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Protein

Transcription factor Ovo-like 2

Gene

OVOL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Ovo-like 2
Short name:
hOvo2
Alternative name(s):
Zinc finger protein 339
Gene namesi
Name:OVOL2
Synonyms:ZNF339
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15804. OVOL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38039.

Polymorphism and mutation databases

BioMutaiOVOL2.
DMDMi23396998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Transcription factor Ovo-like 2PRO_0000047013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BRP0.
PaxDbiQ9BRP0.
PRIDEiQ9BRP0.

PTM databases

PhosphoSiteiQ9BRP0.

Expressioni

Tissue specificityi

Expressed in testis, ovary, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9BRP0.
CleanExiHS_OVOL2.
GenevestigatoriQ9BRP0.

Organism-specific databases

HPAiHPA038531.

Interactioni

Protein-protein interaction databases

BioGridi121825. 1 interaction.
MINTiMINT-2816000.

Structurei

3D structure databases

ProteinModelPortaliQ9BRP0.
SMRiQ9BRP0. Positions 119-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255026.
GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiQ9BRP0.
KOiK09216.
OMAiHPGSTFL.
OrthoDBiEOG786H2K.
PhylomeDBiQ9BRP0.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like_2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVFLVKRR SLGVSVRSWD ELPDEKRADT YIPVGLGRLL HDPPEDCRSD
60 70 80 90 100
GGSSSGSGSS SAGEPGGAES SSSPHAPESE TPEPGDAEGP DGHLATKQRP
110 120 130 140 150
VARSKIKFTT GTCSDSVVHS CDLCGKGFRL QRMLNRHLKC HNQVKRHLCT
160 170 180 190 200
FCGKGFNDTF DLKRHVRTHT GIRPYKCNVC NKAFTQRCSL ESHLKKIHGV
210 220 230 240 250
QQQYAYKQRR DKLYVCEDCG YTGPTQEDLY LHVNSAHPGS SFLKKTSKKL
260 270
AALLQGKLTS AHQENTSLSE EEERK
Length:275
Mass (Da):30,438
Last modified:June 1, 2001 - v1
Checksum:i3563EC44510E04AB
GO
Isoform 2 (identifier: Q9BRP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.

Show »
Length:143
Mass (Da):16,565
Checksum:iD31E5CE44B06FB2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641E → G in BAB14002 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 132132Missing in isoform 2. CuratedVSP_038260Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022284 mRNA. Translation: BAB14002.1.
BT007295 mRNA. Translation: AAP35959.1.
AL121585, AL160411 Genomic DNA. Translation: CAI14857.1.
AL160411, AL121585 Genomic DNA. Translation: CAI22534.1.
CH471133 Genomic DNA. Translation: EAX10258.1.
CH471133 Genomic DNA. Translation: EAX10259.1.
BC006148 mRNA. Translation: AAH06148.1.
AL079276 mRNA. Translation: CAB45151.1.
CCDSiCCDS13132.1. [Q9BRP0-1]
RefSeqiNP_067043.2. NM_021220.3. [Q9BRP0-1]
UniGeneiHs.661013.
Hs.710157.

Genome annotation databases

EnsembliENST00000278780; ENSP00000278780; ENSG00000125850. [Q9BRP0-1]
GeneIDi58495.
KEGGihsa:58495.
UCSCiuc002wqi.1. human. [Q9BRP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022284 mRNA. Translation: BAB14002.1.
BT007295 mRNA. Translation: AAP35959.1.
AL121585, AL160411 Genomic DNA. Translation: CAI14857.1.
AL160411, AL121585 Genomic DNA. Translation: CAI22534.1.
CH471133 Genomic DNA. Translation: EAX10258.1.
CH471133 Genomic DNA. Translation: EAX10259.1.
BC006148 mRNA. Translation: AAH06148.1.
AL079276 mRNA. Translation: CAB45151.1.
CCDSiCCDS13132.1. [Q9BRP0-1]
RefSeqiNP_067043.2. NM_021220.3. [Q9BRP0-1]
UniGeneiHs.661013.
Hs.710157.

3D structure databases

ProteinModelPortaliQ9BRP0.
SMRiQ9BRP0. Positions 119-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121825. 1 interaction.
MINTiMINT-2816000.

PTM databases

PhosphoSiteiQ9BRP0.

Polymorphism and mutation databases

BioMutaiOVOL2.
DMDMi23396998.

Proteomic databases

MaxQBiQ9BRP0.
PaxDbiQ9BRP0.
PRIDEiQ9BRP0.

Protocols and materials databases

DNASUi58495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278780; ENSP00000278780; ENSG00000125850. [Q9BRP0-1]
GeneIDi58495.
KEGGihsa:58495.
UCSCiuc002wqi.1. human. [Q9BRP0-1]

Organism-specific databases

CTDi58495.
GeneCardsiGC20M017937.
HGNCiHGNC:15804. OVOL2.
HPAiHPA038531.
neXtProtiNX_Q9BRP0.
PharmGKBiPA38039.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255026.
GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiQ9BRP0.
KOiK09216.
OMAiHPGSTFL.
OrthoDBiEOG786H2K.
PhylomeDBiQ9BRP0.
TreeFamiTF337552.

Miscellaneous databases

GenomeRNAii58495.
NextBioi64984.
PROiQ9BRP0.

Gene expression databases

BgeeiQ9BRP0.
CleanExiHS_OVOL2.
GenevestigatoriQ9BRP0.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like_2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. The European IMAGE consortium
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-275 (ISOFORM 1).
  7. "Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice."
    Li B., Dai Q., Li L., Nair M., Mackay D.R., Dai X.
    Genomics 80:319-325(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  8. "Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1."
    Wells J., Lee B., Cai A.Q., Karapetyan A., Lee W.J., Rugg E., Sinha S., Nie Q., Dai X.
    J. Biol. Chem. 284:29125-29135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOVOL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP0
Secondary accession number(s): Q5T8B4
, Q9BX22, Q9HA54, Q9Y4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.