Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BRN9 (TM2D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TM2 domain-containing protein 3
Alternative name(s):
Beta-amyloid-binding protein-like protein 2
Short name=BBP-like protein 2
Gene names
Name:TM2D3
Synonyms:BLP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the TM2 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BRN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BRN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-56: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 247218TM2 domain-containing protein 3
PRO_0000298989

Regions

Transmembrane180 – 20021Helical; Potential
Transmembrane216 – 23621Helical; Potential

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence31 – 5626Missing in isoform 2.
VSP_027496

Experimental info

Sequence conflict61L → R in AAK35066. Ref.1
Sequence conflict61L → R in BAB15415. Ref.2
Sequence conflict61L → R in BAG37956. Ref.2
Sequence conflict61L → R in EAX02315. Ref.4
Sequence conflict61L → R in AAH06150. Ref.5
Sequence conflict61L → R in AAH08873. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 9E18F6F1E50E41E7

FASTA24727,118
        10         20         30         40         50         60 
MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT VVPRAAESTE 

        70         80         90        100        110        120 
IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC AVKPSVTCVD QDFKSQKNFI 

       130        140        150        160        170        180 
INMTCRFCWQ LPETDYECTN STSCMTVSCP RQRYPANCTV RDHVHCLGNR TFPKMLYCNW 

       190        200        210        220        230        240 
TGGYKWSTAL ALSITLGGFG ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP 


ADGSLYI 

« Hide

Isoform 2 [UniParc].

Checksum: 6E0623AF1A28FC9D
Show »

FASTA22124,367

References

« Hide 'large scale' references
[1]"Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module."
Kajkowski E.M., Lo C.F., Ning X., Walker S., Sofia H.J., Wang W., Edris W., Chanda P., Wagner E., Vile S., Ryan K., McHendry-Rinde B., Smith S.C., Wood A., Rhodes K.J., Kennedy J.D., Bard J., Jacobsen J.S., Ozenberger B.A.
J. Biol. Chem. 276:18748-18756(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta and Small intestine.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Colon and Muscle.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 168-247.
Tissue: Lymph node.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF353992 mRNA. Translation: AAK35066.1.
AK026257 mRNA. Translation: BAB15415.1.
AK315584 mRNA. Translation: BAG37956.1.
AC090164 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02315.1.
BC006150 mRNA. Translation: AAH06150.1.
BC008873 mRNA. Translation: AAH08873.1.
AL512689 mRNA. Translation: CAC21647.1.
CCDSCCDS10392.1. [Q9BRN9-2]
CCDS10393.1. [Q9BRN9-1]
RefSeqNP_079417.2. NM_025141.3. [Q9BRN9-2]
NP_510883.2. NM_078474.2. [Q9BRN9-1]
UniGeneHs.288912.

3D structure databases

ProteinModelPortalQ9BRN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123181. 2 interactions.
STRING9606.ENSP00000330433.

PTM databases

PhosphoSiteQ9BRN9.

Polymorphism databases

DMDM308153510.

Proteomic databases

MaxQBQ9BRN9.
PaxDbQ9BRN9.
PRIDEQ9BRN9.

Protocols and materials databases

DNASU80213.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333202; ENSP00000330433; ENSG00000184277. [Q9BRN9-1]
ENST00000347970; ENSP00000327584; ENSG00000184277. [Q9BRN9-2]
GeneID80213.
KEGGhsa:80213.
UCSCuc002bxh.3. human. [Q9BRN9-1]
uc002bxj.3. human. [Q9BRN9-2]

Organism-specific databases

CTD80213.
GeneCardsGC15M102173.
HGNCHGNC:24128. TM2D3.
HPAHPA054064.
MIM610014. gene.
neXtProtNX_Q9BRN9.
PharmGKBPA142670800.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269024.
HOGENOMHOG000017272.
HOVERGENHBG061208.
InParanoidQ9BRN9.
OMAADCVECK.
PhylomeDBQ9BRN9.
TreeFamTF314896.

Gene expression databases

ArrayExpressQ9BRN9.
BgeeQ9BRN9.
CleanExHS_TM2D3.
GenevestigatorQ9BRN9.

Family and domain databases

InterProIPR007829. TM2.
[Graphical view]
PfamPF05154. TM2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80213.
NextBio70608.
PROQ9BRN9.
SOURCESearch...

Entry information

Entry nameTM2D3_HUMAN
AccessionPrimary (citable) accession number: Q9BRN9
Secondary accession number(s): B2RDK9, Q9H046, Q9H651
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM