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Q9BRP0

- OVOL2_HUMAN

UniProt

Q9BRP0 - OVOL2_HUMAN

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Protein

Transcription factor Ovo-like 2

Gene

OVOL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. dorsal/ventral pattern formation Source: Ensembl
  3. embryonic digestive tract morphogenesis Source: Ensembl
  4. endocardium formation Source: Ensembl
  5. heart looping Source: Ensembl
  6. heart trabecula formation Source: Ensembl
  7. labyrinthine layer blood vessel development Source: Ensembl
  8. negative regulation of cell proliferation Source: Ensembl
  9. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  10. negative regulation of keratinocyte differentiation Source: BHF-UCL
  11. negative regulation of Notch signaling pathway Source: BHF-UCL
  12. negative regulation of transcription, DNA-templated Source: Ensembl
  13. negative regulation of transcription by competitive promoter binding Source: BHF-UCL
  14. neural crest cell migration Source: Ensembl
  15. neural fold formation Source: Ensembl
  16. positive regulation of transcription, DNA-templated Source: Ensembl
  17. regulation of cell cycle Source: BHF-UCL
  18. regulation of keratinocyte proliferation Source: Ensembl
  19. regulation of transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Ovo-like 2
Short name:
hOvo2
Alternative name(s):
Zinc finger protein 339
Gene namesi
Name:OVOL2
Synonyms:ZNF339
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15804. OVOL2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Transcription factor Ovo-like 2PRO_0000047013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BRP0.
PaxDbiQ9BRP0.
PRIDEiQ9BRP0.

PTM databases

PhosphoSiteiQ9BRP0.

Expressioni

Tissue specificityi

Expressed in testis, ovary, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9BRP0.
CleanExiHS_OVOL2.
GenevestigatoriQ9BRP0.

Organism-specific databases

HPAiHPA038531.

Interactioni

Protein-protein interaction databases

BioGridi121825. 1 interaction.
MINTiMINT-2816000.

Structurei

3D structure databases

ProteinModelPortaliQ9BRP0.
SMRiQ9BRP0. Positions 119-220, 232-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255026.
GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiQ9BRP0.
KOiK09216.
OMAiDTYIPVG.
OrthoDBiEOG786H2K.
PhylomeDBiQ9BRP0.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like_2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRP0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVFLVKRR SLGVSVRSWD ELPDEKRADT YIPVGLGRLL HDPPEDCRSD
60 70 80 90 100
GGSSSGSGSS SAGEPGGAES SSSPHAPESE TPEPGDAEGP DGHLATKQRP
110 120 130 140 150
VARSKIKFTT GTCSDSVVHS CDLCGKGFRL QRMLNRHLKC HNQVKRHLCT
160 170 180 190 200
FCGKGFNDTF DLKRHVRTHT GIRPYKCNVC NKAFTQRCSL ESHLKKIHGV
210 220 230 240 250
QQQYAYKQRR DKLYVCEDCG YTGPTQEDLY LHVNSAHPGS SFLKKTSKKL
260 270
AALLQGKLTS AHQENTSLSE EEERK
Length:275
Mass (Da):30,438
Last modified:June 1, 2001 - v1
Checksum:i3563EC44510E04AB
GO
Isoform 2 (identifier: Q9BRP0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.

Show »
Length:143
Mass (Da):16,565
Checksum:iD31E5CE44B06FB2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641E → G in BAB14002. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 132132Missing in isoform 2. CuratedVSP_038260Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022284 mRNA. Translation: BAB14002.1.
BT007295 mRNA. Translation: AAP35959.1.
AL121585, AL160411 Genomic DNA. Translation: CAI14857.1.
AL160411, AL121585 Genomic DNA. Translation: CAI22534.1.
CH471133 Genomic DNA. Translation: EAX10258.1.
CH471133 Genomic DNA. Translation: EAX10259.1.
BC006148 mRNA. Translation: AAH06148.1.
AL079276 mRNA. Translation: CAB45151.1.
CCDSiCCDS13132.1. [Q9BRP0-1]
RefSeqiNP_067043.2. NM_021220.2. [Q9BRP0-1]
XP_005260840.1. XM_005260783.1. [Q9BRP0-2]
UniGeneiHs.661013.
Hs.710157.

Genome annotation databases

EnsembliENST00000278780; ENSP00000278780; ENSG00000125850. [Q9BRP0-1]
GeneIDi58495.
KEGGihsa:58495.
UCSCiuc002wqi.1. human. [Q9BRP0-1]

Polymorphism databases

DMDMi23396998.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022284 mRNA. Translation: BAB14002.1 .
BT007295 mRNA. Translation: AAP35959.1 .
AL121585 , AL160411 Genomic DNA. Translation: CAI14857.1 .
AL160411 , AL121585 Genomic DNA. Translation: CAI22534.1 .
CH471133 Genomic DNA. Translation: EAX10258.1 .
CH471133 Genomic DNA. Translation: EAX10259.1 .
BC006148 mRNA. Translation: AAH06148.1 .
AL079276 mRNA. Translation: CAB45151.1 .
CCDSi CCDS13132.1. [Q9BRP0-1 ]
RefSeqi NP_067043.2. NM_021220.2. [Q9BRP0-1 ]
XP_005260840.1. XM_005260783.1. [Q9BRP0-2 ]
UniGenei Hs.661013.
Hs.710157.

3D structure databases

ProteinModelPortali Q9BRP0.
SMRi Q9BRP0. Positions 119-220, 232-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121825. 1 interaction.
MINTi MINT-2816000.

PTM databases

PhosphoSitei Q9BRP0.

Polymorphism databases

DMDMi 23396998.

Proteomic databases

MaxQBi Q9BRP0.
PaxDbi Q9BRP0.
PRIDEi Q9BRP0.

Protocols and materials databases

DNASUi 58495.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278780 ; ENSP00000278780 ; ENSG00000125850 . [Q9BRP0-1 ]
GeneIDi 58495.
KEGGi hsa:58495.
UCSCi uc002wqi.1. human. [Q9BRP0-1 ]

Organism-specific databases

CTDi 58495.
GeneCardsi GC20M017937.
HGNCi HGNC:15804. OVOL2.
HPAi HPA038531.
neXtProti NX_Q9BRP0.
PharmGKBi PA38039.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255026.
GeneTreei ENSGT00740000115492.
HOGENOMi HOG000231694.
HOVERGENi HBG053384.
InParanoidi Q9BRP0.
KOi K09216.
OMAi DTYIPVG.
OrthoDBi EOG786H2K.
PhylomeDBi Q9BRP0.
TreeFami TF337552.

Miscellaneous databases

GenomeRNAii 58495.
NextBioi 64984.
PROi Q9BRP0.

Gene expression databases

Bgeei Q9BRP0.
CleanExi HS_OVOL2.
Genevestigatori Q9BRP0.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like_2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. The European IMAGE consortium
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-275 (ISOFORM 1).
  7. "Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice."
    Li B., Dai Q., Li L., Nair M., Mackay D.R., Dai X.
    Genomics 80:319-325(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1."
    Wells J., Lee B., Cai A.Q., Karapetyan A., Lee W.J., Rugg E., Sinha S., Nie Q., Dai X.
    J. Biol. Chem. 284:29125-29135(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOVOL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP0
Secondary accession number(s): Q5T8B4
, Q9BX22, Q9HA54, Q9Y4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3