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Q9BRN9

- TM2D3_HUMAN

UniProt

Q9BRN9 - TM2D3_HUMAN

Protein

TM2 domain-containing protein 3

Gene

TM2D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TM2 domain-containing protein 3
    Alternative name(s):
    Beta-amyloid-binding protein-like protein 2
    Short name:
    BBP-like protein 2
    Gene namesi
    Name:TM2D3
    Synonyms:BLP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:24128. TM2D3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670800.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 247218TM2 domain-containing protein 3PRO_0000298989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9BRN9.
    PaxDbiQ9BRN9.
    PRIDEiQ9BRN9.

    PTM databases

    PhosphoSiteiQ9BRN9.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9BRN9.
    BgeeiQ9BRN9.
    CleanExiHS_TM2D3.
    GenevestigatoriQ9BRN9.

    Organism-specific databases

    HPAiHPA054064.

    Interactioni

    Protein-protein interaction databases

    BioGridi123181. 2 interactions.
    STRINGi9606.ENSP00000330433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TM2 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG269024.
    HOGENOMiHOG000017272.
    HOVERGENiHBG061208.
    InParanoidiQ9BRN9.
    OMAiADCVECK.
    PhylomeDBiQ9BRN9.
    TreeFamiTF314896.

    Family and domain databases

    InterProiIPR007829. TM2.
    [Graphical view]
    PfamiPF05154. TM2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT    50
    VVPRAAESTE IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC 100
    AVKPSVTCVD QDFKSQKNFI INMTCRFCWQ LPETDYECTN STSCMTVSCP 150
    RQRYPANCTV RDHVHCLGNR TFPKMLYCNW TGGYKWSTAL ALSITLGGFG 200
    ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP ADGSLYI 247
    Length:247
    Mass (Da):27,118
    Last modified:October 5, 2010 - v2
    Checksum:i9E18F6F1E50E41E7
    GO
    Isoform 2 (identifier: Q9BRN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         31-56: Missing.

    Show »
    Length:221
    Mass (Da):24,367
    Checksum:i6E0623AF1A28FC9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61L → R in AAK35066. (PubMed:11278849)Curated
    Sequence conflicti6 – 61L → R in BAB15415. (PubMed:14702039)Curated
    Sequence conflicti6 – 61L → R in BAG37956. (PubMed:14702039)Curated
    Sequence conflicti6 – 61L → R in EAX02315. 1 PublicationCurated
    Sequence conflicti6 – 61L → R in AAH06150. (PubMed:15489334)Curated
    Sequence conflicti6 – 61L → R in AAH08873. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei31 – 5626Missing in isoform 2. 3 PublicationsVSP_027496Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF353992 mRNA. Translation: AAK35066.1.
    AK026257 mRNA. Translation: BAB15415.1.
    AK315584 mRNA. Translation: BAG37956.1.
    AC090164 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02315.1.
    BC006150 mRNA. Translation: AAH06150.1.
    BC008873 mRNA. Translation: AAH08873.1.
    AL512689 mRNA. Translation: CAC21647.1.
    CCDSiCCDS10392.1. [Q9BRN9-2]
    CCDS10393.1. [Q9BRN9-1]
    RefSeqiNP_079417.2. NM_025141.3. [Q9BRN9-2]
    NP_510883.2. NM_078474.2. [Q9BRN9-1]
    UniGeneiHs.288912.

    Genome annotation databases

    EnsembliENST00000333202; ENSP00000330433; ENSG00000184277. [Q9BRN9-1]
    ENST00000347970; ENSP00000327584; ENSG00000184277. [Q9BRN9-2]
    GeneIDi80213.
    KEGGihsa:80213.
    UCSCiuc002bxh.3. human. [Q9BRN9-1]
    uc002bxj.3. human. [Q9BRN9-2]

    Polymorphism databases

    DMDMi308153510.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF353992 mRNA. Translation: AAK35066.1 .
    AK026257 mRNA. Translation: BAB15415.1 .
    AK315584 mRNA. Translation: BAG37956.1 .
    AC090164 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02315.1 .
    BC006150 mRNA. Translation: AAH06150.1 .
    BC008873 mRNA. Translation: AAH08873.1 .
    AL512689 mRNA. Translation: CAC21647.1 .
    CCDSi CCDS10392.1. [Q9BRN9-2 ]
    CCDS10393.1. [Q9BRN9-1 ]
    RefSeqi NP_079417.2. NM_025141.3. [Q9BRN9-2 ]
    NP_510883.2. NM_078474.2. [Q9BRN9-1 ]
    UniGenei Hs.288912.

    3D structure databases

    ProteinModelPortali Q9BRN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123181. 2 interactions.
    STRINGi 9606.ENSP00000330433.

    PTM databases

    PhosphoSitei Q9BRN9.

    Polymorphism databases

    DMDMi 308153510.

    Proteomic databases

    MaxQBi Q9BRN9.
    PaxDbi Q9BRN9.
    PRIDEi Q9BRN9.

    Protocols and materials databases

    DNASUi 80213.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333202 ; ENSP00000330433 ; ENSG00000184277 . [Q9BRN9-1 ]
    ENST00000347970 ; ENSP00000327584 ; ENSG00000184277 . [Q9BRN9-2 ]
    GeneIDi 80213.
    KEGGi hsa:80213.
    UCSCi uc002bxh.3. human. [Q9BRN9-1 ]
    uc002bxj.3. human. [Q9BRN9-2 ]

    Organism-specific databases

    CTDi 80213.
    GeneCardsi GC15M102173.
    HGNCi HGNC:24128. TM2D3.
    HPAi HPA054064.
    MIMi 610014. gene.
    neXtProti NX_Q9BRN9.
    PharmGKBi PA142670800.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269024.
    HOGENOMi HOG000017272.
    HOVERGENi HBG061208.
    InParanoidi Q9BRN9.
    OMAi ADCVECK.
    PhylomeDBi Q9BRN9.
    TreeFami TF314896.

    Miscellaneous databases

    GenomeRNAii 80213.
    NextBioi 70608.
    PROi Q9BRN9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BRN9.
    Bgeei Q9BRN9.
    CleanExi HS_TM2D3.
    Genevestigatori Q9BRN9.

    Family and domain databases

    InterProi IPR007829. TM2.
    [Graphical view ]
    Pfami PF05154. TM2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Small intestine.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon and Muscle.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 168-247.
      Tissue: Lymph node.

    Entry informationi

    Entry nameiTM2D3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRN9
    Secondary accession number(s): B2RDK9, Q9H046, Q9H651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3