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Protein

Programmed cell death protein 2-like

Gene

PDCD2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126249-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2-like
Gene namesi
Name:PDCD2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28194. PDCD2L.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: InterPro
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126249.
PharmGKBiPA144596395.

Polymorphism and mutation databases

BioMutaiPDCD2L.
DMDMi74732907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002726452 – 358Programmed cell death protein 2-likeAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei22PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRP1.
MaxQBiQ9BRP1.
PaxDbiQ9BRP1.
PeptideAtlasiQ9BRP1.
PRIDEiQ9BRP1.

PTM databases

iPTMnetiQ9BRP1.
PhosphoSitePlusiQ9BRP1.

Expressioni

Tissue specificityi

Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000126249.
CleanExiHS_PDCD2L.
ExpressionAtlasiQ9BRP1. baseline and differential.
GenevisibleiQ9BRP1. HS.

Interactioni

Protein-protein interaction databases

BioGridi124032. 22 interactors.
IntActiQ9BRP1. 5 interactors.
STRINGi9606.ENSP00000246535.

Structurei

3D structure databases

ProteinModelPortaliQ9BRP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
GeneTreeiENSGT00530000063570.
HOGENOMiHOG000232160.
HOVERGENiHBG060880.
InParanoidiQ9BRP1.
KOiK14801.
OMAiDLMRYEH.
OrthoDBiEOG091G0F9T.
PhylomeDBiQ9BRP1.
TreeFamiTF354282.

Family and domain databases

InterProiIPR007320. PDCD2_C.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLKPVLL GLRDAPVHGS PTGPGAWTAS KLGGIPDALP TVAAPRPVCQ
60 70 80 90 100
RCGQPLALVV QVYCPLEGSP FHRLLHVFAC ACPGCSTGGA RSWKVFRSQC
110 120 130 140 150
LQVPEREAQD AQKQGNSLAA EDWCEGADDW GSDTEEGPSP QFTLDFGNDA
160 170 180 190 200
SSAKDVDWTA RLQDLRLQDA VLGAAHPVPP GLPLFLPYYI CVADEDDYRD
210 220 230 240 250
FVNLDHAHSL LRDYQQREGI AMDQLLSQSL PNDGDEKYEK TIIKSGDQTF
260 270 280 290 300
YKFMKRIAAC QEQILRYSWS GEPLFLTCPT SEVTELPACS QCGGQRIFEF
310 320 330 340 350
QLMPALVSML KSANLGLSVE FGTILVYTCE KSCWPPNHQT PMEEFCIIQE

DPDELLFK
Length:358
Mass (Da):39,417
Last modified:June 1, 2001 - v1
Checksum:i3946A6E4AD760155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008747 Genomic DNA. No translation available.
AC092073 Genomic DNA. No translation available.
BC006146 mRNA. Translation: AAH06146.1.
CCDSiCCDS12438.1.
RefSeqiNP_115722.1. NM_032346.1.
UniGeneiHs.515344.

Genome annotation databases

EnsembliENST00000246535; ENSP00000246535; ENSG00000126249.
GeneIDi84306.
KEGGihsa:84306.
UCSCiuc002nvj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008747 Genomic DNA. No translation available.
AC092073 Genomic DNA. No translation available.
BC006146 mRNA. Translation: AAH06146.1.
CCDSiCCDS12438.1.
RefSeqiNP_115722.1. NM_032346.1.
UniGeneiHs.515344.

3D structure databases

ProteinModelPortaliQ9BRP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124032. 22 interactors.
IntActiQ9BRP1. 5 interactors.
STRINGi9606.ENSP00000246535.

PTM databases

iPTMnetiQ9BRP1.
PhosphoSitePlusiQ9BRP1.

Polymorphism and mutation databases

BioMutaiPDCD2L.
DMDMi74732907.

Proteomic databases

EPDiQ9BRP1.
MaxQBiQ9BRP1.
PaxDbiQ9BRP1.
PeptideAtlasiQ9BRP1.
PRIDEiQ9BRP1.

Protocols and materials databases

DNASUi84306.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246535; ENSP00000246535; ENSG00000126249.
GeneIDi84306.
KEGGihsa:84306.
UCSCiuc002nvj.4. human.

Organism-specific databases

CTDi84306.
GeneCardsiPDCD2L.
HGNCiHGNC:28194. PDCD2L.
MIMi615661. gene.
neXtProtiNX_Q9BRP1.
OpenTargetsiENSG00000126249.
PharmGKBiPA144596395.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
GeneTreeiENSGT00530000063570.
HOGENOMiHOG000232160.
HOVERGENiHBG060880.
InParanoidiQ9BRP1.
KOiK14801.
OMAiDLMRYEH.
OrthoDBiEOG091G0F9T.
PhylomeDBiQ9BRP1.
TreeFamiTF354282.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126249-MONOMER.

Miscellaneous databases

ChiTaRSiPDCD2L. human.
GenomeRNAii84306.
PROiQ9BRP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126249.
CleanExiHS_PDCD2L.
ExpressionAtlasiQ9BRP1. baseline and differential.
GenevisibleiQ9BRP1. HS.

Family and domain databases

InterProiIPR007320. PDCD2_C.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDD2L_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.