENSG00000170473. [Q9BRP8-1]
    GeneIDi84305.
    KEGGihsa:84305.
    UCSCiuc001sie.1. human. [Q9BRP8-2]
    uc001sif.1. human. [Q9BRP8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459406 mRNA. Translation: CAD30677.1 .
    AK096922 mRNA. Translation: BAC04897.1 .
    AC023055 Genomic DNA. No translation available.
    AC025162 Genomic DNA. No translation available.
    BC006135 mRNA. Translation: AAH06135.1 .
    BC014976 mRNA. Translation: AAH14976.1 .
    CCDSi CCDS41795.1. [Q9BRP8-1 ]
    CCDS44916.1. [Q9BRP8-2 ]
    RefSeqi NP_001137325.1. NM_001143853.1. [Q9BRP8-2 ]
    NP_115721.1. NM_032345.2. [Q9BRP8-1 ]
    UniGenei Hs.505687.
    Hs.524488.

    3D structure databases

    ProteinModelPortali Q9BRP8.
    SMRi Q9BRP8. Positions 6-38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124031. 50 interactions.
    DIPi DIP-48413N.
    IntActi Q9BRP8. 10 interactions.
    MINTi MINT-3060675.
    STRINGi 9606.ENSP00000386156.

    PTM databases

    PhosphoSitei Q9BRP8.

    Proteomic databases

    MaxQBi Q9BRP8.
    PaxDbi Q9BRP8.
    PRIDEi Q9BRP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398213 ; ENSP00000381271 ; ENSG00000170473 . [Q9BRP8-2 ]
    ENST00000408946 ; ENSP00000386156 ; ENSG00000170473 . [Q9BRP8-1 ]
    GeneIDi 84305.
    KEGGi hsa:84305.
    UCSCi uc001sie.1. human. [Q9BRP8-2 ]
    uc001sif.1. human. [Q9BRP8-1 ]

    Organism-specific databases

    CTDi 84305.
    GeneCardsi GC12M056295.
    HGNCi HGNC:30258. WIBG.
    HPAi HPA046200.
    neXtProti NX_Q9BRP8.
    PharmGKBi PA142670574.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG114683.
    HOGENOMi HOG000215176.
    HOVERGENi HBG097451.
    InParanoidi Q9BRP8.
    KOi K14294.
    OMAi QQKIPGC.
    OrthoDBi EOG7HMS3N.
    PhylomeDBi Q9BRP8.
    TreeFami TF324615.

    Miscellaneous databases

    GenomeRNAii 84305.
    NextBioi 73984.
    PROi Q9BRP8.

    Gene expression databases

    ArrayExpressi Q9BRP8.
    Bgeei Q9BRP8.
    CleanExi HS_WIBG.
    Genevestigatori Q9BRP8.

    Family and domain databases

    InterProi IPR015362. EJC_Pym.
    [Graphical view ]
    Pfami PF09282. Mago-bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101931. SSF101931. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export."
      Gatfield D., Izaurralde E.
      J. Cell Biol. 159:579-588(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell and Pancreas.
    5. "Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex."
      Bono F., Ebert J., Unterholzner L., Guettler T., Izaurralde E., Conti E.
      EMBO Rep. 5:304-310(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MAGOH AND RBM8A, RNA-BINDING.
    6. "PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs."
      Diem M.D., Chan C.C., Younis I., Dreyfuss G.
      Nat. Struct. Mol. Biol. 14:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN EIF2A-LIKE, INTERACTION WITH MAGOH; RBM8A AND RIBOSOME.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND THR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Disassembly of exon junction complexes by PYM."
      Gehring N.H., Lamprinaki S., Kulozik A.E., Hentze M.W.
      Cell 137:536-548(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAGOH; RBM8A AND RIBOSOME.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWIBG_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRP8
    Secondary accession number(s): B6ZDM5, Q8IXJ8, Q8N8E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3