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Q9BRP0

- OVOL2_HUMAN

UniProt

Q9BRP0 - OVOL2_HUMAN

Protein

Transcription factor Ovo-like 2

Gene

OVOL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation By similarity. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. dorsal/ventral pattern formation Source: Ensembl
    3. embryonic digestive tract morphogenesis Source: Ensembl
    4. endocardium formation Source: Ensembl
    5. heart looping Source: Ensembl
    6. heart trabecula formation Source: Ensembl
    7. labyrinthine layer blood vessel development Source: Ensembl
    8. negative regulation of cell proliferation Source: Ensembl
    9. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
    10. negative regulation of keratinocyte differentiation Source: BHF-UCL
    11. negative regulation of Notch signaling pathway Source: BHF-UCL
    12. negative regulation of transcription, DNA-templated Source: Ensembl
    13. negative regulation of transcription by competitive promoter binding Source: BHF-UCL
    14. neural crest cell migration Source: Ensembl
    15. neural fold formation Source: Ensembl
    16. positive regulation of transcription, DNA-templated Source: Ensembl
    17. regulation of cell cycle Source: BHF-UCL
    18. regulation of keratinocyte proliferation Source: Ensembl
    19. regulation of transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Ovo-like 2
    Short name:
    hOvo2
    Alternative name(s):
    Zinc finger protein 339
    Gene namesi
    Name:OVOL2
    Synonyms:ZNF339
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15804. OVOL2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38039.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Transcription factor Ovo-like 2PRO_0000047013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BRP0.
    PaxDbiQ9BRP0.
    PRIDEiQ9BRP0.

    PTM databases

    PhosphoSiteiQ9BRP0.

    Expressioni

    Tissue specificityi

    Expressed in testis, ovary, heart and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9BRP0.
    CleanExiHS_OVOL2.
    GenevestigatoriQ9BRP0.

    Organism-specific databases

    HPAiHPA038531.

    Interactioni

    Protein-protein interaction databases

    BioGridi121825. 1 interaction.
    MINTiMINT-2816000.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRP0.
    SMRiQ9BRP0. Positions 86-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri119 – 14123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri147 – 16923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri175 – 19824C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri214 – 23724C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG255026.
    HOGENOMiHOG000231694.
    HOVERGENiHBG053384.
    InParanoidiQ9BRP0.
    KOiK09216.
    OMAiDTYIPVG.
    OrthoDBiEOG786H2K.
    PhylomeDBiQ9BRP0.
    TreeFamiTF337552.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR027755. TF_Ovo-like_2.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF193. PTHR10032:SF193. 1 hit.
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRP0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPKVFLVKRR SLGVSVRSWD ELPDEKRADT YIPVGLGRLL HDPPEDCRSD    50
    GGSSSGSGSS SAGEPGGAES SSSPHAPESE TPEPGDAEGP DGHLATKQRP 100
    VARSKIKFTT GTCSDSVVHS CDLCGKGFRL QRMLNRHLKC HNQVKRHLCT 150
    FCGKGFNDTF DLKRHVRTHT GIRPYKCNVC NKAFTQRCSL ESHLKKIHGV 200
    QQQYAYKQRR DKLYVCEDCG YTGPTQEDLY LHVNSAHPGS SFLKKTSKKL 250
    AALLQGKLTS AHQENTSLSE EEERK 275
    Length:275
    Mass (Da):30,438
    Last modified:June 1, 2001 - v1
    Checksum:i3563EC44510E04AB
    GO
    Isoform 2 (identifier: Q9BRP0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-132: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:143
    Mass (Da):16,565
    Checksum:iD31E5CE44B06FB2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti264 – 2641E → G in BAB14002. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 132132Missing in isoform 2. CuratedVSP_038260Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022284 mRNA. Translation: BAB14002.1.
    BT007295 mRNA. Translation: AAP35959.1.
    AL121585, AL160411 Genomic DNA. Translation: CAI14857.1.
    AL160411, AL121585 Genomic DNA. Translation: CAI22534.1.
    CH471133 Genomic DNA. Translation: EAX10258.1.
    CH471133 Genomic DNA. Translation: EAX10259.1.
    BC006148 mRNA. Translation: AAH06148.1.
    AL079276 mRNA. Translation: CAB45151.1.
    CCDSiCCDS13132.1. [Q9BRP0-1]
    RefSeqiNP_067043.2. NM_021220.2. [Q9BRP0-1]
    XP_005260840.1. XM_005260783.1. [Q9BRP0-2]
    UniGeneiHs.661013.
    Hs.710157.

    Genome annotation databases

    EnsembliENST00000278780; ENSP00000278780; ENSG00000125850. [Q9BRP0-1]
    GeneIDi58495.
    KEGGihsa:58495.
    UCSCiuc002wqi.1. human. [Q9BRP0-1]

    Polymorphism databases

    DMDMi23396998.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022284 mRNA. Translation: BAB14002.1 .
    BT007295 mRNA. Translation: AAP35959.1 .
    AL121585 , AL160411 Genomic DNA. Translation: CAI14857.1 .
    AL160411 , AL121585 Genomic DNA. Translation: CAI22534.1 .
    CH471133 Genomic DNA. Translation: EAX10258.1 .
    CH471133 Genomic DNA. Translation: EAX10259.1 .
    BC006148 mRNA. Translation: AAH06148.1 .
    AL079276 mRNA. Translation: CAB45151.1 .
    CCDSi CCDS13132.1. [Q9BRP0-1 ]
    RefSeqi NP_067043.2. NM_021220.2. [Q9BRP0-1 ]
    XP_005260840.1. XM_005260783.1. [Q9BRP0-2 ]
    UniGenei Hs.661013.
    Hs.710157.

    3D structure databases

    ProteinModelPortali Q9BRP0.
    SMRi Q9BRP0. Positions 86-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121825. 1 interaction.
    MINTi MINT-2816000.

    PTM databases

    PhosphoSitei Q9BRP0.

    Polymorphism databases

    DMDMi 23396998.

    Proteomic databases

    MaxQBi Q9BRP0.
    PaxDbi Q9BRP0.
    PRIDEi Q9BRP0.

    Protocols and materials databases

    DNASUi 58495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278780 ; ENSP00000278780 ; ENSG00000125850 . [Q9BRP0-1 ]
    GeneIDi 58495.
    KEGGi hsa:58495.
    UCSCi uc002wqi.1. human. [Q9BRP0-1 ]

    Organism-specific databases

    CTDi 58495.
    GeneCardsi GC20M017937.
    HGNCi HGNC:15804. OVOL2.
    HPAi HPA038531.
    neXtProti NX_Q9BRP0.
    PharmGKBi PA38039.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255026.
    HOGENOMi HOG000231694.
    HOVERGENi HBG053384.
    InParanoidi Q9BRP0.
    KOi K09216.
    OMAi DTYIPVG.
    OrthoDBi EOG786H2K.
    PhylomeDBi Q9BRP0.
    TreeFami TF337552.

    Miscellaneous databases

    GenomeRNAii 58495.
    NextBioi 64984.
    PROi Q9BRP0.

    Gene expression databases

    Bgeei Q9BRP0.
    CleanExi HS_OVOL2.
    Genevestigatori Q9BRP0.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR027755. TF_Ovo-like_2.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF193. PTHR10032:SF193. 1 hit.
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. The European IMAGE consortium
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-275 (ISOFORM 1).
    7. "Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice."
      Li B., Dai Q., Li L., Nair M., Mackay D.R., Dai X.
      Genomics 80:319-325(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1."
      Wells J., Lee B., Cai A.Q., Karapetyan A., Lee W.J., Rugg E., Sinha S., Nie Q., Dai X.
      J. Biol. Chem. 284:29125-29135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiOVOL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRP0
    Secondary accession number(s): Q5T8B4
    , Q9BX22, Q9HA54, Q9Y4M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3