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Protein
Submitted name:

PCTK1 protein

Gene

PCTK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9BRL4.

Names & Taxonomyi

Protein namesi
Submitted name:
PCTK1 proteinImported
Gene namesi
Name:PCTK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33095.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ9BRL4.
PRIDEiQ9BRL4.

Expressioni

Gene expression databases

GenevisibleiQ9BRL4. HS.

Interactioni

Protein-protein interaction databases

IntActiQ9BRL4. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9BRL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 398282Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK08820.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRMKKIKRQ LSMTLSSAPE IVHEDLKMGS DGESDQASAT SSDEVQSPVR
60 70 80 90 100
VRMRNHPPRK ISTEDINKRL SLPADIRLPE GYLEKLTLNS PIFDKPLSRR
110 120 130 140 150
LRRVSLSEIG FGKLETYIKL DKLGEGTYAT VYKGKSKLTD NLVALKEIRL
160 170 180 190 200
EHEEGAPCTA IREVSLLKDL KHANIVTLHD IIHTEKSLTL VFEYLDKDLK
210 220 230 240 250
QYLDDCGNII NMHNVKLFLF QLLRGLAYCH RQKVLHRDLK PQNLLINERG
260 270 280 290 300
ELKLADFGLA RAKSIPTKTY SNEVVTLWYR PPDILLGSTD YSTQIDMWGV
310 320 330 340 350
GCIFYEMATG RPLFPGSTVE EQLHFIFRIL GTPTEETWPG ILSNEEFKTY
360 370 380 390 400
NYPKYRAEAL LSHAPRLDSD GADLLTKLLQ FEGRNRISAE DAMKHPFFLS
410 420 430 440
LGERIHKLPD TTSIFALKEI QLQKEASLRS SSMPDSGRPA FRVVDTEF
Length:448
Mass (Da):51,091
Last modified:June 1, 2001 - v1
Checksum:i604E761BBD217D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006190 mRNA. Translation: AAH06190.1.
RefSeqiNP_001163931.1. NM_001170460.1.
NP_006192.1. NM_006201.4.
UniGeneiHs.496068.

Genome annotation databases

GeneIDi5127.
KEGGihsa:5127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006190 mRNA. Translation: AAH06190.1.
RefSeqiNP_001163931.1. NM_001170460.1.
NP_006192.1. NM_006201.4.
UniGeneiHs.496068.

3D structure databases

ProteinModelPortaliQ9BRL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BRL4. 3 interactions.

Proteomic databases

PeptideAtlasiQ9BRL4.
PRIDEiQ9BRL4.

Protocols and materials databases

DNASUi5127.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5127.
KEGGihsa:5127.

Organism-specific databases

CTDi5127.
PharmGKBiPA33095.

Phylogenomic databases

HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK08820.

Enzyme and pathway databases

SignaLinkiQ9BRL4.

Miscellaneous databases

GenomeRNAii5127.

Gene expression databases

GenevisibleiQ9BRL4. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SkinImported.

Entry informationi

Entry nameiQ9BRL4_HUMAN
AccessioniPrimary (citable) accession number: Q9BRL4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.