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Protein

Ferredoxin-fold anticodon-binding domain-containing protein 1

Gene

FDXACB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-fold anticodon-binding domain-containing protein 1
Short name:
FDX-ACDB domain-containing protein 1
Gene namesi
Name:FDXACB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25110. FDXACB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720055.

Polymorphism and mutation databases

BioMutaiFDXACB1.
DMDMi296439342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624Ferredoxin-fold anticodon-binding domain-containing protein 1PRO_0000325956Add
BLAST

Proteomic databases

MaxQBiQ9BRP7.
PaxDbiQ9BRP7.
PRIDEiQ9BRP7.

PTM databases

iPTMnetiQ9BRP7.
PhosphoSiteiQ9BRP7.

Expressioni

Gene expression databases

BgeeiQ9BRP7.
CleanExiHS_FDXACB1.
ExpressionAtlasiQ9BRP7. baseline and differential.
GenevisibleiQ9BRP7. HS.

Organism-specific databases

HPAiHPA039012.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129333EBI-10297077,EBI-355744

Protein-protein interaction databases

BioGridi124890. 5 interactions.
IntActiQ9BRP7. 1 interaction.
STRINGi9606.ENSP00000260257.

Structurei

3D structure databases

ProteinModelPortaliQ9BRP7.
SMRiQ9BRP7. Positions 489-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini531 – 62494FDX-ACBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FDX-ACB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2783. Eukaryota.
KOG4174. Eukaryota.
ENOG41108X7. LUCA.
GeneTreeiENSGT00530000063467.
HOGENOMiHOG000112565.
HOVERGENiHBG069342.
InParanoidiQ9BRP7.
OMAiRFQHPKT.
PhylomeDBiQ9BRP7.
TreeFamiTF329685.

Family and domain databases

Gene3Di3.30.70.380. 1 hit.
InterProiIPR019446. DUF2431.
IPR005121. PheS_beta_Fdx_antiC-bd.
[Graphical view]
PfamiPF10354. DUF2431. 1 hit.
PF03147. FDX-ACB. 1 hit.
[Graphical view]
SMARTiSM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF54991. SSF54991. 1 hit.
PROSITEiPS51447. FDX_ACB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRRLLLVG EGNFSFAAAL SETLDQSTQL TATCLQRPAE LARDPLAWEN
60 70 80 90 100
LQCLRERGID VRFGVDCTQL ADVFELHERE FDQIYFIFPH CGRKAGVAKN
110 120 130 140 150
RELLAKFFQS CADVLAEEGE VHVALCRGQG GTPADKPQRE WHNSWQVVAM
160 170 180 190 200
AALGGLILSD VYPFSCKAVA GYKCTGYRSQ DKSFHVEGAL NHIFTRSLPF
210 220 230 240 250
EGSQPRIFRI KLGNQWFSFP EPEALVGKLN RGFLEAPSCH PIKTINEKLI
260 270 280 290 300
AELGKVFPLK RLKCSYPLLP QEGTSVLPFW NCDFLSAAFW ISLHEDNSNS
310 320 330 340 350
ESLTGGTSQD VEDFLVSFSE LSLLKNPGRD GKEEACEGTC GQAKICLRPS
360 370 380 390 400
LLVHVQDVIE VPDFLSGSLH ILSGPVFQKC HILPFTMPAF HETLFILGVN
410 420 430 440 450
QNLKDGCLQS LLDHLKGILD SLLTQTLPES SKLSSLVKFV LQSNGKDYMI
460 470 480 490 500
RVKTHNFSPD CTEDLIIGSV ITSATSVIHK DQCFVFVSMN LDLLAMLVWC
510 520 530 540 550
ISDWRMLWTF DNRFLKNFVP GKIEPFKSHS LYPPCYVHDV SFWIDQKKGF
560 570 580 590 600
DELEFHTVAR AVSQDTIISI QFLSRFQHPK TQQVSLCYRL TYQTCDKALT
610 620
QQQVASMQSQ FRKEIQQHLY VIPR
Length:624
Mass (Da):70,416
Last modified:May 18, 2010 - v3
Checksum:i13E0C603F94B3E06
GO
Isoform 2 (identifier: Q9BRP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):53,689
Checksum:i98DAF2D22D7265DD
GO

Sequence cautioni

The sequence AAH06136.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → A.
Corresponds to variant rs59164893 [ dbSNP | Ensembl ].
VAR_062165
Natural varianti87 – 871I → N.2 Publications
Corresponds to variant rs611010 [ dbSNP | Ensembl ].
VAR_060321
Natural varianti475 – 4751T → P.
Corresponds to variant rs3168263 [ dbSNP | Ensembl ].
VAR_060322

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 149149Missing in isoform 2. 1 PublicationVSP_056997Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300795 mRNA. Translation: BAG62454.1.
AP001781 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67156.1.
BC006136 mRNA. Translation: AAH06136.1. Different initiation.
BC127680 mRNA. Translation: AAI27681.1.
CCDSiCCDS44729.1. [Q9BRP7-1]
RefSeqiNP_612387.1. NM_138378.2. [Q9BRP7-1]
UniGeneiHs.697132.

Genome annotation databases

EnsembliENST00000260257; ENSP00000260257; ENSG00000255561. [Q9BRP7-1]
GeneIDi91893.
KEGGihsa:91893.
UCSCiuc001pmc.5. human. [Q9BRP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300795 mRNA. Translation: BAG62454.1.
AP001781 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67156.1.
BC006136 mRNA. Translation: AAH06136.1. Different initiation.
BC127680 mRNA. Translation: AAI27681.1.
CCDSiCCDS44729.1. [Q9BRP7-1]
RefSeqiNP_612387.1. NM_138378.2. [Q9BRP7-1]
UniGeneiHs.697132.

3D structure databases

ProteinModelPortaliQ9BRP7.
SMRiQ9BRP7. Positions 489-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124890. 5 interactions.
IntActiQ9BRP7. 1 interaction.
STRINGi9606.ENSP00000260257.

PTM databases

iPTMnetiQ9BRP7.
PhosphoSiteiQ9BRP7.

Polymorphism and mutation databases

BioMutaiFDXACB1.
DMDMi296439342.

Proteomic databases

MaxQBiQ9BRP7.
PaxDbiQ9BRP7.
PRIDEiQ9BRP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260257; ENSP00000260257; ENSG00000255561. [Q9BRP7-1]
GeneIDi91893.
KEGGihsa:91893.
UCSCiuc001pmc.5. human. [Q9BRP7-1]

Organism-specific databases

CTDi91893.
GeneCardsiFDXACB1.
HGNCiHGNC:25110. FDXACB1.
HPAiHPA039012.
neXtProtiNX_Q9BRP7.
PharmGKBiPA164720055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2783. Eukaryota.
KOG4174. Eukaryota.
ENOG41108X7. LUCA.
GeneTreeiENSGT00530000063467.
HOGENOMiHOG000112565.
HOVERGENiHBG069342.
InParanoidiQ9BRP7.
OMAiRFQHPKT.
PhylomeDBiQ9BRP7.
TreeFamiTF329685.

Miscellaneous databases

NextBioi35475273.
PROiQ9BRP7.

Gene expression databases

BgeeiQ9BRP7.
CleanExiHS_FDXACB1.
ExpressionAtlasiQ9BRP7. baseline and differential.
GenevisibleiQ9BRP7. HS.

Family and domain databases

Gene3Di3.30.70.380. 1 hit.
InterProiIPR019446. DUF2431.
IPR005121. PheS_beta_Fdx_antiC-bd.
[Graphical view]
PfamiPF10354. DUF2431. 1 hit.
PF03147. FDX-ACB. 1 hit.
[Graphical view]
SMARTiSM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF54991. SSF54991. 1 hit.
PROSITEiPS51447. FDX_ACB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-87.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-87.
    Tissue: Lymph.

Entry informationi

Entry nameiFDXA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP7
Secondary accession number(s): A0PJW7, B4DUU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.