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Q9BRN9

- TM2D3_HUMAN

UniProt

Q9BRN9 - TM2D3_HUMAN

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Protein
TM2 domain-containing protein 3
Gene
TM2D3, BLP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
TM2 domain-containing protein 3
Alternative name(s):
Beta-amyloid-binding protein-like protein 2
Short name:
BBP-like protein 2
Gene namesi
Name:TM2D3
Synonyms:BLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:24128. TM2D3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 247218TM2 domain-containing protein 3
PRO_0000298989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BRN9.
PaxDbiQ9BRN9.
PRIDEiQ9BRN9.

PTM databases

PhosphoSiteiQ9BRN9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ9BRN9.
BgeeiQ9BRN9.
CleanExiHS_TM2D3.
GenevestigatoriQ9BRN9.

Organism-specific databases

HPAiHPA054064.

Interactioni

Protein-protein interaction databases

BioGridi123181. 2 interactions.
STRINGi9606.ENSP00000330433.

Structurei

3D structure databases

ProteinModelPortaliQ9BRN9.

Family & Domainsi

Sequence similaritiesi

Belongs to the TM2 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG269024.
HOGENOMiHOG000017272.
HOVERGENiHBG061208.
InParanoidiQ9BRN9.
OMAiADCVECK.
PhylomeDBiQ9BRN9.
TreeFamiTF314896.

Family and domain databases

InterProiIPR007829. TM2.
[Graphical view]
PfamiPF05154. TM2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRN9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT    50
VVPRAAESTE IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC 100
AVKPSVTCVD QDFKSQKNFI INMTCRFCWQ LPETDYECTN STSCMTVSCP 150
RQRYPANCTV RDHVHCLGNR TFPKMLYCNW TGGYKWSTAL ALSITLGGFG 200
ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP ADGSLYI 247
Length:247
Mass (Da):27,118
Last modified:October 5, 2010 - v2
Checksum:i9E18F6F1E50E41E7
GO
Isoform 2 (identifier: Q9BRN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-56: Missing.

Show »
Length:221
Mass (Da):24,367
Checksum:i6E0623AF1A28FC9D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 5626Missing in isoform 2.
VSP_027496Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61L → R in AAK35066. 1 Publication
Sequence conflicti6 – 61L → R in BAB15415. 1 Publication
Sequence conflicti6 – 61L → R in BAG37956. 1 Publication
Sequence conflicti6 – 61L → R in EAX02315. 1 Publication
Sequence conflicti6 – 61L → R in AAH06150. 1 Publication
Sequence conflicti6 – 61L → R in AAH08873. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF353992 mRNA. Translation: AAK35066.1.
AK026257 mRNA. Translation: BAB15415.1.
AK315584 mRNA. Translation: BAG37956.1.
AC090164 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02315.1.
BC006150 mRNA. Translation: AAH06150.1.
BC008873 mRNA. Translation: AAH08873.1.
AL512689 mRNA. Translation: CAC21647.1.
CCDSiCCDS10392.1. [Q9BRN9-2]
CCDS10393.1. [Q9BRN9-1]
RefSeqiNP_079417.2. NM_025141.3. [Q9BRN9-2]
NP_510883.2. NM_078474.2. [Q9BRN9-1]
UniGeneiHs.288912.

Genome annotation databases

EnsembliENST00000333202; ENSP00000330433; ENSG00000184277. [Q9BRN9-1]
ENST00000347970; ENSP00000327584; ENSG00000184277. [Q9BRN9-2]
GeneIDi80213.
KEGGihsa:80213.
UCSCiuc002bxh.3. human. [Q9BRN9-1]
uc002bxj.3. human. [Q9BRN9-2]

Polymorphism databases

DMDMi308153510.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF353992 mRNA. Translation: AAK35066.1 .
AK026257 mRNA. Translation: BAB15415.1 .
AK315584 mRNA. Translation: BAG37956.1 .
AC090164 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02315.1 .
BC006150 mRNA. Translation: AAH06150.1 .
BC008873 mRNA. Translation: AAH08873.1 .
AL512689 mRNA. Translation: CAC21647.1 .
CCDSi CCDS10392.1. [Q9BRN9-2 ]
CCDS10393.1. [Q9BRN9-1 ]
RefSeqi NP_079417.2. NM_025141.3. [Q9BRN9-2 ]
NP_510883.2. NM_078474.2. [Q9BRN9-1 ]
UniGenei Hs.288912.

3D structure databases

ProteinModelPortali Q9BRN9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123181. 2 interactions.
STRINGi 9606.ENSP00000330433.

PTM databases

PhosphoSitei Q9BRN9.

Polymorphism databases

DMDMi 308153510.

Proteomic databases

MaxQBi Q9BRN9.
PaxDbi Q9BRN9.
PRIDEi Q9BRN9.

Protocols and materials databases

DNASUi 80213.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333202 ; ENSP00000330433 ; ENSG00000184277 . [Q9BRN9-1 ]
ENST00000347970 ; ENSP00000327584 ; ENSG00000184277 . [Q9BRN9-2 ]
GeneIDi 80213.
KEGGi hsa:80213.
UCSCi uc002bxh.3. human. [Q9BRN9-1 ]
uc002bxj.3. human. [Q9BRN9-2 ]

Organism-specific databases

CTDi 80213.
GeneCardsi GC15M102173.
HGNCi HGNC:24128. TM2D3.
HPAi HPA054064.
MIMi 610014. gene.
neXtProti NX_Q9BRN9.
PharmGKBi PA142670800.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269024.
HOGENOMi HOG000017272.
HOVERGENi HBG061208.
InParanoidi Q9BRN9.
OMAi ADCVECK.
PhylomeDBi Q9BRN9.
TreeFami TF314896.

Miscellaneous databases

GenomeRNAii 80213.
NextBioi 70608.
PROi Q9BRN9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BRN9.
Bgeei Q9BRN9.
CleanExi HS_TM2D3.
Genevestigatori Q9BRN9.

Family and domain databases

InterProi IPR007829. TM2.
[Graphical view ]
Pfami PF05154. TM2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Small intestine.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon and Muscle.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 168-247.
    Tissue: Lymph node.

Entry informationi

Entry nameiTM2D3_HUMAN
AccessioniPrimary (citable) accession number: Q9BRN9
Secondary accession number(s): B2RDK9, Q9H046, Q9H651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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