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Protein

Vesicle-trafficking protein SEC22c

Gene

SEC22C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB-KW
  • vesicle fusion with Golgi apparatus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22c
Alternative name(s):
SEC22 vesicle-trafficking protein homolog C
SEC22 vesicle-trafficking protein-like 3
Gene namesi
Name:SEC22C
Synonyms:SEC22L3
ORF Names:UNQ459/PRO784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16828. SEC22C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 183183CytoplasmicSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 22319LumenalSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 2484CytoplasmicSequence analysis
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 2701LumenalSequence analysis
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST
Topological domaini292 – 30312CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952972.

Polymorphism and mutation databases

BioMutaiSEC22C.
DMDMi74732899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Vesicle-trafficking protein SEC22cPRO_0000324161Add
BLAST

Proteomic databases

PaxDbiQ9BRL7.
PeptideAtlasiQ9BRL7.
PRIDEiQ9BRL7.

PTM databases

iPTMnetiQ9BRL7.
PhosphoSiteiQ9BRL7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9BRL7.
CleanExiHS_SEC22C.
ExpressionAtlasiQ9BRL7. baseline and differential.
GenevisibleiQ9BRL7. HS.

Organism-specific databases

HPAiHPA031241.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10297029,EBI-743099

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114565. 7 interactions.
IntActiQ9BRL7. 1 interaction.
STRINGi9606.ENSP00000264454.

Structurei

3D structure databases

ProteinModelPortaliQ9BRL7.
SMRiQ9BRL7. Positions 4-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 119112LonginPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000007733.
HOVERGENiHBG053258.
InParanoidiQ9BRL7.
KOiK08520.
OMAiKWHFNYV.
PhylomeDBiQ9BRL7.
TreeFamiTF105933.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVIFFACVV RVRDGLPLSA STDFYHTQDF LEWRRRLKSL ALRLAQYPGR
60 70 80 90 100
GSAEGCDFSI HFSSFGDVAC MAICSCQCPA AMAFCFLETL WWEFTASYDT
110 120 130 140 150
TCIGLASRPY AFLEFDSIIQ KVKWHFNYVS SSQMECSLEK IQEELKLQPP
160 170 180 190 200
AVLTLEDTDV ANGVMNGHTP MHLEPAPNFR MEPVTALGIL SLILNIMCAA
210 220 230 240 250
LNLIRGVHLA EHSLQVAHEE IGNILAFLVP FVACIFQCYL YLFYSPARTM
260 270 280 290 300
KVVLMLLFIC LGNMYLHGLR NLWQILFHIG VAFLSSYQIL TRQLQEKQSD

CGV
Length:303
Mass (Da):34,269
Last modified:June 1, 2001 - v1
Checksum:i24F908848A8A9625
GO
Isoform 2 (identifier: Q9BRL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-250: CYLYLFYSPARTM → DPRSWFCWLDQTS
     251-303: Missing.

Show »
Length:250
Mass (Da):28,148
Checksum:i278379E87068F5DF
GO
Isoform 3 (identifier: Q9BRL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-228: VAHEEIGNILAFL → DPRSWFCWLDQTS
     229-303: Missing.

Show »
Length:228
Mass (Da):25,735
Checksum:i4CAC49089C1AEF48
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 22813VAHEE…ILAFL → DPRSWFCWLDQTS in isoform 3. 1 PublicationVSP_032161Add
BLAST
Alternative sequencei229 – 30375Missing in isoform 3. 1 PublicationVSP_032162Add
BLAST
Alternative sequencei238 – 25013CYLYL…PARTM → DPRSWFCWLDQTS in isoform 2. 3 PublicationsVSP_032163Add
BLAST
Alternative sequencei251 – 30353Missing in isoform 2. 3 PublicationsVSP_032164Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039568 mRNA. Translation: AAD02171.1.
AK292856 mRNA. Translation: BAF85545.1.
AY359041 mRNA. Translation: AAQ89400.1.
CH471055 Genomic DNA. Translation: EAW64653.1.
CH471055 Genomic DNA. Translation: EAW64654.1.
BC006178 mRNA. Translation: AAH06178.1.
BC018437 mRNA. Translation: AAH18437.1.
CR749670 mRNA. Translation: CAH18461.1.
CCDSiCCDS2699.1. [Q9BRL7-2]
CCDS2700.1. [Q9BRL7-1]
CCDS56246.1. [Q9BRL7-3]
PIRiJE0157.
RefSeqiNP_001188501.1. NM_001201572.1. [Q9BRL7-2]
NP_001188513.1. NM_001201584.1. [Q9BRL7-3]
NP_004197.1. NM_004206.3. [Q9BRL7-2]
NP_116752.1. NM_032970.3. [Q9BRL7-1]
XP_005265589.1. XM_005265532.1. [Q9BRL7-1]
XP_011532514.1. XM_011534212.1. [Q9BRL7-1]
UniGeneiHs.445892.

Genome annotation databases

EnsembliENST00000264454; ENSP00000264454; ENSG00000093183. [Q9BRL7-1]
ENST00000273156; ENSP00000273156; ENSG00000093183. [Q9BRL7-2]
ENST00000417572; ENSP00000407564; ENSG00000093183. [Q9BRL7-2]
ENST00000423701; ENSP00000414576; ENSG00000093183. [Q9BRL7-3]
GeneIDi9117.
KEGGihsa:9117.
UCSCiuc003clh.4. human. [Q9BRL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039568 mRNA. Translation: AAD02171.1.
AK292856 mRNA. Translation: BAF85545.1.
AY359041 mRNA. Translation: AAQ89400.1.
CH471055 Genomic DNA. Translation: EAW64653.1.
CH471055 Genomic DNA. Translation: EAW64654.1.
BC006178 mRNA. Translation: AAH06178.1.
BC018437 mRNA. Translation: AAH18437.1.
CR749670 mRNA. Translation: CAH18461.1.
CCDSiCCDS2699.1. [Q9BRL7-2]
CCDS2700.1. [Q9BRL7-1]
CCDS56246.1. [Q9BRL7-3]
PIRiJE0157.
RefSeqiNP_001188501.1. NM_001201572.1. [Q9BRL7-2]
NP_001188513.1. NM_001201584.1. [Q9BRL7-3]
NP_004197.1. NM_004206.3. [Q9BRL7-2]
NP_116752.1. NM_032970.3. [Q9BRL7-1]
XP_005265589.1. XM_005265532.1. [Q9BRL7-1]
XP_011532514.1. XM_011534212.1. [Q9BRL7-1]
UniGeneiHs.445892.

3D structure databases

ProteinModelPortaliQ9BRL7.
SMRiQ9BRL7. Positions 4-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114565. 7 interactions.
IntActiQ9BRL7. 1 interaction.
STRINGi9606.ENSP00000264454.

PTM databases

iPTMnetiQ9BRL7.
PhosphoSiteiQ9BRL7.

Polymorphism and mutation databases

BioMutaiSEC22C.
DMDMi74732899.

Proteomic databases

PaxDbiQ9BRL7.
PeptideAtlasiQ9BRL7.
PRIDEiQ9BRL7.

Protocols and materials databases

DNASUi9117.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264454; ENSP00000264454; ENSG00000093183. [Q9BRL7-1]
ENST00000273156; ENSP00000273156; ENSG00000093183. [Q9BRL7-2]
ENST00000417572; ENSP00000407564; ENSG00000093183. [Q9BRL7-2]
ENST00000423701; ENSP00000414576; ENSG00000093183. [Q9BRL7-3]
GeneIDi9117.
KEGGihsa:9117.
UCSCiuc003clh.4. human. [Q9BRL7-1]

Organism-specific databases

CTDi9117.
GeneCardsiSEC22C.
HGNCiHGNC:16828. SEC22C.
HPAiHPA031241.
MIMi604028. gene.
neXtProtiNX_Q9BRL7.
PharmGKBiPA134952972.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000007733.
HOVERGENiHBG053258.
InParanoidiQ9BRL7.
KOiK08520.
OMAiKWHFNYV.
PhylomeDBiQ9BRL7.
TreeFamiTF105933.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiSEC22C. human.
GenomeRNAii9117.
PROiQ9BRL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRL7.
CleanExiHS_SEC22C.
ExpressionAtlasiQ9BRL7. baseline and differential.
GenevisibleiQ9BRL7. HS.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24."
    Tang B.L., Low D.Y., Hong W.
    Biochem. Biophys. Res. Commun. 243:885-891(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: B-cell.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-303 (ISOFORM 2).
    Tissue: Amygdala.

Entry informationi

Entry nameiSC22C_HUMAN
AccessioniPrimary (citable) accession number: Q9BRL7
Secondary accession number(s): O95152, Q68CX3, Q6UW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.